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1.发明授权
公开(公告)号：US5447940A
公开(公告)日：1995-09-05
申请号：US280917
申请日：1994-07-27
IPC分类号： A61K9/70 , A61F2/02 , A61F2/06 , A61K6/00 , A61K9/00 , A61K31/65 , A61K31/70 , A61K45/00 , A61K47/34 , A61K47/42 , A61L15/00 , A61L27/48 , A61L27/50 , A61L31/00 , A61L31/12 , A61L31/14 , A61P1/00 , A61P31/04 , A01N43/42 , A61K31/47
CPC分类号： A61L31/14 , A61K9/0063 , A61L27/48 , A61L27/50 , A61L31/129 , A61F2/06 , A61F2210/0004 , Y10S514/801
摘要： Absorbable composite materials are described that comprise a collagen matrix reinforced with a layer of a bioabsorbable polymer. A chemotherapeutic agent is dispersed in the composite material. The layer of bioabsorbable polymer is preferably a woven, nonwoven or knitted mesh layer of a synthetic bioabsorbable polymer such as polylactic/polyglycolic acid copolymer, or oxidised regenerated cellulose. The chemotherapeutic agent may be an antibiotic, an anaesthetic, an antiseptic or an anti-inflammatory. Strips of the composite material are inserted into the periodontal pocket, where they are retained in place and provide effective sustained release of the chemotherapeutic agent over an extended period.
摘要翻译： 描述了包含用生物可吸收聚合物层增强的胶原基质的可吸收复合材料。 化疗剂分散在复合材料中。 生物可吸收聚合物层优选为合成的生物可吸收聚合物如聚乳酸/聚乙醇酸共聚物或氧化再生纤维素的织造，非织造或针织网眼层。 化疗剂可以是抗生素，麻醉剂，防腐剂或抗炎剂。 将复合材料的条带插入到牙周袋中，在那里它们被保留在适当的位置，并在长时间内提供化学治疗剂的有效持续释放。
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公开(公告)号：US6106855A
公开(公告)日：2000-08-22
申请号：US35002
申请日：1993-03-22
申请人： Carla A. Haynes , Wilson Harvey
发明人： Carla A. Haynes , Wilson Harvey
IPC分类号： A61K6/00 , A61K8/06 , A61K8/64 , A61K8/65 , A61K8/92 , A61K9/00 , A61K9/16 , A61K9/70 , A61K47/42 , A61L26/00 , A61L27/22 , A61Q19/00 , A61L15/00
CPC分类号： A61K8/062 , A61K47/42 , A61K8/06 , A61K8/64 , A61K8/65 , A61K8/922 , A61K9/0063 , A61K9/1617 , A61K9/1658 , A61K9/7007 , A61L26/0028 , A61L27/22 , A61Q19/00
摘要： Stable oil-in-water emulsions are prepared by mixing oil, water and an insoluble protein at high shear. By varying the amount of insoluble protein the emulsions may be made liquid, semisolid or solid. The preferred insoluble proteins are insoluble fibrous proteins such as collagen. The emulsions may be medicated with hydrophilic or hydrophobic pharmacologically active agents and are useful as or in wound dressings or ointments.
摘要翻译： 稳定的水包油乳液通过在高剪切下混合油，水和不溶性蛋白质来制备。 通过改变不溶性蛋白质的量，乳液可以制成液体，半固体或固体。 优选的不溶性蛋白质是不溶性纤维蛋白质，如胶原蛋白。 乳液可以用亲水或疏水的药理学活性剂来加药，并且可用作伤口敷料或软膏。
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公开(公告)号：US06001895A
公开(公告)日：1999-12-14
申请号：US994276
申请日：1997-12-19
IPC分类号： A61K6/00 , A61K8/04 , A61K9/16 , A61K9/70 , A61L27/48 , A61L27/50 , A61L31/12 , A61Q11/00 , A61Q19/00 , A61F2/00
CPC分类号： A61L27/48 , A61K9/1658 , A61K9/7007 , A61L27/50 , A61L31/129
摘要： A composite surgical material comprising a collagen matrix reinforced by a layer of a synthetic bioabsorbable material such as polylactide/polyglycolide or oxidized regenerated cellulose, and wherein oil droplets are dispersed in the collagen matrix. The oil droplets comprise 1% to 75% of the weight of the composite and result in improved leak-proofing of the composite. The composite, in the form of a sheet or a tube, is especially useful as a temporary, fully bioabsorbable prosthesis, for membranes or blood vessels where a highly leak-proof prosthesis is required. The invention also provides a method of making a composite surgical material comprising the steps of: providing a layer of a synthetic bioabsorbable material; providing a dispersion of collagen in an oil-in-water emulsion; coating at least one face of the layer of synthetic bioabsorbable material with the said dispersion; and drying the composite material thus obtained.
摘要翻译： 一种复合手术材料，其包含由合成的生物可吸收材料层如聚丙交酯/聚乙交酯或氧化再生纤维素增强的胶原基质，并且其中油滴分散在胶原基质中。 油滴占复合材料重量的1％至75％，从而改善了复合材料的防漏性能。 以片或管的形式的复合材料作为需要高度防漏假体的膜或血管的临时的，完全生物可吸收的假体是特别有用的。 本发明还提供一种制备复合外科材料的方法，包括以下步骤：提供合成的生物可吸收材料的层; 提供胶原蛋白在水包油乳液中的分散体; 用所述分散体涂覆合成的生物可吸收材料层的至少一个面; 并干燥由此获得的复合材料。
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公开(公告)号：US5660857A
公开(公告)日：1997-08-26
申请号：US437905
申请日：1995-05-10
申请人： Carla A. Haynes , Wilson Harvey , Paul W. Watt
发明人： Carla A. Haynes , Wilson Harvey , Paul W. Watt
IPC分类号： A61K8/02 , A61K8/04 , A61K8/65 , A61K8/92 , A61K9/16 , A61K9/70 , A61L27/48 , A61Q11/00 , A61Q19/00 , A61K9/48 , A61F2/02
CPC分类号： A61Q19/00 , A61K8/0208 , A61K8/65 , A61K8/92 , A61K8/922 , A61K9/1658 , A61K9/7007 , A61L27/48
摘要： A process for preparing a composite comprising an insoluble protein matrix and an oleaginous material, which is useful as a material for surgical dressings and biomedical implants, and as a cosmetic material for application to the skin. The process comprises the steps of mixing a protein, the oleaginous material and water to form an emulsion of the oleaginous material in an aqueous dispersion of the protein, and subsequently drying or freeze-drying the emulsion to form a film or a sponge.
摘要翻译： 一种制备包含不溶性蛋白质基质和油性材料的复合材料的方法，其可用作外科敷料和生物医学植入物的材料，以及用作施用于皮肤的化妆品材料。 该方法包括以下步骤：将蛋白质，含油材料和水混合以形成含油材料在蛋白质的水分散体中的乳液，然后干燥或冷冻干燥乳液以形成膜或海绵。
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公开(公告)号：US6015844A
公开(公告)日：2000-01-18
申请号：US995228
申请日：1997-12-19
CPC分类号： A61K9/7007 , A61K9/1658 , A61L27/48
摘要： A composite surgical material comprising a collagen matrix reinforced by a layer of a synthetic bioabsorbable material such as polylactide/polyglycolide or oxidised regenerated cellulose, and wherein oil droplets are dispersed in the collagen matrix. The oil droplets comprise 1% to 75% of the weight of the composite and result in improved leak-proofing of the composite. The composite, in the form of a sheet or a tube, is especially useful as a temporary, fully bioabsorbable prosthesis, for membranes or blood vessels where a highly leak-proof prosthesis is required. The invention also provides a method of making a composite surgical material comprising the steps of: providing a layer of a synthetic bioabsorbable material; providing a dispersion of collagen in an oil-in-water emulsion; coating at least one face of the layer of synthetic bioabsorbable material with the said dispersion; and drying the composite material thus obtained.
摘要翻译： 一种复合手术材料，其包含由合成的生物可吸收材料层如聚丙交酯/聚乙交酯或氧化的再生纤维素增强的胶原基质，并且其中油滴分散在胶原基质中。 油滴占复合材料重量的1％至75％，从而改善了复合材料的防漏性能。 以片或管的形式的复合材料作为需要高度防漏假体的膜或血管的临时的，完全生物可吸收的假体是特别有用的。 本发明还提供一种制备复合外科材料的方法，包括以下步骤：提供合成的生物可吸收材料的层; 提供胶原蛋白在水包油乳液中的分散体; 用所述分散体涂覆合成的生物可吸收材料层的至少一个面; 并干燥由此获得的复合材料。
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公开(公告)号：US5789465A
公开(公告)日：1998-08-04
申请号：US280916
申请日：1994-07-27
IPC分类号： A61K9/70 , A61F2/02 , A61F2/06 , A61K6/00 , A61K9/00 , A61K31/65 , A61K31/70 , A61K45/00 , A61K47/34 , A61K47/42 , A61L15/00 , A61L27/48 , A61L27/50 , A61L31/00 , A61L31/12 , A61L31/14 , A61P1/00 , A61P31/04 , A61F2/00 , A01N25/34
CPC分类号： A61L31/14 , A61K9/0063 , A61L27/48 , A61L27/50 , A61L31/129 , A61F2/06 , A61F2210/0004 , Y10S514/801
摘要： A composite surgical material comprising a collagen matrix reinforced by a layer of a synthetic bioabsorbable material such as polylactide/polyglycolide or oxidized regenerated cellulose, and wherein oil droplets are dispersed in the collagen matrix. The oil droplets comprise 1% to 75% of the weight of the composite and result in improved leak-proofing of the composite. The composite, in the form of a sheet or a tube, is especially useful as a temporary, fully bioabsorbable prosthesis, for membranes or blood vessels where a highly leak-proof prosthesis is required. The invention also provides a method of making a composite surgical material comprising the steps of: providing a layer of a synthetic bioabsorbable material; providing a dispersion of collagen in an oil-in-water emulsion; coating at least one face of the layer of synthetic bioabsorbable material with the said dispersion; and drying the composite material thus obtained.
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公开(公告)号：US5611793A
公开(公告)日：1997-03-18
申请号：US325322
申请日：1994-10-25
申请人： Michael Wilson , Wilson Harvey
发明人： Michael Wilson , Wilson Harvey
IPC分类号： A61B18/20 , A61C3/02 , A61K9/08 , A61K31/409 , A61K31/5415 , A61K41/00 , A61K45/00 , A61N5/06 , A61N5/067 , A61P1/02 , A61P31/04 , A61P31/10 , A61P43/00 , A61B17/32
CPC分类号： A61Q11/00 , A61K8/042 , A61N5/0601 , A61N5/062 , A61N5/0624 , A61Q17/005 , A61K2800/434 , A61K2800/81 , A61N2005/0606 , A61N2005/0662 , A61N2005/067
摘要： A method of disinfecting or sterilizing tissues of the oral cavity or a wound or lesion in the oral cavity is provided. The method comprises applying a photosensitizing compound to said tissues, wound or lesion and irradiating said tissues, wound or lesion with laser light at a wavelength absorbed by said photosensitizing compound.
摘要翻译： PCT No.PCT / GB93 / 00909 Sec。 371日期：1994年10月25日 102（e）日期1994年10月25日PCT提交1993年4月30日PCT公布。 公开号WO93 / 21992 日期1993年11月11日提供口腔消毒或消毒组织或伤口或损伤的方法。 该方法包括向所述组织，伤口或损伤施加光敏化合物，并用由所述光敏化合物吸收的波长的激光照射所述组织，伤口或损伤。
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公开(公告)号：US06440940B1
公开(公告)日：2002-08-27
申请号：US08993372
申请日：1997-12-18
IPC分类号： A61K31715
CPC分类号： C08B37/0084 , A61L15/28 , A61L27/20 , A61L31/042 , C08L5/04
摘要： The invention provides oxidized alginates that are bioresorbable. The oxidized alginates are prepared by controlled oxidation of alginates with nitrogen tetroxide or the like, The invention also provides pharmaceutical compositions, wound dressings, surgical implants and prostheses comprising the oxidized alginate derivatives.
摘要翻译： 本发明提供了生物可再吸收的氧化藻酸盐。 氧化的藻酸盐通过用氮氧化物等控制氧化藻酸盐来制备。本发明还提供药物组合物，伤口敷料，外科植入物和包含氧化的藻酸盐衍生物的假体。
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公开(公告)号：US5192362A
公开(公告)日：1993-03-09
申请号：US735752
申请日：1991-07-29
申请人： Wilson Harvey , Michael Wilson
发明人： Wilson Harvey , Michael Wilson
摘要： To combat the accumulation of plaque on dentures, a non self-supporting coating of a non-toxic, negatively charged polysaccharide is applied. The polysaccharide coating is gradually sacrificed or ablated during wear. Ablation appears to remove microorganisms along with coating material. The polysaccharide is further defined by an ability to reduce the adhesion of Streptococcus salivarius cells in a simple in vitro bacterial adhesion test by at least 25% over a control.
摘要翻译： PCT No.PCT / GB89 / 00134 Sec。 371 1990年6月29日第 102（e）日期1990年6月29日PCT提交1989年2月10日PCT公布。 出版物WO89 / 07437 日期1989年8月24日。为了对抗假牙上斑块的积累，应用无毒，带负电荷的多糖的非自支撑涂层。 多糖涂层在磨损期间逐渐被牺牲或消融。 消融似乎与涂层材料一起除去微生物。 多糖还通过在简单的体外细菌粘附试验中将唾液链球菌细胞的粘附力降低至少25％以上的能力来定义。
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公开(公告)号：US5514181A
公开(公告)日：1996-05-07
申请号：US314986
申请日：1994-09-29
CPC分类号： A61L27/58 , A61B17/1146 , A61F2/08 , A61L27/48 , A61B2017/00004 , A61F2002/30062 , A61F2002/30064 , A61F2002/30224 , A61F2002/30291 , A61F2002/30293 , A61F2002/30971 , A61F2210/0004 , A61F2230/0069 , A61F2230/0091 , A61F2240/001 , Y10S623/901
摘要： A fully absorbable prosthesis (1) for the repair of damaged ligaments and/or tendons in the form of a multilayer spiral roll comprising the following spiral layers: a foraminous layer (2) of a synthetic bioabsorbable material; a bioabsorbable film (3); and a layer (4) of a bioabsorbable biopolymer sponge. The invention also provides a method of making such a prosthesis, comprising the steps of: providing a laminate of a foraminous layer of bioabsorbable material and a bioabsorbable film; coating the laminate with a layer of an aqueous gel comprising a bioabsorbable polymer; rolling up the laminate and the gel layer into a spiral roll, followed by drying the gel to form a layer of bioabsorbable sponge. The foraminous layer (2) preferably comprises a synthetic bioabsorbable polymer having high tensile strength. The bioabsorbable film (3) and sponge layer (4) preferably comprise a chemotactic biopolymer such as collagen.
摘要翻译： 一种完全可吸收的假体（1），用于修复包括以下螺旋层的多层螺旋卷形式的受损韧带和/或腱：一种合成的生物可吸收材料的多孔层（2） 生物可吸收膜（3）; 和生物可吸收生物聚合物海绵的层（4）。 本发明还提供了一种制造这种假体的方法，包括以下步骤：提供生物可吸收材料的多孔层和生物可吸收膜的层压体; 用包含生物可吸收聚合物的水性凝胶层涂覆层压体; 将层压体和凝胶层卷起成螺旋卷，然后干燥凝胶以形成生物可吸收海绵层。 多孔层（2）优选包含具有高拉伸强度的合成的生物可吸收聚合物。 生物可吸收膜（3）和海绵层（4）优选包含趋化性生物聚合物如胶原蛋白。
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