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    Use of hydrophobic crosslinking agents to prepare crosslinked biomaterial compositions
    1.
    发明申请
    Use of hydrophobic crosslinking agents to prepare crosslinked biomaterial compositions 审中-公开
    使用疏水性交联剂制备交联的生物材料组合物

    公开(公告)号：US20050154125A1

    公开(公告)日：2005-07-14

    申请号：US10997246

    申请日：2004-11-23

    申请人： Woonza Rhee

    发明人： Woonza Rhee

    IPC分类号： A61F2/00 ,  A61L24/08 ,  A61L26/00 ,  A61L27/20 ,  A61L27/24 ,  A61L31/04 ,  C08H1/00

    CPC分类号： A61L31/044 ,  A61F2310/00365 ,  A61L24/08 ,  A61L26/0033 ,  A61L27/20 ,  A61L27/24 ,  A61L31/042 ,  A61L2400/06 ,  Y10S514/801 ,  C08L5/00

    摘要： The present invention discloses novel crosslinked biomaterial compositions which are prepared using hydrophobic polymers as a crosslinking agent. Preferred hydrophobic polymers are those that contain two or more reactive succinimidyl groups, including disuccinimidyl suberate, bix(sulfosuccinimidyl)suberate, and dithiobis(succinimidylpropionate). Crosslinked biomaterial compositions prepared using mixtures of hydrophobic and hydrophilic crosslinking agents are also disclosed. The compositions of the present invention can be used to prepare formed implants for use in a variety of medical applications.

    摘要翻译： 本发明公开了使用疏水性聚合物作为交联剂制备的新型交联生物材料组合物。 优选的疏水性聚合物是含有两个或更多个反应性琥珀酰亚胺基的那些，包括辛二酸二琥珀酰亚胺酯，辛二酸双（磺基琥珀酰亚胺基）酯和二硫代双（丙烯酸琥珀酰亚胺酯））。 还公开了使用疏水性和亲水性交联剂的混合物制备的交联的生物材料组合物。 本发明的组合物可用于制备用于各种医疗应用的成形植入物。

    Crosslinked polymer compositions
    5.
    发明申请
    Crosslinked polymer compositions 有权
    交联聚合物组合物

    公开(公告)号：US20050159544A1

    公开(公告)日：2005-07-21

    申请号：US11078254

    申请日：2005-03-10

    申请人： Woonza Rhee ,  Frank DeLustro ,  Richard Berg

    发明人： Woonza Rhee ,  Frank DeLustro ,  Richard Berg

    IPC分类号： A61K47/34 ,  A61L24/00 ,  A61L24/04 ,  A61L24/08 ,  A61L27/00 ,  A61L27/26 ,  A61L27/34 ,  A61L27/54 ,  A61L31/00 ,  A61L31/04 ,  A61L31/16 ,  A61L33/00 ,  C08B37/00 ,  C08G65/329 ,  C08G81/00 ,  C08H1/00 ,  C08H1/06 ,  C08L71/02 ,  C08L77/04 ,  C08L101/00

    CPC分类号： A61L31/16 ,  A61L24/043 ,  A61L24/08 ,  A61L27/26 ,  A61L27/34 ,  A61L27/54 ,  A61L31/041 ,  A61L2300/232 ,  A61L2300/252 ,  A61L2300/606 ,  C08B37/0075 ,  C08G65/329 ,  C08H1/00 ,  C08H1/06 ,  C08L71/02 ,  Y10S623/90 ,  Y10S623/901 ,  C08L5/16 ,  C08L71/00

    摘要： Provided are crosslinked polymer compositions that include a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has been modified to contain multiple nucleophilic groups, such as primary amino (—NH2) or thiol (—SH) groups. The second synthetic polymer may be a hydrophilic or hydrophobic synthetic polymer, which contains or has been derivatized to contain, two or more electrophilic groups, such as succinimidyl groups. The compositions may further include other components, such as naturally occurring polysaccharides or proteins (such as glycosaminoglycans or collagen) and/or biologically active agents. Also disclosed are methods for using the crosslinked polymer compositions to effect adhesion between a first surface and a second surface; to effect tissue augmentation; to prevent the formation of surgical adhesions; and to coat a surface of a synthetic implant.

    摘要翻译： 提供的交联聚合物组合物包括含有共价结合到含有多个亲电子基团的第二合成聚合物的多个亲核基团的第一合成聚合物。 第一合成聚合物优选是已经被修饰以含有多个亲核基团的合成多肽或聚乙二醇，例如伯氨基（-NH 2）或硫醇（-SH）基团。 第二合成聚合物可以是亲水或疏水的合成聚合物，其包含或已被衍生化为含有两个或多个亲电基团，例如琥珀酰亚胺基。 组合物还可包括其它组分，例如天然存在的多糖或蛋白质（例如糖胺聚糖或胶原）和/或生物活性剂。 还公开了使用交联聚合物组合物来实现第一表面和第二表面之间的粘合的方法; 进行组织增生; 防止手术粘连的形成; 并涂覆合成植入物的表面。

    Self-expandable helical intravascular stent and stent-graft
    8.
    发明授权
    Self-expandable helical intravascular stent and stent-graft 失效
    自扩张螺旋血管内支架和支架移植

    公开(公告)号：US6165210A

    公开(公告)日：2000-12-26

    申请号：US221815

    申请日：1994-04-01

    申请人： Lilip Lau ,  Charles Thomas Maroney ,  William M. Hartigan ,  Woonza Rhee ,  Kimberly A. McCullough

    发明人： Lilip Lau ,  Charles Thomas Maroney ,  William M. Hartigan ,  Woonza Rhee ,  Kimberly A. McCullough

    IPC分类号： A61F2/00 ,  A61F2/06 ,  A61F2/88 ,  A61F2/92

    CPC分类号： A61F2/88 ,  A61F2/07 ,  A61F2/89 ,  A61F2/91 ,  A61F2/92 ,  A61F2/95 ,  A61F2002/3008 ,  A61F2002/30093 ,  A61F2002/30462 ,  A61F2002/9511 ,  A61F2210/0019 ,  A61F2220/0075 ,  A61F2230/0078 ,  A61F2250/0098

    摘要： This invention is a medical device and a method of using it. The device is a foldable stent or stent-graft which may be percutaneously delivered with (or on) an endovascular catheter or via surgical techniques or using other suitable techniques. The expandable stent structure utilizes at least one torsional member having an undulating shape which is helically deployed to form the generally cylindrical shape used as the stent. The helical winding desirably is aligned to allow those undulating shapes in adjacent turns of the helix to be in phase. The adjacent undulating shapes may be held in phased relationship using a flexible linkage, often made of a polymeric material. The stent may be flared on at least one of its ends to promote smooth blood flow at that flare and to assure that the stent will remain in the chosen position within the body. The stent's configuration allows it to be folded or collapsed to a very small diameter prior to deployment without changing the length of the stent. The stent may be expanded with the use of an installation device such as a balloon but preferably is used as a self-expandable device.

    摘要翻译： 本发明是医疗装置及其使用方法。 该装置是可以通过（或在）血管内导管或通过外科技术或使用其它合适技术经皮递送的可折叠支架或支架移植物。 可扩张的支架结构利用至少一个具有波形形状的扭转构件，该扭转构件螺旋展开以形成用作支架的大致圆柱形形状。 希望将螺旋绕组对准以允许螺旋的相邻匝中的那些起伏形状同相。 相邻的波状形状可以使用通常由聚合物材料制成的柔性连接件保持相位关系。 支架可以在其至少一个端部上扩张，以促进在该扩张处的平滑血流，并确保支架将保持在体内所选择的位置。 支架的构造允许在展开之前将其折叠或折叠到非常小的直径，而不改变支架的长度。 可以使用诸如气囊的安装装置来扩张支架，但优选用作自扩张装置。