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1.发明授权
公开(公告)号：US5447940A
公开(公告)日：1995-09-05
申请号：US280917
申请日：1994-07-27
IPC分类号： A61K9/70 , A61F2/02 , A61F2/06 , A61K6/00 , A61K9/00 , A61K31/65 , A61K31/70 , A61K45/00 , A61K47/34 , A61K47/42 , A61L15/00 , A61L27/48 , A61L27/50 , A61L31/00 , A61L31/12 , A61L31/14 , A61P1/00 , A61P31/04 , A01N43/42 , A61K31/47
CPC分类号： A61L31/14 , A61K9/0063 , A61L27/48 , A61L27/50 , A61L31/129 , A61F2/06 , A61F2210/0004 , Y10S514/801
摘要： Absorbable composite materials are described that comprise a collagen matrix reinforced with a layer of a bioabsorbable polymer. A chemotherapeutic agent is dispersed in the composite material. The layer of bioabsorbable polymer is preferably a woven, nonwoven or knitted mesh layer of a synthetic bioabsorbable polymer such as polylactic/polyglycolic acid copolymer, or oxidised regenerated cellulose. The chemotherapeutic agent may be an antibiotic, an anaesthetic, an antiseptic or an anti-inflammatory. Strips of the composite material are inserted into the periodontal pocket, where they are retained in place and provide effective sustained release of the chemotherapeutic agent over an extended period.
摘要翻译： 描述了包含用生物可吸收聚合物层增强的胶原基质的可吸收复合材料。 化疗剂分散在复合材料中。 生物可吸收聚合物层优选为合成的生物可吸收聚合物如聚乳酸/聚乙醇酸共聚物或氧化再生纤维素的织造，非织造或针织网眼层。 化疗剂可以是抗生素，麻醉剂，防腐剂或抗炎剂。 将复合材料的条带插入到牙周袋中，在那里它们被保留在适当的位置，并在长时间内提供化学治疗剂的有效持续释放。
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公开(公告)号：US6015844A
公开(公告)日：2000-01-18
申请号：US995228
申请日：1997-12-19
CPC分类号： A61K9/7007 , A61K9/1658 , A61L27/48
摘要： A composite surgical material comprising a collagen matrix reinforced by a layer of a synthetic bioabsorbable material such as polylactide/polyglycolide or oxidised regenerated cellulose, and wherein oil droplets are dispersed in the collagen matrix. The oil droplets comprise 1% to 75% of the weight of the composite and result in improved leak-proofing of the composite. The composite, in the form of a sheet or a tube, is especially useful as a temporary, fully bioabsorbable prosthesis, for membranes or blood vessels where a highly leak-proof prosthesis is required. The invention also provides a method of making a composite surgical material comprising the steps of: providing a layer of a synthetic bioabsorbable material; providing a dispersion of collagen in an oil-in-water emulsion; coating at least one face of the layer of synthetic bioabsorbable material with the said dispersion; and drying the composite material thus obtained.
摘要翻译： 一种复合手术材料，其包含由合成的生物可吸收材料层如聚丙交酯/聚乙交酯或氧化的再生纤维素增强的胶原基质，并且其中油滴分散在胶原基质中。 油滴占复合材料重量的1％至75％，从而改善了复合材料的防漏性能。 以片或管的形式的复合材料作为需要高度防漏假体的膜或血管的临时的，完全生物可吸收的假体是特别有用的。 本发明还提供一种制备复合外科材料的方法，包括以下步骤：提供合成的生物可吸收材料的层; 提供胶原蛋白在水包油乳液中的分散体; 用所述分散体涂覆合成的生物可吸收材料层的至少一个面; 并干燥由此获得的复合材料。
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公开(公告)号：US5789465A
公开(公告)日：1998-08-04
申请号：US280916
申请日：1994-07-27
IPC分类号： A61K9/70 , A61F2/02 , A61F2/06 , A61K6/00 , A61K9/00 , A61K31/65 , A61K31/70 , A61K45/00 , A61K47/34 , A61K47/42 , A61L15/00 , A61L27/48 , A61L27/50 , A61L31/00 , A61L31/12 , A61L31/14 , A61P1/00 , A61P31/04 , A61F2/00 , A01N25/34
CPC分类号： A61L31/14 , A61K9/0063 , A61L27/48 , A61L27/50 , A61L31/129 , A61F2/06 , A61F2210/0004 , Y10S514/801
摘要： A composite surgical material comprising a collagen matrix reinforced by a layer of a synthetic bioabsorbable material such as polylactide/polyglycolide or oxidized regenerated cellulose, and wherein oil droplets are dispersed in the collagen matrix. The oil droplets comprise 1% to 75% of the weight of the composite and result in improved leak-proofing of the composite. The composite, in the form of a sheet or a tube, is especially useful as a temporary, fully bioabsorbable prosthesis, for membranes or blood vessels where a highly leak-proof prosthesis is required. The invention also provides a method of making a composite surgical material comprising the steps of: providing a layer of a synthetic bioabsorbable material; providing a dispersion of collagen in an oil-in-water emulsion; coating at least one face of the layer of synthetic bioabsorbable material with the said dispersion; and drying the composite material thus obtained.
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公开(公告)号：US06001895A
公开(公告)日：1999-12-14
申请号：US994276
申请日：1997-12-19
IPC分类号： A61K6/00 , A61K8/04 , A61K9/16 , A61K9/70 , A61L27/48 , A61L27/50 , A61L31/12 , A61Q11/00 , A61Q19/00 , A61F2/00
CPC分类号： A61L27/48 , A61K9/1658 , A61K9/7007 , A61L27/50 , A61L31/129
摘要： A composite surgical material comprising a collagen matrix reinforced by a layer of a synthetic bioabsorbable material such as polylactide/polyglycolide or oxidized regenerated cellulose, and wherein oil droplets are dispersed in the collagen matrix. The oil droplets comprise 1% to 75% of the weight of the composite and result in improved leak-proofing of the composite. The composite, in the form of a sheet or a tube, is especially useful as a temporary, fully bioabsorbable prosthesis, for membranes or blood vessels where a highly leak-proof prosthesis is required. The invention also provides a method of making a composite surgical material comprising the steps of: providing a layer of a synthetic bioabsorbable material; providing a dispersion of collagen in an oil-in-water emulsion; coating at least one face of the layer of synthetic bioabsorbable material with the said dispersion; and drying the composite material thus obtained.
摘要翻译： 一种复合手术材料，其包含由合成的生物可吸收材料层如聚丙交酯/聚乙交酯或氧化再生纤维素增强的胶原基质，并且其中油滴分散在胶原基质中。 油滴占复合材料重量的1％至75％，从而改善了复合材料的防漏性能。 以片或管的形式的复合材料作为需要高度防漏假体的膜或血管的临时的，完全生物可吸收的假体是特别有用的。 本发明还提供一种制备复合外科材料的方法，包括以下步骤：提供合成的生物可吸收材料的层; 提供胶原蛋白在水包油乳液中的分散体; 用所述分散体涂覆合成的生物可吸收材料层的至少一个面; 并干燥由此获得的复合材料。
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公开(公告)号：US5466462A
公开(公告)日：1995-11-14
申请号：US35013
申请日：1993-03-22
IPC分类号： A61L15/28 , A61L15/32 , A61L15/42 , A61L15/44 , A61L15/64 , A61L26/00 , A61F2/02 , A01N25/34 , A61F13/15 , A61K47/38
CPC分类号： A61L26/009 , A61L15/28 , A61L15/32 , A61L15/325 , A61L15/425 , A61L15/44 , A61L15/64 , A61L26/0066 , A61L2300/404 , A61L2300/412 , A61L2300/414 , A61L2300/602
摘要： The invention provides wound dressing and/or implant materials comprising a matrix structure of sponge, at least one substructure and at least one pharmacologically active agent, wherein both the matrix structure and the substructure are formed from bioabsorbable biopolymer materials. The substructure may, for example, comprise biopolymer films, flakes, fibres or microspheres embedded in the matrix structure of sponge. The pharmacologically active agent may comprise antiseptics, antibiotics, analgesics. One or more such active agents may be incorporated separately into the matrix and/or the substructure so as to achieve controlled or phasic release of the active agents into the wound.
摘要翻译： 本发明提供了包含海绵的基质结构，至少一种亚结构和至少一种药理学活性剂的伤口敷料和/或植入材料，其中所述基质结构和所述亚结构均由生物可吸收的生物聚合物材料形成。 子结构可以例如包括嵌入海绵的基质结构中的生物聚合物膜，薄片，纤维或微球。 药理活性剂可以包含防腐剂，抗生素，止痛剂。 一种或多种这样的活性剂可以分开地并入基质和/或亚结构中，以便实现活性剂到伤口中的受控或阶段释放。
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公开(公告)号：US5700476A
公开(公告)日：1997-12-23
申请号：US393963
申请日：1995-02-24
IPC分类号： A61L15/28 , A61L15/32 , A61L15/42 , A61L15/44 , A61L15/64 , A61L26/00 , A61F2/02 , A61F13/15 , A61F13/20 , A61K47/42
CPC分类号： A61L26/009 , A61L15/28 , A61L15/32 , A61L15/325 , A61L15/425 , A61L15/44 , A61L15/64 , A61L26/0066 , A61L2300/404 , A61L2300/412 , A61L2300/414 , A61L2300/602
摘要： The invention provides wound dressing and/or implant materials comprising a matrix structure of sponge, at least one substructure and at least one pharmacologically active agent, wherein both the matrix structure and the substructure are formed from bioabsorbable biopolymer materials. The substructure may, for example, comprise biopolymer films, flakes, fibres or microspheres embedded in the matrix structure of sponge. The pharmacologically active agent may comprise antiseptics, antibiotics, analgesics. One or more such active agents may be incorporated separately into the matrix and/or the substructure so as to achieve controlled or phasic release of the active agents into the wound.
摘要翻译： 本发明提供了包含海绵的基质结构，至少一种亚结构和至少一种药理学活性剂的伤口敷料和/或植入材料，其中所述基质结构和所述亚结构均由生物可吸收的生物聚合物材料形成。 子结构可以例如包括嵌入海绵的基质结构中的生物聚合物膜，薄片，纤维或微球。 药理活性剂可以包含防腐剂，抗生素，止痛剂。 一种或多种这样的活性剂可以分开地并入基质和/或亚结构中，以便实现活性剂到伤口中的受控或阶段释放。
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公开(公告)号：US5660857A
公开(公告)日：1997-08-26
申请号：US437905
申请日：1995-05-10
申请人： Carla A. Haynes , Wilson Harvey , Paul W. Watt
发明人： Carla A. Haynes , Wilson Harvey , Paul W. Watt
IPC分类号： A61K8/02 , A61K8/04 , A61K8/65 , A61K8/92 , A61K9/16 , A61K9/70 , A61L27/48 , A61Q11/00 , A61Q19/00 , A61K9/48 , A61F2/02
CPC分类号： A61Q19/00 , A61K8/0208 , A61K8/65 , A61K8/92 , A61K8/922 , A61K9/1658 , A61K9/7007 , A61L27/48
摘要： A process for preparing a composite comprising an insoluble protein matrix and an oleaginous material, which is useful as a material for surgical dressings and biomedical implants, and as a cosmetic material for application to the skin. The process comprises the steps of mixing a protein, the oleaginous material and water to form an emulsion of the oleaginous material in an aqueous dispersion of the protein, and subsequently drying or freeze-drying the emulsion to form a film or a sponge.
摘要翻译： 一种制备包含不溶性蛋白质基质和油性材料的复合材料的方法，其可用作外科敷料和生物医学植入物的材料，以及用作施用于皮肤的化妆品材料。 该方法包括以下步骤：将蛋白质，含油材料和水混合以形成含油材料在蛋白质的水分散体中的乳液，然后干燥或冷冻干燥乳液以形成膜或海绵。
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公开(公告)号：US6106855A
公开(公告)日：2000-08-22
申请号：US35002
申请日：1993-03-22
申请人： Carla A. Haynes , Wilson Harvey
发明人： Carla A. Haynes , Wilson Harvey
IPC分类号： A61K6/00 , A61K8/06 , A61K8/64 , A61K8/65 , A61K8/92 , A61K9/00 , A61K9/16 , A61K9/70 , A61K47/42 , A61L26/00 , A61L27/22 , A61Q19/00 , A61L15/00
CPC分类号： A61K8/062 , A61K47/42 , A61K8/06 , A61K8/64 , A61K8/65 , A61K8/922 , A61K9/0063 , A61K9/1617 , A61K9/1658 , A61K9/7007 , A61L26/0028 , A61L27/22 , A61Q19/00
摘要： Stable oil-in-water emulsions are prepared by mixing oil, water and an insoluble protein at high shear. By varying the amount of insoluble protein the emulsions may be made liquid, semisolid or solid. The preferred insoluble proteins are insoluble fibrous proteins such as collagen. The emulsions may be medicated with hydrophilic or hydrophobic pharmacologically active agents and are useful as or in wound dressings or ointments.
摘要翻译： 稳定的水包油乳液通过在高剪切下混合油，水和不溶性蛋白质来制备。 通过改变不溶性蛋白质的量，乳液可以制成液体，半固体或固体。 优选的不溶性蛋白质是不溶性纤维蛋白质，如胶原蛋白。 乳液可以用亲水或疏水的药理学活性剂来加药，并且可用作伤口敷料或软膏。
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公开(公告)号：US06309661B1
公开(公告)日：2001-10-30
申请号：US09032607
申请日：1998-02-27
申请人： Carla A. Haynes , Elaine Lorimer
发明人： Carla A. Haynes , Elaine Lorimer
IPC分类号： A61F200
CPC分类号： A61L15/64 , A61L15/225 , A61L15/28 , A61L15/44 , A61L2300/414 , Y10S514/953 , C08L5/00
摘要： Solid, bioabsorbable materials for use as wound dressings comprise at least 50% by weight of a mixture of xanthan and at least one galactomannan, such as guar gum or locust bean gum. The weight ratio of xanthan: total galactomannans is in the range 1:99 to 99:1, preferably 10:99 to 99:10. The material is preferably made in the form of a sponge by freeze drying a mixed aqueous gel of the xanthan and galactomannans.
摘要翻译： 用作伤口敷料的固体，生物可吸收材料包含至少50重量％的黄原胶和至少一种半乳甘露聚糖如瓜尔胶或刺槐豆胶的混合物。 黄原胶：总半乳甘露聚糖的重量比在1:99至99:1，优选10:99至99:10的范围内。 该材料优选通过将黄原胶和半乳甘露聚糖的混合水凝胶冷冻干燥而制成海绵状。
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