公开(公告)号：US11607658B2

公开(公告)日：2023-03-21

申请号：US16315245

申请日：2017-07-07

申请人： President and Fellows of Harvard College ,  Massachusetts Eye and Ear Infirmary

发明人： David A. Weitz ,  Huidan Zhang ,  Nai Wen Cui ,  Fengyang Lei ,  Eleftherios Paschalis Ilios

IPC分类号： B01J13/00 ,  B01J2/08 ,  B01L3/00

摘要： The present invention generally relates to microfluidic droplets and, including forming gels within microfluidic droplets. In some aspects, a fluid containing agarose or other gel precursors is transported into a microfluidic droplet, and caused to harden within the droplet, e.g., to form a gel particle contained within the microfluidic droplet. Surprisingly, a discrete gel particle may be formed even if the fluid containing the agarose or other gel precursor, and the fluid contained within the microfluidic droplet, are substantially immiscible. Other aspects of the present invention are generally directed to techniques for making or using such gels within microfluidic droplets, kits containing such gels within microfluidic droplets, or the like.

公开(公告)号：US10981131B2

公开(公告)日：2021-04-20

申请号：US15780211

申请日：2016-12-16

申请人： MIDATECH PHARMA (WALES) LIMITED

发明人： Paul Seaman ,  Huw Jones ,  Liam McAleer

IPC分类号： B01J2/08 ,  B01J2/04 ,  B01J2/18

摘要： Provided is an apparatus for producing solid polymeric microparticles, the apparatus comprising a plurality of liquid droplet generators for forming liquid droplets of a first liquid, and a nozzle for forming a jet of a second liquid, wherein the plurality of liquid droplet generators and the nozzle are arranged relative to each other such that, in use, liquid droplets from the plurality of liquid droplet generators pass through a gas into said jet of second liquid. Also provided is a process for producing solid microparticles, the process comprising: providing a first liquid comprising a solute and a solvent, the solute comprising a biocompatible polymer, the concentration of polymer in the first liquid being at least 10% w/v, ‘w’ being the weight of the polymer and ‘v’ being the volume of the solvent, providing a plurality of liquid droplet generators operable to generate liquid droplets, providing a jet of a second liquid, causing the plurality of liquid droplet generators to form liquid droplets of the first liquid, passing the liquid droplets through a gas to contact the jet of the second liquid so as to cause the solvent to exit the droplets, thus forming solid microparticles, the solubility of the solvent in the second liquid being at least 5 g of solvent per 100 ml of second liquid, the solvent being substantially miscible with the second liquid.

公开(公告)号：US09717688B2

公开(公告)日：2017-08-01

申请号：US14612739

申请日：2015-02-03

申请人： Australian Nuclear Science & Technology Organisation

发明人： Kim Suzanne Finnie ,  David Jacques ,  Christophe Jean Alexandre Barbe ,  Linggen Kong

IPC分类号： A61K9/16 ,  A61K9/14 ,  A61K9/00 ,  A61K9/50 ,  A61K38/00 ,  B01J2/08 ,  B01J13/02 ,  A61K38/17 ,  A61K38/46 ,  A61K38/48 ,  A61K38/50

CPC分类号： A61K9/14 ,  A61K9/1611 ,  A61K9/1694 ,  A61K9/501 ,  A61K38/1709 ,  A61K38/465 ,  A61K38/482 ,  A61K38/4826 ,  A61K38/50 ,  B01J2/08 ,  B01J13/02 ,  C12Y304/21001 ,  C12Y304/21062 ,  C12Y305/01005 ,  A61K2300/00

摘要： A process is provided for releasably encapsulating a biological entity. The process comprises combining a solution of a surfactant in a non-polar solvent with a precursor material and the biological entity to form an emulsion. The emulsion comprises a polar phase dispersed in a non-polar phase, wherein the polar phase comprises the biological entity. The particles comprising the biological entity are then formed from the polar phase.

公开(公告)号：US09259701B2

公开(公告)日：2016-02-16

申请号：US13876780

申请日：2011-09-30

申请人： Daniel Palmer ,  Owen Shadick

发明人： Daniel Palmer ,  Owen Shadick

IPC分类号： B01J2/06 ,  B01J2/18 ,  B01J2/08

CPC分类号： B01J2/06 ,  B01J2/08 ,  B01J2/18

摘要： A method of forming solid beads, the method comprising:Providing a first liquid comprising a solute and a solventForming liquid droplets of the first liquidContacting the liquid droplets with a second liquid so as to cause the solvent to exit the droplets, thus forming solid beads,the solute comprising a polymer, the concentration of polymer in the first liquid being at least 7% w/v.,the solubility of the solvent in the second liquid being at least 5 g of solvent per 100 ml of second liquid.

摘要翻译： 一种形成固体珠的方法，所述方法包括：提供包含溶质和溶剂的第一液体形成第一液体的液滴将液滴与第二液体接触，以使溶剂离开液滴，从而形成固体 小珠，包含聚合物的溶质，第一液体中聚合物的浓度为至少7％w / v，溶剂在第二液体中的溶解度为每100ml第二液体至少5g溶剂。

公开(公告)号：US09156016B2

公开(公告)日：2015-10-13

申请号：US13876773

申请日：2011-09-30

申请人： Daniel Palmer ,  Owen Shadick

发明人： Daniel Palmer ,  Owen Shadick

IPC分类号： B29B9/00 ,  B01J2/06 ,  B01J2/08 ,  B01J2/18

CPC分类号： B01J2/06 ,  B01J2/08 ,  B01J2/18

摘要： An apparatus for making solid beads is provided, the apparatus comprising at least one liquid droplet generator operable to generate droplets comprising a solute dissolved in a solvent, and at least one flow channel for carrying a second liquid, at least one liquid droplet generator and at least one flow channel being spaced relative to one another so that, in use, liquid droplets pass through a gas into a second liquid provided in said flow channel, the solvent being soluble in the second liquid so as to cause the solvent to exit the droplets, thus forming solid beads. A method of preparing solid beads is also provided.

摘要翻译： 提供了一种用于制造实心珠的装置，该装置包括至少一个液滴发生器，其可操作以产生包含溶解在溶剂中的溶质的液滴，以及用于承载第二液体的至少一个流动通道，至少一个液滴发生器 至少一个流动通道相对于彼此间隔开，使得在使用中，液滴通过气体进入设置在所述流动通道中的第二液体中，溶剂可溶于第二液体中，以使溶剂离开液滴 ，从而形成固体珠粒。 还提供了制备固体珠粒的方法。

公开(公告)号：US5676845A

公开(公告)日：1997-10-14

申请号：US513992

申请日：1995-09-05

申请人： Helmut Derleth ,  Karl-Heinz Bretz ,  Gerhard Neuenfeldt ,  Hubert Schindler ,  Alfred Ottmann

发明人： Helmut Derleth ,  Karl-Heinz Bretz ,  Gerhard Neuenfeldt ,  Hubert Schindler ,  Alfred Ottmann

IPC分类号： B01J2/04 ,  B01J2/08 ,  B01J21/00 ,  B01J21/08 ,  B01J21/18 ,  B01J23/40 ,  B01J23/44 ,  B01J32/00 ,  B01J37/00 ,  C01B13/34 ,  C01B33/16 ,  C01F7/44 ,  C02F1/70 ,  C02F1/72

CPC分类号： B01J21/18 ,  B01J2/04 ,  B01J2/08 ,  B01J23/40 ,  B01J37/0045 ,  B01J37/0072 ,  C01B13/34 ,  C01B33/16 ,  C01F7/441 ,  C02F1/70 ,  C01P2004/01 ,  C01P2004/03 ,  C01P2004/32 ,  C01P2004/52 ,  C01P2004/61 ,  C01P2006/12 ,  C01P2006/14 ,  C01P2006/16 ,  C02F2101/16 ,  Y10S210/908 ,  Y10S210/909

摘要： In a catalytic treatment process for effluents containing organic and inorganic compounds, a noble metal catalyst on a support is used. The support preferably is produced according to the sol-gel process.

摘要翻译： PCT No.PCT / EP94 / 00586 Sec。 371 1995年9月5日第 102（e）1995年9月5日PCT PCT 1994年3月1日PCT公布。 公开号WO94 / 20423 日期1994年9月15日在含有有机和无机化合物的废水的催化处理方法中，使用载体上的贵金属催化剂。 优选地，所述载体根据溶胶 - 凝胶法制备。

公开(公告)号：US5420086A

公开(公告)日：1995-05-30

申请号：US140140

申请日：1993-11-03

申请人： Egbert Brandau ,  Martin Kadner ,  Edwin Brauneis

发明人： Egbert Brandau ,  Martin Kadner ,  Edwin Brauneis

IPC分类号： B01J2/04 ,  B01J2/08 ,  C01G25/02 ,  C04B35/486 ,  C04B35/624 ,  C04B35/626 ,  C04B35/48

CPC分类号： B01J2/08 ,  C01G25/02 ,  C04B35/486 ,  C04B35/624 ,  C04B35/626 ,  C01P2002/54 ,  C01P2006/10 ,  C01P2006/12 ,  C01P2006/22 ,  C01P2006/80 ,  C04B2235/3246

摘要： The invention relates to methods for producing stabilized zirconium oxide powder suitable for pressing shaped elements and subsequent sintering to provide high-density ceramic materials. To this end, an aqueous solution of a zirconium salt containing an additive is converted into droplets. The droplets formed are solidified, by the action of ammonia, into gel particles which are then washed, dewatered dried and calcined.

摘要翻译： PCT No.PCT / EP92 / 00981 Sec。 371日期：1993年11月3日 102（e）日期1993年11月3日PCT提交1992年5月6日PCT公布。 WO92 / 19538 PCT公开号 日本公开日1992年11月12日。本发明涉及适用于压制成形元件和随后烧结的稳定氧化锆粉末的制备方法，以提供高密度陶瓷材料。 为此，将含有添加剂的锆盐水溶液转化为液滴。 形成的液滴通过氨的作用而凝固成凝胶颗粒，然后将其洗涤，脱水干燥并煅烧。

公开(公告)号：US5376347A

公开(公告)日：1994-12-27

申请号：US914364

申请日：1992-07-15

申请人： Masamichi Ipponmatsu ,  Masashi Nishigaki ,  Akira Hirano ,  Tsuyoshi Tsurutani

发明人： Masamichi Ipponmatsu ,  Masashi Nishigaki ,  Akira Hirano ,  Tsuyoshi Tsurutani

IPC分类号： B01J2/06 ,  B01F3/08 ,  B01F5/00 ,  B01F5/04 ,  B01F5/10 ,  B01J2/08 ,  B01J2/20 ,  B01J4/04 ,  B01J19/00 ,  C01B13/36 ,  C01B33/18 ,  C03C4/00 ,  C01B33/141

CPC分类号： C03C4/0007 ,  B01F3/0811 ,  B01F5/045 ,  B01F5/0476 ,  B01F5/102 ,  B01J2/08 ,  B01J4/04 ,  B01F2005/0034

摘要： A method of producing uniform inorganic microspheres with a particle size of 0.01 to 500 .mu.m by injecting an aqueous solution containing a particle-forming material into an organic solvent. The method includes injecting the aqueous solution into the organic solvent through a macromolecular membrane having a hydrophobic surface and having pores substantially uniform in pore size and extending in the direction of thickness of the membrane, substantially straight through the membrane, so that a path length of each of the pores corresponds substantially to a thickness of the membrane, to form, in said organic solvent, a large number of emulsion particles substantially uniform in size and then producing uniform inorganic microspheres from said emulsion particles on a one emulsion particle-to-one microsphere basis. The pores in the membrane are formed by either a corpuscular or laser beam.

摘要翻译： 通过将含有颗粒形成材料的水溶液注入到有机溶剂中来制备粒径为0.01〜500μm的均匀无机微球的方法。 该方法包括通过具有疏水性表面的大分子膜将水溶液注入到有机溶剂中，并且孔径基本上均匀且沿膜的厚度方向延伸，基本上直线穿过膜，使得路径长度 每个孔基本上对应于膜的厚度，在所述有机溶剂中形成大量基本上均匀的乳液颗粒，然后在一个乳液颗粒到一个上由所述乳液颗粒制备均匀的无机微球 微球基础。 膜中的孔由微粒或激光束形成。

公开(公告)号：US5296564A

公开(公告)日：1994-03-22

申请号：US991419

申请日：1992-12-16

申请人： Helmut Derleth ,  Abel Grosjean

发明人： Helmut Derleth ,  Abel Grosjean

IPC分类号： B01J2/04 ,  B01J2/08 ,  B01J21/08 ,  B01J23/26 ,  B01J37/00 ,  B01J37/03 ,  B01J37/34 ,  C01B33/18 ,  C08F2/04 ,  C08F4/00 ,  C08F4/02 ,  C08F4/06 ,  C08F4/24 ,  C08F4/42 ,  C08F8/00 ,  C08F10/00 ,  C08F4/22

CPC分类号： B01J37/0027 ,  B01J2/08 ,  B01J21/08 ,  B01J23/26 ,  B01J37/0045 ,  B01J37/0072 ,  B01J37/036 ,  B01J37/342 ,  C08F10/00

摘要： Process for the polymerization of alpha-olefins in the presence of a catalyst, including providing monodisperse microspheroidal particles by spraying an electrostatically charged gellable liquid material (L) through a spraying orifice and into a chamber, so as to produce macrodrops which break up into microdrops which fall in the chamber and within which gelling is produced after spraying; providing a catalyst for the polymerization of alpha-olefins which contains chromium and which is supported on the monodisperse microspheroidal particles; and polymerizing alpha-olefins in the presence of the catalyst.

摘要翻译： 在催化剂存在下α-烯烃的聚合方法，包括通过喷涂静电电荷的可凝胶液体材料（L），通过喷涂孔喷入室内，从而产生分解成微滴的大分子，从而提供单分散微球形颗粒 其落在室中并且在喷雾之后产生胶凝; 提供用于含有铬的α-烯烃的聚合催化剂，其负载在单分散微球颗粒上; 并在催化剂存在下聚合α-烯烃。

公开(公告)号：US5278106A

公开(公告)日：1994-01-11

申请号：US774978

申请日：1991-10-15

申请人： Tadao Nakashima ,  Masato Kukizaki ,  Masataka Shimizu ,  Yoshiko Nakahara ,  Hiroyuki Kageyama ,  Fujiya Nakahara ,  Masaaki Mizuguchi

发明人： Tadao Nakashima ,  Masato Kukizaki ,  Masataka Shimizu ,  Yoshiko Nakahara ,  Hiroyuki Kageyama ,  Fujiya Nakahara ,  Masaaki Mizuguchi

IPC分类号： B01J2/06 ,  B01F3/08 ,  B01J2/08 ,  B01J13/00 ,  B01J13/04 ,  B01J14/00 ,  B01J19/00 ,  C01B13/36 ,  C01B33/18 ,  C01B33/24 ,  C01B37/02 ,  C01G53/04 ,  C03C3/00

CPC分类号： B01F5/0476 ,  B01F3/0811 ,  B01J13/04 ,  B01J2/08 ,  Y10S516/924

摘要： An inorganic particulate material comprising fine balls approximately uniform in size and 0.1 to 50 .mu.m in mean particle size and prepared by admixing an aqueous solution of at least one compound (i) selected from among halides of alkaline earth metals, inorganic acids, organic acids, ammonium salts or inorganic acids, ammonium salts of organic acids and carbonates of alkali metals with an aqueous solution of at least one inorganic compound (ii) selected from among silicates, carbonates, phosphates or sulfates of alkali metals, halides of alkaline earth metals, and sulfates, hydrochlorides or nitrates of copper family elements o iron family elements before or after admixing an organic solvent (iii) with said aqueous solution of at least one inorganic compound (ii) to form a W/O emulsion, said compound (i) being capable of forming a water-insoluble precipitate when subjected to an aqueous solution reaction with said inorganic compound (ii).

摘要翻译： 一种无机颗粒材料，其包含大小均匀的细球，平均粒度为0.1至50（my）m，并通过混合至少一种选自碱土金属的卤化物，无机酸， 有机酸，铵盐或无机酸，碱金属的铵盐和碱金属的碳酸盐与至少一种选自硅酸盐，碳酸盐，碱金属的磷酸盐或硫酸盐的无机化合物（ii）的水溶液，碱土金属的卤化物 （iii）与所述至少一种无机化合物（ii）的所述水溶液混合之前或之后的铜族元素的金属和硫酸盐，盐酸盐或硝酸盐，以形成W / O乳液，所述化合物 i）当与所述无机化合物（ii）进行水溶液反应时能够形成水不溶性沉淀。