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    Diffusion-controllable coatings on medical device
    1.
    发明授权
    Diffusion-controllable coatings on medical device 有权
    医疗器械上的扩散可控涂层

    公开(公告)号：US07666461B2

    公开(公告)日：2010-02-23

    申请号：US10969280

    申请日：2004-10-20

    申请人： Yongxing Qiu ,  Fiona Patricia Carney ,  Nichola Kotov ,  John Martin Lally ,  Carol Ann Morris

    发明人： Yongxing Qiu ,  Fiona Patricia Carney ,  Nichola Kotov ,  John Martin Lally ,  Carol Ann Morris

    IPC分类号： B05D3/00 ,  G02C7/04 ,  A61F2/14

    CPC分类号： A61L27/34 ,  A61L27/306 ,  A61L31/088 ,  A61L31/10 ,  G02B1/043

    摘要： The present invention provides a method for forming on a medical device, preferably an ophthalmic lens, more preferably a contact lens, a diffusion-controllable coating capable of controlling the out-diffusion or release of guest materials from the medical device. The method of the invention comprises: (1) applying one layer of clay and optionally one or more layers of polyionic materials onto the medical device; or (2) applying alternatively a layer of a first polyionic material and a layer of a second polyionic material having charges opposite of the charges of the first polyionic material onto the medical device and releasing the coated medical device into a releasing medium having a composition capable of imparting a desired permeability to the diffusion-controllable coating on the medical device.

    摘要翻译： 本发明提供了一种用于在医疗装置上形成的方法，优选为眼科镜片，更优选隐形眼镜，能够控制来自医疗装置的客体材料的扩散或释放的扩散控制涂层。 本发明的方法包括：（1）将一层粘土和任选的一层或多层聚离子材料施加到医疗装置上; 或（2）交替地将第一聚离子材料层和具有与第一聚离子材料的电荷相反的电荷的第二聚离子材料层施加到医疗装置上，并将涂覆的医疗装置释放到具有能够 对所述医疗装置上的扩散可控涂层施加期望的渗透性。

    Diffusion-controllable coatings on medical device
    5.
    发明授权
    Diffusion-controllable coatings on medical device 有权
    医疗器械上的扩散可控涂层

    公开(公告)号：US06827966B2

    公开(公告)日：2004-12-07

    申请号：US10153063

    申请日：2002-05-22

    申请人： Yongxing Qiu ,  Fiona Patricia Carney ,  Nichola Kotov ,  John Martin Lally ,  Carol Ann Morris ,  Lynn Cook Winterton

    发明人： Yongxing Qiu ,  Fiona Patricia Carney ,  Nichola Kotov ,  John Martin Lally ,  Carol Ann Morris ,  Lynn Cook Winterton

    IPC分类号： B05D300

    CPC分类号： A61L27/34 ,  A61L27/306 ,  A61L31/088 ,  A61L31/10 ,  G02B1/043

    摘要： The present invention provides a method for forming on a medical device, preferably an ophthalmic lens, more preferably a contact lens, a diffusion-controllable coating capable of controlling the out-diffusion or release of guest materials from the medical device. The method of the invention comprises: (1) applying one layer of clay and optionally one or more layers of polyionic materials onto the medical device; or (2) applying alternatively a layer of a first polyionic material and a layer of a second polyionic material having charges opposite of the charges of the first polyionic material onto the medical device and releasing the coated medical device into a releasing medium having a composition capable of imparting a desired permeability to the diffusion-controllable coating on the medical device.

    摘要翻译： 本发明提供了一种用于在医疗装置上形成的方法，优选为眼科镜片，更优选隐形眼镜，能够控制来自医疗装置的客体材料的扩散或释放的扩散控制涂层。 本发明的方法包括：（1）将一层粘土和任选的一层或多层聚离子材料施加到医疗装置上; 或（2）交替地将第一聚离子材料层和具有与第一聚离子材料的电荷相反的电荷的第二聚离子材料层施加到医疗装置上，并将涂覆的医疗装置释放到具有能够 对所述医疗装置上的扩散可控涂层施加期望的渗透性。

    LENS MOLDS HAVING ATMOSPHERIC PLASMA COATINGS THEREON
    9.
    发明申请
    LENS MOLDS HAVING ATMOSPHERIC PLASMA COATINGS THEREON 有权
    具有大气等离子体涂层的镜片

    公开(公告)号：US20120139137A1

    公开(公告)日：2012-06-07

    申请号：US13303190

    申请日：2011-11-23

    申请人： Yongxing Qiu

    发明人： Yongxing Qiu

    IPC分类号： B29D11/00

    CPC分类号： B29D11/00038 ,  B29D11/00865

    摘要： The invention provides a method of making ophthalmic lenses with an enhanced quality and enhanced yield achieved by reducing mold separation force and lens-mold adhesion. The method comprises the steps of generating an atmospheric plasma flow from a working gas and controlling the continuity of the atmospheric plasma flow with a power generator, and, introducing the atmospheric plasma flow to a molding surface of a mold for making an ophthalmic lens (preferably contact lens, more preferably a silicone hydrogel contact lens) and increasing the surface hydrophobicity of the molding surface of the mold and thereby to reduce a mold separation force after molding a lens formulation in the mold.

    摘要翻译： 本发明提供一种通过降低模具分离力和晶状体模具附着力而制造具有增强的质量和提高的成品率的眼镜片的方法。 该方法包括以下步骤：产生来自工作气体的大气等离子体流，并利用发电机控制大气等离子体流的连续性;以及将大气等离子体流引入用于制造眼用透镜的模具的成型表面 隐形眼镜，更优选硅酮水凝胶隐形眼镜），并且增加模具的模制表面的表面疏水性，从而降低在模具中模制透镜配方之后的模具分离力。

    Methods of making and using surfactant polymers
    10.
    发明授权
    Methods of making and using surfactant polymers 有权
    制造和使用表面活性剂聚合物的方法

    公开(公告)号：US08163302B2

    公开(公告)日：2012-04-24

    申请号：US12062768

    申请日：2008-04-04

    申请人： Roger E. Marchant ,  Tianhong Zhang ,  Yongxing Qiu ,  Mark A. Ruegsegger

    发明人： Roger E. Marchant ,  Tianhong Zhang ,  Yongxing Qiu ,  Mark A. Ruegsegger

    IPC分类号： A61F2/08

    CPC分类号： A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  A61L33/0017 ,  A61L33/08 ,  A61L33/128 ,  C08B37/0021 ,  C08B37/0078 ,  C08F8/00 ,  C08L101/00 ,  C08F26/02 ,  C08F16/06

    摘要： Comblike, surfactant polymers for changing the surface properties of biomaterials are provided. Such surfactant polymers comprise a polymeric backbone of repeating monomeric units having functional groups for coupling with side chains, a plurality of hydrophobic side chains linked to the backbone via the functional groups, and a plurality of hydrophilic side chains linked to said backbone via the functional groups. Medical devices coated with the surfactant polymers are also provided. The surfactant polymers may be used to decrease the thrombogenic properties, encapsulation, and bacterial colonization of medical devices.

    摘要翻译： 提供了梳状，用于改变生物材料表面性质的表面活性剂聚合物。 这种表面活性剂聚合物包含具有用于与侧链偶联的官能团的重复单体单元的聚合物主链，经由官能团与主链连接的多个疏水侧链，以及通过官能团连接至所述骨架的多个亲水侧链 。 还提供了涂有表面活性剂聚合物的医疗装置。 表面活性剂聚合物可用于降低医疗装置的血栓形成性质，包封和细菌定植。