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1.发明授权公开(公告)号：US07135183B1
公开(公告)日：2006-11-14
申请号：US10213257
申请日：2002-08-06
申请人： Yuan-Yuan Wang , Kay-Hooi Khoo , Shui-Tein Chen , Chun-Cheng Lin , Chi-Huey Wong , Chun-Hung Lin , Hong-Sen Chen , Yow-Fu Tsai
发明人： Yuan-Yuan Wang , Kay-Hooi Khoo , Shui-Tein Chen , Chun-Cheng Lin , Chi-Huey Wong , Chun-Hung Lin , Hong-Sen Chen , Yow-Fu Tsai
CPC分类号： A61K36/074 , A23L33/105
摘要： The present invention provides medicinally active extracts and fractions, and a method for preparing the same by extracting and fractioning constituents from the tissue of plant components of Ganoderma lucidum. These active extracts and fractions are useful for inhibiting tumor growth, modulating immune response, and increasing hematopoietic activity.
摘要翻译： 本发明提供了药用活性提取物和级分，以及通过从灵芝植物组分的组织提取和分馏成分的方法及其制备方法。 这些活性提取物和级分可用于抑制肿瘤生长，调节免疫应答和增加造血活性。
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2.发明授权公开(公告)号：US07560114B2
公开(公告)日：2009-07-14
申请号：US11952032
申请日：2007-12-06
申请人： Yuan-Yuan Wang , Kay-Hooi Khoo , Shui-Tein Chen , Chun-Cheng Lin , Chi-Huey Wong , Chun-Hung Lin , Hong-Sen Chen , Yow-Fu Tsai
发明人： Yuan-Yuan Wang , Kay-Hooi Khoo , Shui-Tein Chen , Chun-Cheng Lin , Chi-Huey Wong , Chun-Hung Lin , Hong-Sen Chen , Yow-Fu Tsai
CPC分类号： A61K36/074 , A23L33/105
摘要： The present invention provides methods of modulating an immune response in an organism by administering medicinally active extracts and fractions, and a method for preparing the same by extracting and fractioning constituents from the tissue of components of Ganoderma lucidum.
摘要翻译： 本发明提供了通过施用药物活性提取物和级分来调节生物体中的免疫应答的方法，以及通过从灵芝组分的组织提取和分馏成分的方法。
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3.发明授权公开(公告)号：US07323176B2
公开(公告)日：2008-01-29
申请号：US11553402
申请日：2006-10-26
申请人： Yuan-Yuan Wang , Kay-Hooi Khoo , Shui-Tein Chen , Chun-Cheng Lin , Chi-Huey Wong , Chun-Hung Lin , Hong-Sen Chen , Yow-Fu Tsai
发明人： Yuan-Yuan Wang , Kay-Hooi Khoo , Shui-Tein Chen , Chun-Cheng Lin , Chi-Huey Wong , Chun-Hung Lin , Hong-Sen Chen , Yow-Fu Tsai
CPC分类号： A61K36/074 , A23L33/105
摘要： The present invention provides medicinally active extracts and fractions, and a method for preparing the same by extracting and fractioning constituents from the tissue of components of Ganoderma lucidum. These active extracts and fractions are useful for inhibiting tumor growth, modulating immune response, and increasing hematopoietic activity.
摘要翻译： 本发明提供药物活性提取物和级分，以及通过从灵芝组分的组织提取和分馏成分的方法制备该提取物和级分。 这些活性提取物和级分可用于抑制肿瘤生长，调节免疫应答和增加造血活性。
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4.发明申请IMMUNO-MODULATING ANTITUMOR ACTIVITIES OF GANODERMA LUCIDUM (REISHI) POLYSACCHARIDES 有权甘露聚糖（REISHI）多糖的免疫调节抗肿瘤活性公开(公告)号：US20080267991A1
公开(公告)日：2008-10-30
申请号：US11952032
申请日：2007-12-06
申请人： Yuan-Yuan Wang , Kay-Hooi Khoo , Shui-Tein Chen , Chun-Cheng Lin , Chi-Huey Wong , Chun-Hung Lin , Hong-Sen Chen , Yow-Fu Tsai
发明人： Yuan-Yuan Wang , Kay-Hooi Khoo , Shui-Tein Chen , Chun-Cheng Lin , Chi-Huey Wong , Chun-Hung Lin , Hong-Sen Chen , Yow-Fu Tsai
IPC分类号： A61K36/074
CPC分类号： A61K36/074 , A23L33/105
摘要： The present invention provides methods of modulating an immune response in an organism by administering medicinally active extracts and fractions, and a method for preparing the same by extracting and fractioning constituents from the tissue of components of Ganoderma lucidum.
摘要翻译： 本发明提供了通过施用药物活性提取物和级分来调节生物体中的免疫应答的方法，以及通过从灵芝组分的组织提取和分馏成分的方法。
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5.发明申请IMMUNO-MODULATING ANTITUMOR ACTIVITIES OF GANODERMA LUCIDUM (REISHI) POLYSACCHARIDES 有权甘露聚糖（REISHI）多糖的免疫调节抗肿瘤活性公开(公告)号：US20070104729A1
公开(公告)日：2007-05-10
申请号：US11553402
申请日：2006-10-26
申请人： Yuan-Yuan Wang , Kay-Hooi Khoo , Shui-Tein Chen , Chun-Cheng Lin , Chi-Huey Wong , Chun-Hung Lin , Hong-Sen Chen , Yow-Fu Tsai
发明人： Yuan-Yuan Wang , Kay-Hooi Khoo , Shui-Tein Chen , Chun-Cheng Lin , Chi-Huey Wong , Chun-Hung Lin , Hong-Sen Chen , Yow-Fu Tsai
CPC分类号： A61K36/074 , A23L33/105
摘要： The present invention provides medicinally active extracts and fractions, and a method for preparing the same by extracting and fractioning constituents from the tissue of components of Ganoderma lucidum. These active extracts and fractions are useful for inhibiting tumor growth, modulating immune response, and increasing hematopoietic activity.
摘要翻译： 本发明提供药物活性提取物和级分，以及通过从灵芝组分的组织提取和分馏成分的方法制备该提取物和级分。 这些活性提取物和级分可用于抑制肿瘤生长，调节免疫应答和增加造血活性。
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6.发明授权One-pot enzymatic sulfation process using 3'-phosphoadenosine-5'-phosphosulfate and recycled phosphorylated adenosine intermediates 失效使用3'-磷酸腺苷-5'-磷酸硫酸盐和再循环的磷酸化腺苷中间体的一锅酶硫酸化方法
公开(公告)号：US5919673A
公开(公告)日：1999-07-06
申请号：US408774
申请日：1995-03-22
申请人： Chi-Huey Wong , Chun-Hung Lin , Gwo-Jenn Shen
发明人： Chi-Huey Wong , Chun-Hung Lin , Gwo-Jenn Shen
CPC分类号： C12N9/13 , C12N9/1205 , C12N9/1241 , C12P11/00 , C12P19/26 , C12P19/30
摘要： A process for the enzymatic synthase of sulfate esters is disclosed in which intermediate phosphorylated adenosine compounds are recycled to minimize enzyme inhibition. Exemplary enzymes include ATP sulfurylase, APS kinase and a sulfotransferase.
摘要翻译： 公开了一种硫酸酯酶合成酶的方法，其中中间磷酸化腺苷化合物被循环以使酶抑制最小化。 示例性的酶包括ATP硫酸化酶，APS激酶和磺基转移酶。
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7.发明授权Ketoaldonic acids having formed stereogenic centers of R configuration: methods and compositions 失效形成R构型立体中心的酮糖酸：方法和组合物公开(公告)号：US06353095B1
公开(公告)日：2002-03-05
申请号：US07946546
申请日：1992-09-17
申请人： Chi-Huey Wong , Chun-Hung Lin
发明人： Chi-Huey Wong , Chun-Hung Lin
IPC分类号： C07H504
摘要： The present invention provides a ketoaldonic acid such as an octulosonic or nonulosonic acid having a formed stereogenic center of R configuration, as well as methods of synthesizing the same.
摘要翻译： 本发明提供了具有形成的R构型的立体中心的酮戊二酸，例如具有立体定向中心的八环或非酮酸，以及其合成方法。
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公开(公告)号：US5830871A
公开(公告)日：1998-11-03
申请号：US744744
申请日：1996-10-28
摘要： Inhibitors of E-, P- and L-selectin binding are synthesized by an aldol addition reaction between a glycoside aldehyde precursor and dihydroxyacetone phosphate or a derivative thereof. The addition reaction is catalyzed by aldolase. The inhibitors exhibit an activity comparable to sialyl Lewis X with respect to the E-selectin binding assay and high activities in the P- and L-selectin binding assays. The inhibitors are employable for blocking neutrophil inflamatory conditions.
摘要翻译： 通过醛糖醛前体和磷酸二羟丙酮或其衍生物之间的醛醇醛加成反应合成E-，P-和L-选择蛋白结合的抑制剂。 加成反应由醛缩酶催化。 相对于E-选择蛋白结合测定，抑制剂表现出与唾液酸基路易斯X相当的活性，并且P-和L-选择蛋白结合测定中的高活性。 抑制剂可用于阻断嗜中性粒细胞炎症状况。
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公开(公告)号：US5962660A
公开(公告)日：1999-10-05
申请号：US933775
申请日：1997-09-19
申请人： Chi-Huey Wong , Chun-Cheng Lin , Tetsuya Kajimoto
发明人： Chi-Huey Wong , Chun-Cheng Lin , Tetsuya Kajimoto
IPC分类号： C07H5/04 , A61K31/35 , A61K31/351 , A61K31/70 , A61K31/7008 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61K38/00 , A61P7/02 , A61P9/00 , A61P29/00 , A61P31/04 , A61P35/00 , A61P37/00 , A61P37/08 , C07D309/10 , C07H7/02 , C07H15/04 , C07H15/22 , C07K9/00 , C07H15/00
摘要： Sialyl Lewis X mimetics incorporating fucopeptides are synthesized and shown to mimic the configuration and essential functional groups of sialyl Lewis X in space. The fucopeptides exhibit substantially the same biological activity as sialyl Lewis X in the E-selectin binding assay and can be employed for blocking neutrophil inflamatory conditions.
摘要翻译： 合成了唾液酸路易斯X模拟物，其中含有梧基肽，并显示出模拟空间中唾液酸基路易斯X的构型和必需官能团。 在E-选择蛋白结合测定中，fucopeptides表现出与唾液酸基路易斯X基本相同的生物学活性，并且可用于阻断嗜中性粒细胞炎症病症。
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公开(公告)号：US09816981B2
公开(公告)日：2017-11-14
申请号：US13159339
申请日：2011-06-13
申请人： Masaaki Sawa , Chi-Huey Wong , Tsui-Ling Hsu , Sarah Hanson
发明人： Masaaki Sawa , Chi-Huey Wong , Tsui-Ling Hsu , Sarah Hanson
IPC分类号： C07H15/04 , C07H19/10 , G01N33/50 , G01N33/533
CPC分类号： G01N33/5005 , G01N33/5008 , G01N33/533 , G01N2400/00
摘要： Methods for metabolic oligosaccharide engineering that incorporates derivatized alkyne-bearing sugar analogs as “tags” into cellular glycoconjugates are disclosed. Alkynyl derivatized Fuc and alkynyl derivatized ManNAc sugars are incorporated into cellular glycoconjugates. Chemical probes comprising an azide group and a visual or fluorogenic probe and used to label alkyne-derivatized sugar-tagged glycoconjugates are disclosed. Chemical probes bind covalently to the alkynyl group by Cu(I)-catalyzed [3+2] azide-alkyne cycloaddition and are visualized at the cell surface, intracellularly, or in a cellular extract. The labeled glycoconjugate is capable of detection by flow cytometry, SDS-PAGE, Western blot, ELISA, confocal microscopy, and mass spectrometry.
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