公开(公告)号：US06391647B1

公开(公告)日：2002-05-21

申请号：US08784678

申请日：1997-01-21

申请人： Michael Sperling ,  Albert Gilmutdinov

发明人： Michael Sperling ,  Albert Gilmutdinov

IPC分类号： G01N2162

CPC分类号： G01N21/74 ,  Y10T436/25875

摘要： The present invention refers to a method for atomic absorption spectroscopy of an analyte which is contained in a sample to be analyzed and which is converted into free atoms in an absorption volume of an atomizer, said method comprising the steps of (a) position- and time-dependent measuring of the atomic absorption over the cross-section of the absorption volume and (b) simultaneous determination of surface temperatures of the atomizer. This method is characterized by the steps of (c) reconstructing the temperature field in said absorption volume on the basis of the surface temperatures determined, (d) determining position- and time-dependent numbers of particles of the absorbing atoms of the analyte on the basis of the measurements of the position- and time-dependent atomic absorption and the absorption profile that has been determined with due regard to effects influencing the line profile of the analyte and with due regard to the reconstructed temperature field, and (e) determining the time-dependent total number of the absorbing atoms of the analyte on the basis of the position- and time-dependent numbers of particles. In addition, the present invention concerns a device for carrying out this method.

摘要翻译： 本发明涉及一种分析物的原子吸收光谱法，该分析物包含在待分析的样品中，并被转化成雾化器的吸收体积中的游离原子，所述方法包括以下步骤：（a）定位和 时间依赖性测量吸收体积横截面上的原子吸收和（b）同时测定雾化器的表面温度。 该方法的特征在于以下步骤：（c）基于确定的表面温度重建所述吸收体积中的温度场，（d）确定分析物的吸收原子的颗粒的位置和时间依赖数 测量位置和时间依赖的原子吸收和吸收曲线的基础，其已经考虑到影响分析物的线轮廓的影响并且适当地考虑到重建的温度场而被确定，以及（e）确定 基于颗粒的位置和时间依赖数量的分析物的吸收原子的时间依赖性总数。 此外，本发明涉及一种用于执行该方法的装置。

公开(公告)号：US06743637B2

公开(公告)日：2004-06-01

申请号：US09986613

申请日：2001-11-09

申请人： Tomoya Sato

发明人： Tomoya Sato

IPC分类号： G01N2162

CPC分类号： G01N21/35 ,  G01N21/3563

摘要： The object of the present invention is to provide a disease type and/or condition determination method and apparatus that enables rapid and reliable determination by spectral analysis of the energy state of cells or drugs, and a drug screening method and apparatus that enables efficient screening of a target drug. In order to achieve this object, for example, the disease type and/or condition determination method according to the present invention determines disease type and condition by measuring the absorption spectrum in, for example, the infrared region for cells obtained from a specimen, and determining whether or not a coinciding absorption spectrum exists for those measurement results by using as indices at least two infrared absorption spectra.

摘要翻译： 本发明的目的是提供能够通过对细胞或药物的能量状态的光谱分析进行快速和可靠的测定的疾病类型和/或病症测定方法和装置，以及能够有效筛选 目标药物。 为了实现该目的，例如，本发明的疾病类型和/或状况判定方法，通过测定例如从试样获得的细胞的红外线区域的吸收光谱来确定疾病的种类和状态， 通过使用至少两个红外吸收光谱作为指标，确定对于那些测量结果是否存在一致的吸收光谱。

公开(公告)号：US06642533B2

公开(公告)日：2003-11-04

申请号：US09768065

申请日：2001-01-24

申请人： Hideo Haraguchi ,  Izuru Matsuda ,  Shigeyuki Yamamoto

发明人： Hideo Haraguchi ,  Izuru Matsuda ,  Shigeyuki Yamamoto

IPC分类号： G01N2162

CPC分类号： H01L21/67265 ,  H01L21/67772 ,  Y10S414/136 ,  Y10S414/137

摘要： A substrate detection sensor is operatively connected to a door moving mechanism for opening/closing a front door with respect to a sealed container accommodating therein a plurality of substrates. The substrate detection sensor enters the sealed container and detects the substrates successively as it is lowered integrally with the front door, and retracts from the sealed container when all of the substrates have been detected.

摘要翻译： 基板检测传感器可操作地连接到门移动机构，用于相对于容纳多个基板的密封容器打开/关闭前门。 基板检测传感器进入密封容器，并与前门一体地下降地连续地检测基板，并且当检测到所有的基板时，从密封容器缩回。

公开(公告)号：US06613577B1

公开(公告)日：2003-09-02

申请号：US09787270

申请日：2001-05-09

申请人： Giuseppe Da Cruz

发明人： Giuseppe Da Cruz

IPC分类号： G01N2162

CPC分类号： G01N31/005 ,  Y10T436/103332

摘要： The antioxidant power of an organic or inorganic liquid is determined by causing it to enter into competition with bathocuproine (BC) in a copper sulphate solution. Bathocuproine (BC) forms stable complexes with the monovalent Cu. Such a reaction is specific for Cu(I) and not for divalent Cu(II). Cu(II) in solution can be reduced to Cu(I) by a number of reducing compositions belonging to a class of compositions consisting prevailingly of both liposoluble and water soluble non-enzymatic antioxidants. When the reaction occurs in a bathocuproine (BC) buffer, the complex being formed is characterized by the concentration of the reducing agents and then, by good approximation, of the antioxidants present in the system. The quantitative analysis of such a reaction can be easily made by spectrophotometry at 480 nm both by macro- and micromethods with the use of a number of reducing standard compositions with known concentrations.

摘要翻译： 有机或无机液体的抗氧化能力通过使其与硫酸铜溶液（BC）进入竞争来确定。 Bathocuproine（BC）与一价Cu形成稳定的络合物。 这种反应对于Cu（I）而不是二价Cu（II）。 溶液中的Cu（II）可以通过许多属于一种主要含脂溶性和水溶性非酶抗氧化剂的组合物的还原组合物还原成Cu（I）。 当反应发生在巴铜酸（BC）缓冲液中时，形成的络合物的特征在于还原剂的浓度，然后通过良好的近似计算体系中存在的抗氧化剂的浓度。 通过使用已知浓度的许多还原标准组合物，通过宏观和微观方法在480nm下通过分光光度法容易地进行定量分析。

公开(公告)号：US06808929B1

公开(公告)日：2004-10-26

申请号：US09763826

申请日：2001-04-12

申请人： Brian Law ,  Bryan J A Miller ,  Christopher M Turner ,  John E A Shaw

发明人： Brian Law ,  Bryan J A Miller ,  Christopher M Turner ,  John E A Shaw

IPC分类号： G01N2162

CPC分类号： G01N27/44791 ,  B01J2219/00702 ,  G01N30/0005 ,  Y10T436/117497 ,  Y10T436/25375 ,  Y10T436/2575

摘要： The invention relates to a microfabricated device for use in measuring the physical properties of compounds, where the properties measured using such devices are those which involve partitioning of the compound between two phases, measuring partition coefficients, distribution coefficients, acid-base dissociation constants, solubility and vapour pressure. The device comprises a microfabricated conduit, in which two fluids flow creating at least two phases between which the compound may partition, and a detector for measuring the amount of compound in each or both fluids.

摘要翻译： 本发明涉及用于测量化合物的物理性质的微制造装置，其中使用这些装置测量的性质是涉及在两相之间分配化合物的性质，测量分配系数，分配系数，酸碱解离常数，溶解度 和蒸气压。 该装置包括微制造管道，其中两个流体流动产生至少两个相，化合物可以在其间分隔，以及用于测量每一种或两种流体中的化合物的量的检测器。

公开(公告)号：US06603538B1

公开(公告)日：2003-08-05

申请号：US09721403

申请日：2000-11-21

申请人： Hakeem Oluseyi ,  Moshe Sarfaty

发明人： Hakeem Oluseyi ,  Moshe Sarfaty

IPC分类号： G01N2162

CPC分类号： G01N21/73

摘要： A method and an apparatus system feature detecting faults in process conditions of a plasma-based semiconductor processing system by sensing the spectral emissions of the plasma. As a result, the method includes sensing optical energy produced by the plasma and identifying the fault in the process conditions as a function of one or more of the plurality of spectral bands. To that end, the apparatus includes a detector in optical communication with the processing chamber to sense optical energy generated by the plasma, and a spectrum analyzer, in electrical communication with the optical detector. The spectrum analyzer resolves the spectral bands and produces information corresponding thereto. A processor is in electrical communication with the spectrum analyzer, and a memory is in electrical communication with the processor. The memory includes a computer-readable medium having a computer-readable program embodied therein that controls the system to carry-out the method.

摘要翻译： 一种通过感测等离子体的光谱发射来检测基于等离子体的半导体处理系统的处理条件中的故障的方法和装置系统。 结果，该方法包括感测由等离子体产生的光能并且根据多个光谱带中的一个或多个的功能识别处理条件中的故障。 为此，该装置包括与处理室光学通信的检测器，用于感测由等离子体产生的光能，以及与光学检测器电连通的频谱分析仪。 频谱分析仪解析频谱带并产生与之对应的信息。 处理器与频谱分析仪电气通信，并且存储器与处理器电通信。 存储器包括具有其中体现的计算机可读程序的计算机可读介质，其控制系统执行该方法。

公开(公告)号：US06569685B1

公开(公告)日：2003-05-27

申请号：US09412732

申请日：1999-10-05

申请人： Robert H. Carlson ,  Ian E. Burbulis ,  Roger Brent

发明人： Robert H. Carlson ,  Ian E. Burbulis ,  Roger Brent

IPC分类号： G01N2162

CPC分类号： G01N33/582 ,  G01N33/542 ,  G01N33/6803

摘要： A system and method for characterizing protein molecules. A protein molecule of interest is isolated from other types of protein molecules. The protein molecule of interest is modified to a one-dimensional structure from the natural three-dimensional structure of the protein molecule. Each of a first type of amino acid residue of the protein molecule is labeled with a first tag. Each of a second type of amino acid residue of the protein molecule is labeled with a second tag. The first and second tags impart to the protein molecule a detectable set of characteristic ancillary properties that facilitates distinction of the protein molecule of interest from other types of protein molecules. When these ancillary properties are detected, a fingerprint of the protein molecule is revealed. A listing of known protein molecules and of the fingerprints corresponding to each of the known protein molecules serves as a library to facilitate identification of unknown proteins. A fingerprint of a protein molecule of interest determined in the same manner as the fingerprints of known proteins listed in the library is compared with fingerprints of the known protein molecules to identify the protein molecule of interest.

摘要翻译： 用于表征蛋白质分子的系统和方法。 感兴趣的蛋白质分子从其他类型的蛋白质分子中分离出来。 将目的蛋白质分子从蛋白质分子的天然三维结构修饰成一维结构。 蛋白质分子的第一类氨基酸残基中的每一个用第一标签标记。 蛋白质分子的第二类型的氨基酸残基中的每一个用第二个标签标记。 第一和第二标签赋予蛋白质分子可检测的一组特征性辅助性质，其有助于将目的蛋白质分子与其它类型的蛋白质分子区分开。 当检测到这些辅助性质时，显示出蛋白质分子的指纹图谱。 已知蛋白质分子和对应于每个已知蛋白质分子的指纹的列表用作有助于鉴定未知蛋白质的文库。 将以与文库中列出的已知蛋白质的指纹相同的方式测定的感兴趣的蛋白质分子的指纹与已知蛋白质分子的指纹进行比较，以鉴定感兴趣的蛋白质分子。

公开(公告)号：US06541271B1

公开(公告)日：2003-04-01

申请号：US08946135

申请日：1997-10-07

申请人： Eric W. McFarland ,  William Archibald

发明人： Eric W. McFarland ,  William Archibald

IPC分类号： G01N2162

CPC分类号： G01N29/2425 ,  B01J19/0046 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00364 ,  B01J2219/00378 ,  B01J2219/0043 ,  B01J2219/00443 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00511 ,  B01J2219/00515 ,  B01J2219/0052 ,  B01J2219/00527 ,  B01J2219/00536 ,  B01J2219/00583 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00628 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00689 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/00722 ,  B01J2219/00738 ,  B01J2219/00745 ,  B01J2219/00747 ,  B01J2219/0075 ,  B01J2219/00754 ,  B82Y30/00 ,  C07F15/0066 ,  C07F15/045 ,  C40B20/08 ,  C40B30/08 ,  C40B40/14 ,  C40B40/18 ,  C40B50/14 ,  C40B60/12 ,  C40B60/14 ,  G01H13/00 ,  G01J4/00 ,  G01N9/002 ,  G01N11/16 ,  G01N21/211 ,  G01N21/253 ,  G01N21/6402 ,  G01N21/6452 ,  G01N21/66 ,  G01N25/4813 ,  G01N29/022 ,  G01N29/036 ,  G01N29/2418 ,  G01N29/30 ,  G01N29/348 ,  G01N29/42 ,  G01N29/4418 ,  G01N29/4427 ,  G01N31/10 ,  G01N2009/006 ,  G01N2203/0094 ,  G01N2291/014 ,  G01N2291/0224 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/02818 ,  G01N2291/02827 ,  G01N2291/02863 ,  G01N2291/0422 ,  G01N2291/0423 ,  G01N2291/0427 ,  G01N2291/106 ,  H01J49/0409 ,  H01J49/0468

摘要： Methods and apparatus for screening diverse arrays of materials using infrared imaging techniques are provided. Typically, each of the individual materials on the array will be screened or interrogated for the same material characteristic. Once screened, the individual materials may be ranked or otherwise compared relative to each other with respect to the material characteristic under investigation. According to one aspect, infrared imaging techniques are used to identify the active sites within an array of compounds by monitoring the temperature change resulting from a reaction. This same technique can also be used to quantify the stability of each new material within an array of compounds. According to another aspect, identification and characterization of condensed phase products is achieved, wherein library elements are activated by a heat source serially, or in parallel. According to another aspect, a Fourier transform infrared spectrometer is used to rapidly characterize a large number of chemical reactions contained within a combinatorial library.

摘要翻译： 提供了使用红外成像技术筛选各种材料阵列的方法和装置。 通常，对于相同的材料特性，阵列上的每个单独的材料将被筛选或询问。 一旦筛选，单个材料可以相对于被调查的材料特性相对于彼此进行排序或以其他方式比较。 根据一个方面，红外成像技术用于通过监测由反应产生的温度变化来鉴定化合物阵列内的活性位点。 也可以使用相同的技术来量化化合物阵列内的每种新材料的稳定性。 根据另一方面，实现冷凝相产物的鉴定和表征，其中文库元素被串联或并联的热源活化。 根据另一方面，使用傅里叶变换红外光谱仪来快速表征包含在组合文库中的大量化学反应。

公开(公告)号：US06473175B1

公开(公告)日：2002-10-29

申请号：US09552734

申请日：2000-04-19

申请人： Mark Leonard Malczewski

发明人： Mark Leonard Malczewski

IPC分类号： G01N2162

CPC分类号： G01N33/0014 ,  G01N33/0018

摘要： A method of analyzing a sample gas for the presence of at least one gas impurity by combining a stream of sample gas with a stream of carrier gas to provide a combined stream of gas, directing the combined stream of gas through a column which preferentially removes the sample gas from the combined stream to produce a retentate stream of gas, and analyzing the retentate stream of gas for the presence of the at least one gas impurity.

摘要翻译： 通过将样品气体流与载气流组合来提供气体杂质的存在来分析样品气体的方法，以提供组合的气体流，将气体流引导通过优选除去 来自组合流的样品气体以产生滞留气体流，并且分析气体的滞留物流以存在至少一种气体杂质。