公开(公告)号：US20240335485A1

公开(公告)日：2024-10-10

申请号：US18497412

申请日：2023-10-30

申请人： DUPONT NUTRITION BIOSCIENCES APS

发明人： REMY BURCELIN ,  DIDIER CARCANO ,  SAMPO LAHTINEN ,  LOTTA STENMAN ,  JOHN KONHILAS

IPC分类号： A61K35/745 ,  A23C9/123 ,  A23L33/135 ,  A61K31/155 ,  A61K31/715 ,  A61K35/00 ,  A61K35/744 ,  A61K35/747 ,  A61K38/26 ,  A61K38/28 ,  A61K45/06

CPC分类号： A61K35/745 ,  A23C9/1234 ,  A23L33/135 ,  A61K31/155 ,  A61K31/715 ,  A61K35/744 ,  A61K35/747 ,  A61K38/26 ,  A61K38/28 ,  A61K45/06 ,  A23V2002/00 ,  A23V2200/324 ,  A23V2200/326 ,  A23V2200/328 ,  A23V2200/332 ,  A23V2400/181 ,  A23V2400/51 ,  A23V2400/515 ,  A23V2400/531 ,  A61K2035/115 ,  A61K2300/00

摘要： This invention relates to new uses of Bifidobacteria (particularly, although not exclusively, probiotic Bifidobacteria), and to food products, feed products, dietary supplements and pharmaceutical formulations containing them. The bacteria are suitable for the treatment of myocardial infarction and congestive heart failure.

公开(公告)号：US12109245B2

公开(公告)日：2024-10-08

申请号：US16580826

申请日：2019-09-24

申请人： LABORATOIRES EXPANSCIENCE

发明人： Alex Saunois ,  Caroline Baudouin ,  Sophie Leclere-Bienfait ,  Sebastien Garnier ,  Philippe Msika

IPC分类号： A61K8/49 ,  A23L33/105 ,  A61K8/368 ,  A61K8/9789 ,  A61K31/05 ,  A61K31/197 ,  A61K31/198 ,  A61K31/201 ,  A61K31/341 ,  A61K31/42 ,  A61K31/57 ,  A61K31/585 ,  A61K31/715 ,  A61K31/717 ,  A61K33/30 ,  A61K36/28 ,  A61K36/31 ,  A61K36/48 ,  A61K36/54 ,  A61K36/899 ,  A61K38/00 ,  A61K45/00 ,  A61Q19/08

CPC分类号： A61K36/31 ,  A23L33/105 ,  A61K8/368 ,  A61K8/498 ,  A61K8/9789 ,  A61K31/05 ,  A61K31/197 ,  A61K31/198 ,  A61K31/201 ,  A61K31/341 ,  A61K31/42 ,  A61K31/57 ,  A61K31/585 ,  A61K31/715 ,  A61K31/717 ,  A61K33/30 ,  A61K36/28 ,  A61K36/48 ,  A61K36/54 ,  A61K36/899 ,  A61K38/00 ,  A61K45/00 ,  A61Q19/08 ,  A61K2800/805

摘要： The invention relates to an extract of aerial parts of Maca rich in polyphenols, and also to a composition comprising such an extract and, where appropriate, a suitable excipient. The invention also relates to a process for extracting an extract of aerial parts of Maca rich in polyphenols, and also to the extract that can be obtained by means of said process. The invention also relates to such a composition or such an extract for use thereof in preventing or treating disorders or pathological conditions of the skin, the mucous membranes or the superficial body growths and/or for use thereof in preventing and/or treating vascular disorders. Finally, the invention relates to a cosmetic care process for the skin, the superficial body growths or the mucous membranes, with a view to improving the condition thereof or the appearance thereof, which comprises the administration of such a composition or of such an extract.

公开(公告)号：US20240285697A1

公开(公告)日：2024-08-29

申请号：US18620483

申请日：2024-03-28

申请人： Seed Health, Inc.

发明人： Sheri Simmons ,  Joseph E. Kovarik

IPC分类号： A61K35/741 ,  A61K31/58 ,  A61K31/715 ,  A61K35/00 ,  A61K35/74 ,  A61K35/745 ,  A61K35/747 ,  A61K38/17 ,  C12N1/20

CPC分类号： A61K35/741 ,  A61K31/58 ,  A61K31/715 ,  A61K35/74 ,  A61K35/745 ,  A61K35/747 ,  A61K38/1709 ,  A61K38/1758 ,  C12N1/20 ,  A61K2035/11 ,  A61K2035/115

摘要： The present invention is directed to beneficially directing the bidirectional communication that exists between the brain and the gut so as to influence brain physiology, psychological responses and ultimately behavior in a positive manner by regulating an individual's mood, psychological symptoms, such as anxiety and depression and stress-related changes in brain function, by modifying the gut microbiome of an individual. In various embodiments, an individual's microbiome is modified in a manner to reduce the likelihood of stress, to reduce or treat symptoms affecting mental health and to promote the mental health of the individual. In certain embodiments, administration to an individual of at least three different bacteria species are combined to modify an individual's microbiome, selected from the group of Lacticaseibacillus paracasei, Coprococcus, Roseburia, Bifidobacterium, L. caseiand Faecalibacterium prausnitzii, to reduce adverse psychological and/or physiological responses attendant to psychological stress.

公开(公告)号：US12064447B1

公开(公告)日：2024-08-20

申请号：US18399599

申请日：2023-12-28

申请人： Jilin Agricultural University

发明人： Qi Wang ,  Ling Su ,  Yan Zhang ,  Yu Li ,  Min Gao ,  Xueyu Shang ,  Tianci Wang

IPC分类号： A61K31/715 ,  A61P1/00 ,  A61P29/00 ,  A61P39/06

CPC分类号： A61K31/715 ,  A61P1/00 ,  A61P29/00 ,  A61P39/06

摘要： A Lyophyllum decastes polysaccharide, a preparation method and an application thereof are provided in the present disclosure, relating to the technical field of biomedicine. The preparation method includes the following steps: (1) adding an aqueous solution containing EDTA-2Na into a fruiting body of Lyophyllum decastes, performing ultrasonic treatment, and then performing water extraction treatment to obtain an extractive solution; (2) concentrating the extractive solution, adding anhydrous ethanol for precipitation, followed by centrifuging to obtain precipitates, then obtaining a crude Lyophyllum decastes polysaccharide; and (3) conducting removal of proteins and dialysis of the crude Lyophyllum decastes polysaccharide to obtain the Lyophyllum decastes polysaccharide.

公开(公告)号：US20240189256A1

公开(公告)日：2024-06-13

申请号：US18532735

申请日：2023-12-07

申请人： TM Nutrition LLC

发明人： Thea MARX

IPC分类号： A61K31/07 ,  A61K9/00 ,  A61K31/197 ,  A61K31/198 ,  A61K31/355 ,  A61K31/375 ,  A61K31/4172 ,  A61K31/59 ,  A61K31/7016 ,  A61K31/715 ,  A61K33/00 ,  A61K33/06 ,  A61K33/24 ,  A61K33/30 ,  A61K33/32 ,  A61K33/34 ,  A61P3/02

CPC分类号： A61K31/07 ,  A61K9/009 ,  A61K31/197 ,  A61K31/198 ,  A61K31/355 ,  A61K31/375 ,  A61K31/4172 ,  A61K31/59 ,  A61K31/7016 ,  A61K31/715 ,  A61K33/00 ,  A61K33/06 ,  A61K33/24 ,  A61K33/30 ,  A61K33/32 ,  A61K33/34 ,  A61P3/02

摘要： Compositions and methods disclosed herein are configured to be administered to a subject prior to surgery. Compositions and methods disclosed herein are configured to provide nutrition and counteract physiological effects of a surgery. Compositions and methods disclosed herein can enable a subject to mitigate the stress response responsible for drastic shifts in metabolic and biochemical pathways, which can often leave a subject susceptible to a risk of higher mortality.

公开(公告)号：US20240156878A1

公开(公告)日：2024-05-16

申请号：US18535722

申请日：2023-12-11

申请人： Seed Health, Inc.

发明人： Tye Jensen ,  Joseph E. Kovarik ,  Raja Dhir

IPC分类号： A61K35/74 ,  A61K31/58 ,  A61K31/715 ,  A61K38/17

CPC分类号： A61K35/74 ,  A61K31/58 ,  A61K31/715 ,  A61K38/1709 ,  A61K38/1758 ,  A61K2035/11

摘要： Compositions, systems and methods of improving the health of the microbiome of an individual's skin relate to the provision of skin contacting formulations containing beneficial bacteria and other microbe components to foster the growth and maintenance of a healthy skin microbiome. Embodiments include methods for treating an individual suffering from acne valgaris by topically administering a composition that includes live bacteria selected from the group consisting of L reuteri, L johnsonii, L crispatus, C. acnes, and Nitrosomonas eutropha, that have been modified by using a using a clustered regularly interspaced short palindromic repeats (CRISPR) CRISPR associated protein (Cas) system or a CRISPR from Prevotella and Francisella 1 (Cpf1) system to reduce the production of a virulence factor of the bacteria.

公开(公告)号：US11980643B2

公开(公告)日：2024-05-14

申请号：US18234132

申请日：2023-08-15

申请人： Seed Health, Inc.

发明人： Sherri Simmons ,  Joseph E. Kovarik

IPC分类号： A61K35/741 ,  A61K31/58 ,  A61K31/715 ,  A61K35/00 ,  A61K35/74 ,  A61K35/745 ,  A61K35/747 ,  A61K38/17 ,  C12N1/20

CPC分类号： A61K35/741 ,  A61K31/58 ,  A61K31/715 ,  A61K35/74 ,  A61K35/745 ,  A61K35/747 ,  A61K38/1709 ,  A61K38/1758 ,  C12N1/20 ,  A61K2035/11 ,  A61K2035/115

摘要： The present invention is directed to beneficially directing the bidirectional communication that exists between the brain and the gut so as to influence brain physiology, psychological responses and ultimately behavior in a positive manner by regulating an individual's mood, psychological symptoms, such as anxiety and depression and stress-related changes in brain function, by modifying the gut microbiome of an individual. An various embodiments, an individual's microbiome is modified in a manner to reduce the likelihood of stress, to reduce or treat symptoms affecting mental health and to promote the mental health of the individual. In certain embodiments, administration to an individual of at least three different bacteria species are combined to modify an individual's microbiome, selected from the group of Lacticaseibacillus paracasei, Coprococcus, Roseburia, Bifidobacterium, L. casei and Faecalibacterium prausnitzii, to reduce adverse psychological and/or physiological responses attendant to psychological stress. Other embodiments reduce certain bacterial populations, such as Veillonella and Megasphaer, while in other embodiments, bacteria that produce hydrogen sulfide, methane and acetate are reduced to beneficially affect an individual's mental health.

公开(公告)号：US11975121B2

公开(公告)日：2024-05-07

申请号：US17083267

申请日：2020-10-28

申请人： PETVIVO HOLDINGS, INC.

发明人： David B. Masters ,  Eric P. Berg

IPC分类号： A61K31/726 ,  A61K8/64 ,  A61K8/65 ,  A61K31/70 ,  A61K31/715 ,  A61K31/727 ,  A61K31/728 ,  A61K35/545 ,  A61K38/39 ,  A61K45/06 ,  A61L27/20 ,  A61L27/22 ,  A61L27/24 ,  A61L27/34 ,  A61L27/48 ,  A61L27/50 ,  A61L31/10 ,  A61L33/12 ,  A61Q19/08 ,  A61K38/00 ,  A61M25/00

CPC分类号： A61L27/24 ,  A61K8/64 ,  A61K8/65 ,  A61K31/70 ,  A61K31/715 ,  A61K31/726 ,  A61K31/727 ,  A61K31/728 ,  A61K35/545 ,  A61K38/39 ,  A61K45/06 ,  A61L27/20 ,  A61L27/22 ,  A61L27/227 ,  A61L27/34 ,  A61L27/48 ,  A61L27/507 ,  A61L31/10 ,  A61L33/12 ,  A61Q19/08 ,  A61K38/00 ,  A61K2800/91 ,  A61M25/0045 ,  A61L27/34 ,  C08L89/00 ,  A61L27/48 ,  C08L89/00 ,  A61L31/10 ,  C08L89/00 ,  A61L27/20 ,  C08L5/00

摘要： The present invention relates to protein biocoacervates and biomaterials and the methods of making and using protein biocoacervates and biomaterials. More specifically the present invention relates to protein biocoacervates and biomaterials that may be utilized for various medical applications including, but not limited to, drug delivery devices for the controlled release of pharmacologically active agents, coated medical devices (e.g. stents, valves . . . ), vessels, tubular grafts, vascular grafts, wound healing devices including protein suture biomaterials and biomeshes, dental plugs and implants, skin/bone/tissue grafts, tissue fillers, protein biomaterial adhesion prevention barriers, cell scaffolding and other biocompatible biocoacervate or biomaterial devices.

公开(公告)号：US20240124617A1

公开(公告)日：2024-04-18

申请号：US18546073

申请日：2022-02-10

申请人： DANSTAR FERMENT AG

发明人： Frédéric DURMONT

IPC分类号： C08B37/00 ,  A01N43/16 ,  A61K31/715 ,  A61P31/16 ,  A61P31/20 ,  C12P19/04

CPC分类号： C08B37/006 ,  A01N43/16 ,  A61K31/715 ,  A61P31/16 ,  A61P31/20 ,  C12P19/04

摘要： The present disclosure relates to exopolysaccharides produced by marine bacteria, compositions thereof, the use of aid compositions, and a method for attenuating the virulence of a microbial pathogen infection, either bacterial or viral infections, by inhibiting or reducing colonization of said microbial pathogens onto biological and/or non-biological surfaces.

公开(公告)号：US11951140B2

公开(公告)日：2024-04-09

申请号：US18143399

申请日：2023-05-04

申请人： Seed Health, Inc.

发明人： Tye Jensen ,  Joseph E. Kovarik

IPC分类号： A61K35/74 ,  A61K31/58 ,  A61K31/715 ,  A61K35/00 ,  A61K38/17

CPC分类号： A61K35/74 ,  A61K31/58 ,  A61K31/715 ,  A61K38/1709 ,  A61K38/1758 ,  A61K2035/11

摘要： Various embodiments of the present invention are directed to the field of treating and preventing osteoporosis, with particular embodiments directed to a method of ameliorating, treating, or preventing osteoporosis in a human subject employing tomatidine, xylitol, rapamycin, etc., as well as modifying an individual's microbiome to reduce the likelihood of osteoporosis.