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1.发明授权Protein inhibitors of phospholipase A.sub.2 purified from inflammatory sites and production process 失效从炎症部位纯化的磷脂酶A2蛋白抑制剂和生产工艺
公开(公告)号：US5344764A
公开(公告)日：1994-09-06
申请号：US47379
申请日：1993-04-16
申请人： Yorimasa Suwa , Atsushi Imaizumi , Masahiro Okada , Ichiro Kudo , Keizo Inoue , Yoji Suzuki
发明人： Yorimasa Suwa , Atsushi Imaizumi , Masahiro Okada , Ichiro Kudo , Keizo Inoue , Yoji Suzuki
CPC分类号： C07K14/4703 , A61K38/00
摘要： Protein inhibitors of phospholipase A.sub.2 purified from inflammatory sites which have an amino acid sequence given in FIGS. 3-1 through 3-3 or an amino acid sequence physiologically equivalent thereto, a process for preparation of said inhibitory protein wherein serum of mammalian animal is enzymatically treated, and a gene coding said inhibitory protein.
摘要翻译： 从具有图1和2中给出的氨基酸序列的炎症部位纯化的磷脂酶A2的蛋白质抑制剂。 3-1至3-3或与其生理等同的氨基酸序列，其中哺乳动物血清被酶处理的所述抑制性蛋白质的制备方法和编码所述抑制性蛋白质的基因。
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2.发明授权
公开(公告)号：US5116942A
公开(公告)日：1992-05-26
申请号：US295724
申请日：1988-12-02
申请人： Keizo Inoue , Atsushi Imaizumi , Takashi Kamimura , Yorimasa Suwa , Masahiro Okada , Yoji Suzuki , Ichiro Kudo
发明人： Keizo Inoue , Atsushi Imaizumi , Takashi Kamimura , Yorimasa Suwa , Masahiro Okada , Yoji Suzuki , Ichiro Kudo
IPC分类号： C12P21/00 , A61K38/00 , A61K38/55 , A61P29/00 , C07K1/20 , C07K14/00 , C07K14/435 , C07K14/47
CPC分类号： C07K14/4703 , A61K38/00
摘要： Protein having inflammatory phospholipase A.sub.2 inhibitory activity wherein said protein has a nature to be induced from cells by administration of glucocorticoid, for example, having a molecular weight of 40 K and the amino acid sequence from the N-terminal consisting of a N-terminal amino acid-Asp-Val-Pro-Ala-Ala-Asp-Leu-Ser-Asp-.
摘要翻译： PCT No.PCT / JP88 / 00318 Sec。 371日期：1988年12月2日 102（e）日期1988年12月2日PCT提交1988年3月30日PCT公布。 出版物WO88 / 07552 日期：1988年10月6日。具有炎性磷脂酶A2抑制活性的蛋白质，其中所述蛋白质具有通过施用糖皮质激素（例如分子量为40K）和来自N-末端的氨基酸序列从细胞诱导的性质 由N-末端氨基酸-asp-Val-Pro-Ala-Ala-Asp-Leu-Ser-Asp-组成。
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3.发明授权
公开(公告)号：US5374713A
公开(公告)日：1994-12-20
申请号：US861962
申请日：1992-06-18
申请人： Yorimasa Suwa , Atsushi Imaizumi , Masahiro Okada , Chieko Azuma , Ichiro Kudo , Keizo Inoue
发明人： Yorimasa Suwa , Atsushi Imaizumi , Masahiro Okada , Chieko Azuma , Ichiro Kudo , Keizo Inoue
CPC分类号： C07K14/4703 , A61K38/00
摘要： Peptide inhibitors of phospholipase A.sub.2 from inflammatory sites having the amino acid sequence given in formula SEQ. I.D. NO: 1 ##STR1##
摘要翻译： PCT No.PCT / JP91 / 01424 371日期：1992年6月18日 102（e）日期1992年6月18日PCT 1991年10月17日PCT公布。 第WO92 / 06997号公报 日期：1992年4月30日。具有式SEQ。中给出的氨基酸序列的来自炎症部位的磷脂酶A2的肽抑制剂。 ID。 NO：1
[I] -
公开(公告)号：US4810780A
公开(公告)日：1989-03-07
申请号：US903549
申请日：1986-09-04
CPC分类号： C07K14/4721 , Y10S530/848
摘要： Protein having a phospholipase A.sub.2 inhibitory activity which has the nature to be induced from cells upon administration of glucocorticoid and has a phospholipase A.sub.2 inhibitory activity.
摘要翻译： 具有磷脂酶A2抑制活性的蛋白质，其在施用糖皮质激素后具有从细胞诱导的性质并且具有磷脂酶A2抑制活性。
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公开(公告)号：US20090098568A1
公开(公告)日：2009-04-16
申请号：US10569883
申请日：2004-08-24
申请人： Tsuyoshi Yamada , Yorimasa Suwa , Takeshi Tsutsumi
发明人： Tsuyoshi Yamada , Yorimasa Suwa , Takeshi Tsutsumi
CPC分类号： G01N33/543 , Y10T436/25 , Y10T436/255
摘要： This invention provides a method for immobilizing proteins comprising: step 1 of purifying target proteins to be immobilized, which have a first tag portion and a second tag portion, with the use of the first tag portion; step 2 of activating reactive groups capable of covalently binding to the proteins on a carrier for immobilization; and step 3 of allowing a solution containing the proteins purified in step 1 to react with the carrier after step 2, wherein, in step 3, the proteins are immobilized on the carrier via interactions between the second tag portion and the site of the carrier to which the second tag portion binds and via covalent binding between the reactive groups and the proteins. This method enables the stable immobilization of various types of target proteins on a carrier regardless of the amounts of target proteins and without nonspecific immobilization of contaminating proteins.
摘要翻译： 本发明提供了一种固定蛋白质的方法，包括：使用第一标签部分纯化具有第一标签部分和第二标签部分的待固定的靶蛋白质的步骤1; 启动能够共价结合载体上的蛋白质以进行固定的反应性基团的步骤2; 和步骤3，使步骤2中纯化的蛋白质溶液与载体反应，其中在步骤3中，蛋白质通过第二标签部分和载体位点之间的相互作用固定在载体上， 其中第二标签部分结合并且通过反应性基团和蛋白质之间的共价结合。 这种方法可以使各种类型的靶蛋白稳定地固定在载体上，而不管靶蛋白的量如何，并且不污染蛋白质的非特异性固定。
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6.发明申请公开(公告)号：US20090233274A1
公开(公告)日：2009-09-17
申请号：US11577575
申请日：2005-10-09
申请人： Tadakazu Yamauchi , Hideaki Sueoka , Koichi Tsuchiya , Katsuhisa Murayama , Ken Horiuchi , Kazuo Komiya , Morikazu Kito , Takeshi Kito , Takeshi Tsutsumi , Yuko Isono , Yorimasa Suwa
发明人： Tadakazu Yamauchi , Hideaki Sueoka , Koichi Tsuchiya , Katsuhisa Murayama , Ken Horiuchi , Kazuo Komiya , Morikazu Kito , Takeshi Kito , Takeshi Tsutsumi , Yuko Isono , Yorimasa Suwa
IPC分类号： C12Q1/68 , C12Q1/02 , C12N15/63 , G01N33/566 , G01N33/68 , C07K2/00 , C07K16/18 , C07K1/107 , C07H21/00 , C07J71/00 , C07D498/14 , C07D207/34
CPC分类号： C07C211/27 , A61K31/40 , C07H21/00 , C07J71/00 , C07K14/47 , G01N33/53 , G01N33/6896 , G01N33/9406 , G01N2800/2821
摘要： The present invention provides novel target proteins and target genes for drug discovery, and the means that enable the development of novel drugs using the same. More particularly, the present invention provides NCS proteins and genes thereof; screening methods for drug (for example, anti-central nervous disease drug); agents for regulating disease (for example, central nervous disease); production methods of a drug derivative; a complex comprising a drug and NCS protein, and a method of producing the complex; a kits comprising a drug or a salt thereof; determination methods for the onset or risk of onset of a specified disease, determination methods for susceptibility to a drug, and determination kits used for the determination methods; and the like.
摘要翻译： 本发明提供用于药物发现的新型靶蛋白和靶基因，以及能够开发使用其的新药物的方法。 更具体地说，本发明提供了NCS蛋白质及其基因; 药物筛选方法（如抗中枢神经病药物）; 用于调节疾病（例如中枢神经疾病）的药剂; 药物衍生物的生产方法; 包含药物和NCS蛋白质的复合物及其制备方法; 包含药物或其盐的试剂盒; 确定特定疾病发作或发病风险的方法，对药物易感性的测定方法和用于测定方法的测定试剂盒; 等等。
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7.发明授权公开(公告)号：US08178077B2
公开(公告)日：2012-05-15
申请号：US11577575
申请日：2005-10-19
申请人： Tadakazu Yamauchi , Hideaki Sueoka , Kouichi Tsuchiya , Katsuhisa Murayama , Ken Horiuchi , Kazuo Komiya , Morikazu Kito , Takeshi Tsutsumi , Yuko Isono , Yorimasa Suwa
发明人： Tadakazu Yamauchi , Hideaki Sueoka , Kouichi Tsuchiya , Katsuhisa Murayama , Ken Horiuchi , Kazuo Komiya , Morikazu Kito , Takeshi Tsutsumi , Yuko Isono , Yorimasa Suwa
IPC分类号： A61K49/00 , A01N43/64 , C07D207/00
CPC分类号： C07C211/27 , A61K31/40 , C07H21/00 , C07J71/00 , C07K14/47 , G01N33/53 , G01N33/6896 , G01N33/9406 , G01N2800/2821
摘要： The present invention provides novel target proteins and target genes for drug discovery, and the means that enable the development of novel drugs using the same. More particularly, the present invention provides NCS proteins and genes thereof; screening methods for drug (for example, anti-central nervous disease drug); agents for regulating disease (for example, central nervous disease); production methods of a drug derivative; a complex comprising a drug and NCS protein, and a method of producing the complex; a kits comprising a drug or a salt thereof; determination methods for the onset or risk of onset of a specified disease, determination methods for susceptibility to a drug, and determination kits used for the determination methods; and the like.
摘要翻译： 本发明提供用于药物发现的新型靶蛋白和靶基因，以及能够开发使用其的新药物的方法。 更具体地说，本发明提供了NCS蛋白质及其基因; 药物筛选方法（如抗中枢神经病药物）; 用于调节疾病（例如中枢神经疾病）的药剂; 药物衍生物的生产方法; 包含药物和NCS蛋白质的复合物及其制备方法; 包含药物或其盐的试剂盒; 确定特定疾病发作或发病风险的方法，对药物易感性的测定方法和用于测定方法的测定试剂盒; 等等。
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8.发明申请公开(公告)号：US20090143285A1
公开(公告)日：2009-06-04
申请号：US11909634
申请日：2006-03-24
申请人： Hideaki Sueoka , Tadakazu Yamauchi , Kouichi Tsuchiya , Katsuhisa Murayama , Morikazu Kito , Takeshi Tsutsumi , Yuko Isono , Kazuo Komiya , Noriyuki Inomata , Yorimasa Suwa , Ken Horiuchi
发明人： Hideaki Sueoka , Tadakazu Yamauchi , Kouichi Tsuchiya , Katsuhisa Murayama , Morikazu Kito , Takeshi Tsutsumi , Yuko Isono , Kazuo Komiya , Noriyuki Inomata , Yorimasa Suwa , Ken Horiuchi
IPC分类号： A61K38/16 , C12Q1/68 , G01N33/566
CPC分类号： G01N33/5023 , G01N33/68 , G01N2500/00
摘要： The present invention provides target proteins and target genes for bioactive substances such as drugs, and means that enable the development of novel bioactive substances using the same. More specifically, the present invention provides target proteins and target genes for bioactive substances; screening methods for substances capable of regulating bioactivities; bioactivity regulators; a bioactive substance derivative production method; a complex comprising a bioactive substance and a target protein, and a method of producing the complex; and kits comprising a bioactive substance or a salt thereof; determination methods for the onset or risk of onset of a specified disease or condition, determination methods for susceptibility to a bioactive substance, and determination kits used for the determination methods, and the like.
摘要翻译： 本发明提供了用于生物活性物质如药物的靶蛋白和靶基因，并且使得能够开发使用其的新型生物活性物质的手段。 更具体地，本发明提供用于生物活性物质的靶蛋白和靶基因; 能够调节生物活性的物质的筛选方法; 生物活性调节剂 生物活性物质衍生物生产方法; 包含生物活性物质和靶蛋白质的复合物，以及生产该复合物的方法; 和包含生物活性物质或其盐的试剂盒; 特定疾病或病症的发病或发病风险的确定方法，对生物活性物质易感性的测定方法和用于测定方法的测定试剂盒等。
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公开(公告)号：US20090136482A1
公开(公告)日：2009-05-28
申请号：US12065303
申请日：2006-09-01
申请人： Yorimasa Suwa , Tadakazu Yamauchi , Morikazu Kito , Yuko Isono , Tsuruki Tamura , Motoi Tobita
发明人： Yorimasa Suwa , Tadakazu Yamauchi , Morikazu Kito , Yuko Isono , Tsuruki Tamura , Motoi Tobita
IPC分类号： A61K39/395 , G01N33/00 , C12Q1/68 , G01N33/566 , A61K38/02 , A61K31/7088 , A61K31/7105
CPC分类号： G01N33/68 , A61K45/06 , C07K14/47 , G01N33/5008 , G01N33/502 , G01N33/6845 , G01N33/94 , G01N2500/00 , Y10T436/143333
摘要： The present invention provides target proteins and target genes for bioactive substances such as drugs, and means that enable the development of novel bioactive substances using the same. More specifically, the present invention provides target proteins and target genes for bioactive substances; screening methods for substances capable of regulating bioactivities; bioactivity regulators; a bioactive substance derivative production method; a complex comprising a bioactive substance and a target protein, and a method of producing the complex; and kits comprising a bioactive substance or a salt thereof; determination methods for the onset or risk of onset of a specified disease or condition, determination methods for susceptibility to a bioactive substance, and determination kits used for the determination methods, and the like.
摘要翻译： 本发明提供了用于生物活性物质如药物的靶蛋白和靶基因，并且使得能够开发使用其的新型生物活性物质的手段。 更具体地，本发明提供用于生物活性物质的靶蛋白和靶基因; 能够调节生物活性的物质的筛选方法; 生物活性调节剂 生物活性物质衍生物生产方法; 包含生物活性物质和靶蛋白质的复合物，以及生产该复合物的方法; 和包含生物活性物质或其盐的试剂盒; 特定疾病或病症的发病或发病风险的确定方法，对生物活性物质易感性的测定方法和用于测定方法的测定试剂盒等。
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10.发明授权公开(公告)号：US08153385B2
公开(公告)日：2012-04-10
申请号：US11577350
申请日：2005-10-18
申请人： Tadakazu Yamauchi , Hideaki Sueoka , Kouichi Tsuchiya , Katsuhisa Murayama , Kazuo Komiya , Morikazu Kito , Takeshi Tsutsumi , Yuko Isono , Motoi Tobita , Yorimasa Suwa
发明人： Tadakazu Yamauchi , Hideaki Sueoka , Kouichi Tsuchiya , Katsuhisa Murayama , Kazuo Komiya , Morikazu Kito , Takeshi Tsutsumi , Yuko Isono , Motoi Tobita , Yorimasa Suwa
IPC分类号： G01N33/53
CPC分类号： C07D211/22 , C07D235/30 , C07D235/32 , C07D295/08 , C07D409/06 , C07D417/04 , G01N33/6893 , G01N2500/00
摘要： The present invention provides a novel target protein and a gene for drug discovery, and a means that enables development of a novel pharmaceutical agent by using the same. More particularly, the present invention provides CARP and genes thereof; screening methods for drugs (e.g., antiallergic drugs); a regulator of diseases (e.g., allergic diseases); a drug derivative production method; a complex comprising a drug and CARP, and a production method thereof; kits comprising a drug or a salt thereof; determination methods for the onset or risk of onset of a specified disease, determination methods for susceptibility to a drug, and determination kits used for said methods, and the like.
摘要翻译： 本发明提供了一种新的靶蛋白和用于药物发现的基因，并且是通过使用它们能够开发新型药剂的方法。 更具体地，本发明提供CARP及其基因; 药物筛选方法（如抗过敏药物）; 疾病调节剂（如过敏性疾病）; 药物衍生物生产方法; 包含药物和CARP的复合物及其制备方法; 包含药物或其盐的试剂盒; 确定特定疾病发病或发病风险的方法，对药物易感性的测定方法和用于所述方法的测定试剂盒等。
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