Stable composite material comprising supported porous gels
    6.
    发明授权
    Stable composite material comprising supported porous gels 有权
    稳定的复合材料包括支撑的多孔凝胶

    公开(公告)号:US08133840B2

    公开(公告)日:2012-03-13

    申请号:US11628805

    申请日:2005-06-06

    Abstract: This invention relates to a stable composite material comprising a support member that has a plurality of pores extending through the support member, and a macroporous crosslinked gel that is located in, and fills, the pores of the support member, in which crosslinked gel is entrapped a stabilizing polymer, which stabilizing polymer is neutral, linear or branched, non-crosslinked, and substantially water-insoluble. The presence of the stabilizing polymer is such that it allows the composite material to largely retain its porosity and morphology after being dried. The invention also relates to a process for preparing the stable composite material described above, and to its use. The stable composite material is suitable, for example, for separation of substances, for example by filtration or adsorption, including chromatography, for use as a support in synthesis or for use as a support for cell growth.

    Abstract translation: 本发明涉及一种稳定的复合材料,其包括具有延伸穿过支撑构件的多个孔的支撑构件和位于并填充支撑构件的孔中并且填充有交联凝胶的孔的大孔交联凝胶 稳定聚合物,其稳定聚合物是中性的,直链或支链的,非交联的,基本上不溶于水的。 稳定聚合物的存在使得其允许复合材料在干燥后大大保持其孔隙率和形态。 本发明还涉及制备上述稳定复合材料及其用途的方法。 稳定的复合材料例如用于分离物质,例如通过过滤或吸附,包括色谱法,用作合成中的载体或用作细胞生长的载体。

    Chromatography Membranes Stable Under Caustic Conditions
    9.
    发明申请
    Chromatography Membranes Stable Under Caustic Conditions 审中-公开
    色谱膜在苛性碱条件下稳定

    公开(公告)号:US20140273158A1

    公开(公告)日:2014-09-18

    申请号:US14200615

    申请日:2014-03-07

    Inventor: Amro Ragheb

    Abstract: Disclosed are composite materials and methods of using them for chromatography. The composite materials retain their performance characteristics, such as binding capacity, flux, or percent recovery, under caustic conditions (e.g., 1 M NaOH for 24 h). In certain embodiments, the composite materials or membranes comprise a support member, comprising a plurality of pores extending through the support member; and a cross-linked gel. Importantly, the cross-linker and the monomer do not contain backbone ester linkages. The composite materials may be used in the separation or purification of a biological molecule or biological ion.

    Abstract translation: 公开了将其用于色谱法的复合材料和方法。 在苛性碱条件下(例如1M NaOH 24小时),复合材料保持其性能特征,例如结合能力,通量或回收百分比。 在某些实施例中,复合材料或膜包括支撑构件,其包括延伸穿过支撑构件的多个孔; 和交联凝胶。 重要的是,交联剂和单体不含骨架酯键。 复合材料可用于分离或纯化生物分子或生物离子。

Patent Agency Ranking