-
公开(公告)号：US06426189B1
公开(公告)日：2002-07-30
申请号：US09676713
申请日：2000-09-29
申请人： William Helbert , Henri Dominique Chanzy , Steffen Ernst , Martin Schulein , Tommy Lykke Husum , Lars Kongsbak
发明人： William Helbert , Henri Dominique Chanzy , Steffen Ernst , Martin Schulein , Tommy Lykke Husum , Lars Kongsbak
IPC分类号： C12Q168
CPC分类号： C08J5/18 , C08J2301/02 , C08L1/02 , C12N15/1034 , C12Q1/00 , C12Q1/34 , G01N33/548
摘要： The invention relates to a cellulose film comprising microfibrillated cellulose and to the use of it for screening of a biological compound and nucleic acids encoding a biological compound.
摘要翻译： 本发明涉及包含微纤化纤维素的纤维素膜，并且涉及其用于筛选生物化合物和编码生物化合物的核酸。
-
公开(公告)号：US06613528B2
公开(公告)日：2003-09-02
申请号：US10151658
申请日：2002-05-20
申请人： William Helbert , Henri Dominique Chanzy , Steffen Ernst , Martin Schulein , Tommy Lykke Husum , Lars Kongsbak
发明人： William Helbert , Henri Dominique Chanzy , Steffen Ernst , Martin Schulein , Tommy Lykke Husum , Lars Kongsbak
IPC分类号： C12Q168
CPC分类号： C08J5/18 , C08J2301/02 , C08L1/02 , C12N15/1034 , C12Q1/00 , C12Q1/34 , G01N33/548
摘要： The invention relates to a ellulose film comprising microfibrillated cellulose and to the use of it for screening of a biological compound and nucleic acids encoding a biological compound.
-
公开(公告)号：US20070116744A1
公开(公告)日：2007-05-24
申请号：US11605148
申请日：2006-11-28
申请人： Lene Andersen , Martin Schulein , Niels Lange , Mads Bjornvad , Soren Moller , Sanne O Glad , Markus Kauppinen , Kirk Schnorr , Lars Kongsbak
发明人： Lene Andersen , Martin Schulein , Niels Lange , Mads Bjornvad , Soren Moller , Sanne O Glad , Markus Kauppinen , Kirk Schnorr , Lars Kongsbak
CPC分类号： C12N9/2465 , A23K10/14 , A23K20/189 , C07K2319/20 , C11D3/386 , C12N9/88 , D06L4/40 , D06M16/003 , D21C5/005 , Y10T442/20
摘要： The present invention relates to pectate lyases comprising the amino acid sequence Asn Leu Asn Ser Arg Val Pro (NLNSRVP) (amino acids 236-242 of SEQ ID NO: 2) belonging to Family 1 of polysaccharide lyases have good performance in industrial processes under neutral or alkaline conditions such as laundering and textile processing. The pectate lyase may be derivable from Bacillus species.
-
公开(公告)号：US08192937B2
公开(公告)日：2012-06-05
申请号：US11100897
申请日：2005-04-07
申请人： Nana Jacobsen , Lars Kongsbak , Sakari Kauppinen , Søren Morgenthaler Echwald , Peter Mouritzen , Peter Stein Nielsen , Mikkel Nørholm
发明人： Nana Jacobsen , Lars Kongsbak , Sakari Kauppinen , Søren Morgenthaler Echwald , Peter Mouritzen , Peter Stein Nielsen , Mikkel Nørholm
CPC分类号： C12Q1/6816 , C12Q1/6809 , C12Q2533/107 , C12Q2525/207 , C12Q2525/155 , C12Q2561/101
摘要： The invention relates to ribonucleic acids, probes and methods for detection, quantification as well as monitoring the expression of mature microRNAs and small interfering RNAs (siRNAs). The invention furthermore relates to methods for monitoring the expression of other non-coding RNAs, mRNA splice variants, as well as detecting and quantifying RNA editing, allelic variants of single transcripts, mutations, deletions, or duplications of particular exons in transcripts, e.g., alterations associated with human disease such as cancer. The invention furthermore relates to methods for detection, quantification as well as monitoring the expression of deoxy nucleic acids.
摘要翻译： 本发明涉及核糖核酸，探针和检测，定量的方法以及监测成熟微小RNA和小干扰RNA（siRNA）的表达。 本发明还涉及用于监测其他非编码RNA，mRNA剪接变体表达的方法，以及检测和定量RNA编辑，单个转录物的等位基因变体，突变，缺失或转录本中特定外显子的重复，例如， 与人类疾病如癌症相关的改变。 本发明还涉及用于检测，定量以及监测脱氧核酸表达的方法。
-
5.发明申请公开(公告)号：US20110076675A1
公开(公告)日：2011-03-31
申请号：US12476193
申请日：2009-06-01
申请人： Nana Jacobsen , Lars Kongsbak , Sakari Kauppinen , Søren Morgenthaler Echwald , Peter Mouritzen , Peter Stein Nielsen , Mikkel Nørholm
发明人： Nana Jacobsen , Lars Kongsbak , Sakari Kauppinen , Søren Morgenthaler Echwald , Peter Mouritzen , Peter Stein Nielsen , Mikkel Nørholm
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6816 , C12Q1/6809 , C12Q2533/107 , C12Q2525/207 , C12Q2525/155 , C12Q2561/101
摘要： The invention relates to ribonucleic acids, probes and methods for detection, quantification as well as monitoring the expression of mature microRNAs and small interfering RNAs (siRNAs). The invention furthermore relates to methods for monitoring the expression of other non-coding RNAs, mRNA splice variants, as well as detecting and quantifying RNA editing, allelic variants of single transcripts, mutations, deletions, or duplications of particular exons in transcripts, e.g., alterations associated with human disease such as cancer. The invention furthermore relates to methods for detection, quantification as well as monitoring the expression of deoxy nucleic acids.
摘要翻译： 本发明涉及核糖核酸，探针和检测，定量的方法以及监测成熟微小RNA和小干扰RNA（siRNA）的表达。 本发明还涉及用于监测其他非编码RNA，mRNA剪接变体表达的方法，以及检测和定量RNA编辑，单个转录物的等位基因变体，突变，缺失或转录本中特定外显子的重复，例如， 与人类疾病如癌症相关的改变。 本发明还涉及用于检测，定量以及监测脱氧核酸表达的方法。
-
6.发明申请公开(公告)号：US20050245449A1
公开(公告)日：2005-11-03
申请号：US11175639
申请日：2005-07-06
申请人： Lars Kongsbak , Niels Bergenhem , Lars Petersen , Ole Thastrup , Don Foster , Mirella Ezban , Agneta Siegbahn
发明人： Lars Kongsbak , Niels Bergenhem , Lars Petersen , Ole Thastrup , Don Foster , Mirella Ezban , Agneta Siegbahn
CPC分类号： G01N33/5041 , A61K38/36 , A61K38/4846 , G01N33/5008 , G01N33/5011 , G01N33/5044 , G01N33/5064 , G01N33/86 , G01N2333/96447
摘要： A novel intracellular signalling activity of coagulation factor VII (FVII) in cells expressing tissue factor (TF) is described. The present invention relates to use of FVIIa or another TF agonist, or FVIIai or another TF antagonist for the preparation of a medicament for modulation of FVIIa-induced activation of the MAPK signalling pathway in a patient. Moreover the present invention relates to a method of treatment, and a method of detecting the activity of compounds, in particular drug candidates, that interact with the FVIIa mediated intracellular signalling pathway.
摘要翻译： 描述了表达组织因子（TF）的细胞中凝血因子VII（FVII）的新型细胞内信号传导活性。 本发明涉及FVIIa或另一种TF激动剂或FVIIa或另一种TF拮抗剂在制备用于调节FVIIa诱导的患者中MAPK信号通路的激活的药物中的用途。 此外，本发明涉及一种治疗方法和检测与FVIIa介导的细胞内信号传导途径相互作用的化合物，特别是候选药物的活性的方法。
-
7.发明授权Methods for modifying cell motility using factor VIIa or inactivated factor VIIa 有权使用因子VIIa或灭活因子Ⅶa修饰细胞运动的方法公开(公告)号：US06461610B1
公开(公告)日：2002-10-08
申请号：US09372888
申请日：1999-08-12
申请人： Lars Kongsbak , Niels Bergenhem , Lars Christian Petersen , Ole Thastrup , Don Foster , Mirella Ezban , Agneta Siegbahn
发明人： Lars Kongsbak , Niels Bergenhem , Lars Christian Petersen , Ole Thastrup , Don Foster , Mirella Ezban , Agneta Siegbahn
IPC分类号： A61K3848
CPC分类号： G01N33/5041 , A61K38/4846 , G01N33/5008 , G01N33/5011 , G01N33/5035 , G01N33/5044 , G01N33/5064 , G01N33/86 , G01N2333/96447
摘要： The present invention provides methods for modifying the motility of tissue factor (TF)-expressing cells, which are carried out by contacting such cells with an effective amount of Factor VIIai Factor VIIa agonist.
摘要翻译： 本发明提供了通过使这些细胞与有效量的因子VIIai因子VIIa激动剂接触而进行的改变组织因子（TF）表达细胞运动性的方法。
-
公开(公告)号：US06677147B2
公开(公告)日：2004-01-13
申请号：US10072152
申请日：2002-02-07
申请人： Lene Nonboe Andersen , Martin Schülein , Niels Erik Krebs Lange , Mads Eskelund Bjørnvad , Søren Møller , Sanne O. Schroder Glad , Markus Sakari Kauppinen , Kirk Schnorr , Lars Kongsbak
发明人： Lene Nonboe Andersen , Martin Schülein , Niels Erik Krebs Lange , Mads Eskelund Bjørnvad , Søren Møller , Sanne O. Schroder Glad , Markus Sakari Kauppinen , Kirk Schnorr , Lars Kongsbak
IPC分类号： C12N988
CPC分类号： C12N9/2465 , A23K10/14 , A23K20/189 , C07K2319/20 , C11D3/386 , C12N9/88 , D06L4/40 , D06M16/003 , D21C5/005 , Y10T442/20
摘要： The present invention relates to pectate lyases comprising the amino acid sequence Asn Leu Asn Ser Arg Val Pro (NLNSRVP) (SEQ ID NO: 2) belonging to Family 1 of polysaccharide lyases have good performance in industrial processes under neutral or alkaline conditions such as laundering and textile processing. The pectate lyase may be derivable from Bacillus species.
摘要翻译： 本发明涉及属于多糖裂解酶1族的氨基酸序列Asn Leu Asn Ser Arg Val Pro（NLNSRVP）（SEQ ID NO：2）的果胶酸裂解酶在中性或碱性条件下的工业过程中具有良好的性能，例如洗涤 和纺织加工。 果胶裂解酶可以衍生自芽孢杆菌属物种。
-
9.发明授权Identification of drug candidates modulating factor VII-mediated intracellular signaling 失效鉴定药物候选物调节因子VII介导的细胞内信号传导公开(公告)号：US06268163B1
公开(公告)日：2001-07-31
申请号：US09116748
申请日：1998-07-16
IPC分类号： C12Q148
CPC分类号： G01N33/5008 , A61K38/4846 , G01N33/5011 , G01N33/5035 , G01N33/5041 , G01N33/5044 , G01N33/5064 , G01N33/86 , G01N2333/96447
摘要： The present invention provides methods for identifying candidate drugs that modulate factor VIIa-mediated intracellular signaling by measuring the effects of such drugs on the activation of the mitogen-activated protein kinase (MAP kinase) signaling pathway.
摘要翻译： 本发明提供了通过测量这些药物对丝裂原活化蛋白激酶（MAP激酶）信号通路的激活的影响来鉴定调节因子VIIa介导的细胞内信号传导的候选药物的方法。
-
公开(公告)号：US08383344B2
公开(公告)日：2013-02-26
申请号：US12476193
申请日：2009-06-01
申请人： Nana Jacobsen , Lars Kongsbak , Sakari Kauppinen , Søren Morgenthaler Echwald , Peter Mouritzen , Peter Stein Nielsen , Mikkel Nørholm
发明人： Nana Jacobsen , Lars Kongsbak , Sakari Kauppinen , Søren Morgenthaler Echwald , Peter Mouritzen , Peter Stein Nielsen , Mikkel Nørholm
CPC分类号： C12Q1/6816 , C12Q1/6809 , C12Q2533/107 , C12Q2525/207 , C12Q2525/155 , C12Q2561/101
摘要： The invention relates to ribonucleic acids, probes and methods for detection, quantification as well as monitoring the expression of mature microRNAs and small interfering RNAs (siRNAs). The invention furthermore relates to methods for monitoring the expression of other non-coding RNAs, mRNA splice variants, as well as detecting and quantifying RNA editing, allelic variants of single transcripts, mutations, deletions, or duplications of particular exons in transcripts, e.g., alterations associated with human disease such as cancer. The invention furthermore relates to methods for detection, quantification as well as monitoring the expression of deoxy nucleic acids.
摘要翻译： 本发明涉及核糖核酸，探针和检测，定量的方法以及监测成熟微小RNA和小干扰RNA（siRNA）的表达。 本发明还涉及用于监测其他非编码RNA，mRNA剪接变体表达的方法，以及检测和定量RNA编辑，单个转录物的等位基因变体，突变，缺失或转录本中特定外显子的重复，例如， 与人类疾病如癌症相关的改变。 本发明还涉及用于检测，定量以及监测脱氧核酸表达的方法。
-
-
-
-
-
-
-
-
-
搜索结果
17 条记录 (耗时 0.049 秒)
