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    ENVIRONMENTALLY-FRIENDLY PREPARATION METHOD OF COMPOSITION CONTAINING ANTI-INFLAMMATORY ACTIVE INGREDIENTS AND USE OF COMPOSITION
    3.
    发明申请
    ENVIRONMENTALLY-FRIENDLY PREPARATION METHOD OF COMPOSITION CONTAINING ANTI-INFLAMMATORY ACTIVE INGREDIENTS AND USE OF COMPOSITION 有权

    公开(公告)号：US20220000956A1

    公开(公告)日：2022-01-06

    申请号：US17280069

    申请日：2020-10-12

    申请人： SHANGHAI JAKA BIOTECH CO., LTD.

    发明人： Xinliang WANG ,  Yina LU ,  Jun TIAN

    IPC分类号： A61K36/539 ,  A61K36/489 ,  A61K36/484 ,  A61P29/00

    摘要： An environmentally-friendly preparation method of a composition containing anti-inflammatory ingredients and use of the composition are provided. The method includes: S1. weighing a specified volume of water and adjusting the pH, adding Sophora flavescens roots, and subjecting a resulting mixture to extraction at a high temperature; S2. adjusting pH of an obtained solution in step S1, adding Glycyrrhiza inflata roots, and heating a resulting mixture to boiling for extraction; S3. adding Scutellaria baicalensis roots to an obtained boiling solution from the extraction in step S2, and subjecting a resulting mixture to extraction, filtration, and pH adjustment; S4. adding activated carbon to an obtained filtrate in step S3, and subjecting a resulting mixture to incubation and filtration; S5. adding a clarifying agent to an obtained filtrate in step S4, and subjecting a resulting mixture to standing and filtration; and S6. subjecting an obtained filtrate in step S5 to membrane separation.

    PLANT-DERIVED EXOSOME AS WELL AS PREPARATION METHOD AND APPLICATION THEREOF
    4.
    发明申请
    PLANT-DERIVED EXOSOME AS WELL AS PREPARATION METHOD AND APPLICATION THEREOF 有权

    公开(公告)号：US20210213089A1

    公开(公告)日：2021-07-15

    申请号：US17148808

    申请日：2021-01-14

    申请人： Zhejiang University ,  Jiangsu Nanfang Medical Co., Ltd.

    发明人： Jianqing GAO ,  Liming LI ,  Jiachen CHEN ,  Ping LI

    IPC分类号： A61K36/489 ,  A61L27/36

    摘要： Disclosed a plant-derived exosome as well as a preparation method and an application thereof in preparation of drugs or scaffolds for animal tissue regeneration therapy. The preparation method includes: soaking and infiltrating any part of a natural plant with a 2-(N-morpholine) ethanesulfonic acid buffer solution; removing a supernatant; collecting a wet treated sample; refrigerating, centrifuging and extracting the sample to obtain apoplastic fluid, wherein the soaking and infiltrating method is as follows: vacuum supply is performed within 6-24 h after soaking for 2-5 times, vacuum supply time is independently 5-15 s each time, and interval time between two adjacent times of vacuum supply is independently 10 s-1 min; and centrifuging the apoplastic fluid at an ultra-high speed to obtain the plant-derived exosome, wherein ultra-high speed centrifugation conditions are as follows: centrifugal force is not lower than 100000 g, centrifugation time is 1-7 h, and a temperature is 0-4° C.