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公开(公告)号：US06355472B2
公开(公告)日：2002-03-12
申请号：US09727578
申请日：2000-12-04
IPC分类号： C12N120
摘要： A method for producing nucleoside-5′-phosphate esters inexpensively and in high yields by phosphorylating a nucleoside with a phosphate group donor using an acid phosphatase having an increased affinity for the nucleoside and/or an increased temperature stability at a pH of pH 3.0 to 5.5, to produce a nucleoside-5′-phosphate ester. Mutant acid phosphatases having increased affinity for nucleosides and/or an enhanced temperature stability are also provided.
摘要翻译： 通过使用对核苷具有增加的亲和力的酸性磷酸酶和/或在pH3.0至pH3.0的pH升高的温度稳定性磷酸化磷酸基团供体的核苷而廉价且高收率地制备核苷-5'-磷酸酯的方法， 5.5，生成核苷-5'-磷酸酯。 还提供了对核苷具有增加的亲和力和/或提高的温度稳定性的突变型酸性磷酸酶。
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公开(公告)号：US6010851A
公开(公告)日：2000-01-04
申请号：US750145
申请日：1997-01-21
摘要： Nucleoside-5'-phosphate ester is produced inexpensively and efficiently by allowing an acid phosphatase, especially an acid phosphatase having a lowered phosphomonoesterase activity to act under a condition of pH 3.0 to 5.5 on a nucleoside and a phosphate group donor selected from the group consisting of polyphosphoric acid or a salt thereof, phenylphosphoric acid or a salt thereof, and carbamyl phosphate or a salt thereof to produce nucleoside-5'-phosphate ester, and collecting it.
摘要翻译： PCT No.PCT / JP96 / 01402 Sec。 371日期1997年1月21日 102（e）1997年1月21日PCT PCT 1996年5月24日PCT公布。 WO96 / 37603 PCT出版物 日期：1996年11月28日核苷-5'-磷酸酯是通过使酸性磷酸酶，特别是磷酸单酯酶活性降低的酸性磷酸酶在pH3.0〜5.5的条件下在核苷和磷酸基供体上起作用而廉价而有效地生产的 选自多磷酸或其盐，苯基磷酸或其盐，磷酸氨基戊酯或其盐，以制备核苷-5'-磷酸酯，并将其收集。
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公开(公告)号：US06207435B1
公开(公告)日：2001-03-27
申请号：US09417090
申请日：1999-10-13
IPC分类号： C12N916
摘要： A method for producing nucleoside-5′-phosphate esters inexpensively and in high yields by phosphorylating a nucleoside with a phospahte group donor using an acid phosphatase having an increased affinity for the nucleoside and/or an increased temperature stability at a pH of pH 3.0 to 5.5, to produce a nucleoside-5′-phosphate ester. Mutant acid phosphatases having increased affinity for nucleosides and/or an enhanced temperature stability are also provided.
摘要翻译： 通过使用对核苷具有增加的亲和性的酸性磷酸酶和/或在pH3.0至pH3.0的pH升高的温度稳定性，磷酸化具有磷酸基供体的核苷的方法，以高产率生产核苷-5'-磷酸酯 5.5，生成核苷-5'-磷酸酯。 还提供了对核苷具有增加的亲和力和/或提高的温度稳定性的突变型酸性磷酸酶。
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公开(公告)号：US06015697A
公开(公告)日：2000-01-18
申请号：US975698
申请日：1997-11-21
IPC分类号： C12N15/09 , C12N1/21 , C12N9/16 , C12N15/00 , C12N15/55 , C12P19/30 , C12P19/36 , C12R1/01 , C12R1/185 , C12R1/19 , C12R1/22 , C12R1/425 , C12P19/38
摘要： A method for producing nucleoside-5'-phosphate esters inexpensively and in high yields by phosphorylating a nucleoside with a phospahte group donor using an acid phosphatase having an increased affinity for the nucleoside and/or an increased temperature stability at a pH of pH 3.0 to 5.5, to produce a nucleoside-5'-phosphate ester. Mutant acid phosphatases having increased affinity for nucleosides and/or an enhanced temperature stability are also provided.
摘要翻译： 通过使用对核苷具有增加的亲和性的酸性磷酸酶和/或在pH3.0至pH3.0的pH升高的温度稳定性，磷酸化具有磷酸基供体的核苷的方法，以高产率生产核苷-5'-磷酸酯 5.5，生成核苷-5'-磷酸酯。 还提供了对核苷具有增加的亲和力和/或提高的温度稳定性的突变型酸性磷酸酶。
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公开(公告)号：US09410241B2
公开(公告)日：2016-08-09
申请号：US12439887
申请日：2007-08-31
摘要： The present invention provides a method for separating a surface layer of a diamond, which comprises implanting ions into a diamond to form a non-diamond layer near a surface of the diamond; and etching the non-diamond layer in the diamond by applying an alternating-current voltage across electrodes in an electrolytic solution; and a method for separating a grown layer of a diamond, which further comprises the step of growing a diamond by a vapor-phase synthesis method, after forming a non-diamond layer according to the above-described method. The invention is applicable to various single-crystal and polycrystal diamonds. More specifically, even with a large single-crystal diamond, a portion of the single-crystal diamond can be efficiently separated in a reusable form in a relatively short period of time.
摘要翻译： 本发明提供一种用于分离金刚石的表面层的方法，其包括将离子注入金刚石以在金刚石的表面附近形成非金刚石层; 以及通过在电解液中跨越电极施加交流电压来蚀刻金刚石中的非金刚石层; 以及分离金刚石生长层的方法，其还包括根据上述方法在形成非金刚石层之后通过气相合成法生长金刚石的步骤。 本发明适用于各种单晶和多晶钻石。 更具体地，即使使用大的单晶金刚石，一部分单晶金刚石可以在相对较短的时间内以可重复使用的形式被有效地分离。
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公开(公告)号：US08940266B2
公开(公告)日：2015-01-27
申请号：US12646163
申请日：2009-12-23
IPC分类号： B01J3/06 , C30B33/06 , C30B23/00 , B01J19/08 , C23C14/00 , C30B29/04 , C30B33/00 , C01B31/06 , C30B25/00
摘要： The present invention provides a method for producing a large substrate of single-crystal diamond, including the steps of preparing a plurality of single-crystal diamond layers separated form an identical parent substrate, placing the single-crystal diamond layers in a mosaic pattern on a flat support, and growing a single-crystal diamond by a vapor-phase synthesis method on faces of the single-crystal diamond layers where they have been separated from the parent substrate.According to the method of the invention, a mosaic single-crystal diamond having a large area and good quality can be produced relatively easily.
摘要翻译： 本发明提供一种用于制造大型单晶金刚石基板的方法，包括以下步骤：制备从相同的母基板分离的多个单晶金刚石层，将单晶金刚石层以马赛克图案放置在 平面支撑，并通过气相合成法在单晶金刚石层的与母体基底分离的面上生长单晶金刚石。 根据本发明的方法，可以相对容易地制造面积大，质量好的马赛克单晶金刚石。
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公开(公告)号：US08575919B2
公开(公告)日：2013-11-05
申请号：US12843818
申请日：2010-07-26
申请人： Hideaki Yamada , Michihiro Nagaishi
发明人： Hideaki Yamada , Michihiro Nagaishi
摘要： An inclination detection method is disclosed, which uses a pair of electrodes placed so as to face each other and having a fixed positional relation and an electric conductor which can move between the pair of electrodes, wherein the pair of electrodes is in either a conducting state or a nonconducting state depending on the position of the movable electric conductor, the conducting state in a predetermined period is expressed as any one of a plurality of level values, and a movement state of the pair of electrodes is estimated based on which of the plurality of level values the conducting state takes on.
摘要翻译： 公开了一种倾斜检测方法，其使用一对彼此相对放置并具有固定的位置关系的电极和能够在该对电极之间移动的电导体，其中该对电极处于导通状态 或取决于可动电导体的位置的不导电状态，将预定周期中的导通状态表示为多个电平值中的任何一个，并且基于多个电极中的哪一个来估计该对电极的移动状态 的执行状态的水平值。
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8.发明授权Clock generating device and jitter reducing method in the clock generating device 有权时钟发生装置中的时钟发生装置和抖动减少方法公开(公告)号：US08339160B2
公开(公告)日：2012-12-25
申请号：US12619947
申请日：2009-11-17
申请人： Hideaki Yamada
发明人： Hideaki Yamada
IPC分类号： H03B21/00
摘要： A clock generating device includes: a DDS circuit that generates a periodic signal; and a comparator that compares an input signal and a reference signal and outputs a binary signal. The clock generating device includes a rate-of-change correcting unit that applies correction for increasing a rate of change at a crossing point with the reference signal to the periodic signal generated by the DDS circuit.
摘要翻译： 时钟发生装置包括：产生周期信号的DDS电路; 以及比较器，其比较输入信号和参考信号，并输出二进制信号。 时钟发生装置包括变化率校正单元，其对与DDS电路产生的周期信号相对应的参考信号将交叉点的变化率提高的校正。
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公开(公告)号：US20100260274A1
公开(公告)日：2010-10-14
申请号：US12756888
申请日：2010-04-08
申请人： Hideaki Yamada
发明人： Hideaki Yamada
IPC分类号： H04L27/00
CPC分类号： H03M5/14
摘要： A communication method includes: (a) dividing one bit data group into a plurality of bit groups, the one bit data group being taken out from a plurality of bit data groups defined by a communication protocol for transmitting predetermined information, and exerting no substantial influence on the predetermined information even when arbitrarily inverting a value of the bit; (b) determining whether or not the values of the bits constituting the bit group are all the same by each of the plurality of bit groups divided into in step (a); (c) inverting at least one of the values of the bits of the bit group determined in step (b) that the values of the bits are all the same; and (d) arranging the plurality of bit groups, each of which has at least one of the values of the bits inverted in step (c), in the plurality of bit data groups except the one bit data group at regular intervals.
摘要翻译： 一种通信方法包括：（a）将一个比特数据组划分成多个比特组，从由用于发送预定信息的通信协议定义的多个比特数据组中取出一比特数据组，并且不施加实质影响 即使当任意地反转位的值时，也可以对预定信息进行处理; （b）通过步骤（a）中划分的多个比特组中的每一个来确定构成比特组的比特的值是否全部相同; （c）将在步骤（b）中确定的比特组的比特的值中的至少一个值反转为比特的值全部相同; 以及（d）在所述多个比特数据组中排列多个比特组，每个比特组具有在步骤（c）中反转的比特值中的至少一个的值，该比特数据组除了一个比特数据组以规则的间隔。
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公开(公告)号：US20100186514A1
公开(公告)日：2010-07-29
申请号：US12656209
申请日：2010-01-21
IPC分类号： G01L11/04
CPC分类号： G01L9/0025 , G01L9/008
摘要： A sensor chip has a substrate and a comb-teeth electrode arranged on the substrate. The sensor chip is fixed to a diaphragm structure to be distorted by receiving pressure, and is fixed to the diaphragm structure only through a predetermined fix area so as to detect the pressure. The fix area is defined on only a part of the sensor chip opposing to the diaphragm structure. The sensor chip is restrained by the diaphragm structure in a direction of transmitting surface acoustic wave. Flexibility of the sensor chip in a perpendicular direction approximately perpendicular to the wave transmitting direction is larger than that in the transmitting direction.
摘要翻译： 传感器芯片具有布置在基板上的基板和梳齿电极。 传感器芯片固定在膜片结构上，通过接受压力而变形，并且仅通过预定的固定区域固定到膜片结构，以便检测压力。 固定区仅限于与隔膜结构相对的传感器芯片的一部分。 传感器芯片在传播表面声波的方向上被隔膜结构约束。 传感器芯片在大致垂直于波浪传播方向的垂直方向上的灵活性大于传送方向的灵敏度。
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