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    Samples delivering device, method of manufacturing samples applicator, method of delivering samples, and base activation device
    3.
    发明申请
    Samples delivering device, method of manufacturing samples applicator, method of delivering samples, and base activation device 失效
    样品递送装置，制造样品涂布器的方法，递送样品的方法和基底激活装置

    公开(公告)号：US20040037750A1

    公开(公告)日：2004-02-26

    申请号：US10445646

    申请日：2003-05-27

    申请人： Bio Strand, Inc.

    发明人： Donald I. Stimpson ,  Hideji Tajima

    IPC分类号： B01L003/00

    CPC分类号： B01L3/50853 ,  B01L3/0244 ,  B01L3/0255 ,  B01L3/563 ,  B01L9/547 ,  B01L2200/12 ,  B01L2300/046 ,  B01L2300/0829 ,  G01N35/1074 ,  G01N2035/1037 ,  Y10T436/110833 ,  Y10T436/15 ,  Y10T436/2575

    摘要： The present invention relates to a samples delivering device, a method of manufacturing a samples applicator, a method of delivering samples, and a base activation device which can handle a plurality of various samples, efficiently and promptly. The invention is constructed so as to have: one or more sets of vessels capable of accommodating fluids containing predetermined samples to be delivered to a base or one or more sets of vessels, a samples supply section having a samples applicator, wherein two or more retention tips capable of retaining a small quantity of fluids by being dipped in each of the fluids accommodated in the vessels are arranged according to the vessels, and a transfer means for relatively moving between the base and the one or more sets of vessels, and the applicator.

    摘要翻译： 本发明涉及样品输送装置，制造样品涂布器的方法，输送样品的方法以及能够有效且及时地处理多种样品的基体激活装置。 本发明构造成具有：一组或多组能够容纳含有预定样品的流体的容器以便输送到基底或一组或多组容器，样品供应部分具有样品涂布器，其中两个或更多个保留 根据容器布置能够通过浸入容纳在容器中的每个流体中来保留少量流体的尖端，以及用于在基部和一组或多组容器之间相对移动的转移装置，以及施加器 。

    Microarray printing device including printing pins with flat tips and exterior channel and method of manufacture
    4.
    发明授权
    Microarray printing device including printing pins with flat tips and exterior channel and method of manufacture 失效
    微阵列印刷装置包括具有扁平尖端和外部通道的印刷销和制造方法

    公开(公告)号：US6101946A

    公开(公告)日：2000-08-15

    申请号：US191935

    申请日：1998-11-13

    申请人： Richard S Martinsky

    发明人： Richard S Martinsky

    IPC分类号： B01J19/00 ,  B01L3/00 ,  B01L3/02 ,  C40B60/14

    CPC分类号： B01L3/0244 ,  B01J19/0046 ,  B01L3/0248 ,  B01L3/0255 ,  B01L9/547 ,  B01J2219/00387 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00659 ,  B01L2200/025 ,  B01L2200/12 ,  C40B60/14

    摘要： The invention herein describes a device for fabricating microarrays of biochemical substances, consisting of a holder and one or more printing pins. The holder contains apertures with regular spacing that define the location of one or more printing pins during the printing process. The tip of each printing pin contains a sample channel that holds a predetermined volume of biological or chemical sample and a point that is machined to precision with an electronic discharge machine (EDM). The device can be attached to a motion control system for precise and automated movement in three dimensions. The flat tips of the pins are immersed in a biochemical sample such that a predefined volume of sample fills the sample channel of each pin. The holder and pins are then moved in proximity to a printing substrate whereby direct contact between the flat tips of the pins and the surface results in the transfer of a small amount of the sample onto the solid surface. The holder and pins are mass produced at high precision to ensure that the printed elements in the resultant microarray contains approximately the same quantity of sample. In one preferred embodiment, the device is employed to manufacture arrays of nucleic acids or derivatives thereof.

    摘要翻译： 本文的发明描述了一种用于制造生物化学物质微阵列的装置，其由保持器和一个或多个印刷销组成。 保持器包含具有规则间隔的孔，其在打印过程中限定一个或多个打印销的位置。 每个印刷针的尖端包含保持预定体积的生物或化学样品的样品通道和用电子放电机（EDM）精加工的点。 该装置可以连接到运动控制系统，用于三维精确和自动运动。 引脚的扁平尖端浸入生化样品中，使得预定体积的样品填充每个引脚的样品通道。 然后将保持器和销移动到印刷基板附近，由此销的扁平末端与表面之间的直接接触导致少量样品转移到固体表面上。 保持器和针脚以高精度批量生产，以确保所得微阵列中的印刷元件含有大致相同量的样品。 在一个优选实施方案中，该装置用于制备核酸阵列或其衍生物。

    Apparatus for process automation using a pin and bushing array
    7.
    发明授权
    Apparatus for process automation using a pin and bushing array 有权
    使用销和套管阵列的过程自动化设备

    公开(公告)号：US08554362B2

    公开(公告)日：2013-10-08

    申请号：US13409620

    申请日：2012-03-01

    申请人： Sasan Raghibizadeh ,  Charles Boone

    发明人： Sasan Raghibizadeh ,  Charles Boone

    IPC分类号： G06F7/00

    CPC分类号： B01L9/52 ,  A61L2/24 ,  B01L9/543 ,  B01L9/547 ,  B01L2300/0819 ,  G01N35/0099 ,  G01N35/1011 ,  G01N35/1074 ,  G01N2035/00326 ,  G01N2035/042 ,  G01N2035/1037

    摘要： An apparatus comprises a plurality of bushings arranged and held together in an array; and a plurality of pins residing in the plurality of bushings, wherein the plurality of pins are for transferring samples. Manufacturing tolerances for inside diameters of the bushings and outside diameters of the pins substantially match to allowing the pins to slide freely within the bushings. The plurality of bushings can reside in one or more plates, each of which having plurality of holes, with the plurality of bushings being held together in the array.

    摘要翻译： 一种装置包括以阵列布置和保持在一起的多个衬套; 以及位于所述多个衬套中的多个销，其中所述多个销用于传送样品。 衬套的内径和销的外径的制造公差基本上匹配于允许销在衬套内自由滑动。 多个衬套可以驻留在一个或多个板中，每个板具有多个孔，多个衬套在阵列中保持在一起。

    Microarraying process and apparatus
    8.
    发明授权
    Microarraying process and apparatus 有权
    微阵列工艺和设备

    公开(公告)号：US07208124B2

    公开(公告)日：2007-04-24

    申请号：US10298948

    申请日：2002-11-19

    申请人： David Elverd ,  James Keith Haslam ,  Trevor Ruddock

    发明人： David Elverd ,  James Keith Haslam ,  Trevor Ruddock

    IPC分类号： B01N3/02 ,  G01N1/10

    CPC分类号： B01L3/0244 ,  B01J2219/00387 ,  B01J2219/00691 ,  B01L9/547 ,  B01L99/00 ,  B01L2200/04 ,  C12M33/04 ,  C40B60/14 ,  G01N35/0099 ,  G01N2035/1076 ,  Y10T436/2575

    摘要： A high throughput microarraying or colony picking robot with an automatic mechanism for exchanging pin heads and an automated washing and drying apparatus. The robot allows a dirty pin head to be deposited on the automated washing and drying apparatus for cleaning without use of the xyz-positioner, while spotting or picking can continue by picking up a clean pin head without having to wait for the dirty pin head to be cleaned. In this way, the speed of operation can be increased without any increase in the acceleration or speed of the x-, y- and z-drives. The dead time normally associated with the washing and drying cycle, which is usually several minutes, is therefore eliminated, and replaced with the much shorter dead time, of only a few tens of seconds, needed for changing between heads.

    摘要翻译： 具有用于更换针头的自动机构和自动洗涤和干燥装置的高通量微阵列或集落拾取机器人。 机器人可以将脏针头沉积在自动洗涤和干燥设备上，无需使用xyz定位器进行清洁，同时通过拾取干净的针头可以继续点样或拾取，而无需等待脏针头 被清理 以这种方式，可以在不增加x，y和z驱动器的加速度或速度的情况下提高运行速度。 因此，通常与洗涤和干燥循环相关联的通常几分钟的死区时间被消除，并且被更换为头部之间需要更短的几十秒的死区时间。

    Specimen distributing device, coating part manufacturing method, specimen distributing method and substrate activating device
    9.
    发明申请
    Specimen distributing device, coating part manufacturing method, specimen distributing method and substrate activating device 审中-公开
    试件分配装置，涂装部件制造方法，试样分配方法和基板激活装置

    公开(公告)号：US20060088447A1

    公开(公告)日：2006-04-27

    申请号：US10515710

    申请日：2003-05-27

    申请人： Donald Stimpson ,  Hideji Tajima

    发明人： Donald Stimpson ,  Hideji Tajima

    IPC分类号： B01L3/00

    CPC分类号： B01L3/50853 ,  B01L3/0244 ,  B01L3/0255 ,  B01L3/563 ,  B01L9/547 ,  B01L2200/12 ,  B01L2300/046 ,  B01L2300/0829 ,  G01N35/1074 ,  G01N2035/1037 ,  Y10T436/110833 ,  Y10T436/15 ,  Y10T436/2575

    摘要： The present invention relates to a samples delivering device, a method of manufacturing a samples applicator, a method of delivering samples, and a base activation device which can handle a plurality of various samples, efficiently and promptly. The invention is constructed so as to have: one or more sets of vessels capable of accommodating fluids containing predetermined samples to be delivered to a base or one or more sets of vessels, a samples supply section having a samples applicator, wherein two or more retention tips capable of retaining a small quantity of fluids by being dipped in each of the fluids accommodated in the vessels are arranged according to the vessels, and a transfer means for relatively moving between the base and the one or more sets of vessels, and the applicator.

    摘要翻译： 本发明涉及样品输送装置，制造样品涂布器的方法，输送样品的方法以及能够有效且及时地处理多种样品的基体激活装置。 本发明构造成具有：一组或多组能够容纳含有预定样品的流体的容器以便输送到基底或一组或多组容器，样品供应部分具有样品涂布器，其中两个或更多个保留 根据容器布置能够通过浸入容纳在容器中的每个流体中来保留少量流体的尖端，以及用于在基部和一组或多组容器之间相对移动的转移装置，以及施加器 。

    Micro-ejection device
    10.
    发明授权
    Micro-ejection device 失效
    微型喷射装置

    公开(公告)号：US08657412B2

    公开(公告)日：2014-02-25

    申请号：US13358345

    申请日：2012-01-25

    申请人： Sang Jin Kim ,  Bo Sung Ku

    发明人： Sang Jin Kim ,  Bo Sung Ku

    IPC分类号： B41J2/14

    CPC分类号： B01L9/547 ,  B01L3/0248 ,  B01L2200/023 ,  B01L2300/123

    摘要： There is provided a micro-ejection device including: an ejector ejecting a fluid; and a body having an installation space in which the ejector is installed, wherein the installation space is provided with a guide unit inducing a line-contact or a point-contact between the ejector and the body.

    摘要翻译： 提供一种微型喷射装置，包括：喷射器喷射流体; 以及具有其中安装有喷射器的安装空间的主体，其中所述安装空间设置有引导所述喷射器和所述主体之间的线接触或点接触的引导单元。