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公开(公告)号：US20130023561A1
公开(公告)日：2013-01-24
申请号：US13559065
申请日：2012-07-26
申请人： William F. DeGrado , Gregory N. Tew , Michael L. Klein , Dahui Liu , Jing Yuan , Sungwook Choi
发明人： William F. DeGrado , Gregory N. Tew , Michael L. Klein , Dahui Liu , Jing Yuan , Sungwook Choi
IPC分类号： A61K31/167 , A61K31/404 , A01N43/38 , A61K31/4545 , A01P1/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/00 , A01N37/24 , A01N43/40
CPC分类号： A61K31/17 , A61K31/16 , A61K31/165 , A61K31/495 , C07C233/64 , C07C323/42 , C07C323/44 , C08G18/3225 , C08G73/028 , C08L75/02
摘要： The present invention discloses methods of use of facially amphiphilic polymers and oligomers, including pharmaceutical uses of the polymers and oligomers as antimicrobial agents and antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polymers and oligomers and their compositions, including pharmaceutical compositions. The present invention further discloses the design and synthesis of facially amphiphilic polymers and oligomers.
摘要翻译： 本发明公开了使用表面两亲性聚合物和低聚物的方法，包括聚合物和低聚物作为抗微生物剂的药物用途和与肝素治疗相关的出血并发症的解毒剂。 本发明还公开了新颖的表面两亲聚合物和低聚物及其组合物，包括药物组合物。 本发明还公开了表面两亲聚合物和低聚物的设计和合成。
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公开(公告)号：US07173102B2
公开(公告)日：2007-02-06
申请号：US10471028
申请日：2002-03-07
申请人： William F. DeGrado , Gregory N. Tew , Michael L. Klein , Dahui Liu , Jing Yuan
发明人： William F. DeGrado , Gregory N. Tew , Michael L. Klein , Dahui Liu , Jing Yuan
CPC分类号： A61L15/44 , A01N25/10 , A01N37/18 , A01N37/22 , A01N37/24 , A01N37/28 , A01N37/30 , A01N37/42 , A01N47/22 , A01N47/30 , A01N47/44 , A61K31/74 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/20 , A61L2300/216 , A61L2300/404 , C08G18/2865 , C08G18/3225 , C08G61/02 , C08G61/10 , C08G61/122 , C08G69/26 , C08G73/028 , C08G73/22 , C08G2261/312 , Y10T428/193 , Y10T428/24207 , Y10T428/24446 , Y10T428/24455 , Y10T428/29 , Y10T428/31 , Y10T428/31504 , Y10T428/31678 , Y10T428/31725 , Y10T428/8305
摘要： Facially amphiphilic polymers and articles made therefrom having biocidal surfaces are disclosed. The polymers can inhibit the growth of microorganisms in contact with the surface or in areas adjacent to said biocidal surface. There is also disclosed a method to identify and optimize the facial amphiphilicity of polyamide, polyester, polyurea, polyurethane, polycarbonate and polyphenylene polymers. Utility as a contact disinfectant is disclosed.
摘要翻译： 公开了两性聚合物和由其制成的制品具有杀生物面。 聚合物可以抑制与表面或邻近所述杀生物表面的区域接触的微生物的生长。 还公开了一种鉴定和优化聚酰胺，聚酯，聚脲，聚氨酯，聚碳酸酯和聚亚苯基聚合物的面部两亲性的方法。 公开了作为接触消毒剂的效用。
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公开(公告)号：US08455490B2
公开(公告)日：2013-06-04
申请号：US13559065
申请日：2012-07-26
申请人： William F. DeGrado , Gregory N. Tew , Michael L. Klein , Dahui Liu , Jing Yuan , Sungwook Choi
发明人： William F. DeGrado , Gregory N. Tew , Michael L. Klein , Dahui Liu , Jing Yuan , Sungwook Choi
IPC分类号： A01N43/58 , A01N43/60 , A01N43/54 , A61K31/50 , A61K31/495 , C07D239/42 , C07D471/04 , C07D471/22 , C07D487/04
CPC分类号： A61K31/17 , A61K31/16 , A61K31/165 , A61K31/495 , C07C233/64 , C07C323/42 , C07C323/44 , C08G18/3225 , C08G73/028 , C08L75/02
摘要： The present invention discloses methods of use of facially amphiphilic polymers and oligomers, including pharmaceutical uses of the polymers and oligomers as antimicrobial agents and antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polymers and oligomers and their compositions, including pharmaceutical compositions. The present invention further discloses the design and synthesis of facially amphiphilic polymers and oligomers.
摘要翻译： 本发明公开了使用表面两亲性聚合物和低聚物的方法，包括聚合物和低聚物作为抗微生物剂的药物用途和与肝素治疗相关的出血并发症的解毒剂。 本发明还公开了新颖的表面两亲聚合物和低聚物及其组合物，包括药物组合物。 本发明还公开了表面两亲聚合物和低聚物的设计和合成。
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公开(公告)号：US20080176807A1
公开(公告)日：2008-07-24
申请号：US11980785
申请日：2007-10-31
申请人： William F. DeGrado , Gregory N. Tew , Michael L. Klein , Dahui Liu , Jing Yuan , Sungwook Choi
发明人： William F. DeGrado , Gregory N. Tew , Michael L. Klein , Dahui Liu , Jing Yuan , Sungwook Choi
IPC分类号： A61K38/07 , A61K38/05 , C07K5/10 , A61P31/04 , A61P31/12 , A01P1/00 , A61P31/10 , A01N37/44 , C07C233/64
CPC分类号： A61K31/17 , A61K31/16 , A61K31/165 , A61K31/495 , C07C233/64 , C07C323/42 , C07C323/44 , C08G18/3225 , C08G73/028 , C08L75/02
摘要： The present invention discloses methods of use of facially amphiphilic polymers and oligomers, including pharmaceutical uses of the polymers and oligomers as antimicrobial agents and antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polymers and oligomers and their compositions, including pharmaceutical compositions. The present invention further discloses the design and synthesis of facially amphiphilic polymers and oligomers.
摘要翻译： 本发明公开了使用表面两亲性聚合物和低聚物的方法，包括聚合物和低聚物作为抗微生物剂的药物用途和与肝素治疗相关的出血并发症的解毒剂。 本发明还公开了新颖的表面两亲聚合物和低聚物及其组合物，包括药物组合物。 本发明还公开了表面两亲聚合物和低聚物的设计和合成。
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公开(公告)号：US09241917B2
公开(公告)日：2016-01-26
申请号：US10801951
申请日：2004-03-17
申请人： William F. DeGrado , Gregory N. Tew , Michael L. Klein , Dahui Liu , Jing Yuan , Sungwook Choi
发明人： William F. DeGrado , Gregory N. Tew , Michael L. Klein , Dahui Liu , Jing Yuan , Sungwook Choi
IPC分类号： C08G18/00 , A61K31/16 , A61K31/165 , A61K31/495 , C07C233/64 , C07C323/42 , C07C323/44 , C08G18/32 , C08G73/02 , C08L75/02
CPC分类号： A61K31/17 , A61K31/16 , A61K31/165 , A61K31/495 , C07C233/64 , C07C323/42 , C07C323/44 , C08G18/3225 , C08G73/028 , C08L75/02
摘要： The present invention discloses methods of use of facially amphiphilic polymers and oligomers, including pharmaceutical uses of the polymers and oligomers as antimicrobial agents and antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polymers and oligomers and their compositions, including pharmaceutical compositions. The present invention further discloses the design and synthesis of facially amphiphilic polymers and oligomers.
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公开(公告)号：US08236800B2
公开(公告)日：2012-08-07
申请号：US11980785
申请日：2007-10-31
申请人： William F. DeGrado , Gregory N. Tew , Michael L. Klein , Dahui Liu , Jing Yuan , Sungwook Choi
发明人： William F. DeGrado , Gregory N. Tew , Michael L. Klein , Dahui Liu , Jing Yuan , Sungwook Choi
IPC分类号： A01N43/58 , A01N43/60 , A01N43/54 , A61K31/50 , A61K31/495 , C07D239/42 , C07D471/04 , C07D471/22 , C07D487/04
CPC分类号： A61K31/17 , A61K31/16 , A61K31/165 , A61K31/495 , C07C233/64 , C07C323/42 , C07C323/44 , C08G18/3225 , C08G73/028 , C08L75/02
摘要： The present invention discloses methods of use of facially amphiphilic polymers and oligomers, including pharmaceutical uses of the polymers and oligomers as antimicrobial agents and antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polymers and oligomers and their compositions, including pharmaceutical compositions. The present invention further discloses the design and synthesis of facially amphiphilic polymers and oligomers.
摘要翻译： 本发明公开了使用表面两亲性聚合物和低聚物的方法，包括聚合物和低聚物作为抗微生物剂的药物用途和与肝素治疗相关的出血并发症的解毒剂。 本发明还公开了新颖的表面两亲聚合物和低聚物及其组合物，包括药物组合物。 本发明还公开了表面两亲聚合物和低聚物的设计和合成。
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7.发明授权Facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers and uses thereof 有权表面两亲性聚芳基和聚芳基炔基聚合物和低聚物及其用途公开(公告)号：US08222456B2
公开(公告)日：2012-07-17
申请号：US11038787
申请日：2005-01-21
IPC分类号： C07C211/27 , C07C279/06 , C07C233/77 , A61K31/135 , A61K31/155 , A61K31/16 , A61K31/132
CPC分类号： C07C279/12 , A61K31/74 , C07C211/27 , C07C217/58 , C07C233/78
摘要： The present invention discloses methods of use of facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers, including, but not limited to, pharmaceutical uses of the polymers and oligomers as antimicrobial agents and as antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers, compositions of the novel polymers and oligomers, including pharmaceutical compositions, and methods of designing and synthesizing the facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers.
摘要翻译： 本发明公开了使用表面两亲聚芳基和聚芳基炔基聚合物和低聚物的方法，包括但不限于聚合物和低聚物作为抗微生物剂的药物用途和用于与肝素治疗相关的出血并发症的解毒剂。 本发明还公开了新颖的表面两亲聚芳基和聚芳基炔基聚合物和低聚物，新型聚合物和低聚物的组合物，包括药物组合物，以及设计和合成表面两亲聚芳基和聚芳基炔基聚合物和低聚物的方法。
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8.发明授权Facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers and uses thereof 有权表面两亲性聚芳基和聚芳基炔基聚合物和低聚物及其用途公开(公告)号：US08716530B2
公开(公告)日：2014-05-06
申请号：US13365840
申请日：2012-02-03
IPC分类号： C07C211/27 , C07C279/06 , C07C233/77 , A61K31/135 , A61K31/155 , A61K31/16 , A61K31/132
CPC分类号： C07C279/12 , A61K31/74 , C07C211/27 , C07C217/58 , C07C233/78
摘要： The present invention discloses methods of use of facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers, including, but not limited to, pharmaceutical uses of the polymers and oligomers as antimicrobial agents and as antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers, compositions of the novel polymers and oligomers, including pharmaceutical compositions, and methods of designing and synthesizing the facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers.
摘要翻译： 本发明公开了使用表面两亲聚芳基和聚芳基炔基聚合物和低聚物的方法，包括但不限于聚合物和低聚物作为抗微生物剂的药物用途和用于与肝素治疗相关的出血并发症的解毒剂。 本发明还公开了新颖的表面两亲聚芳基和聚芳基炔基聚合物和低聚物，新型聚合物和低聚物的组合物，包括药物组合物，以及设计和合成表面两亲聚芳基和聚芳基炔基聚合物和低聚物的方法。
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公开(公告)号：US08889163B2
公开(公告)日：2014-11-18
申请号：US10471029
申请日：2002-03-07
IPC分类号： A01N25/34 , A01N43/56 , A61K31/136 , A61K31/16 , A61K31/132 , C08G73/10 , C07C211/27 , C07C279/06 , A61K31/74 , C08G18/28 , A61L15/44 , C08G73/22 , C08G61/10 , A61L31/16 , C08G61/02 , C08G61/12 , C08G18/32 , A01N25/10 , A61L27/54 , A61L29/16
CPC分类号： A61L15/44 , A01N25/10 , A01N37/18 , A01N37/22 , A01N37/24 , A01N37/28 , A01N37/30 , A01N37/42 , A01N47/22 , A01N47/30 , A01N47/44 , A61K31/74 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/20 , A61L2300/216 , A61L2300/404 , C08G18/2865 , C08G18/3225 , C08G61/02 , C08G61/10 , C08G61/122 , C08G69/26 , C08G73/028 , C08G73/22 , C08G2261/312 , Y10T428/193 , Y10T428/24207 , Y10T428/24446 , Y10T428/24455 , Y10T428/29 , Y10T428/31 , Y10T428/31504 , Y10T428/31678 , Y10T428/31725 , Y10T428/8305
摘要： Facially amphiphilic polyphenylene and heteroarylene polymers and articles made therform having biocidal surfaces are disclosed. The polymers can inhibit the growth of microorganisms in contact with the surface or in areas adjacent to said biocidal surface. There is also disclosed a methods to attach facially amphiphilic polmers to a solid support. Utility as a contact disinfectant is disclosed.
摘要翻译： 公开了具有杀生物表面的具有两亲性的聚亚苯基和亚杂芳基聚合物和制品。 聚合物可以抑制与表面或邻近所述杀生物表面的区域接触的微生物的生长。 还公开了将表面两亲性聚合物附着在固体支持物上的方法。 公开了作为接触消毒剂的效用。
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公开(公告)号：US20100105703A1
公开(公告)日：2010-04-29
申请号：US12605584
申请日：2009-10-26
申请人： William F. DeGrado , Dahui Liu , Richard W. Scott , Yongjiang Xu , Haizhong Tang , Bozena Korczak
发明人： William F. DeGrado , Dahui Liu , Richard W. Scott , Yongjiang Xu , Haizhong Tang , Bozena Korczak
IPC分类号： A61K31/506 , C07D403/14 , A61P31/04
CPC分类号： C07D403/14
摘要： The present invention provides arylamide compounds and methods of making and using them as antibiotics.
摘要翻译： 本发明提供芳基酰胺化合物及其制备和使用它们作为抗生素的方法。
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