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1.发明申请FLUORESCENT MEASUREMENT IN A DISPOSABLE MICROFLUIDIC DEVICE, AND METHOD THEREOF 审中-公开可置换微流体装置中的荧光测量及其方法公开(公告)号：US20120208292A1
公开(公告)日：2012-08-16
申请号：US13326999
申请日：2011-12-15
IPC分类号： G01N21/64
CPC分类号： G01N21/6428 , B01L3/502715 , B01L2300/0654 , B01L2300/0816 , B01L2300/168 , B82Y15/00 , G01N33/54346 , G01N33/54366 , G01N33/588
摘要： A device including a shallow chamber for analyzing a target analyte in a body fluid using the signal generated by fluorescent detector molecules specific for the target analyte and attenuating the signal emitted by fluorescent detector molecules non-specifically bound to the surfaces of the chamber by a signal attenuating dye; and method thereof.
摘要翻译： 一种装置，其包括用于使用由目标分析物特异的荧光检测器分子产生的信号来分析体液中的目标分析物的浅室，并且通过信号衰减由荧光检测器分子非特异性结合到所述室的表面的信号 减毒染料; 及其方法。
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公开(公告)号：US20150036121A1
公开(公告)日：2015-02-05
申请号：US14127337
申请日：2012-07-02
CPC分类号： G01N21/51 , G01N15/06 , G01N2015/0693 , G01N2021/4726 , G01N2201/06113
摘要： The invention relates to a method for measuring the scattered light (L2) of particles (P, PK) in a measuring medium (F), wherein a measuring container (1) is supplied with the measuring medium (F) and incident light (L1) is shone through the measuring medium (F) at least in some regions over a certain path length (1) and in a certain direction and the light (L2) scattered from the incident light (L1) is measured within a certain angle range (α).It is provided according to the invention that the incident light (L1) is guided parallel to a longitudinal axis (S) of the measuring container (1).By these measures, known methods can be improved and it is readily possible to use the invention even for very small measuring volumes of the measuring medium (F) with the associated small dimensions of the measuring container (1).
摘要翻译： 本发明涉及一种在测量介质（F）中测量颗粒（P，PK）的散射光（L2）的方法，其中向测量容器（1）供应测量介质（F）和入射光 ）至少在某些区域中通过测量介质（F）在特定路径长度（1）和某一方向上照射，并且在一定角度范围内测量从入射光（L1）散射的光（L2） α）。 根据本发明提供入射光（L1）平行于测量容器（1）的纵向轴线（S）引导。 通过这些措施，可以改进已知的方法，并且即使对于具有测量容器（1）的相关小尺寸的测量介质（F）的非常小的测量体积也可以容易地使用本发明。
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公开(公告)号：US08795607B2
公开(公告)日：2014-08-05
申请号：US12999323
申请日：2009-06-02
申请人： Dirk Kurowski , Berthold Lange , Dirk Osterloh
发明人： Dirk Kurowski , Berthold Lange , Dirk Osterloh
CPC分类号： B01L3/502715 , B01L3/505 , B01L2200/027 , B01L2200/0605 , B01L2200/0684 , B01L2200/16 , B01L2300/044 , B01L2300/047 , B01L2300/0672 , B01L2300/0809 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , B01L2400/0481 , Y10T137/1714 , Y10T137/1729
摘要： The invention relates to a container (1) for a fluid for metering a reagent into a microfluidic system. The container comprises a chamber (4) and a first film (3) which seals off the chamber (4) so that the fluid is encapsulated in the chamber. Advantageously, the first film (3) is an aluminum sealing film. A second film (7) is sealingly arranged on the first film, for example by adhesive bonding of the film layers. The films differ in their tear strength such that when pressure is applied simultaneously to both films the first film tears while the second film deforms elastically and/or plastically. By tearing the first film a connection is produced between the container chamber and an inlet channel so that a fluid contained in the chamber flows into the microfluidic system.
摘要翻译： 本发明涉及一种用于将试剂计量到微流体系统中的流体的容器（1）。 容器包括室（4）和密封室（4）的第一膜（3），使得流体被封装在室中。 有利地，第一膜（3）是铝密封膜。 第二膜（7）密封地布置在第一膜上，例如通过胶片粘合。 膜的撕裂强度不同，使得当两个膜同时施加压力时，第一膜在第二膜弹性和/或塑性变形的同时撕裂。 通过撕裂第一膜，在容器室和入口通道之间产生连接，使得容纳在腔室中的流体流入微流体系统。
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4.发明申请BLISTER PACKAGING FOR LIQUID AND USE THEREOF AND METHOD FOR SUPPLYING A LIQUID TO A FLUIDIC ASSEMBLY 审中-公开用于液体及其用途的吸塑包装和液体向液体装置供应的方法公开(公告)号：US20130327672A1
公开(公告)日：2013-12-12
申请号：US13883896
申请日：2011-11-03
申请人： Dirk Kurowski , Oliver Paul
发明人： Dirk Kurowski , Oliver Paul
IPC分类号： B65D85/00
CPC分类号： B65D85/00 , B01L3/502715 , B01L3/52 , B01L2400/0481 , B01L2400/0683 , B65D75/368 , B65D2205/02 , B65D2221/00 , B65D2575/362 , B65D2575/367
摘要： A packaging, particularly a blister packaging, is proposed, having at least one cavity for holding a liquid and having an integrated opening device. The packaging can be used as a reservoir for a liquid for connecting to a fluidic assembly. The packaging is opened by partial deformation of the packaging.
摘要翻译： 提出了一种包装，特别是泡罩包装，其具有至少一个用于保持液体并具有集成打开装置的空腔。 该包装可用作用于连接流体组件的液体的储存器。 包装通过包装的部分变形而打开。
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公开(公告)号：US20120275972A1
公开(公告)日：2012-11-01
申请号：US13500139
申请日：2010-10-05
CPC分类号： B29C65/606 , B01L3/502707 , B01L2200/025 , B01L2200/0689 , B01L2300/0816 , B01L2300/0887 , B29C65/08 , B29C65/8207 , B29C65/8215 , B29C66/12461 , B29C66/24221 , B29C66/5412 , B29C66/542 , B29C66/71 , B29C66/81417 , B29C66/81422 , B29C66/8322 , B29C66/91411 , B29C66/91421 , B29C66/919 , B29C66/91921 , B29C66/91933 , B29C66/91943 , B29C66/929 , B29C66/949 , B29K2023/06 , B29K2023/12 , B29K2025/00 , B29K2033/12 , B29K2069/00 , B29K2071/00 , B29L2031/756 , B81B2201/058 , B81C3/001 , B81C2203/032 , B81C2203/051 , B29K2067/00 , B29K2023/38
摘要： The invention relates to joining plastic components into a microfluidic cartridge (20). The invention in particular relates to cartridges (20) for diagnostic analysis devices. The cartridge (20) comprises a fluidically conductive floor element (11), a cover (2), and a film (3) disposed between the elements (1, 2). The cover (2) or the floor element (1) and the film (3) comprise a filling opening (5) for filling microfluidic channels (4) in one of the elements having sample fluid. Pins (6) formed integrally with one of the board-shaped elements (1, 2) engage in corresponding holes (7) in the film (3) and the associated element (1, 2) for each.By means of deforming a pin (6), a friction fit is produced between a deformed pin and the wall of a hole, and a head (9) contacting the associated substrate in a form-fitting manner is formed. For the joining process, a press tool (12) is placed on a head end (9) of a pin (6) at a predetermined pressure P, and heat transfer into the pin (6) takes place during a weld time tS. The pin material is brought to above the glass transition temperature and/or the melting point, and a friction fit between the pin (6) and the wall of the hole (7) is formed by flowing the pin material in the hole (7).
摘要翻译： 本发明涉及将塑料部件接合到微流体盒（20）中。 本发明特别涉及用于诊断分析装置的药筒（20）。 盒（20）包括流体导电的地板元件（11），盖子（2）和设置在元件（1,2）之间的薄膜（3）。 盖（2）或地板元件（1）和薄膜（3）包括用于在具有样品流体的元件之一中填充微流体通道（4）的填充开口（5）。 与一个板状元件（1,2）一体形成的销钉（6）与胶片（3）中的相应孔（7）和每个相关元件（1,2）啮合。 通过使销（6）变形，在变形的销和孔的壁之间产生摩擦配合，并且形成以接合方式与相关联的基板接触的头部（9）。 对于接合过程，在预定压力P下将压制工具（12）放置在销（6）的头端（9）上，并且在焊接时间tS期间发生传热到销（6）。 引脚材料达到高于玻璃化转变温度和/或熔点，并且通过使销材料流入孔（7）中而形成销（6）和孔（7）的壁之间的摩擦配合， 。
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公开(公告)号：US20130206253A1
公开(公告)日：2013-08-15
申请号：US13810468
申请日：2011-07-05
申请人： Dirk Kurowski , Gert Blankenstein , Dirk Osterloh , Marc Prenger , Ying Yu
发明人： Dirk Kurowski , Gert Blankenstein , Dirk Osterloh , Marc Prenger , Ying Yu
CPC分类号： B01L3/00 , B01L3/502707 , B01L2200/025 , B01L2200/12 , B01L2300/044 , B01L2300/0887 , B23P19/00 , Y10T29/49826 , Y10T29/49865 , Y10T137/7036
摘要： A microfluidic device and a method of producing it are proposed, in which a film covers a chamber in a carrier. The film is locally re-tightened in the region of the chamber after the film has been secured to the carrier. In this way it is possible to prevent undesirable bulging of the film into the chamber.
摘要翻译： 提出一种微流体装置及其制造方法，其中膜覆盖载体中的室。 在胶片已经固定到载体上之后，膜在室的区域中被局部地再次拧紧。 以这种方式，可以防止膜进入腔室的不希望的膨胀。
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公开(公告)号：US20130112612A1
公开(公告)日：2013-05-09
申请号：US13640393
申请日：2011-04-01
IPC分类号： G01N1/28
CPC分类号： G01N1/28 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502746 , B01L3/502753 , B01L2200/027 , B01L2300/0681 , B01L2300/0851 , B01L2300/087 , B01L2300/0887 , B01L2400/0406 , B29C65/548 , G01N33/491 , G01N33/492
摘要： The invention relates to a device for sample separation, particularly for blood separation, in which the sample liquid is introduced into a feed device. The sample flows vertically through a separating device such as a filter or a membrane, so that sample particles are retained and separated off.The sample liquid thus separated, particularly blood plasma, is received by an inlet chamber underneath the separating device and conveyed by means of a channel in the lateral direction out of the inlet chamber.Particularly advantageously, the channel extends into the inlet chamber, the channel being formed by a recess in the base of the inlet chamber.
摘要翻译： 本发明涉及用于样品分离的装置，特别是用于血液分离的装置，其中将样品液体引入进料装置。 样品垂直通过诸如过滤器或膜的分离装置，使样品颗粒保持和分离。 由此分离的样品液体，特别是血浆，被分离装置下方的入口室接收，并且通过横向方向的通道从入口室输送。 特别有利的是，通道延伸到入口室中，通道由入口室的底部中的凹部形成。
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公开(公告)号：US20110186466A1
公开(公告)日：2011-08-04
申请号：US12999323
申请日：2009-06-02
申请人： Dirk Kurowski , Berthold Lange , Dirk Osterloh
发明人： Dirk Kurowski , Berthold Lange , Dirk Osterloh
CPC分类号： B01L3/502715 , B01L3/505 , B01L2200/027 , B01L2200/0605 , B01L2200/0684 , B01L2200/16 , B01L2300/044 , B01L2300/047 , B01L2300/0672 , B01L2300/0809 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , B01L2400/0481 , Y10T137/1714 , Y10T137/1729
摘要： The invention relates to a container (1) for a fluid for metering a reagent into a microfluidic system. The container comprises a chamber (4) and a first film (3) which seals off the chamber (4) so that the fluid is encapsulated in the chamber. Advantageously, the first film (3) is an aluminium sealing film. A second film (7) is sealingly arranged on the first film, for example by adhesive bonding of the film layers. The films differ in their tear strength such that when pressure is applied simultaneously to both films the first film tears while the second film deforms elastically and/or plastically. By tearing the first film a connection is produced between the container chamber and an inlet channel so that a fluid contained in the chamber flows into the microfluidic system.
摘要翻译： 本发明涉及一种用于将试剂计量到微流体系统中的流体的容器（1）。 容器包括室（4）和密封室（4）的第一膜（3），使得流体被封装在室中。 有利地，第一膜（3）是铝密封膜。 第二膜（7）密封地布置在第一膜上，例如通过胶片粘合。 膜的撕裂强度不同，使得当两个膜同时施加压力时，第一膜在第二膜弹性和/或塑性变形的同时撕裂。 通过撕裂第一膜，在容器室和入口通道之间产生连接，使得容纳在室中的流体流入微流体系统。
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公开(公告)号：US20100126927A1
公开(公告)日：2010-05-27
申请号：US12519293
申请日：2007-12-07
CPC分类号： B81C1/00119 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L2200/0636 , B01L2200/12 , B01L2300/0681 , B01L2300/0867 , B01L2300/0887 , B01L2300/123 , B01L2400/0406 , B01L2400/0481 , B01L2400/0655 , B01L2400/0688 , B81B2201/058 , Y10T137/8593 , Y10T156/10
摘要： A device for the intake or manipulation of a fluid, in particular, a liquid, and a method for the production of a device of this type in which a flat, non-preformed covering film is laminated onto a carrier, a three-dimensionally shaped or convex chamber wall being formed solely by means of the laminating process. The chamber wall which forms a boundary of a chamber for the fluid is partially deformable. The device is simple to produce and can be used universally.
摘要翻译： 用于吸入或操纵流体，特别是液体的装置，以及用于制造这种类型的装置的方法，其中平坦的未预成型的覆盖膜层压在载体上，三维形状 或凸室壁仅通过层压工艺形成。 形成用于流体的室的边界的室壁是部分可变形的。 该设备生产简单，可以普遍使用。
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10.发明授权Process for producing a microfluidic apparatus and related laminating devices 有权用于生产微流体装置和相关层压装置的方法公开(公告)号：US09522520B2
公开(公告)日：2016-12-20
申请号：US13819050
申请日：2011-08-30
申请人： Dirk Kurowski , Oliver Paul
发明人： Dirk Kurowski , Oliver Paul
CPC分类号： B32B37/30 , B01L3/502707 , B01L3/502738 , B01L2200/12 , B01L2300/0816 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0655 , F16K99/0001 , F16K99/0015 , F16K2099/008 , Y10T156/16
摘要： A process and a laminating device for producing a microfluidic device are proposed, wherein a film is pressed onto a carrier under the effect of heat and thereby attached to it. During the attachment the film is lifted by the blowing in of gas on the carrier side to prevent it adhering in a non-attachment region and is vented on the remote side. The device is compressed between a holder and a thermode of the laminating device during the lamination. An elastic intermediate layer is arranged in each case between the device and the holder and between the device and the thermode, for evening out the contact pressure and obtaining uniform attachment of the film to the carrier.
摘要翻译： 提出了一种用于制造微流体装置的方法和层压装置，其中膜在热作用下被压在载体上并由此附着于其上。 在安装期间，通过在载体侧上的气体吹入而使膜被提升，以防止粘附在非附着区域并且在远端侧排出。 在层压期间，该装置在夹持器和层压装置的热电偶之间被压缩。 弹性中间层在每种情况下都布置在装置和夹持器之间以及装置与热电极之间，用于使接触压力过夜，并获得薄膜到载体的均匀附着。
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