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    PAPAYA MOSAIC VIRUS COMPOSITIONS AND USES THEREOF FOR STIMULATION OF THE INNATE IMMUNE RESPONSE
    1.
    发明申请
    PAPAYA MOSAIC VIRUS COMPOSITIONS AND USES THEREOF FOR STIMULATION OF THE INNATE IMMUNE RESPONSE 审中-公开
    PAPAYA MOSAIC VIRUS组合物及其用于刺激免疫应答的用途

    公开(公告)号：US20140154288A1

    公开(公告)日：2014-06-05

    申请号：US14117363

    申请日：2012-05-01

    申请人： Denis Leclerc ,  Alain Lamarre

    发明人： Denis Leclerc ,  Alain Lamarre

    IPC分类号： A61K39/12

    CPC分类号： A61K39/12 ,  A61K39/39 ,  C12N2760/10011 ,  C12N2760/16111 ,  C12N2770/26023 ,  C12N2770/26034 ,  C12N2770/26042 ,  Y02A50/403 ,  Y02A50/407 ,  Y02A50/478

    摘要： The use of compositions comprising a papaya mosaic virus (PapMV) moiety for stimulation of the innate immune response is provided. The PapMV moiety may be papaya mosaic virus or PapMV virus-like particles (VLPs). The PapMV compositions stimulate a sufficiently strong innate immune response to provide protection against subsequent pathogen challenge or to treat an established infection. The use of PapMV compositions to protect a subject from potential infection by a pathogen, such as a viral pathogen, a bacterial pathogen or a fungal pathogen, and the use of PapMV compositions to treat an established infection, are also provided. The PapMV compositions be administered, for example, via intranasal or pulmonary routes to elicit effects within the mucosa and/or in the respiratory system.

    摘要翻译： 提供了包含番木瓜花叶病毒（PapMV）部分的组合物用于刺激先天免疫应答的用途。 PapMV部分可以是番木瓜花叶病毒或PapMV病毒样颗粒（VLP）。 PapMV组合物刺激足够强的先天免疫应答以提供针对随后的病原体攻击的保护或治疗已建立的感染。 还提供了使用PapMV组合物来保护受试者免受病原体（例如病毒病原体，细菌病原体或真菌病原体）的潜在感染，以及使用PapMV组合物治疗已建立的感染。 PapMV组合物例如通过鼻内或肺部途径施用以在粘膜和/或呼吸系统内引发作用。

    Multivalent Vaccines Based on Papaya Mosaic Virus and Uses Thereof
    5.
    发明申请
    Multivalent Vaccines Based on Papaya Mosaic Virus and Uses Thereof 审中-公开
    基于番木瓜花叶病毒的多价疫苗及其用途

    公开(公告)号：US20110206727A1

    公开(公告)日：2011-08-25

    申请号：US13056962

    申请日：2009-05-15

    申请人： Denis Leclerc

    发明人： Denis Leclerc

    IPC分类号： A61K39/295 ,  A61P37/04 ,  A61P31/16

    CPC分类号： A61K39/0275 ,  A61K2039/523 ,  A61K2039/5258 ,  A61K2039/545 ,  A61K2039/55516 ,  A61K2039/70 ,  C12N2760/16111 ,  C12N2760/16211 ,  C12N2770/26023 ,  Y02A50/482 ,  Y02A50/484

    摘要： A multivalent vaccine composition that comprises a papaya mosaic virus (PapMV) component and one or more antigens is provided. The composition can further optionally comprise a Salmonella spp. porin component. The PapMV component can be PapMV or PapMV virus-like particles (VLPs). The porin component can be a Salmonella spp. OmpC, OmpF or a combination thereof, and can be combined with the PapMV component or conjugated to the PapMV component. The PapMV component in the multivalent vaccine composition functions as an adjuvant and/or an immunostimulant with respect to the one or more antigens. Use of the multivalent vaccine compositions to provide protection against a plurality of strains of a pathogen, or against more than one pathogen, are also provided.

    摘要翻译： 提供了包含番木瓜花叶病毒（PapMV）组分和一种或多种抗原的多价疫苗组合物。 组合物还可以任选地包含沙门氏菌属。 孔蛋白成分。 PapMV组分可以是PapMV或PapMV病毒样颗粒（VLP）。 孔蛋白组分可以是沙门氏菌属。 OmpC，OmpF或其组合，并且可以与PapMV组分组合或与PapMV组分缀合。 多价疫苗组合物中的PapMV组分用作一种或多种抗原的佐剂和/或免疫刺激剂。 还提供了使用多价疫苗组合物来提供针对多种病原体菌株或针对多于一种病原体的保护。

    Condition control system, device and process for message transmission
    7.
    发明授权
    Condition control system, device and process for message transmission 有权
    条件控制系统，消息传输的设备和过程

    公开(公告)号：US08117253B2

    公开(公告)日：2012-02-14

    申请号：US11574977

    申请日：2007-03-02

    申请人： Julien Robinson ,  Mathieu Boussard ,  Denis Leclerc ,  Fabien Bataille ,  Abdelkrim Hebbar ,  Bruno Mongazon-Cazavet

    发明人： Julien Robinson ,  Mathieu Boussard ,  Denis Leclerc ,  Fabien Bataille ,  Abdelkrim Hebbar ,  Bruno Mongazon-Cazavet

    IPC分类号： G06F15/16 ,  H04W4/00 ,  H04Q9/00 ,  G06Q10/00

    CPC分类号： G06Q50/22 ,  H04L51/14 ,  H04W4/12

    摘要： The invention concerns in particular a system comprising: a first terminal (1); a second terminal (21 or 22 or 23); at least a first messaging system (31 or 32 or 33) able to transmit, to the second terminal, at least the message body of a message (10) from the first terminal; at least one device (4) controlling at least one condition (11), at least once, the said control device allowing the first messaging system to transmit to the second terminal at least the message body of the said message if the condition control result is positive, the said control device preventing the first messaging system from transmitting to the second terminal at least the message body of the said message if the condition control is negative, at least during the time for which the condition control result remains negative; at least one data server (51 or 52 or 53 or 54) external to the control device; at least one link providing communication through the Internet between on the hand the external server, or at least one of the external servers, and on the other hand the control device, the condition control device being designed to: store a message sent by the first terminal; receive at least one item of information from at least one external server; at least partially perform the condition control relating to the said message stored by means of the information received from the external server.

    摘要翻译： 本发明尤其涉及一种系统，包括：第一终端（1）; 第二终端（21或22或23）; 至少第一消息系统（31或32或33）能够从所述第一终端向所述第二终端至少传送消息（10）的消息主体; 至少一个设备（4）控制至少一个条件（11）至少一次所述控制设备，允许所述第一消息系统至少将所述消息的消息体发送到所述第二终端，如果所述条件控制结果是 肯定的是，至少在条件控制结果保持为负的时间内，如果条件控制是否定的，则所述控制设备防止第一消息传送系统至少向所述消息的消息体发送至第二终端; 在所述控制设备外部的至少一个数据服务器（51或52或53或54）; 至少一个链路，通过互联网提供在外部服务器或外部服务器之间的至少一个上的通信，另一方面，控制设备，条件控制设备被设计为：存储由第一 终奌站; 从至少一个外部服务器接收至少一个信息项; 至少部分地通过从外部服务器接收的信息来执行与所述消息有关的条件控制。

    Method of manufacturing an integrated optical component comprising a thick waveguide coupled to a thin waveguide
    9.
    发明授权
    Method of manufacturing an integrated optical component comprising a thick waveguide coupled to a thin waveguide 有权
    制造集成光学部件的方法，其包括耦合到薄波导的厚波导

    公开(公告)号：US6040246A

    公开(公告)日：2000-03-21

    申请号：US148480

    申请日：1998-09-08

    申请人： Leon Goldstein ,  Denis Leclerc ,  Beatrice Dagens

    发明人： Leon Goldstein ,  Denis Leclerc ,  Beatrice Dagens

    IPC分类号： G02B6/12 ,  G02B6/122 ,  G02B6/26 ,  H01S5/026 ,  H01L21/02 ,  G02B6/13 ,  G02B6/136 ,  H01L21/20 ,  H01L21/3065

    CPC分类号： G02B6/26 ,  G02B6/12004 ,  G02B6/1228 ,  H01S5/026

    摘要： To form an integrated optical component comprising a thick waveguide coupled to a thin waveguide, the method consists in:depositing a first guiding layer of said thick waveguide on a substrate;locally etching said first guiding layer over a portion allocated both to a coupling interface and to the thin waveguide;depositing a second guiding layer on the first guiding layer and on the locally etched portion so as to form said thick waveguide in a manner such that it has a maximum thickness in a first zone, a graded-thickness section in a second zone, and a reduced-thickness section in a third zone;locally etching the second guiding layer over a portion of the third zone, said portion being allocated to the thin waveguide; anddepositing a third guiding layer in said portion of said third zone so as to form said thin waveguide.

    摘要翻译： 为了形成包括耦合到薄波导的厚波导的集成光学部件，该方法包括：在衬底上沉积所述厚波导的第一引导层; 在分配给耦合接口和薄波导的部分上局部蚀刻所述第一引导层; 在第一引导层和局部蚀刻部分上沉积第二引导层，以便形成所述厚波导，使得其在第一区域具有最大厚度，在第二区域中具有最大厚度，在第二区域中具有渐变厚度部分， 第三区的厚度减薄部分; 在第三区域的一部分上局部蚀刻第二引导层，所述部分被分配给薄波导; 以及在所述第三区的所述部分中沉积第三引导层以形成所述薄波导。