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    Method for detecting abnormal morphology of erythrocytes
    2.
    发明授权
    Method for detecting abnormal morphology of erythrocytes 失效
    检测红细胞异常形态的方法

    公开(公告)号：US6067158A

    公开(公告)日：2000-05-23

    申请号：US67296

    申请日：1998-04-27

    申请人： Yuji Itose ,  Kayo Hatanaka ,  Tomohiro Sakurai

    发明人： Yuji Itose ,  Kayo Hatanaka ,  Tomohiro Sakurai

    IPC分类号： G01N33/48 ,  G01N15/14 ,  G01N33/49 ,  G01N21/00

    CPC分类号： G01N1/38 ,  G01N15/1459 ,  G01N2015/1497

    摘要： A method for detecting abnormality in the morphology of erythrocytes, which comprises:(1) mixing a sample containing erythrocytes with a sphere-forming reagent;(2) introducing the sample treated in the preceding step into a detector area of a flow cytometer;(3) measuring at least one scattered light at an angle reflecting the morphology of erythrocyte among the scattered lights emitted from the sample to obtain cell distribution data; and(4) comparing the cell distribution data with cell distribution data on normal erythrocytes that were determined beforehand.

    摘要翻译： 一种检测红细胞形态异常的方法，包括：（1）将含有红细胞的样品与球形试剂混合; （2）将前述步骤处理的样品导入流式细胞仪的检测器区域; （3）从样品发射的散射光中以反映红细胞形态的角度测量至少一个散射光，以获得细胞分布数据; 和（4）将细胞分布数据与预先确定的正常红细胞的细胞分布数据进行比较。

    Reagent for partially lysing a cell membrane of a red blood cell, a reagent for detecting malaria infected red blood cells, and a sample analyzing method for detecting malaria infected red blood cells
    3.
    发明申请
    Reagent for partially lysing a cell membrane of a red blood cell, a reagent for detecting malaria infected red blood cells, and a sample analyzing method for detecting malaria infected red blood cells 有权
    用于部分裂解红细胞的细胞膜的试剂，用于检测疟疾感染的红细胞的试剂和用于检测疟疾感染的红细胞的样品分析方法

    公开(公告)号：US20060223137A1

    公开(公告)日：2006-10-05

    申请号：US11390298

    申请日：2006-03-28

    申请人： Ayumu Yoshida ,  Kinya Uchihashi ,  Yuji Itose ,  Aya Konishi ,  Hiromitsu Iizuka

    发明人： Ayumu Yoshida ,  Kinya Uchihashi ,  Yuji Itose ,  Aya Konishi ,  Hiromitsu Iizuka

    IPC分类号： C12Q1/04

    CPC分类号： G01N33/80 ,  G01N33/56905 ,  Y02A50/58

    摘要： A reagent for partially lysing a cell membrane of a red blood cell infected with a malaria parasite, comprising: a first surfactant which has predetermined lysing ability for the red blood cell membrane; and a second surfactant which has weaker lysing ability than that of the first surfactant; wherein the reagent has pH of 5 to 7 and osmotic pressure of 200 to 300 mOsm/kg·H2O; and wherein the reagent partially lyses the malaria infected red blood cell membrane such that a malaria parasite is retained in the red blood cell and fluorescent dye passes through the cell membrane, is disclosed. A reagent for detecting malaria infected red blood cells, and a sample analyzing method for detecting malaria infected red blood cells, are also disclosed.

    摘要翻译： 一种用于部分溶解感染疟原虫的红细胞的细胞膜的试剂，其包含：对红细胞膜具有预定的裂解能力的第一表面活性剂; 和具有比第一表面活性剂弱的裂解能力的第二表面活性剂; 其中所述试剂的pH为5至7，渗透压为200至300mOsm / kg.H 2 O; 并且其中所述试剂部分地裂解疟疾感染的红细胞膜，使得疟原虫被保留在红细胞中，荧光染料通过细胞膜。 还公开了用于检测疟疾感染的红细胞的试剂和用于检测疟疾感染的红细胞的样品分析方法。

    BLOOD ANALYZER, BLOOD ANALYSIS METHOD, HEMOLYTIC AGENT AND STAINING AGENT
    5.
    发明申请
    BLOOD ANALYZER, BLOOD ANALYSIS METHOD, HEMOLYTIC AGENT AND STAINING AGENT 有权
    血液分析仪，血液分析方法，HEMOLYTIC AGENT AND STAINING AGENT

    公开(公告)号：US20110053212A1

    公开(公告)日：2011-03-03

    申请号：US12942752

    申请日：2010-11-09

    申请人： Hideaki Matsumoto ,  Kinya Uchihashi ,  Yuji Itose ,  Aya Konishi ,  Ayumu Yoshida

    发明人： Hideaki Matsumoto ,  Kinya Uchihashi ,  Yuji Itose ,  Aya Konishi ,  Ayumu Yoshida

    IPC分类号： C12Q1/04 ,  C12M1/34

    CPC分类号： C12Q1/68 ,  G01N33/5094 ,  G01N33/56905 ,  G01N2333/44 ,  Y02A50/58

    摘要： This blood analyzer includes a sample preparation portion preparing a first measurement sample containing a blood sample and a hemolytic agent and a second measurement sample containing the blood sample, the same hemolytic agent as the hemolytic agent and a staining agent and a control portion classifying white blood cells in the first measurement sample into at least four groups of monocytes, neutrophils, eosinophils and others on the basis of fluorescent information and two types of scattered light information generated by a light information generation portion and classifying blood cells in the second measurement sample into at least malaria-infected red blood cells and others on the basis of fluorescent information and scattered light information generated by the light information generation portion.

    摘要翻译： 该血液分析装置具备准备含有血液试样和溶血剂的第一测定试样和含有血液试样的第二测定试样，与溶血剂相同的溶血剂和染色剂的试样调制部以及白血病分级对照部 基于荧光信息和由光信息生成部生成的两种类型的散射光信息将第一测量样品中的细胞分成至少四组单核细胞，嗜中性粒细胞，嗜酸性粒细胞等，并将第二测量样品中的血细胞分类为 基于由光信息生成部生成的荧光信息和散射光信息，最少疟疾感染的红细胞等。

    Blood analyzer, blood analysis method, hemolytic agent and staining agent
    7.
    发明授权
    Blood analyzer, blood analysis method, hemolytic agent and staining agent 有权
    血液分析仪，血液分析法，溶血剂和染色剂

    公开(公告)号：US08920726B2

    公开(公告)日：2014-12-30

    申请号：US12942752

    申请日：2010-11-09

    申请人： Hideaki Matsumoto ,  Kinya Uchihashi ,  Yuji Itose ,  Aya Konishi ,  Ayumu Yoshida

    发明人： Hideaki Matsumoto ,  Kinya Uchihashi ,  Yuji Itose ,  Aya Konishi ,  Ayumu Yoshida

    IPC分类号： G01N33/00 ,  G01N1/00 ,  G01N33/569 ,  G01N33/50 ,  B01L3/00

    CPC分类号： C12Q1/68 ,  G01N33/5094 ,  G01N33/56905 ,  G01N2333/44 ,  Y02A50/58

    摘要： This blood analyzer includes a sample preparation portion preparing a first measurement sample containing a blood sample and a hemolytic agent and a second measurement sample containing the blood sample, the same hemolytic agent as the hemolytic agent and a staining agent and a control portion classifying white blood cells in the first measurement sample into at least four groups of monocytes, neutrophils, eosinophils and others on the basis of fluorescent information and two types of scattered light information generated by a light information generation portion and classifying blood cells in the second measurement sample into at least malaria-infected red blood cells and others on the basis of fluorescent information and scattered light information generated by the light information generation portion.

    摘要翻译： 该血液分析装置具备准备含有血液试样和溶血剂的第一测定试样和含有血液试样的第二测定试样，与溶血剂相同的溶血剂和染色剂的试样调制部以及白血病分级对照部 基于荧光信息和由光信息生成部生成的两种类型的散射光信息将第一测量样品中的细胞分成至少四组单核细胞，嗜中性粒细胞，嗜酸性粒细胞等，并将第二测量样品中的血细胞分类为 基于由光信息生成部生成的荧光信息和散射光信息，最少疟疾感染的红细胞等。

    Reagent container and reagent set
    8.
    发明授权
    Reagent container and reagent set 有权
    试剂容器和试剂组

    公开(公告)号：US08679425B2

    公开(公告)日：2014-03-25

    申请号：US12837869

    申请日：2010-07-16

    申请人： Sachiko Ueda ,  Yusuke Mori ,  Hiroyuki Ohashi ,  Yuji Itose ,  Kinya Uchihashi ,  Yoichi Nakamura ,  Kohei Sugitani

    发明人： Sachiko Ueda ,  Yusuke Mori ,  Hiroyuki Ohashi ,  Yuji Itose ,  Kinya Uchihashi ,  Yoichi Nakamura ,  Kohei Sugitani

    IPC分类号： B01L3/00 ,  B01L9/00 ,  B01L99/00 ,  B65D21/02 ,  B65D1/24 ,  B65D25/04 ,  B65D57/00 ,  B65D85/00 ,  G01N21/00 ,  G01N31/00 ,  G01N33/00 ,  A47B77/00 ,  B65D6/28

    CPC分类号： B01L3/0293 ,  B01L3/527 ,  B01L9/00 ,  B01L2200/185 ,  B01L2300/021 ,  G01N35/1002

    摘要： A reagent container set is disclosed which comprises: a first reagent container for accommodating a first reagent to be used in a sample analyzer, the top part of the first reagent container having a first aspiration opening for inserting a first reagent aspirating tube to aspirate the first reagent; a waste fluid container for accommodating the first reagent used in the sample analyzer as a waste fluid, the top of the waste fluid container having a discharge opening for inserting a waste fluid discharging tube to discharge the waste fluid into the waste fluid container; a box for accommodating the first reagent container and the waste fluid container; and a container holding member for holding the first reagent container and the waste fluid container so that the first aspiration opening and the discharge opening are disposed at predetermined positions, the container holding member being maintained at a predetermined position within the box.

    摘要翻译： 公开了一种试剂容器组，其包括：第一试剂容器，用于容纳待用于样本分析仪的第一试剂，所述第一试剂容器的顶部具有用于插入第一试剂抽吸管的第一抽吸开口， 试剂; 用于将用于样品分析器中的第一试剂用作废液的废液容器，废液容器的顶部具有用于插入废液排放管的排出口，以将废液排放到废液容器中; 用于容纳第一试剂容器和废液容器的箱体; 以及容器保持构件，用于保持第一试剂容器和废液容器，使得第一抽吸开口和排出口设置在预定位置，容器保持构件保持在箱内的预定位置。

    REAGENT CONTAINER AND REAGENT SET
    10.
    发明申请
    REAGENT CONTAINER AND REAGENT SET 有权
    试剂容器和试剂组

    公开(公告)号：US20110014095A1

    公开(公告)日：2011-01-20

    申请号：US12837869

    申请日：2010-07-16

    申请人： Sachiko UEDA ,  Yusuke Mori ,  Hiroyuki Ohashi ,  Yuji Itose ,  Kinya Uchihashi ,  Yoichi Nakamura ,  Kohei Sugitani

    发明人： Sachiko UEDA ,  Yusuke Mori ,  Hiroyuki Ohashi ,  Yuji Itose ,  Kinya Uchihashi ,  Yoichi Nakamura ,  Kohei Sugitani

    IPC分类号： G01N33/48 ,  G01N1/28 ,  B01L3/00

    CPC分类号： B01L3/0293 ,  B01L3/527 ,  B01L9/00 ,  B01L2200/185 ,  B01L2300/021 ,  G01N35/1002

    摘要： A reagent container set is disclosed which comprises: a first reagent container for accommodating a first reagent to be used in a sample analyzer, the top part of the first reagent container having a first aspiration opening for inserting a first reagent aspirating tube to aspirate the first reagent; a waste fluid container for accommodating the first reagent used in the sample analyzer as a waste fluid, the top of the waste fluid container having a discharge opening for inserting a waste fluid discharging tube to discharge the waste fluid into the waste fluid container; a box for accommodating the first reagent container and the waste fluid container; and a container holding member for holding the first reagent container and the waste fluid container so that the first aspiration opening and the discharge opening are disposed at predetermined positions, the container holding member being maintained at a predetermined position within the box.

    摘要翻译： 公开了一种试剂容器组，其包括：第一试剂容器，用于容纳待用于样本分析仪的第一试剂，所述第一试剂容器的顶部具有用于插入第一试剂抽吸管的第一抽吸开口， 试剂; 用于将用于样品分析器中的第一试剂用作废液的废液容器，废液容器的顶部具有用于插入废液排放管的排出口，以将废液排放到废液容器中; 用于容纳第一试剂容器和废液容器的箱体; 以及容器保持构件，用于保持第一试剂容器和废液容器，使得第一抽吸开口和排出口设置在预定位置，容器保持构件保持在箱内的预定位置。