利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

107 条记录 (耗时 0.087 秒)

    Vanilloid receptor ligands and their use in treatments
    1.
    发明申请
    Vanilloid receptor ligands and their use in treatments 失效
    香草素受体配体及其在治疗中的应用

    公开(公告)号：US20060084640A1

    公开(公告)日：2006-04-20

    申请号：US11251445

    申请日：2005-10-14

    申请人： Vijay Gore ,  Vu Ma ,  Mark Norman ,  Vassil Ognyanov ,  Ning Xi

    发明人： Vijay Gore ,  Vu Ma ,  Mark Norman ,  Vassil Ognyanov ,  Ning Xi

    IPC分类号： A61K31/551 ,  A61K31/496 ,  A61K31/454 ,  A61K31/4439 ,  C07D403/02

    CPC分类号： C07D233/64 ,  C07D401/12

    摘要： Therapeutic benzimidazoles and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

    摘要翻译： 治疗性苯并咪唑和含有它们的组合物，用于治疗急性，炎性和神经性疼痛，牙痛，一般头痛，偏头痛，丛集性头痛，混合血管和非血管综合征，紧张性头痛，一般炎症，关节炎，风湿性疾病，骨关节炎 ，炎症性肠病，炎症性眼病，炎症性或不稳定性膀胱病，银屑病，皮肤炎症成分炎症，慢性炎性病症，炎性疼痛及相关的痛觉过敏和异常性疼痛，神经性疼痛及相关的痛觉过敏和异常性疼痛，糖尿病性神经病疼痛，灼痛，交感神经痛 维持疼痛，输血综合征，哮喘，上皮组织损伤或功能障碍，单纯疱疹，呼吸道，泌尿生殖道，胃肠道或血管区内脏运动紊乱，伤口，烧伤，过敏性皮肤反应，瘙痒，白癜风，一般胃肠道疾病，胃溃疡 十二指肠溃疡，腹泻，坏死因子诱导的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。

    SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE
    5.
    发明申请
    SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE 有权
    取代的氨基嘧啶化合物及其使用方法

    公开(公告)号：US20150087658A1

    公开(公告)日：2015-03-26

    申请号：US14488296

    申请日：2014-09-17

    申请人： Ning Xi ,  Liang Wang ,  Tingjin Wang

    发明人： Ning Xi ,  Liang Wang ,  Tingjin Wang

    IPC分类号： C07D413/14 ,  C07D401/14

    CPC分类号： C07D413/14 ,  A61K31/506 ,  A61K31/517 ,  A61K45/06 ,  C07D401/14 ,  C07D403/14 ,  C07D417/14 ,  Y02A50/409 ,  A61K2300/00

    摘要： The invention relates to the preparation and use of new aminopyrimidine derivatives as drug candidates in free form or in pharmaceutically acceptable salt form and formulations thereof for the modulation of a disorder or disease which is mediated by the activity of the PI3K enzymes. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of disorders or diseases, such as disorders of immunity and inflammation in which PI3K enzymes play a role in leukocyte function, and hyperproliferative disorders associated with PI3K activity, including but not restricted to leukemias and solid tumors, in mammals, especially humans.

    摘要翻译： 本发明涉及新的氨基嘧啶衍生物作为游离形式的候选药物或其药学上可接受的盐形式及其制剂用于调节由PI3K酶的活性介导的病症或疾病的制备和用途。 本发明还提供包含这些化合物的药学上可接受的组合物和使用该组合物治疗疾病或疾病的方法，例如PI3K酶在白细胞功能中起作用的免疫和炎症紊乱，以及与PI3K活性相关的过度增生性疾病， 包括但不限于白血病和实体瘤，哺乳动物，特别是人类。

    End Effector for Nano Manufacturing
    8.
    发明申请
    End Effector for Nano Manufacturing 有权
    纳米制造的终极效应

    公开(公告)号：US20090217508A1

    公开(公告)日：2009-09-03

    申请号：US11989036

    申请日：2006-07-21

    申请人： Ning Xi ,  Uchechukwu Wejinya ,  Yantao Shen

    发明人： Ning Xi ,  Uchechukwu Wejinya ,  Yantao Shen

    IPC分类号： B81C3/00 ,  B81C5/00

    CPC分类号： B81C99/002 ,  Y10S977/872 ,  Y10T29/49998 ,  Y10T29/53991

    摘要： An end-effector is provided for use on a micro/nano manipulation device. The end-effector is comprised of: a micropump fluidly coupled to a microtube; a piezoelectric sensing structure disposed in the microtube; and a processing circuit electrically coupled to the sensing structure for determining the force of the fluid flowing through the microtube. The end-effector is a closed loop control-enabled micro/nano manipulation system.

    摘要翻译： 提供用于微/纳米操纵装置的末端执行器。 末端执行器包括：流体耦合到微管的微型泵; 设置在微管中的压电感测结构; 以及电耦合到感测结构以用于确定流过微管的流体的力的处理电路。 末端执行器是一个闭环控制的微/纳米操纵系统。

    VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS
    9.
    发明申请
    VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS 失效
    VANILLOID受体配体及其在治疗中的应用

    公开(公告)号：US20090143575A1

    公开(公告)日：2009-06-04

    申请号：US12367352

    申请日：2009-02-06

    申请人： Chenera Balan ,  Yunxin Bo ,  Celia Dominguez ,  Christopher H. Fotsch ,  Vijay K. Gore ,  Vu Van Ma ,  Mark H. Norman ,  Vassil I. Ognyanov ,  Yi-xin Qian ,  Xianghong Wang ,  Ning Xi ,  Shimin Xu

    发明人： Chenera Balan ,  Yunxin Bo ,  Celia Dominguez ,  Christopher H. Fotsch ,  Vijay K. Gore ,  Vu Van Ma ,  Mark H. Norman ,  Vassil I. Ognyanov ,  Yi-xin Qian ,  Xianghong Wang ,  Ning Xi ,  Shimin Xu

    IPC分类号： C07D413/14 ,  C07D471/04 ,  C07D401/14

    CPC分类号： C07D401/04 ,  C07D235/30 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

    摘要： Therapeutic benzimidazoles and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotizing agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

    摘要翻译： 治疗性苯并咪唑和含有它们的组合物，用于治疗急性，炎性和神经性疼痛，牙痛，一般头痛，偏头痛，丛集性头痛，混合血管和非血管综合征，紧张性头痛，一般炎症，关节炎，风湿性疾病，骨关节炎 ，炎症性肠病，炎症性眼病，炎症性或不稳定性膀胱病，银屑病，皮肤炎症成分炎症，慢性炎性病症，炎性疼痛及相关的痛觉过敏和异常性疼痛，神经性疼痛及相关的痛觉过敏和异常性疼痛，糖尿病性神经病疼痛，灼痛，交感神经痛 维持疼痛，输血综合征，哮喘，上皮组织损伤或功能障碍，单纯疱疹，呼吸道，泌尿生殖道，胃肠道或血管区内脏运动紊乱，伤口，烧伤，过敏性皮肤反应，瘙痒，白癜风，一般胃肠道疾病，胃溃疡 十二指肠溃疡，腹泻，坏死因子诱发的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。