公开(公告)号：US5053535A

公开(公告)日：1991-10-01

申请号：US618058

申请日：1990-11-23

申请人： Yoshikazu Shima ,  Takafumi Abe ,  Hirofumi Higuchi ,  Koichi Kida

发明人： Yoshikazu Shima ,  Takafumi Abe ,  Hirofumi Higuchi ,  Koichi Kida

IPC分类号： B01J31/08 ,  C07B61/00 ,  C07C51/09 ,  C07C59/01

CPC分类号： C07C51/09

摘要： A process for producing an .alpha.-hydroxyisobutyric acid which comprises hydrolyzing .alpha.-hydroxyisobutyric acid ester in the presence of an organic sulfonic acid catalyst, using an .alpha.-hydroxyisobutyric acid ester as the starting material.According to said process, .alpha.-hydroxyisobutyric acid can be efficiently produced.

公开(公告)号：US5663382A

公开(公告)日：1997-09-02

申请号：US729384

申请日：1996-10-11

申请人： Masaki Takemoto ,  Yoshikazu Shima ,  Takafumi Abe

发明人： Masaki Takemoto ,  Yoshikazu Shima ,  Takafumi Abe

IPC分类号： B01J23/86 ,  B01J31/02 ,  C07B61/00 ,  C07D307/06 ,  C07D307/08

CPC分类号： C07D307/06

摘要： A process for preparing 3-methyltetrahydrofuran is herein disclosed which comprises reacting a methacrylic acid ester with carbon monoxide and a lower aliphatic alcohol to obtain a methylsuccinic acid diester, and hydrogenating and dehydrating/cyclizing this methylsuccinic acid diester. According to this process, 3-methyltetrahydrofuran can efficiently be obtained from inexpensive starting materials.

摘要翻译： 本文公开了制备3-甲基四氢呋喃的方法，其包括使甲基丙烯酸酯与一氧化碳和低级脂族醇反应，得到甲基琥珀酸二酯，并使该甲基琥珀酸二酯氢化和脱水/环化。 根据该方法，可以从廉价的原料得到3-甲基四氢呋喃。

公开(公告)号：US5371273A

公开(公告)日：1994-12-06

申请号：US135066

申请日：1993-10-12

申请人： Yoshikazu Shima ,  Takafumi Abe ,  Hirofumi Higuchi

发明人： Yoshikazu Shima ,  Takafumi Abe ,  Hirofumi Higuchi

IPC分类号： B01J29/08 ,  C07B61/00 ,  C07C67/327 ,  C07C69/54 ,  C07C67/00

CPC分类号： C07C67/327

摘要： There is disclosed a process for producing methyl methacrylate through gas-phase catalytic reaction of methyl .alpha.-hydroxyisobutyrate which comprises feeding methanol in an amount by weight of 0.1 to 3.0 times the methyl .alpha.-hydroxyisobutyrate in a reactor along therewith and proceeding with the reaction at a reaction temperature in the range of 230.degree. to 300.degree. C. by the use of a transition-type synthetic faujasite zeolite having a specific lattice constant and a specific Na content (Na/Al) as the catalyst. The process is capable of stably producing the objective product having excellent quality in high yield for a long period of time while preventing the problems of early deterioration of the catalyst and coloring of reaction product.

摘要翻译： 公开了一种通过甲基α-羟基异丁酸甲酯的气相催化反应生产甲基丙烯酸甲酯的方法，该方法包括在反应器中沿着反应器进料甲醇的量为0.1-3.0倍的甲基α-羟基异丁酸甲酯，并进行反应 通过使用具有特定晶格常数和特定Na含量（Na / Al）作为催化剂的过渡型合成八面沸石，反应温度在230℃至300℃的范围内。 该方法能够长期稳定地生产高质量的高品质的目标产物，同时防止催化剂的早期劣化和反应产物的着色。

公开(公告)号：US5225594A

公开(公告)日：1993-07-06

申请号：US759468

申请日：1991-09-13

申请人： Yoshikazu Shima ,  Takafumi Abe ,  Hirofumi Higuchi

发明人： Yoshikazu Shima ,  Takafumi Abe ,  Hirofumi Higuchi

IPC分类号： B01J23/34 ,  B01J23/72 ,  B01J23/755 ,  C07B61/00 ,  C07C51/377 ,  C07C57/04 ,  C07C57/065 ,  C07C67/20

CPC分类号： C07C51/377 ,  C07C67/20 ,  Y02P20/582

摘要： A process for producing methacrylic acid which comprises: (I) producing acetonecyanohydrin from prussic acid and acetone; (II) hydrating the acetonecyanohydrin obtained in step (I) to form .alpha.-hydroxyisobutyric acid amide; (III) reacting the .alpha.-hydroxyisobutyric acid amide obtained in step (II) with methyl formate or with methanol and carbon monoxide to form methyl .alpha.-hydroxyisobutyrate and formamide; (IV) hydrolyzing the methyl .alpha.-hydroxyisobutyrate obtained in step (III) to form .alpha.-hydroxyisobutyric acid; (V) dehydrating the .alpha.-hydroxyisobutyric acid obtained in step (IV) to form methacrylic acid; and (VI) dehydrating the formamide separated from the products obtained in step (III) to form prussic acid and recycling the prussic acid to step (I) as a starting material. The process is capable of producing methacrylic acid from readily available starting materials with a high yield and selectivity, without forming undesirable by-product or waste materials, such as ammonium sulfate.

公开(公告)号：US6162946A

公开(公告)日：2000-12-19

申请号：US387050

申请日：1999-08-31

申请人： Yoshikazu Shima ,  Takafumi Abe

发明人： Yoshikazu Shima ,  Takafumi Abe

IPC分类号： B01J31/12 ,  C07B61/00 ,  C07C67/03 ,  C07C69/675 ,  C07C69/66

CPC分类号： C07C67/03 ,  C07C69/675

摘要： There is disclosed a process for producing allyl 2-hydroxyisobutyrate useful as a raw material for agrochemicals and pharmaceuticals, which comprises reacting methyl 2-hydroxyisobutyrate with allyl alcohol preferably by means of reactional distillation in the presence of a transesterification catalyst preferably comprising titanium tetramethoxide or titanium tetraisopropoxide under solventless mild reaction conditions including a reaction temperature in the range of 80 to 150.degree. C. and a reaction time in the range of 10 minutes to 12 hours. The process enables efficient and easy production of the objective allyl 2-hydroxxyisobutyrate in high yield and high efficiency without the need of troublesome operations.

摘要翻译： 公开了一种生产用作农业化学品和药物原料的2-羟基异丁酸烯丙酯的方法，其包括使2-羟基异丁酸甲酯与烯丙醇反应，优选通过在优选包含四甲氧基钛或钛的酯交换催化剂的存在下进行反应蒸馏 四异丙醇在无反应的温和反应条件下反应，反应温度为80-150℃，反应时间为10分钟至12小时。 该方法能够以高产率和高效率高效且容易地生产目标2-羟基异丁酸烯丙酯，而不需要麻烦的操作。

公开(公告)号：US5824818A

公开(公告)日：1998-10-20

申请号：US698478

申请日：1996-08-15

申请人： Takafumi Abe ,  Toshiyuki Gotoh ,  Takako Uchiyama ,  Hirofumi Higuchi ,  Yoshikazu Shima ,  Kazuto Ikemoto

发明人： Takafumi Abe ,  Toshiyuki Gotoh ,  Takako Uchiyama ,  Hirofumi Higuchi ,  Yoshikazu Shima ,  Kazuto Ikemoto

IPC分类号： C07C67/20 ,  C07C69/66

CPC分类号： C07C67/20

摘要： A process for preparing a lactate which includes: (a) preparing lactonitrile from prussic acid and acetaldehyde, (b) hydrating the lactonitrile to form lactamide, (c) forming the desired lactate and formamide from lactamide and formate (or methanol and carbon monoxide), (d) separating and collecting components, having a lower boiling point than that of lactate from the reaction liquid in step (c), by distillation under specified conditions, and (e) dehydrating formamide from step (d) to form prussic acid and recycling the prussic acid to step (a). Heretofore, lactates had been manufactured by forming lactonitrile (cyanohydrin) from acetaldehyde and prussic acid, and then esterifying lactonitrile with a mineral acid or the like. However, in this conventional process, ammonium salts were formed as by-products in an amount equal to that of the lactate. According to the present invention, a lactate can be efficiently manufactured on a commercial scale without forming a large amount of the ammonium salts as by-products. In particular, the yield of the lactate can be increased by controlling the formation of 2-formyloxy propionate and also a dimer of a lactate.

摘要翻译： 一种制备乳酸的方法，其包括：（a）从丙二酸和乙醛制备乳腈，（b）使乳腈水合形成乳酰胺，（c）从乳酰胺和甲酸盐（或甲醇和一氧化碳）形成所需的乳酸盐和甲酰胺， ，（d）在步骤（c）中通过蒸馏从特定条件下蒸馏分离和收集沸点低于乳酸盐的组分，并且（e）从步骤（d）中将甲酰胺脱水形成二甲苯， 将重要的酸回收到步骤（a）。 迄今为止，已经通过从乙醛和氢溴酸形成乳腈（氰醇），然后用无机酸等使乳腈酯化来制造乳酸盐。 然而，在该常规方法中，形成铵盐，其量等于乳酸盐的副产物。 根据本发明，可以以商业规模有效地制造乳酸盐，而不会形成大量的作为副产物的铵盐。 特别地，通过控制2-甲酰氧基丙酸酯和乳酸二聚体的形成可以提高乳酸产率。

公开(公告)号：US5075493A

公开(公告)日：1991-12-24

申请号：US618040

申请日：1990-11-23

申请人： Yoshikazu Shima ,  Takafumi Abe ,  Hirofumi Higuchi ,  Koichi Kida

发明人： Yoshikazu Shima ,  Takafumi Abe ,  Hirofumi Higuchi ,  Koichi Kida

IPC分类号： B01J27/053 ,  B01J27/16 ,  B01J29/08 ,  C07B61/00 ,  C07C67/327 ,  C07C69/54

CPC分类号： C07C67/327

摘要： A process for producing .alpha., .beta.-unsaturated carboxylic acid ester which comprises catalytically reacting .alpha.-hydroxycarboxylic acid ester with crystalline aluminosilicate catalyst, and then catalytic reacting the resulting reaction product with solid acid catalyst.According to the process, .alpha., .beta.-unsaturated carboxylic acid ester of a high purity, and a high quality, without by-product, can be produced efficiently.

公开(公告)号：US08575277B2

公开(公告)日：2013-11-05

申请号：US12672152

申请日：2008-08-04

申请人： Yasuhiro Kushida ,  Yuuichi Sugano ,  Tatsuya Yamauchi ,  Hideyuki Sato ,  Yoshikazu Shima

发明人： Yasuhiro Kushida ,  Yuuichi Sugano ,  Tatsuya Yamauchi ,  Hideyuki Sato ,  Yoshikazu Shima

IPC分类号： C08F8/04

CPC分类号： G11B7/2533 ,  B01J21/06 ,  B01J21/066 ,  B01J23/44 ,  B01J35/0066 ,  B01J37/0203 ,  C08F8/04 ,  C08F212/08 ,  C08F220/18 ,  C08F2800/10 ,  C08F2810/50 ,  C08F220/14

摘要： A safe and stable production method of a hydrogenated polymer having high transparency, which is a production method of a hydrogenated polymer by hydrogenating aromatic rings of an aromatic vinyl compound-(meth)acrylate copolymer, in which (1) a solvent solution of the copolymer is added to a reactor, which has a solvent and a supported palladium catalyst charged therein, under a hydrogen atmosphere at a rate of from 0.01 to 15 g/hour in terms of the copolymer per unit mass (g) of the supported palladium catalyst, thereby performing hydrogenation reaction, and then such an operation is performed repeatedly that (2) a hydrogenated polymer is obtained from 30 to 90% by mass of the resulting reaction mixed solution, and a fresh solvent solution of the copolymer is added to the reactor, in which the residual reaction mixed solution is left, or to which the residual reaction mixed solution is returned, at a rate of from 0.01 to 15 g/hour in terms of the copolymer per unit mass (g) of the supported palladium catalyst, thereby performing hydrogenation reaction.

摘要翻译： 通过氢化芳香族乙烯基化合物 - （甲基）丙烯酸酯共聚物的芳香环，是氢化聚合物的制造方法的高透明性的安全稳定的制造方法，其中（1）共聚物的溶剂溶液 加入到反应器中，其中，在氢气氛下，以负载的钯催化剂的单位质量（g）的共聚物为0.01〜15g /小时，加入溶剂和负载的钯催化剂， 进行氢化反应，然后重复进行这样的操作：（2）得到的反应混合溶液的氢化聚合物的质量为30〜90质量％，将共聚物的新鲜溶剂溶液加入到反应器中， 残留的反应混合溶液返回残余反应混合溶液，以每单位质量（g）的共聚物计，为0.01〜15g /小时 报告钯催化剂，从而进行氢化反应。

公开(公告)号：US20130041179A1

公开(公告)日：2013-02-14

申请号：US13582182

申请日：2011-03-04

申请人： Takako Uchiyama ,  Shinyou Shirai ,  Yoshikazu Shima ,  Masaki Takemoto ,  Genki Nogami

发明人： Takako Uchiyama ,  Shinyou Shirai ,  Yoshikazu Shima ,  Masaki Takemoto ,  Genki Nogami

IPC分类号： B01J23/34 ,  C07C231/06

CPC分类号： B01J23/002 ,  B01J23/34 ,  B01J23/688 ,  B01J23/8472 ,  B01J23/8892 ,  B01J27/043 ,  B01J35/023 ,  B01J37/0009 ,  B01J37/009 ,  B01J37/031 ,  B01J37/06 ,  B01J2523/00 ,  C07C231/065 ,  B01J2523/22 ,  B01J2523/36 ,  B01J2523/54 ,  B01J2523/72 ,  B01J2523/55 ,  C07C235/06

摘要： The present provides a high-efficiency amide compound production catalyst to be used in producing an amide compound through hydration of a nitrile compound and a production method using it. The amide compound production catalyst is for producing an amide compound through reaction of a nitrile compound and water, and comprises a manganese oxide catalyst containing bismuth and further containing yttrium or vanadium. The method for producing an amide compound comprises reacting a nitrile compound and water in a liquid phase in the presence of the amide compound production catalyst.

摘要翻译： 本发明提供了通过腈化合物的水合制备酰胺化合物和使用它的制备方法中使用的高效酰胺化合物制备催化剂。 酰胺化合物的制造催化剂是通过腈化合物与水的反应来制造酰胺化合物，含有含有铋的氧化锰催化剂，还含有钇或钒。 酰胺化合物的制造方法包括在酰胺化合物制造催化剂的存在下，使腈化合物和水以液相反应。

公开(公告)号：US08022233B2

公开(公告)日：2011-09-20

申请号：US11993999

申请日：2006-06-30

申请人： Rieko Nakano ,  Masaki Takemoto ,  Yoshikazu Shima

发明人： Rieko Nakano ,  Masaki Takemoto ,  Yoshikazu Shima

IPC分类号： C07D301/12 ,  C08F283/10

CPC分类号： C07D301/12 ,  C07D303/16

摘要： An efficient process for producing glycidyl 2-hydroxyisobutyrate useful as a reactive diluent is provided. When glycidyl 2-hydroxyisobutyrate is produced by reacting allyl 2-hydroxyisobutyrate with hydrogen peroxide, a solution in which allyl 2-hydroxyisobutyrate is dissolved in an aliphatic ester as a solvent is reacted with hydrogen peroxide in the presence of a crystalline titanosilicate catalyst. Thus, a production process of glycidyl 2-hydroxyisobutyrate, which is small in degradation of purity and yield due to generation of peroxides or the like, and products thereof are provided.

摘要翻译： 提供了一种生产用作反应性稀释剂的2-羟基异丁酸缩水甘油酯的有效方法。 当2-羟基异丁酸缩水甘油酯是通过使2-羟基异丁酸烯丙酯与过氧化氢反应来制备的，其中将2-羟基异丁酸烯丙酯溶解在作为溶剂的脂肪族酯中的溶液与过氧化氢在结晶钛硅酸盐催化剂存在下反应。 因此，提供了由于产生过氧化物等而导致的纯度和产率降低小的2-羟基异丁酸缩水甘油酯的制备方法及其产物。