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公开(公告)号：US5770358A
公开(公告)日：1998-06-23
申请号：US946239
申请日：1992-09-16
IPC分类号： C12N15/09 , B01J19/00 , C07B61/00 , C07H19/10 , C07H19/14 , C07H21/00 , C07H21/02 , C07H21/04 , C07K1/04 , C07K1/06 , C07K5/00 , C07K7/00 , C08F8/00 , C08G85/00 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , C40B70/00 , C12Q1/68 , A61K38/00 , G01N33/53
CPC分类号： C07K1/047 , B01J19/0046 , B01J19/0093 , C07H19/10 , C07H19/14 , C07H21/00 , B01J2219/00306 , B01J2219/00313 , B01J2219/00459 , B01J2219/00466 , B01J2219/005 , B01J2219/00502 , B01J2219/00536 , B01J2219/00542 , B01J2219/00545 , B01J2219/00547 , B01J2219/00554 , B01J2219/00563 , B01J2219/00565 , B01J2219/00572 , B01J2219/00574 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00689 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , C07B2200/11 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , C40B70/00 , Y10S435/81 , Y10T436/143333
摘要： A general stochastic method for synthesizing random oligomers can be used to synthesize compounds to screen for desired properties. The use of identification tags on the oligomers facilitates identification of oligomers with desired properties.
摘要翻译： 可以使用用于合成无规低聚物的通用随机方法来合成化合物以筛选所需的性质。 在寡聚体上使用鉴定标签便于鉴定具有所需性质的低聚物。
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公开(公告)号：US6140493A
公开(公告)日：2000-10-31
申请号：US151467
申请日：1998-09-11
IPC分类号： C12N15/09 , B01J19/00 , C07B61/00 , C07H19/10 , C07H19/14 , C07H21/00 , C07H21/02 , C07H21/04 , C07K1/04 , C07K1/06 , C07K5/00 , C07K7/00 , C08F8/00 , C08G85/00 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , C40B70/00 , B01J20/26
CPC分类号： C07K1/047 , B01J19/0046 , B01J19/0093 , C07H19/10 , C07H19/14 , C07H21/00 , B01J2219/00306 , B01J2219/00313 , B01J2219/00459 , B01J2219/00466 , B01J2219/005 , B01J2219/00502 , B01J2219/00536 , B01J2219/00542 , B01J2219/00545 , B01J2219/00547 , B01J2219/00554 , B01J2219/00563 , B01J2219/00565 , B01J2219/00572 , B01J2219/00574 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00689 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , C07B2200/11 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , C40B70/00 , Y10S435/81 , Y10T436/143333
摘要： A general stochastic method for synthesizing random oligomers can be used to synthesize compounds to screen for desired properties. The use of identification tags on the oligomers facilitates identification of oligomers with desired properties.
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公开(公告)号：US5639603A
公开(公告)日：1997-06-17
申请号：US146886
申请日：1993-11-02
IPC分类号： B01J19/00 , C07B61/00 , C07H19/10 , C07H19/14 , C07H21/00 , C07K1/04 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , C12Q1/68
CPC分类号： C07K1/047 , B01J19/0046 , B01J19/0093 , C07H19/10 , C07H19/14 , C07H21/00 , B01J2219/00286 , B01J2219/00308 , B01J2219/00313 , B01J2219/00412 , B01J2219/00418 , B01J2219/00423 , B01J2219/00466 , B01J2219/00484 , B01J2219/00495 , B01J2219/005 , B01J2219/00502 , B01J2219/00536 , B01J2219/00542 , B01J2219/00545 , B01J2219/00547 , B01J2219/00554 , B01J2219/00563 , B01J2219/00565 , B01J2219/00572 , B01J2219/00574 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00689 , B01J2219/00695 , B01J2219/00698 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , C07B2200/11 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14
摘要： A general stochastic method for synthesizing compounds can be used to generate large collections of tagged compounds that can be screened to identify and isolate compounds with useful properties.
摘要翻译： 可以使用用于合成化合物的通用随机方法来产生大量的标记化合物，其可以筛选以鉴定和分离具有有用特性的化合物。
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公开(公告)号：US06416949B1
公开(公告)日：2002-07-09
申请号：US09256838
申请日：1999-02-24
IPC分类号： C12Q168
CPC分类号： C07K1/047 , B01J19/0046 , B01J19/0093 , B01J2219/00306 , B01J2219/00313 , B01J2219/00459 , B01J2219/00466 , B01J2219/005 , B01J2219/00502 , B01J2219/00536 , B01J2219/00542 , B01J2219/00545 , B01J2219/00547 , B01J2219/00554 , B01J2219/00563 , B01J2219/00565 , B01J2219/00572 , B01J2219/00574 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00689 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , C07B2200/11 , C07H19/10 , C07H19/14 , C07H21/00 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , C40B70/00 , Y10S435/81 , Y10T436/143333
摘要： A general stochastic method for synthesizing random oligomers can be used to synthesize compounds to screen for desired properties. The use of identification tags on the oligomers facilitates identification of oligomers with desired properties.
摘要翻译： 可以使用用于合成无规低聚物的通用随机方法来合成化合物以筛选所需的性质。 在寡聚体上使用鉴定标签便于鉴定具有所需性质的低聚物。
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公开(公告)号：US07413536B1
公开(公告)日：2008-08-19
申请号：US09661927
申请日：2000-09-14
IPC分类号： C40B30/04
CPC分类号： G01N33/5088 , A61K49/0004 , C07C271/22 , C07C2603/18 , C07D271/08 , C07D277/32 , C07D311/16 , C07K1/047 , C12N15/1034 , C12N15/1086 , C40B40/00 , G01N33/5008 , G01N33/533 , G01N33/566 , G01N33/92
摘要： A variety of methods for assaying libraries of test compounds as ligands and/or substrates of transport proteins, including both carrier-type and receptor-type transport proteins, are provided. Both in vitro and in vivo screening methods are disclosed. Also provided are methods for screening DNA libraries to identify members that encode transport proteins. Pharmaceutical compositions including compounds identified via the screening methods are also provided.
摘要翻译： 提供了用于测定测试化合物的文库作为载体蛋白质（包括载体型和受体型转运蛋白）的转运蛋白质的配体和/或底物的多种方法。 公开了体外和体内筛选方法。 还提供了筛选DNA文库以鉴定编码转运蛋白的成员的方法。 还提供了包括通过筛选方法鉴定的化合物的药物组合物。
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公开(公告)号：US5789162A
公开(公告)日：1998-08-04
申请号：US484505
申请日：1995-06-07
IPC分类号： C12N15/09 , B01J19/00 , C07B61/00 , C07H19/10 , C07H19/14 , C07H21/00 , C07H21/02 , C07H21/04 , C07K1/04 , C07K1/06 , C07K5/00 , C07K7/00 , C08F8/00 , C08G85/00 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , C40B70/00 , C12Q1/68 , C07H19/00 , C07K1/00 , C12M1/34
CPC分类号： C07K1/047 , B01J19/0046 , B01J19/0093 , C07H19/10 , C07H19/14 , C07H21/00 , B01J2219/00306 , B01J2219/00313 , B01J2219/00459 , B01J2219/00466 , B01J2219/005 , B01J2219/00502 , B01J2219/00536 , B01J2219/00542 , B01J2219/00545 , B01J2219/00547 , B01J2219/00554 , B01J2219/00563 , B01J2219/00565 , B01J2219/00572 , B01J2219/00574 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00689 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , C07B2200/11 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , C40B70/00 , Y10S435/81 , Y10T436/143333
摘要： A general stochastic method for synthesizing random oligomers on particles is disclosed. A further aspect of the invention relates to the use of identification tags on the particles to facilitate identification of the sequence of the monomers in the oligomer.
摘要翻译： 公开了用于在颗粒上合成无规低聚物的通用随机方法。 本发明的另一方面涉及在颗粒上使用识别标签以便于鉴定寡聚体中单体的序列。
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公开(公告)号：US5708153A
公开(公告)日：1998-01-13
申请号：US488470
申请日：1995-06-07
IPC分类号： C12N15/09 , B01J19/00 , C07B61/00 , C07H19/10 , C07H19/14 , C07H21/00 , C07H21/02 , C07H21/04 , C07K1/04 , C07K1/06 , C07K5/00 , C07K7/00 , C08F8/00 , C08G85/00 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , C40B70/00 , C12Q1/00 , C07H19/00 , C07K1/00 , C12M1/34
CPC分类号： C07K1/047 , B01J19/0046 , B01J19/0093 , C07H19/10 , C07H19/14 , C07H21/00 , B01J2219/00306 , B01J2219/00313 , B01J2219/00459 , B01J2219/00466 , B01J2219/005 , B01J2219/00502 , B01J2219/00536 , B01J2219/00542 , B01J2219/00545 , B01J2219/00547 , B01J2219/00554 , B01J2219/00563 , B01J2219/00565 , B01J2219/00572 , B01J2219/00574 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00689 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , C07B2200/11 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , C40B70/00 , Y10S435/81 , Y10T436/143333
摘要： A general stochastic method for synthesizing random oligomers on particles is disclosed. A further aspect of the invention relates to the use of identification tags on the particles to facilitate identification of the sequence of the monomers in the oligomer.
摘要翻译： 公开了用于在颗粒上合成无规低聚物的通用随机方法。 本发明的另一方面涉及在颗粒上使用识别标签以便于鉴定寡聚体中单体的序列。
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公开(公告)号：US6165717A
公开(公告)日：2000-12-26
申请号：US78403
申请日：1998-05-13
IPC分类号： C12N15/09 , B01J19/00 , C07B61/00 , C07H19/10 , C07H19/14 , C07H21/00 , C07H21/02 , C07H21/04 , C07K1/04 , C07K1/06 , C07K5/00 , C07K7/00 , C08F8/00 , C08G85/00 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , C40B70/00 , C12Q1/68 , A61K38/00 , G01N33/00
CPC分类号： C07K1/047 , B01J19/0046 , B01J19/0093 , B01J2219/00306 , B01J2219/00313 , B01J2219/00459 , B01J2219/00466 , B01J2219/005 , B01J2219/00502 , B01J2219/00536 , B01J2219/00542 , B01J2219/00545 , B01J2219/00547 , B01J2219/00554 , B01J2219/00563 , B01J2219/00565 , B01J2219/00572 , B01J2219/00574 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00689 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , C07B2200/11 , C07H19/10 , C07H19/14 , C07H21/00 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , C40B70/00 , Y10S435/81 , Y10T436/143333
摘要： A general stochastic method for synthesizing random oligomers on particles is disclosed. A further aspect of the invention relates to the use of identification tags on the particles to facilitate identification of the sequence of the monomers in the oligomer.
摘要翻译： 公开了用于在颗粒上合成无规低聚物的通用随机方法。 本发明的另一方面涉及在颗粒上使用识别标签以便于鉴定寡聚体中单体的序列。
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公开(公告)号：US6143497A
公开(公告)日：2000-11-07
申请号：US36599
申请日：1998-03-06
IPC分类号： C12N15/09 , B01J19/00 , C07B61/00 , C07H19/10 , C07H19/14 , C07H21/00 , C07H21/02 , C07H21/04 , C07K1/04 , C07K1/06 , C07K5/00 , C07K7/00 , C08F8/00 , C08G85/00 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , C40B70/00 , C12Q1/68 , C12P19/34 , C12Q1/70
CPC分类号： C07K1/047 , B01J19/0046 , B01J19/0093 , C07H19/10 , C07H19/14 , C07H21/00 , B01J2219/00306 , B01J2219/00313 , B01J2219/00459 , B01J2219/00466 , B01J2219/005 , B01J2219/00502 , B01J2219/00536 , B01J2219/00542 , B01J2219/00545 , B01J2219/00547 , B01J2219/00554 , B01J2219/00563 , B01J2219/00565 , B01J2219/00572 , B01J2219/00574 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/00596 , B01J2219/00689 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , C07B2200/11 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , C40B70/00 , Y10S435/81 , Y10T436/143333
摘要： A general stochastic method for synthesizing random oligomers on particles is disclosed. A further aspect of the invention relates to the use of identification tags on the particles to facilitate identification of the sequence of the monomers in the oligomer.
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10.发明授权Mesophasic forms of (3S)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use 有权（3S） - 氨基甲基-5-甲基 - 己酸前药的中间形式及其使用方法公开(公告)号：US07868043B2
公开(公告)日：2011-01-11
申请号：US12358507
申请日：2009-01-23
申请人： Fenmei Yao , Mark A. Gallop , Ronald W. Barrett , Peter A. Virsik
发明人： Fenmei Yao , Mark A. Gallop , Ronald W. Barrett , Peter A. Virsik
IPC分类号： A61K31/221 , C07C229/22
CPC分类号： C07C271/22 , C07B2200/13
摘要： Mesophasic forms of (3S)-aminomethyl-5-hexanoic acid prodrugs and methods of preparing and methods of using mesophasic forms of (3S)-aminomethyl-5-hexanoic acid prodrugs are provided.
摘要翻译： 提供（3S） - 氨基甲基-5-己酸前药的间期形式及其制备方法和使用（3S） - 氨基甲基-5-己酸前体药物的中间形式的方法。
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