公开(公告)号：US12121547B2

公开(公告)日：2024-10-22

申请号：US16747406

申请日：2020-01-20

申请人： Inguran, LLC

发明人： Hein van der Steen ,  Gregg Bevier

IPC分类号： A01K67/027 ,  A61B1/04 ,  A61B1/313 ,  A61B6/00 ,  A61B6/12 ,  A61D19/02 ,  A61K35/52

CPC分类号： A61K35/52 ,  A61B1/044 ,  A61B1/3132 ,  A61B6/12 ,  A61B6/485 ,  A61D19/027

摘要： The invention relates to methods of increasing genetic merit of swine by establishing a plurality of mating subtypes for a line of swine, and determining a percentage of progeny that are male for each of the mating subtypes, or a percentage of progeny that are female for each of the mating subtypes, that would result, relative to a control, in an increase in genetic merit in the line; the invention further relates to sorting a sperm cell sample from a male swine in one of the mating subtypes into one or more subpopulations of sperm cells, wherein a majority of sperm cells in a subpopulation of sperm cells bear X chromosomes or Y chromosomes, and inseminating one or more female swine in the one of the mating subtypes with the subpopulation of sperm cells to achieve the percentage of progeny that are male, or the percentage of progeny that are female, determined to increase genetic merit relative to the control.

公开(公告)号：US11883438B2

公开(公告)日：2024-01-30

申请号：US16327817

申请日：2017-08-23

申请人： National University Corporation Nagoya University ,  Gifu University ,  Gifu Prefecture

发明人： Tokunori Yamamoto ,  Satoshi Suzuki ,  Yasuhito Funahashi ,  Yoshihisa Matsukawa ,  Momokazu Gotoh ,  Tomohiro Kitayama ,  Yoichiro Hoshino ,  Tetsuma Murase

IPC分类号： A61K35/50 ,  A61K35/51 ,  A61K35/52 ,  A61P15/08 ,  A61K35/32 ,  A61K35/54 ,  A61K35/28 ,  A61K35/35 ,  A61D19/00 ,  A61D19/02 ,  A61K35/00 ,  C12N5/076 ,  C12N5/0775

CPC分类号： A61K35/50 ,  A61D19/00 ,  A61D19/02 ,  A61K35/00 ,  A61K35/28 ,  A61K35/32 ,  A61K35/35 ,  A61K35/51 ,  A61K35/52 ,  A61K35/54 ,  A61P15/08 ,  C12N5/061 ,  C12N5/0664 ,  C12N5/0665 ,  C12N5/0667 ,  C12N2500/80

摘要： It is an object to provide a technique useful for embryo transfer and development of reproductive medical care. Provided are a sperm activator containing a disrupted product of one or more cells selected from the group consisting of adipose tissue-derived stem cells, dental pulp-derived stem cells, bone marrow-derived stem cells, and umbilical cord blood-derived stem cells as an active ingredient, and an artificial insemination method utilizing the same.

公开(公告)号：US11819245B2

公开(公告)日：2023-11-21

申请号：US17010299

申请日：2020-09-02

申请人： CrossBay Medical, Inc.

发明人： Steven R. Bacich ,  Matthew Thomas Yurek ,  Piush Vidyarthi

IPC分类号： A61B17/43 ,  A61M39/24 ,  A61M25/10 ,  A61B1/00 ,  A61B1/303 ,  A61B1/32 ,  A61B17/02 ,  A61B17/34 ,  A61M29/02 ,  A61B17/12 ,  A61F6/18 ,  A61F6/22 ,  A61M25/01 ,  A61F2/00 ,  A61B17/00 ,  A61B17/42 ,  A61D19/02 ,  A61D19/04 ,  A61B17/29 ,  A61M25/00 ,  A61B90/00

CPC分类号： A61B17/43 ,  A61B1/00082 ,  A61B1/303 ,  A61B1/32 ,  A61B17/0218 ,  A61B17/1204 ,  A61B17/12099 ,  A61B17/12136 ,  A61B17/3423 ,  A61F2/0027 ,  A61F6/18 ,  A61F6/22 ,  A61M25/0119 ,  A61M25/10 ,  A61M25/1002 ,  A61M25/1011 ,  A61M25/1025 ,  A61M25/10181 ,  A61M25/10182 ,  A61M29/02 ,  A61M39/24 ,  A61B2017/00115 ,  A61B2017/00557 ,  A61B2017/00805 ,  A61B2017/0225 ,  A61B2017/2946 ,  A61B2017/345 ,  A61B2017/3435 ,  A61B2017/4216 ,  A61B2017/4225 ,  A61B2090/037 ,  A61B2090/0807 ,  A61B2090/0809 ,  A61B2090/0811 ,  A61D19/027 ,  A61D19/04 ,  A61M25/104 ,  A61M2025/0004 ,  A61M2025/0175 ,  A61M2025/1004 ,  A61M2025/1013 ,  A61M2025/1052 ,  A61M2025/1059 ,  A61M2025/1065

摘要： Everting balloon systems and methods for using the same are disclosed herein. The systems can be configured to access and dilate body lumen and cavities. For example, the systems can be used to dilate the cervix and access the uterine cavity. The systems can also be used to occlude the cervix. The systems can also be used to occlude the urethra.

公开(公告)号：US20230292743A1

公开(公告)日：2023-09-21

申请号：US18322906

申请日：2023-05-24

申请人： IMV TECHNOLOGIES ,  UNIVERSITE GRENOBLE ALPES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  SWISSGENETICS

发明人： Christophe ARNOULT ,  Eric SCHMITT ,  Guillaume MARTINEZ ,  Jessica ESCOFFIER

IPC分类号： A01N1/02 ,  A61D19/02 ,  A61K31/14 ,  A61K31/4748

CPC分类号： A01N1/0226 ,  A01N1/0221 ,  A61D19/024 ,  A61D19/027 ,  A61K31/14 ,  A61K31/4748

摘要： The invention relates to a method for increasing the lifespan of animal sperm comprising contacting said sperm with an inhibitor of Slo3 potassium channel.
The invention also relates to a use of an inhibitor of Slo3 potassium channel, for increasing the lifespan of animal sperm or motility of capacitated animal sperm, comprising contacting an inhibitor of Slo3 potassium channel with said sperm. Moreover, the invention relates to an artificial insemination instrument for use in artificial insemination of an animal, comprising animal sperm in contact with an inhibitor of Slo3 potassium channel.
The invention also relates to a method for artificially inseminating an animal using said artificial insemination instrument.
Eventually, the invention relates to a method for increasing the fertility of an animal, comprising contacting sperm of said animal with an inhibitor of Slo3 potassium channel; then artificially inseminating said animal with said sperm.

公开(公告)号：US11653635B2

公开(公告)日：2023-05-23

申请号：US16708007

申请日：2019-12-09

申请人： Inguran, LLC

发明人： Juan Moreno ,  Gregg Bevier ,  John Dobrinsky

IPC分类号： A01K67/00 ,  A01K67/02 ,  A61D19/02 ,  A61B34/20 ,  G16B20/40 ,  A61B1/04 ,  A61B1/015 ,  A61B1/303 ,  A61B1/313 ,  A61B8/08 ,  A61B10/00 ,  A61M31/00 ,  G16B20/00

CPC分类号： A01K67/02 ,  A61B1/015 ,  A61B1/04 ,  A61B1/303 ,  A61B1/313 ,  A61B8/08 ,  A61B10/0012 ,  A61B34/20 ,  A61D19/027 ,  A61M31/002 ,  G16B20/40 ,  A01K2227/108 ,  A61B2034/2057 ,  G16B20/00

摘要： The invention relates to methods of increasing the genetic progress of a line, breed or herd of swine through the use of sex-selected sperm cells in artificial insemination techniques. The invention also encompasses methods of artificially inseminating a swine via deep intrauterine catheter or via a laparoscopic procedure, which allow the use of reduced doses of sex-selected sperm cells.

公开(公告)号：US20230042628A1

公开(公告)日：2023-02-09

申请号：US17791432

申请日：2021-01-08

申请人： Inoveo

发明人： Carlo BERTOZZI ,  Emilie HENROTTE ,  Christophe BOCCART ,  Vincent BAETEN ,  Frédéric DEHARENG

IPC分类号： G01N21/31 ,  A61D19/02

摘要： A method is for determining the quality of an animal's semen. The method includes the steps of collecting at least one fresh or frozen semen sample, and measuring at least one absorption spectrum Xj of at least one sample of the semen. The sample is collected to a straw for artificial insemination with animal semen obtained by implementing the method. A computer and software are used for the implementation of the method.

公开(公告)号：US20220387075A1

公开(公告)日：2022-12-08

申请号：US17773101

申请日：2020-10-30

申请人： UNIVERSIDAD DE MURCIA

发明人： Rafael LATORRE REVIRIEGO ,  Analuce CANHA GOUVEIA

IPC分类号： A61B17/435 ,  A61D19/04 ,  A61D19/02 ,  A61B17/43

摘要： A device for collecting uterine fluid is described which can be used in vivo in both animals and humans, without said use causing dilution of fluid components or damage to the endometrium.

公开(公告)号：US20220220438A1

公开(公告)日：2022-07-14

申请号：US17651505

申请日：2022-02-17

申请人： University of Massachusetts

发明人： Pablo E. Visconti ,  Felipe Navarrete

IPC分类号： C12N5/073 ,  A01N1/02 ,  A61K48/00 ,  C12N5/076 ,  C12N15/00 ,  A61B17/43 ,  A61B17/435 ,  A61D19/02 ,  A61D19/04

摘要： Methods for improving the functionality and/or fertility of sperm, for example, by enhancing motility and/or extending the lifespan of sperm by subjecting the isolated sperm to a starvation protocol and/or ionophore are provided. Such methods may be used in, for example, artificial insemination to reduce the number of sperm needed for insemination and to improve conception rates.

公开(公告)号：US11372225B2

公开(公告)日：2022-06-28

申请号：US16467034

申请日：2018-08-22

申请人： HUNAN CHANGSHA OURTOOL BIOLOGICAL TECHNOLOGY CO., LTD.

发明人： Jianjun Peng

IPC分类号： G02B21/32 ,  G02B21/00 ,  C12M3/00 ,  G02B21/26 ,  A61D19/02

摘要： There are provided a microscopic mirror imaging device, a system and a method for calibrating a posture of a microneedle. The microscopic mirror imaging device includes a motion actuator, a mirror image former support and a mirror image former. The motion actuator is fixedly mounted on a microscope stage. One end of the mirror image former support is connected to the motion actuator. The mirror image former includes a plane mirror mounted on the other end of the mirror image former support. An angle formed between a mirror surface of the plane mirror and a horizontal plane of the microscope stage is equal to 45°, and an angle formed between the mirror surface of the plane mirror and a coronal plane of the microscope stage is equal to 45°.

公开(公告)号：US20220175508A1

公开(公告)日：2022-06-09

申请号：US17538095

申请日：2021-11-30

申请人： Stacy Alexis NOLAND

发明人： Stacy Alexis NOLAND

IPC分类号： A61D19/02 ,  A01K15/02 ,  A61H19/00

摘要： A doll shaped as a female canine comprising a body coupled to a plurality of adjustable limbs and having a rear hole, a tubular insert that is removable and sterilizable, wherein the rear hole is a cylindrical hollow portion designed as a tubular channel to receive the tubular insert with a plastic lining that collects the semen flow into the hollow body of the tubular insert and after using the tubular insert is removed and disinfected for the next use.