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    On-chip electrochemical flow cell
    1.
    发明申请
    On-chip electrochemical flow cell 审中-公开
    片上电化学流通池

    公开(公告)号：US20070145262A1

    公开(公告)日：2007-06-28

    申请号：US11454364

    申请日：2006-06-16

    申请人： Yu-Chong Tai ,  Jun Xie ,  Darron Young

    发明人： Yu-Chong Tai ,  Jun Xie ,  Darron Young

    IPC分类号： H01J49/00

    CPC分类号： H01J49/165 ,  H01J49/0018

    摘要： A microfluidic device including at least one microfabricated electrochemical flow cell and method of manufacturing such a device are disclosed herein. The electrochemical cell comprising at least a substrate, wherein the substrate has a front face and a back face; a channel wall bonded to the front face of the substrate without using a spacer, wherein the wall and the substrate define a microchannel having an inlet for receiving a fluid and an outlet for transmitting the fluid; a plurality of electrodes inside the microchannel, wherein said plurality of electrodes comprises one or more working electrodes and one or more counter electrodes, wherein the fluid flows over the surface of the plurality of electrodes and wherein optionally a length of the microchannel over the one or more working electrodes is greater than a height of the microchannel over the one or more working electrodes. Other peripherals may also be included in the microfluidic device of the current invention, including an electrospray ionization (ESI) nozzle, one or more detectors, a chromatographic column, etc. each of which may be microfluidically coupled to the electrochemical flow cells to create more complicated analytic devices.

    摘要翻译： 本文公开了包括至少一个微加工电化学流动池的微流体装置及其制造方法。 所述电化学电池至少包括衬底，其中所述衬底具有正面和背面; 通道壁，其不使用间隔件结合到所述基板的前表面，其中所述壁和所述基板限定具有用于接收流体的入口和用于传输所述流体的出口的微通道; 微通道内的多个电极，其中所述多个电极包括一个或多个工作电极和一个或多个反电极，其中所述流体流过所述多个电极的表面，并且其中可选地，所述微通道的长度在所述一个或多个 更多的工作电极大于在一个或多个工作电极上的微通道的高度。 其他外围设备也可以包括在本发明的微流体装置中，包括电喷雾离子化（ESI）喷嘴，一个或多个检测器，色谱柱等，其中每一个可以微流体耦合到电化学流动池以产生更多的 复杂的分析设备。

    Electrochemical flow cell, an assembly of and a method of fabrication of the same
    2.
    发明申请
    Electrochemical flow cell, an assembly of and a method of fabrication of the same 审中-公开
    电化学流通池，其组装及其制造方法

    公开(公告)号：US20070102293A1

    公开(公告)日：2007-05-10

    申请号：US11517123

    申请日：2006-09-06

    申请人： Yu-Chong Tai ,  Jun Xie ,  Darron Young

    发明人： Yu-Chong Tai ,  Jun Xie ,  Darron Young

    IPC分类号： G01N27/26

    CPC分类号： G01N27/403 ,  G01N30/64

    摘要： An electrochemical flow cell comprises a substrate having an insulated surface, a polymer gasket integrally disposed on the surface, and a top cover disposed on the gasket. The components define a fluidic channel when assembled. An electrode(s) on the substrate surface provides for electrochemical detection of analytes in the fluid flowing over the electrode in the fluidic channel. The electrode(s) can be also integrated to the substrate. The assembly can be packaged. The flow cell inexpensive, versatile, and disposable. Small dimensions can facilitate good sensitivity and selectivity. Applications include environmental, life sciences, pharmaceuticals, and proteomics. The cell can be adapted for both detector and electrospray ionization applications.

    摘要翻译： 电化学流动池包括具有绝缘表面的基底，整体设置在表面上的聚合物垫片和设置在垫圈上的顶盖。 组件在组装时定义流体通道。 衬底表面上的电极提供了在流体通道中电极上流动的流体中的分析物的电化学检测。 电极也可以与衬底集成。 组装可以包装。 流通池廉价，通用，一次性。 小尺寸可以促进良好的灵敏度和选择性。 应用包括环境，生命科学，药物和蛋白质组学。 电池可以适用于检测器和电喷雾电离应用。

    Integrated electrostatic peristaltic pump method and apparatus
    4.
    发明授权
    Integrated electrostatic peristaltic pump method and apparatus 有权
    集成式静电蠕动泵方法及装置

    公开(公告)号：US07090471B2

    公开(公告)日：2006-08-15

    申请号：US10757973

    申请日：2004-01-13

    申请人： Jun Xie ,  Jason Shih ,  Yu-Chong Tai

    发明人： Jun Xie ,  Jason Shih ,  Yu-Chong Tai

    IPC分类号： F04B17/03 ,  E03B1/00

    CPC分类号： B81C1/00119 ,  B81B2201/036 ,  B81B2203/0127 ,  B81B2203/0338 ,  F04B43/043 ,  F04B43/082 ,  F04B43/12 ,  Y10T137/87692

    摘要： An electrostatic fluid regulating device and methods. The device has a substrate. The device also has a first electrode coupled to the substrate. The device has a polymer based diaphragm. A second electrode is coupled to the diaphragm. A polymer based fluid chamber is coupled to the diaphragm. The device also has an inlet coupled to the polymer based fluid chamber and an outlet coupled to the polymer based fluid chamber.

    摘要翻译： 一种静电流体调节装置及方法。 该装置具有基板。 该器件还具有耦合到衬底的第一电极。 该装置具有基于聚合物的隔膜。 第二电极耦合到隔膜。 基于聚合物的流体室耦合到隔膜。 该装置还具有连接到基于聚合物的流体室的入口和连接到基于聚合物的流体室的出口。

    Integrated capacitive microfluidic sensors method and apparatus
    5.
    发明授权
    Integrated capacitive microfluidic sensors method and apparatus 失效
    集成电容微流体传感器的方法和装置

    公开(公告)号：US06945116B2

    公开(公告)日：2005-09-20

    申请号：US10802667

    申请日：2004-03-16

    申请人： Jun Xie ,  Jason Shih ,  Yu-Chong Tai

    发明人： Jun Xie ,  Jason Shih ,  Yu-Chong Tai

    IPC分类号： G01N27/22 ,  G01N27/447 ,  G01L9/12

    CPC分类号： G01N27/226 ,  B81B7/02 ,  B81B2201/0292 ,  B81B2201/058 ,  G01L9/0042 ,  G01L9/0072

    摘要： A microfluidic device and method for capacitive sensing. The device includes a fluid channel including an inlet at a first end and an outlet at a second end, a cavity region coupled to the fluid channel, and a polymer based membrane coupled between the fluid channel and the cavity region. Additionally, the device includes a first capacitor electrode coupled to the membrane, a second capacitor electrode coupled to the cavity region and physically separated from the first capacitor electrode by at least the cavity region, and an electrical power source coupled between the first capacitor electrode and the second capacitor electrode and causing an electric field at least within the cavity region. The polymer based membrane includes a polymer.

    摘要翻译： 用于电容感测的微流体装置和方法。 该装置包括流体通道，其包括在第一端处的入口和在第二端处的出口，耦合到流体通道的空腔区域以及耦合在流体通道和腔区域之间的基于聚合物的膜。 另外，该器件包括耦合到膜的第一电容器电极，耦合到空腔区域的第二电容器电极，并且至少通过腔区域与第一电容器电极物理分离;以及电源，耦合在第一电容器电极和 所述第二电容器电极至少在所述腔区域内引起电场。 基于聚合物的膜包括聚合物。

    Integrated capacitive microfluidic sensors method and apparatus
    6.
    发明授权
    Integrated capacitive microfluidic sensors method and apparatus 有权
    集成电容微流体传感器的方法和装置

    公开(公告)号：US07796371B2

    公开(公告)日：2010-09-14

    申请号：US11830581

    申请日：2007-07-30

    申请人： Jun Xie ,  Jason Shih ,  Yu-Chong Tai

    发明人： Jun Xie ,  Jason Shih ,  Yu-Chong Tai

    IPC分类号： H01G7/00

    CPC分类号： G01N27/226 ,  B81B7/02 ,  B81B2201/0292 ,  B81B2201/058 ,  G01L9/0042 ,  G01L9/0072

    摘要： A micro fluidic device and method for capacitive sensing. The device includes a fluid channel including an inlet at a first end and an outlet at a second end, a cavity region coupled to the fluid channel, and a polymer based membrane coupled between the fluid channel and the cavity region. Additionally, the device includes a first capacitor electrode coupled to the membrane, a second capacitor electrode coupled to the cavity region and physically separated from the first capacitor electrode by at least the cavity region, and an electrical power source coupled between the first capacitor electrode and the second capacitor electrode and causing an electric field at least within the cavity region. The polymer based membrane includes a polymer.

    摘要翻译： 一种用于电容式感测的微流体装置和方法。 该装置包括流体通道，其包括在第一端处的入口和在第二端处的出口，耦合到流体通道的空腔区域以及耦合在流体通道和腔区域之间的基于聚合物的膜。 另外，该器件包括耦合到膜的第一电容器电极，耦合到空腔区域的第二电容器电极，并且至少通过腔区域与第一电容器电极物理分离;以及电源，耦合在第一电容器电极和 所述第二电容器电极至少在所述腔区域内引起电场。 基于聚合物的膜包括聚合物。

    Integrated surface-machined micro flow controller method and apparatus
    7.
    发明申请
    Integrated surface-machined micro flow controller method and apparatus 审中-公开
    综合表面加工微流量控制器的方法和装置

    公开(公告)号：US20080210306A1

    公开(公告)日：2008-09-04

    申请号：US11515794

    申请日：2006-09-06

    申请人： Jun Xie ,  Jason Shih ,  Yu-Chong Tai

    发明人： Jun Xie ,  Jason Shih ,  Yu-Chong Tai

    IPC分类号： B81B3/00 ,  F16K31/02 ,  F17D1/00 ,  H01L41/22 ,  H01L41/083 ,  F15C5/00

    CPC分类号： F16K99/0001 ,  F16K99/0015 ,  F16K99/0044 ,  F16K99/0051 ,  F16K99/0061 ,  F16K2099/0074 ,  F16K2099/008 ,  G01F1/6845 ,  G01F15/005 ,  G05D7/0694 ,  Y10T29/49412 ,  Y10T137/0391

    摘要： A surface-micromachined mass flow controller (MFC) comprises an electrostatically actuated microvalve integrated with a thermal flow sensor. The microvalve comprises a normally-open diaphragm defining an aperture allowing fluid communication between first and second flow channels. The diaphragm includes a second electrode actuable toward a valve seat including a first electrode. Fabricated utilizing a multilayer Parylene process, the active microvalve and the flow sensor are integrated onto a single chip to perform closed-loop flow control. For flow control, both Pulse Width Modulation (PWM) and actuation voltage adjustment are demonstrated.

    摘要翻译： 表面微加工质量流量控制器（MFC）包括与热流传感器集成的静电致动微型阀。 微型阀包括限定允许第一和第二流动通道之间流体连通的孔的常开的隔膜。 隔膜包括能够朝向包括第一电极的阀座致动的第二电极。 采用多层Parylene工艺制造，将活性微型阀和流量传感器集成到单个芯片上，以执行闭环流量控制。 对于流量控制，展示了脉宽调制（PWM）和启动电压调节。

    On-chip temperature controlled liquid chromatography methods and devices
    8.
    发明申请
    On-chip temperature controlled liquid chromatography methods and devices 失效
    片上温度控制液相色谱方法和装置

    公开(公告)号：US20050274174A1

    公开(公告)日：2005-12-15

    申请号：US11059625

    申请日：2005-02-17

    申请人： Yu-Chong Tai ,  Jun Xie ,  Chi-yuan Shih ,  Qing He

    发明人： Yu-Chong Tai ,  Jun Xie ,  Chi-yuan Shih ,  Qing He

    IPC分类号： G01N1/00 ,  G01N30/30 ,  G01N30/54 ,  G01N30/60 ,  G01N35/00

    CPC分类号： G01N30/54 ,  G01N30/30 ,  G01N30/6095 ,  G01N2030/3007 ,  G01N2030/3015 ,  G01N2030/303 ,  G01N2030/3053 ,  G01N2035/00108

    摘要： An apparatus for liquid chromatography comprises a liquid chromatography separation column on a substrate, wherein the separation column is coupled to a heater on the substrate. A chip-based temperature controlled liquid chromatography device comprises a substrate, a thermal isolation zone, and a separation column thermally isolated from the substrate by the thermal isolation zone. An apparatus for chip-based liquid chromatography comprising a cooling device is provided. A temperature gradient liquid chromatography system comprises a chip-based temperature controlled liquid chromatography device, a fluidic coupling, and an electrical interface. Methods of making and methods of using of chip-based temperature gradient liquid chromatography devices are also provided.

    摘要翻译： 用于液相色谱的装置包括在基底上的液相色谱分离柱，其中分离柱与基底上的加热器相连。 基于芯片的温度控制液相色谱装置包括基底，热隔离区和通过热隔离区与基底热隔离的分离柱。 提供了一种包括冷却装置的基于芯片的液相色谱仪。 温度梯度液相色谱系统包括基于芯片的温度控制液相色谱装置，流体耦合和电接口。 还提供了制备方法和使用基于芯片的温度梯度液相色谱装置的方法。

    On-chip temperature controlled liquid chromatography methods and devices
    10.
    发明授权
    On-chip temperature controlled liquid chromatography methods and devices 失效
    片上温度控制液相色谱方法和装置

    公开(公告)号：US07530259B2

    公开(公告)日：2009-05-12

    申请号：US11059625

    申请日：2005-02-17

    申请人： Yu-Chong Tai ,  Jun Xie ,  Chi-yuan Shih ,  Qing He

    发明人： Yu-Chong Tai ,  Jun Xie ,  Chi-yuan Shih ,  Qing He

    IPC分类号： G01N1/00 ,  G01N30/00

    CPC分类号： G01N30/54 ,  G01N30/30 ,  G01N30/6095 ,  G01N2030/3007 ,  G01N2030/3015 ,  G01N2030/303 ,  G01N2030/3053 ,  G01N2035/00108

    摘要： An apparatus for liquid chromatography comprises a liquid chromatography separation column on a substrate, wherein the separation column is coupled to a heater on the substrate. A chip-based temperature controlled liquid chromatography device comprises a substrate, a thermal isolation zone, and a separation column thermally isolated from the substrate by the thermal isolation zone. An apparatus for chip-based liquid chromatography comprising a cooling device is provided. A temperature gradient liquid chromatography system comprises a chip-based temperature controlled liquid chromatography device, a fluidic coupling, and an electrical interface. Methods of making and methods of using of chip-based temperature gradient liquid chromatography devices are also provided.

    摘要翻译： 用于液相色谱的装置包括在基底上的液相色谱分离柱，其中分离柱与基底上的加热器相连。 基于芯片的温度控制液相色谱装置包括基底，热隔离区和通过热隔离区与基底热隔离的分离柱。 提供了一种包括冷却装置的基于芯片的液相色谱仪。 温度梯度液相色谱系统包括基于芯片的温度控制液相色谱装置，流体耦合和电接口。 还提供了制备方法和使用基于芯片的温度梯度液相色谱装置的方法。