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4541 条记录 (耗时 0.035 秒)

    Topical Application of Lactobacillus Crispatus to Ameliorate Barrier Damage and Inflammation
    1.
    发明申请
    Topical Application of Lactobacillus Crispatus to Ameliorate Barrier Damage and Inflammation 有权

    公开(公告)号：US20230131201A1

    公开(公告)日：2023-04-27

    申请号：US18087545

    申请日：2022-12-22

    申请人： SEED HEALTH, INC.

    发明人： Sheri Simmons ,  Shanthi Parkar ,  Erin A. Miller ,  Joseph E. Kovarik

    IPC分类号： A61K35/74 ,  A61K31/715 ,  A61K31/58 ,  A61K38/17

    摘要： Compositions, systems and methods of improving the health of the microbiome of an individual's skin relate to the provision of skin contacting formulations containing beneficial bacteria and other microbe components to foster the growth and maintenance of a healthy skin microbiome. A topical application of Lactobacillus crispatus is employed to ameliorate skin barrier damage and inflammation using unique combinations of probiotics, prebiotics, and other skin-beneficial ingredients, effectively treating inflammatory skin diseases, such as atopic dermatitis, psoriasis and acne. The topical application of Lactobacillus crispatus to an individual's skin reduces inflammation through the production of tryptophan metabolites that act as AHR agonists.

    Cold Medicine Composition, Preparation Method and Use Thereof
    3.
    发明申请
    Cold Medicine Composition, Preparation Method and Use Thereof 有权

    公开(公告)号：US20230015630A1

    公开(公告)日：2023-01-19

    申请号：US17379160

    申请日：2021-07-19

    申请人： Chuckie C Weber

    发明人： Chuckie C Weber

    IPC分类号： A61K36/886 ,  A61K35/02 ,  A61K31/715 ,  A61K31/045

    摘要： The invention relates to a medicinal composition for treating a cold, a preparation method and application thereof. The cold medication composition is made from aloe vera soap, an isopropyl alcohol solution, sea salt, distilled water, and natural gum resin. The invention also relates to a preparation method of the composition and the application of the composition for treating the cold.

    Method and system for reducing the likelihood of developing colorectal cancer in an individual human being
    4.
    发明授权
    Method and system for reducing the likelihood of developing colorectal cancer in an individual human being 有权

    公开(公告)号：US11529379B2

    公开(公告)日：2022-12-20

    申请号：US17835204

    申请日：2022-06-08

    申请人： SEED HEALTH, INC.

    发明人： Joseph E. Kovarik

    IPC分类号： A61K35/74 ,  A61K31/715 ,  A61K31/58 ,  A61K38/17 ,  A61K35/00

    摘要： A method for reducing the likelihood of an individual developing colorectal cancer includes the use of a CRISPR system to selectively kill pathogenic bacteria, such as Klebsiella and E coli, within the individual. Preferrably, the growth of a beneficial bacteria, such as Akkermansia, Bacteroides, Bifidobacterium, Clostridium, Enterococcus, Fusobacterium, Coprococcus, Lactobacillus, Propionibacterium, Ruminococcus, Veillonella, Prevotella, and Streptococcus bacteria, is also enhanced. Reduction of certain virulence factors, such as colibactin, using a CRISPR system, as well the employment of immune checkpoint inhibitors, is effective in treating individuals with cancer and who suffer from a chronic infectious disease.

    COMPOSITION OF PHYTONUTRIENTS FOR OBESITY PREVENTION
    5.
    发明申请
    COMPOSITION OF PHYTONUTRIENTS FOR OBESITY PREVENTION 有权

    公开(公告)号：US20220378814A1

    公开(公告)日：2022-12-01

    申请号：US17741157

    申请日：2022-05-10

    申请人： ROSEMAN UNIVERSITY OF HEALTH SCIENCES

    发明人： Thuc T. LE ,  Yasuyo Urasaki

    IPC分类号： A61K31/7048 ,  A61P3/02 ,  A61K31/47 ,  A61P3/06 ,  A61K31/05 ,  A61K31/353 ,  A61K31/715

    摘要： The present disclosure relates to compositions of phytonutrients and methods of treating obesity by administering these compositions to subjects in need thereof. The compositions described herein are rationally designed compositions of phytonutrients that interfere with fat cell differentiation, a process commonly known as “adipogenesis”, to prevent weight gain and improve glycemic control. The phytonutrients are rationally combined based on their complementary effects on the expression level of six adipogenic biomarker proteins. Exemplary compositions can include one or more of berberine, luteolin, resveratrol, fisetin, quercetin, fucoidan, epigallocatechin gallate (EGCG), hesperidin, or curcumin.

    Method for preparing okra polygalacturonic acid having uric acid-lowering effect
    7.
    发明授权
    Method for preparing okra polygalacturonic acid having uric acid-lowering effect 有权

    公开(公告)号：US11479616B2

    公开(公告)日：2022-10-25

    申请号：US17138926

    申请日：2020-12-31

    申请人： Institute of Biological and Medical Engineering, Guangdong Academy of Sciences

    发明人： Juan Liu ,  Junjia Chen ,  Chuanli Lu ,  Nianfang Ma ,  Peizi Kang

    IPC分类号： C08B37/00 ,  A61P13/12 ,  A61K31/715

    摘要： An okra polygalacturonic acid having a uric acid-lowering effect, a method for preparing the same, and use of the same are disclosed. The method includes: smashing an okra, lixiviating the okra in ethanol, and filtering to obtain a filtrate and a residue; removing the filtrate, and lixiviating the residue in heated water to obtain an extraction solution; adding the ethanol into the extraction solution to precipitate okra crude polysaccharides; purifying the okra crude polysaccharides over an anion exchange column by eluting with water or a NaCl solution, a Tris-HCl solution or a NaCl-containing Tris-HCl solution, or a phosphate solution or a NaCl-containing phosphate solution, and collecting a fraction eluted by the NaCl solution, the NaCl-containing Tris-HCl solution, or the NaCl-containing phosphate solution; and concentrating, dialyzing and drying the fraction to obtain the okra polygalacturonic acid.

    Methods and compositions for administration of iron
    10.
    发明授权
    Methods and compositions for administration of iron 有权

    公开(公告)号：US11433091B2

    公开(公告)日：2022-09-06

    申请号：US15958930

    申请日：2018-04-20

    申请人： American Regent, Inc.

    发明人： Mary Jane Helenek ,  Marc L. Tokars ,  Richard P. Lawrence

    IPC分类号： A61K31/7135 ,  A61K31/715 ,  A61K31/721 ,  C07H23/00

    摘要： The present invention generally relates to treatment of iron-related conditions with iron carbohydrate complexes. One aspect of the invention is a method of treatment of iron-related conditions with a single unit dosage of at least about 0.6 grams of elemental iron via an iron carbohydrate complex. The method generally employs iron carbohydrate complexes with nearly neutral pH, physiological osmolarity, and stable and non-immunogenic carbohydrate components so as to rapidly administer high single unit doses of iron intravenously to patients in need thereof.