Nanoparticles In a Flash Memory Using Chaperonin Proteins
    1.
    发明申请
    Nanoparticles In a Flash Memory Using Chaperonin Proteins 有权
    纳米颗粒在闪存中使用伴侣蛋白

    公开(公告)号:US20080191265A1

    公开(公告)日:2008-08-14

    申请号:US11915039

    申请日:2006-05-22

    IPC分类号: H01L29/788 H01L21/336

    摘要: A method for fabricating a flash memory device where the flash memory device includes a substantially uniform size and spatial distribution of nanoparticles on a tunnel oxide layer to form a floating gate. The flash memory device may be fabricated by defining active areas in a substrate and forming an oxide layer on the substrate. A self-assembled protein lattice may be formed on top of the oxide layer where the self-assembled protein lattice includes a plurality of molecular chaperones. The cavities of the chaperones may provide confined spaces where nanocrystals can be trapped thereby forming an ordered nanocrystal lattice. A substantially uniform distribution of nanocrystals may be formed on the oxide layer upon removal of the self-assembled protein lattice such as through high temperature annealing.

    摘要翻译: 一种用于制造闪速存储器件的方法,其中闪存器件包括在隧道氧化物层上的纳米颗粒的基本均匀的尺寸和空间分布以形成浮动栅极。 闪存器件可以通过在衬底中限定有源区域并在衬底上形成氧化物层来制造。 自组装蛋白质晶格可以形成在氧化物层的顶部,其中自组装蛋白质晶格包括多个分子伴侣。 分子伴侣的空腔可以提供限制的空间,其中可以捕获纳米晶体,从而形成有序的纳米晶格。 在去除自组装蛋白质晶格例如通过高温退火之后,可以在氧化物层上形成基本均匀的纳米晶体分布。

    Tapered hollow metallic microneedle array assembly and method of making and using the same
    3.
    发明授权
    Tapered hollow metallic microneedle array assembly and method of making and using the same 失效
    锥形中空金属微针阵列组件及其制造和使用方法

    公开(公告)号:US07627938B2

    公开(公告)日:2009-12-08

    申请号:US10966987

    申请日:2004-10-15

    IPC分类号: B23P25/00

    摘要: The present invention includes device, system, method of using and making a microneedle array including the steps of forming one or more pins on a substrate, depositing one or more layers on the one or more pins and the substrate, exposing a portion of the one or more pins, and separating the one or more pins from the one or more layers to form the hollow microneedle array.

    摘要翻译: 本发明包括使用和制造微针阵列的装置,系统,方法,包括以下步骤:在衬底上形成一个或多个销,在一个或多个销和衬底上沉积一个或多个层,暴露一个 或更多的销,并且将一个或多个销与一个或多个层分离以形成中空微针阵列。

    Modified reoviral therapy
    4.
    发明授权
    Modified reoviral therapy 有权
    改良的呼肠孤病毒治疗

    公开(公告)号:US07223388B2

    公开(公告)日:2007-05-29

    申请号:US10211218

    申请日:2002-08-02

    摘要: The present invention relates to hyperproliferative diseases. Specifically, the present invention encompasses pharmaceutical compositions comprising a modified Reoviridae virus, wherein the Reoviridae virus is conjugated to a hydroxylated hydrocarbon or a polycationic polymer to reduce the clearance of the composition and reduce the immunogenicity of the composition. Yet further, the invention relates to methods of treating a hyperproliferative disease by administering to a patient an effective amount of the modified Reoviridae virus.

    摘要翻译: 本发明涉及过度增生性疾病。 具体地说,本发明包括包含修饰的呼肠弧病毒病毒的药物组合物,其中病毒科病毒与羟基化烃或聚阳离子聚合物结合以减少组合物的清除率并降低组合物的免疫原性。 此外,本发明涉及通过向患者施用有效量的经修饰的病毒科病毒来治疗过度增殖性疾病的方法。