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公开(公告)号：US5308889A
公开(公告)日：1994-05-03
申请号：US984197
申请日：1992-12-02
申请人： Woonza Rhee , Louis Fries , Ramesh Damani , Kimberly McCullough , Frank DeLustro
发明人： Woonza Rhee , Louis Fries , Ramesh Damani , Kimberly McCullough , Frank DeLustro
IPC分类号： A61L27/00 , A61F2/00 , A61F2/06 , A61K38/00 , A61K38/17 , A61K38/21 , A61K38/22 , A61K45/06 , A61K47/48 , A61L15/22 , A61L24/10 , A61L26/00 , A61L27/18 , A61L27/20 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/54 , A61L29/04 , A61L29/06 , A61L29/16 , A61L31/04 , A61L31/10 , A61L31/12 , A61P17/00 , A61P43/00 , C07K14/495 , C07K14/78 , C08B37/08 , C08G81/00 , C08H1/00 , C08H1/06 , C08L89/00 , C08L89/06 , C09J189/06 , G02B1/04 , C08G63/48 , C08G63/91
CPC分类号： C08L89/06 , A61K47/48215 , A61K47/4823 , A61K47/48292 , A61L15/225 , A61L24/102 , A61L26/0033 , A61L27/18 , A61L27/20 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/54 , A61L29/043 , A61L29/045 , A61L29/06 , A61L29/16 , A61L31/041 , A61L31/042 , A61L31/044 , A61L31/10 , A61L31/125 , C07K14/495 , C07K14/78 , C08B37/0069 , C08B37/0072 , C08H1/06 , C09J189/06 , G02B1/043 , A61F2/07 , A61F2310/00365 , A61K38/00 , A61L2300/252 , A61L2300/414 , A61L2300/426 , A61L2300/62 , A61L2300/802 , A61L2430/16 , Y10S525/937
摘要： Medical articles in the form of strings are formed by covalently binding collagen to pharmaceutically pure, synthetic, hydrophilic polymers via specific types of chemical bonds to provide collagen/polymer conjugate formulations which are extruded to make the strings. The collagen may be recombinantly produced human collagen or collagen extracted from any source, such as a bovine source or human placenta, and purified and can be of various types and may be fibrillar or non-fibrillar. The synthetic hydrophilic polymer may be polyethylene glycol and derivatives thereof having an average molecular weight over a range of from about 100 to about 20,000. The string can be designed to incorporate other components such as fluid, pharmaceutically acceptable carriers to form injectable formulations, and/or biologically active proteins such as growth factors or cytokines. The strings contain large amounts of water when extruded and may then be dehydrated to form relatively solid but flexible strings. The strings can be injected into a living being for the purpose of providing soft tissue augmentation. Once in place, the strings rehydrate and expand in size five fold or more. Aqueous solution can be provided to enhance the rate of rehydration. The strings can also be used to suture wounds which strings can be chemically designed to dissolve in situ.
摘要翻译： 通过特定类型的化学键将胶原与药学上纯的，合成的亲水性聚合物共价结合形成的药物形式，以提供被挤出以制备丝束的胶原/聚合物缀合物制剂。 胶原蛋白可以是重组产生的人胶原或从任何来源例如牛源或人胎盘提取的胶原，并且可以是各种类型的，并且可以是纤维状或非纤维状的。 合成亲水性聚合物可以是平均分子量在约100至约20,000范围内的聚乙二醇及其衍生物。 该串可被设计成结合其它组分如流体，药学上可接受的载体以形成可注射制剂，和/或生物活性蛋白如生长因子或细胞因子。 当挤出时，该串含有大量的水，然后可以脱水以形成相对固体但柔性的串。 为了提供软组织增加的目的，可以将线注射到活体中。 一旦到位，字符串水合并扩大五倍以上。 可以提供水溶液以提高再水合速率。 弦也可用于缝合可以化学设计的弦可以原位溶解的伤口。
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公开(公告)号：US5264214A
公开(公告)日：1993-11-23
申请号：US930142
申请日：1992-08-14
申请人： Woonza Rhee , Donald G. Wallace , Alan S. Michaels , Ramon A. Burns, Jr. , Louis Fries , Frank DeLustro , Hanne Bentz
发明人： Woonza Rhee , Donald G. Wallace , Alan S. Michaels , Ramon A. Burns, Jr. , Louis Fries , Frank DeLustro , Hanne Bentz
IPC分类号： A61F2/00 , A61F2/06 , A61L24/10 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/54 , A61L31/04 , A61L31/10 , A61L31/12 , C08H1/06 , C08L89/06 , C09J189/06 , C08G63/48 , A61F13/00
CPC分类号： C08L89/06 , A61L24/102 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/54 , A61L31/041 , A61L31/044 , A61L31/10 , A61L31/125 , C08H1/06 , C09J189/06 , A61F2/07 , A61F2310/00365 , A61L2300/414 , A61L2300/602 , A61L2430/02 , A61L2430/16
摘要： Collagen, particularly atelopeptide collagen, exhibits improved handling characteristics when chemically conjugated and/or crosslinked with a synthetic hydrophilic polymer.
摘要翻译： 当与合成亲水性聚合物进行化学共轭和/或交联时，胶原，特别是肽肽胶原表现出改进的处理特性。
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公开(公告)号：US5413791A
公开(公告)日：1995-05-09
申请号：US198128
申请日：1994-02-17
申请人： Woonza Rhee , Donald G. Wallace , Alan S. Michaels , Ramon A. Burns, Jr. , Louis Fries , Frank DeLustro , Hanne Bentz
发明人： Woonza Rhee , Donald G. Wallace , Alan S. Michaels , Ramon A. Burns, Jr. , Louis Fries , Frank DeLustro , Hanne Bentz
IPC分类号： A61L27/00 , A61F2/00 , A61F2/06 , A61K38/00 , A61K38/17 , A61K38/21 , A61K38/22 , A61K45/06 , A61K47/48 , A61L15/22 , A61L24/10 , A61L26/00 , A61L27/18 , A61L27/20 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/54 , A61L29/04 , A61L29/06 , A61L29/16 , A61L31/04 , A61L31/10 , A61L31/12 , A61P17/00 , A61P43/00 , C07K14/495 , C07K14/78 , C08B37/08 , C08G81/00 , C08H1/00 , C08H1/06 , C08L89/00 , C08L89/06 , C09J189/06 , G02B1/04 , A61F13/00 , A61K9/14 , A61K9/50
CPC分类号： C08L89/06 , A61K47/48215 , A61K47/4823 , A61K47/48292 , A61L15/225 , A61L24/102 , A61L26/0033 , A61L27/18 , A61L27/20 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/54 , A61L29/043 , A61L29/045 , A61L29/06 , A61L29/16 , A61L31/041 , A61L31/042 , A61L31/044 , A61L31/10 , A61L31/125 , C07K14/495 , C07K14/78 , C08B37/0069 , C08B37/0072 , C08H1/06 , C09J189/06 , G02B1/043 , A61F2/07 , A61F2310/00365 , A61K38/00 , A61L2300/252 , A61L2300/414 , A61L2300/426 , A61L2300/62 , A61L2300/802 , A61L2430/16 , Y10S525/937
摘要： Pharmaceutically acceptable, non-immunogenic compositions are formed by covalently binding atelopeptide collagen to pharmaceutically pure, synthetic, hydrophilic polymers via specific types of chemical bonds to provide collagen/polymer conjugates. The atelopeptide collagen can be type I, type II or type III and may be fibrillar or non-fibrillar. The synthetic hydrophilic polymer may be polyethylene glycol and derivatives thereof having a weight average molecular weight over a range of from about 100 to about 20,000. The compositions may include other components such as liquid, pharmaceutically acceptable, carriers to form injectable formulations, and/or biologically active proteins such as growth factors. The collagen-polymer conjugates of the invention generally contain large amounts of water when formed. The conjugates can be dehydrated to form a relatively solid object. The dehydrated, solid object can be ground into particles which can be suspended in a non-aqueous fluid such as an oil and injected into a living being for the purpose of providing soft tissue augmentation. Once in place, the particles rehydrate and expand in size five fold or more.
摘要翻译： 药学上可接受的非免疫原性组合物通过经由特定类型的化学键共价结合肽肽胶原与药学纯合成的亲水性聚合物形成，以提供胶原/聚合物共轭物。 糖尿病胶原可以是I型，II型或III型，并且可以是纤维状或非纤维状的。 合成亲水性聚合物可以是重均分子量在约100至约20,000范围内的聚乙二醇及其衍生物。 组合物可以包括其它组分，例如液体，药学上可接受的，载体以形成可注射制剂，和/或生物活性蛋白质例如生长因子。 当形成时，本发明的胶原 - 聚合物共轭物通常含有大量的水。 可以将共轭物脱水形成相对固体的物体。 脱水的固体可以被研磨成可以悬浮在诸如油之类的非水性流体中的颗粒，并注入活体以提供软组织增加。 一旦就位，颗粒再水合并扩大五倍以上。
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公开(公告)号：US5446091A
公开(公告)日：1995-08-29
申请号：US368874
申请日：1995-01-05
申请人： Woonza Rhee , Donald G. Wallace , Alan S. Michaels , Ramon A. Burns, Jr. , Louis Fries , Frank DeLustro , Hanne Bentz
发明人： Woonza Rhee , Donald G. Wallace , Alan S. Michaels , Ramon A. Burns, Jr. , Louis Fries , Frank DeLustro , Hanne Bentz
IPC分类号： A61L27/00 , A61F2/00 , A61F2/06 , A61K38/00 , A61K38/17 , A61K38/21 , A61K38/22 , A61K45/06 , A61K47/48 , A61L15/22 , A61L24/10 , A61L26/00 , A61L27/18 , A61L27/20 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/54 , A61L29/04 , A61L29/06 , A61L29/16 , A61L31/04 , A61L31/10 , A61L31/12 , A61P17/00 , A61P43/00 , C07K14/495 , C07K14/78 , C08B37/08 , C08G81/00 , C08H1/00 , C08H1/06 , C08L89/00 , C08L89/06 , C09J189/06 , G02B1/04 , C08G63/48 , C08G63/91
CPC分类号： C08L89/06 , A61K47/48215 , A61K47/4823 , A61K47/48292 , A61L15/225 , A61L24/102 , A61L26/0033 , A61L27/18 , A61L27/20 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/54 , A61L29/043 , A61L29/045 , A61L29/06 , A61L29/16 , A61L31/041 , A61L31/042 , A61L31/044 , A61L31/10 , A61L31/125 , C07K14/495 , C07K14/78 , C08B37/0069 , C08B37/0072 , C08H1/06 , C09J189/06 , G02B1/043 , A61F2/07 , A61F2310/00365 , A61K38/00 , A61L2300/252 , A61L2300/414 , A61L2300/426 , A61L2300/62 , A61L2300/802 , A61L2430/16 , Y10S525/937
摘要： Pharmaceutically acceptable, non-immunogenic compositions are formed by covalently binding atelopeptide collagen to pharmaceutically pure, synthetic, hydrophilic polymers via specific types of chemical bonds to provide collagen/polymer conjugates. The atelopeptide collagen can be type I, type II or type III and may be fibrillar or non-fibrillar. The synthetic hydrophilic polymer may be polyethylene glycol and derivatives thereof having a weight average molecular weight over a range of from about 100 to about 20,000. The compositions may include other components such as liquid, pharmaceutically acceptable, carriers to form injectable formulations, and/or biologically active proteins such as growth factors. The collagen-polymer conjugates of the invention generally contain large amounts of water when formed. The conjugates can be dehydrated to form a relatively solid object. The dehydrated, solid object can be ground into particles which can be suspended in a non-aqueous fluid such as an oil and injected into a living being for the purpose of providing soft tissue augmentation. Once in place, the particles rehydrate and expand in size five fold or more.
摘要翻译： 药学上可接受的非免疫原性组合物通过经由特定类型的化学键共价结合肽肽胶原与药学纯合成的亲水性聚合物形成，以提供胶原/聚合物共轭物。 糖尿病胶原可以是I型，II型或III型，并且可以是纤维状或非纤维状的。 合成亲水性聚合物可以是重均分子量在约100至约20,000范围内的聚乙二醇及其衍生物。 组合物可以包括其它组分，例如液体，药学上可接受的，载体以形成可注射制剂，和/或生物活性蛋白质例如生长因子。 当形成时，本发明的胶原 - 聚合物共轭物通常含有大量的水。 可以将共轭物脱水形成相对固体的物体。 脱水的固体可以被研磨成可以悬浮在诸如油之类的非水性流体中的颗粒，并注入活体以提供软组织增加。 一旦就位，颗粒再水合并扩大五倍以上。
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公开(公告)号：US5376375A
公开(公告)日：1994-12-27
申请号：US177578
申请日：1994-01-05
申请人： Woonza Rhee , Donald G. Wallace , Alan S. Michaels , Ramon A. Burns, Jr. , Louis Fries , Frank DeLustro , Hanne Bentz
发明人： Woonza Rhee , Donald G. Wallace , Alan S. Michaels , Ramon A. Burns, Jr. , Louis Fries , Frank DeLustro , Hanne Bentz
IPC分类号： A61F2/00 , A61F2/06 , A61K9/22 , A61K9/38 , A61L24/10 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/54 , A61L31/04 , A61L31/10 , A61L31/12 , C08H1/06 , C08L89/06 , C09J189/06 , A61F13/00 , A61K9/14 , A61K9/50
CPC分类号： C08L89/06 , A61L24/102 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/54 , A61L31/041 , A61L31/044 , A61L31/10 , A61L31/125 , C08H1/06 , C09J189/06 , A61F2/07 , A61F2310/00365 , A61L2300/414 , A61L2300/426 , A61L2300/602 , A61L2430/02 , A61L2430/16 , Y10S525/935 , Y10S525/937 , Y10S530/84
摘要： Collagen, particularly atelopeptide collagen, exhibits improved handling characteristics when chemically conjugated and/or crosslinked with a synthetic hydrophilic polymer.
摘要翻译： 当与合成亲水性聚合物进行化学共轭和/或交联时，胶原，特别是肽肽胶原表现出改进的处理特性。
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公开(公告)号：US5324775A
公开(公告)日：1994-06-28
申请号：US907518
申请日：1992-07-02
申请人： Woonza Rhee , Donald G. Wallace , Alan S. Michaels , Ramon A. Burns, Jr. , Louis Fries , Frank DeLustro , Hanne Bentz
发明人： Woonza Rhee , Donald G. Wallace , Alan S. Michaels , Ramon A. Burns, Jr. , Louis Fries , Frank DeLustro , Hanne Bentz
IPC分类号： A61L27/00 , A61F2/00 , A61F2/06 , A61K38/00 , A61K38/17 , A61K38/21 , A61K38/22 , A61K45/06 , A61K47/48 , A61L15/22 , A61L24/10 , A61L26/00 , A61L27/18 , A61L27/20 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/54 , A61L29/04 , A61L29/06 , A61L29/16 , A61L31/04 , A61L31/10 , A61L31/12 , A61P17/00 , A61P43/00 , C07K14/495 , C07K14/78 , C08B37/08 , C08G81/00 , C08H1/00 , C08H1/06 , C08L89/00 , C08L89/06 , C09J189/06 , G02B1/04 , C08G63/48 , C08G63/91 , C08G63/40
CPC分类号： C08L89/06 , A61K47/48215 , A61K47/4823 , A61K47/48292 , A61L15/225 , A61L24/102 , A61L26/0033 , A61L27/18 , A61L27/20 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/54 , A61L29/043 , A61L29/045 , A61L29/06 , A61L29/16 , A61L31/041 , A61L31/042 , A61L31/044 , A61L31/10 , A61L31/125 , C07K14/495 , C07K14/78 , C08B37/0069 , C08B37/0072 , C08H1/06 , C09J189/06 , G02B1/043 , A61F2/07 , A61F2310/00365 , A61K38/00 , A61L2300/252 , A61L2300/414 , A61L2300/426 , A61L2300/62 , A61L2300/802 , A61L2430/16 , Y10S525/937
摘要： Pharmaceutically acceptable, non-immunogenic compositions are formed by covalently binding biologically inactive, natural, biocompatible polymer to pharmaceutically pure, synthetic, hydrophilic polymers via specific types of chemical bonds to provide biocompatible conjugates. The synthetic hydrophilic polymer may be polyethylene glycol and derivatives thereof having a weight average molecular weight over a range of from about 100 to about 20,000. The compositions may include other components such as liquid, pharmaceutically acceptable, carriers to form injectable formulations, and/or biologically active proteins such as growth factors. The conjugates of the invention generally contain large amounts of water when formed. The conjugates can be dehydrated to form a relatively solid object. The dehydrated, solid object can be ground into particles which can be suspended in a non-aqueous fluid such as an oil and injected into a living (preferably human) being for the purpose of providing soft tissue augmentation. Once in place, the particles rehydrate and expand in size five fold or more.
摘要翻译： 药学上可接受的非免疫原性组合物通过经由特定类型的化学键共价结合生物活性的，天然的，生物相容的聚合物与药学纯的，合成的，亲水的聚合物形成，以提供生物相容的共轭物。 合成亲水性聚合物可以是重均分子量在约100至约20,000范围内的聚乙二醇及其衍生物。 组合物可以包括其它组分，例如液体，药学上可接受的，载体以形成可注射制剂，和/或生物活性蛋白质例如生长因子。 当形成时，本发明的共轭物通常含有大量的水。 可以将共轭物脱水形成相对固体的物体。 脱水的固体物体可以研磨成可以悬浮在非水性流体例如油中的颗粒，并且注入到生物（优选人）中，以提供软组织增加。 一旦就位，颗粒再水合并扩大五倍以上。
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公开(公告)号：US5328955A
公开(公告)日：1994-07-12
申请号：US922541
申请日：1992-07-30
申请人： Woonza Rhee , Donald G. Wallace , Alan S. Michaels , Ramon A. Burns, Jr. , Louis Fries , Frank DeLustro , Hanne Bentz
发明人： Woonza Rhee , Donald G. Wallace , Alan S. Michaels , Ramon A. Burns, Jr. , Louis Fries , Frank DeLustro , Hanne Bentz
IPC分类号： A61L27/00 , A61F2/00 , A61F2/06 , A61K38/00 , A61K38/17 , A61K38/21 , A61K38/22 , A61K45/06 , A61K47/48 , A61L15/22 , A61L24/10 , A61L26/00 , A61L27/18 , A61L27/20 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/54 , A61L29/04 , A61L29/06 , A61L29/16 , A61L31/04 , A61L31/10 , A61L31/12 , A61P17/00 , A61P43/00 , C07K14/495 , C07K14/78 , C08B37/08 , C08G81/00 , C08H1/00 , C08H1/06 , C08L89/00 , C08L89/06 , C09J189/06 , G02B1/04 , C08G63/48 , A61F13/00
CPC分类号： C08L89/06 , A61K47/48215 , A61K47/4823 , A61K47/48292 , A61L15/225 , A61L24/102 , A61L26/0033 , A61L27/18 , A61L27/20 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/54 , A61L29/043 , A61L29/045 , A61L29/06 , A61L29/16 , A61L31/041 , A61L31/042 , A61L31/044 , A61L31/10 , A61L31/125 , C07K14/495 , C07K14/78 , C08B37/0069 , C08B37/0072 , C08H1/06 , C09J189/06 , G02B1/043 , A61F2/07 , A61F2310/00365 , A61K38/00 , A61L2300/252 , A61L2300/414 , A61L2300/426 , A61L2300/62 , A61L2300/802 , A61L2430/16 , Y10S525/937
摘要： Pharmaceutically acceptable, non-immunogenic compositions are formed by covalently binding atelopeptide collagen to pharmaceutically pure, synthetic, hydrophilic polymers via specific types of chemical bonds to provide collagen/polymer conjugates. The atelopeptide collagen can be type I, type II or type III and may be fibrillar or non-fibrillar. The synthetic hydrophilic polymer may be polyethylene glycol and derivatives thereof having a weight average molecular weight over a range of from about 100 to about 20,000. The compositions may include other components such as liquid, pharmaceutically acceptable, carriers to form injectable formulations, and/or biologically active proteins such as growth factors. The collagen-polymer conjugates of the invention generally contain large amounts of water when formed. The conjugates can be dehydrated to form a relatively solid object. The dehydrated, solid object can be ground into particles which can be suspended in a non-aqueous fluid such as an oil and injected into a living being for the purpose of providing soft tissue augmentation. Once in place, the particles rehydrate and expand in size five fold or more.
摘要翻译： 药学上可接受的非免疫原性组合物通过经由特定类型的化学键共价结合肽肽胶原与药学纯合成的亲水性聚合物形成，以提供胶原/聚合物共轭物。 糖尿病胶原可以是I型，II型或III型，并且可以是纤维状或非纤维状的。 合成亲水性聚合物可以是重均分子量在约100至约20,000范围内的聚乙二醇及其衍生物。 组合物可以包括其它组分，例如液体，药学上可接受的，载体以形成可注射制剂，和/或生物活性蛋白质例如生长因子。 当形成时，本发明的胶原 - 聚合物共轭物通常含有大量的水。 可以将共轭物脱水形成相对固体的物体。 脱水的固体可以被研磨成可以悬浮在诸如油之类的非水性流体中的颗粒，并注入活体以提供软组织增加。 一旦就位，颗粒再水合并扩大五倍以上。
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公开(公告)号：US5304595A
公开(公告)日：1994-04-19
申请号：US998802
申请日：1992-12-30
申请人： Woonza Rhee , Donald G. Wallace , Alan S. Michaels , Ramon A. Burns, Jr. , Louis Fries , Frank DeLustro , Hanne Bentz
发明人： Woonza Rhee , Donald G. Wallace , Alan S. Michaels , Ramon A. Burns, Jr. , Louis Fries , Frank DeLustro , Hanne Bentz
IPC分类号： A61F2/00 , A61F2/06 , A61L24/10 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/54 , A61L31/04 , A61L31/10 , A61L31/12 , C08H1/06 , C08L89/06 , C09J189/06 , C08G63/48 , C08G63/91
CPC分类号： A61L24/102 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/54 , A61L31/041 , A61L31/044 , A61L31/10 , A61L31/125 , C08H1/06 , C08L89/06 , C09J189/06 , A61F2/07 , A61F2310/00365 , A61L2300/414 , A61L2300/602 , A61L2430/02 , A61L2430/16
摘要： Collagen, particularly atelopeptide collagen, exhibits improved handling characteristics when chemically conjugated and/or crosslinked with a synthetic hydrophilic polymer.
摘要翻译： 当与合成亲水性聚合物化学共轭和/或交联时，胶原蛋白，特别是肽肽胶原蛋白，表现出改善的处理特性。
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9.发明授权
公开(公告)号：US5550188A
公开(公告)日：1996-08-27
申请号：US478510
申请日：1995-06-07
申请人： Woonza Rhee , Donald G. Wallace , Alan S. Michaels , Ramon A. Burns, Jr. , Louis Fries , Frank DeLustro , Hanne Bentz
发明人： Woonza Rhee , Donald G. Wallace , Alan S. Michaels , Ramon A. Burns, Jr. , Louis Fries , Frank DeLustro , Hanne Bentz
IPC分类号： A61L27/00 , A61F2/00 , A61F2/06 , A61K38/00 , A61K38/17 , A61K38/21 , A61K38/22 , A61K45/06 , A61K47/48 , A61L15/22 , A61L24/10 , A61L26/00 , A61L27/18 , A61L27/20 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/54 , A61L29/04 , A61L29/06 , A61L29/16 , A61L31/04 , A61L31/10 , A61L31/12 , A61P17/00 , A61P43/00 , C07K14/495 , C07K14/78 , C08B37/08 , C08G81/00 , C08H1/00 , C08H1/06 , C08L89/00 , C08L89/06 , C09J189/06 , G02B1/04 , G02C7/04
CPC分类号： C08L89/06 , A61K47/48215 , A61K47/4823 , A61K47/48292 , A61L15/225 , A61L24/102 , A61L26/0033 , A61L27/18 , A61L27/20 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/54 , A61L29/043 , A61L29/045 , A61L29/06 , A61L29/16 , A61L31/041 , A61L31/042 , A61L31/044 , A61L31/10 , A61L31/125 , C07K14/495 , C07K14/78 , C08B37/0069 , C08B37/0072 , C08H1/06 , C09J189/06 , G02B1/043 , A61F2/07 , A61F2310/00365 , A61K38/00 , A61L2300/252 , A61L2300/414 , A61L2300/426 , A61L2300/62 , A61L2300/802 , A61L2430/16 , Y10S525/937
摘要： Pharmaceutically acceptable, non-immunogenic compositions are formed by covalently binding atelopeptide collagen to pharmaceutically pure, synthetic, hydrophilic polymers via specific types of chemical bonds to provide collagen/polymer conjugates. The atelopeptide collagen can be type I, type II or type III and may be fibrillar or non-fibrillar. The synthetic hydrophilic polymer may be polyethylene glycol and derivatives thereof having a weight average molecular weight over a range of from about 100 to about 20,000. The compositions may include other components such as liquid, pharmaceutically acceptable, carriers to form injectable formulations, and/or biologically active proteins such as growth factors. The collagen-polymer conjugates of the invention generally contain large amounts of water when formed. The conjugates can be dehydrated to form a relatively solid object. The dehydrated, solid object can be ground into particles which can be suspended in a non-aqueous fluid such as an oil and injected into a living being for the purpose of providing soft tissue augmentation. Once in place, the particles rehydrate and expand in size five fold or more.
摘要翻译： 药学上可接受的非免疫原性组合物通过经由特定类型的化学键共价结合肽肽胶原与药学纯合成的亲水性聚合物形成，以提供胶原/聚合物共轭物。 糖尿病胶原可以是I型，II型或III型，并且可以是纤维状或非纤维状的。 合成亲水性聚合物可以是重均分子量在约100至约20,000范围内的聚乙二醇及其衍生物。 组合物可以包括其它组分，例如液体，药学上可接受的，载体以形成可注射制剂，和/或生物活性蛋白质例如生长因子。 当形成时，本发明的胶原 - 聚合物共轭物通常含有大量的水。 可以将共轭物脱水形成相对固体的物体。 脱水的固体可以被研磨成可以悬浮在诸如油之类的非水性流体中的颗粒，并注入活体以提供软组织增加。 一旦就位，颗粒再水合并扩大五倍以上。
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公开(公告)号：US5543441A
公开(公告)日：1996-08-06
申请号：US427576
申请日：1995-04-24
申请人： Woonza Rhee , Donald G. Wallace , Alan S. Michaels , Ramon A. Burns, Jr. , Louis Fries , Frank DeLustro , Hanne Bentz
发明人： Woonza Rhee , Donald G. Wallace , Alan S. Michaels , Ramon A. Burns, Jr. , Louis Fries , Frank DeLustro , Hanne Bentz
IPC分类号： A61F2/00 , A61F2/06 , A61K9/22 , A61K9/38 , A61L24/10 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/54 , A61L31/04 , A61L31/10 , A61L31/12 , C08H1/06 , C08L89/06 , C09J189/06
CPC分类号： C08L89/06 , A61L24/102 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/54 , A61L31/041 , A61L31/044 , A61L31/10 , A61L31/125 , C08H1/06 , C09J189/06 , A61F2/07 , A61F2310/00365 , A61L2300/414 , A61L2300/426 , A61L2300/602 , A61L2430/02 , A61L2430/16 , Y10S525/935 , Y10S525/937 , Y10S530/84
摘要： Collagen, particularly atelopeptide collagen, exhibits improved handling characteristics when chemically conjugated and/or crosslinked with a synthetic hydrophilic polymer.
摘要翻译： 当与合成亲水性聚合物进行化学共轭和/或交联时，胶原，特别是肽肽胶原表现出改进的处理特性。
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