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1.发明授权公开(公告)号：US06410773B1
公开(公告)日：2002-06-25
申请号：US09512281
申请日：2000-02-24
IPC分类号： C07C31100
CPC分类号： C07C303/30 , C07B2200/07 , C07C309/64 , C07C309/66 , C07C309/73 , C07C327/32 , C07D317/24
摘要： Novel and useful optical active 2-aralkyl-3-sulfonyloxy-1-propanol and 2-aralkyl-3-sulfonyloxypropionic acid are provided by using an optical active 2-aralkyl-3-acyloxy-1-propanol as a starting material. Furthermore, an optical active 2-aralkyl-3-thiopropionic acid, which is an important intermediate of enkephalinase inhibitor, is provided. According to the present invention, industrially useful optical active sulfonic acid ester derivatives can be provided.
摘要翻译： 通过使用光学活性2-芳烷基-3-酰氧基-1-丙醇作为起始原料提供了新的和有用的光学活性2-芳烷基-3-磺酰氧基-1-丙醇和2-芳烷基-3-磺酰氧基丙酸。 此外，提供了作为脑啡肽酶抑制剂的重要中间体的光学活性2-芳烷基-3-硫代丙酸。 根据本发明，可以提供工业上有用的光学活性磺酸酯衍生物。
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公开(公告)号：US6046354A
公开(公告)日：2000-04-04
申请号：US143653
申请日：1998-08-31
IPC分类号： C07C33/26 , C07C33/46 , C07C69/28 , C07C69/30 , C07C69/63 , C07C309/66 , C07C309/73 , C07D249/08 , C07D301/30 , C07D303/14 , C07D521/00 , C12P7/20 , C12P7/62 , C12P41/00 , C07C69/66 , C07C69/67
CPC分类号： C07D249/08 , C07C309/66 , C07C309/73 , C07C33/26 , C07C33/46 , C07C69/28 , C07C69/30 , C07C69/63 , C07D231/12 , C07D233/56 , C07D303/14 , C12P41/004 , C12P7/20 , C12P7/62
摘要： A novel glycerol derivative, a process for preparing the same, and a process for preparing a triazole derivative. An optically active 2-arylglycerol derivative which is novel and useful as a synthetic intermediate of medicament is provided, and furthermore, (R)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazole-1-yl)-propane-1,2-diol, which is useful as an antifungal agent, is prepared.
摘要翻译： 一种新型甘油衍生物，其制备方法和制备三唑衍生物的方法。 提供新的可用作药物合成中间体的光学活性2-芳基甘油衍生物，此外，（R）-2-（2,4-二氟苯基）-3-（1H-1,2,4-三唑 -1-基） - 丙烷-1,2-二醇，其可用作抗真菌剂。
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公开(公告)号：US5654472A
公开(公告)日：1997-08-05
申请号：US553558
申请日：1995-12-18
IPC分类号： C07C33/26 , C07C33/46 , C07C69/28 , C07C69/30 , C07C69/63 , C07C309/66 , C07C309/73 , C07D249/08 , C07D301/30 , C07D303/14 , C07D521/00 , C12P7/20 , C12P7/62 , C12P41/00 , C07C51/36 , C07C31/20 , C07C69/66
CPC分类号： C07D249/08 , C07C309/66 , C07C309/73 , C07C33/26 , C07C33/46 , C07C69/28 , C07C69/30 , C07C69/63 , C07D231/12 , C07D233/56 , C07D303/14 , C12P41/004 , C12P7/20 , C12P7/62
摘要： The present invention relates to a novel glycerol derivative and a process for preparing the same, and a process for preparing a triazole derivative.According to the present invention, an optical active 2-arylglycerol derivative which is a novel and useful as a synthetic intermediate of medicament can be provided and furthermore, (R)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazole-1-yl)-propane-1,2-diol which is useful as an antifungal agent can be prepared.
摘要翻译： PCT No.PCT / JP95 / 00749 Sec。 371 1995年12月18日第 102（e）1995年12月18日日期PCT提交1995年4月17日PCT公布。 出版物WO95 / 28374 日期：1995年10月26日本发明涉及新型甘油衍生物及其制备方法，以及制备三唑衍生物的方法。 根据本发明，可以提供新的可用作药物合成中间体的光学活性2-芳基甘油衍生物，此外，（R）-2-（2,4-二氟苯基）-3-（1H- 1,2,4-三唑-1-基） - 丙烷-1,2-二醇，可用作抗真菌剂。
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4.发明授权
公开(公告)号：US6121477A
公开(公告)日：2000-09-19
申请号：US230686
申请日：1999-01-29
IPC分类号： C07C303/30 , C07C309/64 , C07C309/66 , C07C309/73 , C07C327/32 , C07D317/24 , C07C309/75 , C07C309/65
CPC分类号： C07C303/30 , C07C309/64 , C07C309/66 , C07C309/73 , C07C327/32 , C07D317/24 , C07B2200/07
摘要： Optically active 2-aralkyl-3-sulfonyloxy-1-propanol and 2-aralkyl-3-sulfonyloxypropionic acid are provided by using an optically active 2-aralkyl-3-acyloxy-1-propanol as a starting material. Furthermore, an optically active 2-aralkyl-3-thiopropionic acid, which is an important intermediate for synthesis of enkephalinase inhibitors, is provided. According to the present invention, industrially useful optically active sulfonic acid ester derivatives can be provided.
摘要翻译： PCT No.PCT / JP97 / 02699 Sec。 371日期1999年1月29日第 102（e）1999年1月29日PCT PCT 1997年8月1日PCT公布。 公开号WO98 / 05634 日期1998年2月12日光学活性2-芳烷基-3-磺酰氧基-1-丙醇和2-芳烷基-3-磺酰氧基丙酸通过使用光学活性2-芳烷基-3-酰氧基-1-丙醇作为起始原料提供。 此外，提供了作为合成脑啡肽酶抑制剂的重要中间体的光学活性2-芳烷基-3-硫代丙酸。 根据本发明，可提供工业上有用的光学活性磺酸酯衍生物。
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公开(公告)号：US5840553A
公开(公告)日：1998-11-24
申请号：US815440
申请日：1997-03-11
IPC分类号： C07C33/26 , C07C33/46 , C07C69/28 , C07C69/30 , C07C69/63 , C07C309/66 , C07C309/73 , C07D249/08 , C07D301/30 , C07D303/14 , C07D521/00 , C12P7/20 , C12P7/62 , C12P41/00 , C07C27/00 , C12P7/04 , C12P7/22 , C12P7/24
CPC分类号： C07D249/08 , C07C309/66 , C07C309/73 , C07C33/26 , C07C33/46 , C07C69/28 , C07C69/30 , C07C69/63 , C07D231/12 , C07D233/56 , C07D303/14 , C12P41/004 , C12P7/20 , C12P7/62
摘要： A novel glycerol derivative, a process for preparing the same, and a process for preparing a triazole derivative. An optically active 2-arylglycerol derivative which is novel and useful as a synthetic intermediate of medicament is provided, and furthermore, (R)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazole-1-yl)-propane-1,2-diol, which is useful as an antifungal agent, is prepared.
摘要翻译： 一种新型甘油衍生物，其制备方法和制备三唑衍生物的方法。 提供新的可用作药物合成中间体的光学活性2-芳基甘油衍生物，此外，（R）-2-（2,4-二氟苯基）-3-（1H-1,2,4-三唑 -1-基） - 丙烷-1,2-二醇，其可用作抗真菌剂。
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6.发明授权Bonding method of dissimilar materials made from metals and bonding structure thereof 有权由金属制成的不同材料的接合方法及其结合结构公开(公告)号：US08507825B2
公开(公告)日：2013-08-13
申请号：US13248141
申请日：2011-09-29
申请人： Kenji Miyamoto , Shigeyuki Nakagawa
发明人： Kenji Miyamoto , Shigeyuki Nakagawa
IPC分类号： B23K11/11
CPC分类号： B23K11/115 , B23K11/20 , B23K2103/20 , Y10T428/12028 , Y10T428/12389 , Y10T428/24942
摘要： Disclosed is a bonding method for dissimilar materials made from metals and its resulting structures. The materials to be bonded are formed by layering three or more sheets such that a dissimilar material interface and a same material interface are formed. A first current is conducted between a three-sheet layered plate material wherein an aluminum alloy plate, a zinc plated steel plate and a bare steel plate, for example, are layered in order. A nugget is formed in an interface between the zinc plated steel plate and the bare steel plate, which are the same materials. Then, a second current greater than the first current is conducted, and a nugget is formed in an interface between the aluminum alloy plate and the zinc plated steel plate.
摘要翻译： 公开了一种用金属制成的不同材料及其结构的接合方法。 要结合的材料通过层叠三个或更多个片材形成，使得形成不同材料界面和相同的材料界面。 第一电流在例如铝合金板，镀锌钢板和裸钢板之间的三层叠层板材之间进行。 在镀锌钢板和裸钢板之间的界面上形成熔核，这是相同的材料。 然后，进行大于第一电流的第二电流，并且在铝合金板和镀锌钢板之间的界面中形成熔核。
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7.发明授权Bonding method of dissimilar materials made from metals and bonding structure thereof 有权由金属制成的不同材料的接合方法及其结合结构公开(公告)号：US08058584B2
公开(公告)日：2011-11-15
申请号：US12049758
申请日：2008-03-17
申请人： Kenji Miyamoto , Shigeyuki Nakagawa
发明人： Kenji Miyamoto , Shigeyuki Nakagawa
IPC分类号： B23K11/16
CPC分类号： B23K11/115 , B23K11/20 , B23K2103/20 , Y10T428/12028 , Y10T428/12389 , Y10T428/24942
摘要： Disclosed is a bonding method for dissimilar materials made from metals and its resulting structures. The materials to be bonded are formed by layering three or more sheets such that a dissimilar material interface and a same material interface are formed. A first current is conducted between a three-sheet layered plate material wherein an aluminum alloy plate, a zinc plated steel plate and a bare steel plate, for example, are layered in order. A nugget is formed in an interface between the zinc plated steel plate and the bare steel plate, which are the same materials. Then, a second current greater than the first current is conducted, and a nugget is formed in an interface between the aluminum alloy plate and the zinc plated steel plate.
摘要翻译： 公开了一种用金属制成的不同材料及其结构的接合方法。 要结合的材料通过层叠三个或更多个片材形成，使得形成不同材料界面和相同的材料界面。 第一电流在例如铝合金板，镀锌钢板和裸钢板之间的三层叠层板材之间进行。 在镀锌钢板和裸钢板之间的界面上形成熔核，这是相同的材料。 然后，进行大于第一电流的第二电流，并且在铝合金板和镀锌钢板之间的界面中形成熔核。
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公开(公告)号：US07984840B2
公开(公告)日：2011-07-26
申请号：US12944417
申请日：2010-11-11
申请人： Kojiro Kobayashi , Akio Hirose , Shigeyuki Nakagawa , Kenji Miyamoto , Minoru Kasukawa , Masayuki Inoue , Tetsuji Morita
发明人： Kojiro Kobayashi , Akio Hirose , Shigeyuki Nakagawa , Kenji Miyamoto , Minoru Kasukawa , Masayuki Inoue , Tetsuji Morita
CPC分类号： B23K11/20 , B23K11/166 , B23K20/2275 , B23K26/211 , B23K26/32 , B23K26/323 , B23K2101/34 , B23K2103/08 , B23K2103/20 , B23K2103/50 , Y10T29/49885
摘要： According to a metal joining method of the present invention, first and second dissimilar metals are joined together by interposing between the first and second metal materials a third metal material dissimilar to the first and second metal materials and causing eutectic melting at least either at an interface between the first and third metal materials or at an interface between the second and third metal materials.
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9.发明授权公开(公告)号：US07935908B2
公开(公告)日：2011-05-03
申请号：US11633629
申请日：2006-12-05
CPC分类号： B23K15/0093 , B23K26/0093 , B23K26/037 , B23K26/211 , B23K26/244 , B23K33/00 , B23K2101/006 , B23K2101/34 , B23K2103/08 , B23K2103/20 , F16B5/04 , Y10T428/12493 , Y10T428/12799
摘要： A method of joining dissimilar materials of the present invention has a step of lapping a high melting point material on a low melting point material with a third material interposed therebetween. The third material is different from the high and low melting point materials. Further, the method has a step of irradiating an energy beam onto the high melting point material and a step of pressing the high and low melting point materials to cause eutectic melting between at least one of the high and low melting point materials and the third material and to join the high and low melting point materials in the form of a line.
摘要翻译： 本发明的不同材料的接合方法具有将第3材料插入其中的低熔点材料上研磨高熔点材料的工序。 第三种材料与高低熔点材料不同。 此外，该方法具有将能量束照射到高熔点材料上的步骤，以及对高熔点材料和低熔点材料进行挤压以在高熔点材料和低熔点材料中的至少一种和第三材料之间产生共晶熔化的步骤 并以一条线的形式加入高低熔点材料。
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10.发明申请公开(公告)号：US20110045548A1
公开(公告)日：2011-02-24
申请号：US12863555
申请日：2009-01-09
申请人： Kenji Miyamoto , Hiromichi Ohta
发明人： Kenji Miyamoto , Hiromichi Ohta
CPC分类号： C12R1/13 , C12N9/0036 , C12P7/42 , C12P13/222
摘要： It is an object of the present invention to provide DNA encoding novel NADH oxidase from a microorganism belonging to the genus Brevibacterium having excellent pH stability and thermostability. The present invention relates to DNA encoding NADH oxidase from a microorganism belonging to the genus Brevibacterium that is the following (a) or (b): (a) NADH oxidase comprising the amino acid sequence of SEQ ID NO: 18; or (b) NADH oxidase comprising an amino acid sequence derived from the amino acid sequence of SEQ ID NO: 18 by deletion, substitution, or addition of 1 or more amino acid(s) and having NADH oxidase activity.
摘要翻译： 本发明的目的是从具有优异的pH稳定性和热稳定性的短杆菌属中提供编码新型NADH氧化酶的DNA。 本发明涉及来自属于以下（a）或（b）的短杆菌属的微生物的NADH氧化酶的DNA：（a）包含SEQ ID NO：18的氨基酸序列的NADH氧化酶; 或（b）通过缺失，取代或加入1个或多个氨基酸并具有NADH氧化酶活性的包含源自SEQ ID NO：18的氨基酸序列的氨基酸序列的NADH氧化酶。
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