Microvalve device and method of manufacturing the same
    5.
    发明授权
    Microvalve device and method of manufacturing the same 有权
    微阀装置及其制造方法

    公开(公告)号:US09267618B2

    公开(公告)日:2016-02-23

    申请号:US13110452

    申请日:2011-05-18

    IPC分类号: B01L99/00 F16K99/00 B01L3/00

    摘要: A microvalve device comprises: a first substrate having a first surface, where at least one fluidic channel is formed into the first surface of the first substrate; and at least one valve seat is formed in the fluidic channel; a second substrate having a second surface, the second substrate comprising at least one air channel and at least one air chamber formed on the second surface of the second substrate, where the air chamber is connected to the air channel; and an elastic film interposed between the first substrate and the second substrate, where an upper portion of the valve seat is lower than the first surface of the first substrate.

    摘要翻译: 微阀装置包括:具有第一表面的第一基板,其中至少一个流体通道形成在第一基板的第一表面中; 并且至少一个阀座形成在流体通道中; 具有第二表面的第二基板,所述第二基板包括至少一个空气通道和形成在所述第二基板的第二表面上的至少一个空气室,其中所述空气室连接到所述空气通道; 以及插入在第一基板和第二基板之间的弹性膜,其中阀座的上部比第一基板的第一表面低。

    Cell lysis device and methods of lysing cells or viruses
    6.
    发明授权
    Cell lysis device and methods of lysing cells or viruses 有权
    细胞裂解装置和裂解细胞或病毒的方法

    公开(公告)号:US08986986B2

    公开(公告)日:2015-03-24

    申请号:US13284364

    申请日:2011-10-28

    CPC分类号: C12M1/00 C12M1/33 C12M47/06

    摘要: A method of lysing at least one of a cell and a virus, the method including: contacting a sample, which includes at least one of a cell and a virus, with a plurality of beads which are disposed in a first chamber to obtain a combination of the sample and the beads; and agitating the combination of the sample and the beads to lyse the at least one of the cell and the virus, wherein in the first chamber a liquid volume fraction is 0.6 or less, and wherein the liquid volume fraction is a value obtained by dividing a liquid volume of the first chamber by a pure void volume equivalent to a sum of the liquid volume of the first chamber and a void volume of the first chamber.

    摘要翻译: 一种裂解细胞和病毒中的至少一种的方法,所述方法包括:将包括细胞和病毒中的至少一种的样品与设置在第一室中的多个珠接触以获得组合 的样品和珠粒; 并搅拌样品和珠的组合以裂解细胞和病毒中的至少一种,其中在第一室中液体体积分数为0.6或更小,并且其中液体体积分数是通过将 第一室的液体体积相当于第一室的液体体积和第一室的空隙体积的总和的纯空隙体积。

    Micro-fluid supplying device having gas bubble trapping function
    8.
    发明授权
    Micro-fluid supplying device having gas bubble trapping function 有权
    具有气泡捕集功能的微流体供给装置

    公开(公告)号:US09061277B2

    公开(公告)日:2015-06-23

    申请号:US13298482

    申请日:2011-11-17

    IPC分类号: C12M3/00 B01L3/00

    摘要: A micro-fluid supplying device having a gas bubble trapping function. The micro-fluid supplying device includes: a fluid supplier including a fluid having a biomaterial; a trap chamber in which a gas bubble is removed from the fluid supplied from the fluid supplier; and a fluid discharger which externally discharges a material supplied from the trap chamber. Material properties of a side wall and a bottom of an inside of the trap chamber are different from each other. The side wall has a better property of wetting with respect to the fluid supplied from the fluid supplier than the bottom.

    摘要翻译: 具有气泡捕获功能的微流体供给装置。 微流体供应装置包括:流体供应器,其包括具有生物材料的流体; 捕集室,其中气体从流体供应器供应的流体中移除; 以及从所述收集室供给的材料外部排出的流体排出器。 捕集室的侧壁和底部的材料性质彼此不同。 相对于从流体供应者供应的流体而言,侧壁具有比底部更好的润湿性能。

    Method and apparatus for controlling quality of a microfluidic device
    10.
    发明授权
    Method and apparatus for controlling quality of a microfluidic device 有权
    用于控制微流体装置质量的方法和装置

    公开(公告)号:US08411277B2

    公开(公告)日:2013-04-02

    申请号:US12765956

    申请日:2010-04-23

    IPC分类号: G01N21/84 G01N21/55

    CPC分类号: G01N21/95607

    摘要: A method for determining the quality of a microfluidic device, the method including placing a microfluidic device including a valve on a stage; radiating light on the valve of the microfluidic device; detecting light reflected from the valve using a photodetector; opening the valve of the microfluidic device; and comparing a change of the light reflected from the valve when the valve is opened with previously-stored reference data to evaluate a quality of the microfluidic device, wherein the valve of the microfluidic device includes a valve seat, which protrudes into a microfluidic path, and a polymer film, which opens and closes the valve.

    摘要翻译: 一种用于确定微流体装置的质量的方法,所述方法包括将包括阀的微流体装置放置在载物台上; 在微流体装置的阀上照射光; 使用光电检测器检测从所述阀反射的光; 打开微流体装置的阀门; 以及比较当阀打开时从阀反射的光的变化与预先存储的参考数据进行比较,以评估微流体装置的质量,其中微流体装置的阀包括突出到微流体路径中的阀座, 以及打开和关闭阀的聚合物膜。