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公开(公告)号：US12029708B2
公开(公告)日：2024-07-09
申请号：US17817927
申请日：2022-08-05
申请人： Acucela Inc.
发明人： Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas L Little, Jr. , Anna Gall , Feng Hong
IPC分类号： A61K31/137 , A61K31/165 , A61K31/222 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C217/84 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C309/06 , C07C317/28 , C07C323/25 , C07C323/33 , C07D277/24 , C07D309/06
CPC分类号： A61K31/137 , A61K31/165 , A61K31/222 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C217/84 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C309/06 , C07C317/28 , C07C323/25 , C07C323/33 , C07D277/24 , C07D309/06 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42
摘要： The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
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公开(公告)号：US09974758B2
公开(公告)日：2018-05-22
申请号：US15181826
申请日：2016-06-14
IPC分类号： A61K31/135 , A61K31/40 , C07C215/28 , C07C323/32 , C07D263/06 , C07D295/092 , C07C217/64 , C07C233/18
CPC分类号： A61K31/135 , A61K31/40 , C07C215/28 , C07C217/64 , C07C233/18 , C07C323/32 , C07D263/06 , C07D295/092
摘要： Provided are inhibitors of sphingosine kinase Type I that are useful in a number of applications, indications and diseases, as well as for monitoring pharmacokinetics and patient management. These compounds are applicable to treating tumors of the central nervous system, such as glioblastoma multiforme (GBM).
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3.发明授权公开(公告)号：US09549924B2
公开(公告)日：2017-01-24
申请号：US14922373
申请日：2015-10-26
申请人： OrphoMed Inc.
IPC分类号： A61K31/485 , A61K9/00 , A61K31/137 , A61K31/167 , C07C217/64 , C07C217/70 , C07C233/25 , C07D489/02 , C07D489/08 , C07D489/12 , C07D519/00
CPC分类号： A61K31/167 , A61K9/0053 , A61K9/20 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K31/137 , A61K31/485 , A61K45/06 , C07C217/64 , C07C217/70 , C07C217/74 , C07C233/16 , C07C233/25 , C07C233/43 , C07C2601/14 , C07D489/00 , C07D489/02 , C07D489/08 , C07D489/12 , C07D519/00
摘要： The present invention provides method and compositions for the treatment of peripheral neuropathic pain by administering to a patient a therapeutically effective amount of a buprenorphine dimer compound, wherein the two buprenorphine portions are linked via an ethylene spacer, and wherein the spacer is bonded to the two opioid molecules via an ether bond. Preferably, the active agent is provided in the form of an injectable depot.
摘要翻译： 本发明提供了用于治疗周围神经性疼痛的方法和组合物，其通过向患者施用治疗有效量的丁丙诺啡二聚体化合物，其中所述两个丁丙诺啡部分通过乙烯间隔物连接，并且其中所述间隔物结合到两个 阿片样物质通过醚键分子。 优选地，活性剂以可注射贮库的形式提供。
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4.发明授权Methods of treating pain or fever using pharmaceutically active acetaminophen dimers linked through phenolic hydroxyl groups 有权使用通过酚羟基连接的药用活性对乙酰氨基酚二聚体治疗疼痛或发烧的方法公开(公告)号：US09480665B2
公开(公告)日：2016-11-01
申请号：US14922362
申请日：2015-10-26
申请人： OrphoMed, Inc.
IPC分类号： A61K31/167 , A61K31/16 , A61K45/06 , A61K9/20 , A61K9/00 , A61K31/137 , A61K31/485 , C07C217/64 , C07C217/70 , C07C233/25 , C07D489/02 , C07D489/08 , C07D489/12 , C07D519/00
CPC分类号： A61K31/167 , A61K9/0053 , A61K9/20 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K31/137 , A61K31/485 , A61K45/06 , C07C217/64 , C07C217/70 , C07C217/74 , C07C233/16 , C07C233/25 , C07C233/43 , C07C2601/14 , C07D489/00 , C07D489/02 , C07D489/08 , C07D489/12 , C07D519/00
摘要： Provided herein are methods for treating pain such as acute or chronic pain or fever in subject without risking hepatotoxicity. The subject may be at risk of hepatotoxicity if administrated an acetaminophen monomer. The method includes administering a pharmaceutical composition containing an acetaminophen dimer compound, wherein the phenolic hydroxyl groups of two acetaminophen compounds are linked via an ethylene spacer.
摘要翻译： 本文提供了治疗疼痛的方法，例如受试者的急性或慢性疼痛或发烧，而没有肝毒性风险。 如果给予对乙酰氨基酚单体，受试者可能存在肝毒性风险。 该方法包括施用含有对乙酰氨基酚二聚体化合物的药物组合物，其中两个对乙酰氨基酚化合物的酚羟基通过乙烯间隔物连接。
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公开(公告)号：US09458088B2
公开(公告)日：2016-10-04
申请号：US14631763
申请日：2015-02-25
申请人： Acucela Inc.
发明人： Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas L. Little, Jr. , Anna Gall , Feng Hong
IPC分类号： C09B11/02 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C317/28 , C07C323/25 , C07D277/24 , C07D309/06 , C07C215/20 , C07C309/06 , C07C217/84 , C07C323/33
CPC分类号： A61K31/137 , A61K31/165 , A61K31/222 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C217/84 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C309/06 , C07C317/28 , C07C323/25 , C07C323/33 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D277/24 , C07D309/06
摘要： The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
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6.发明授权公开(公告)号：US09321780B2
公开(公告)日：2016-04-26
申请号：US14697174
申请日：2015-04-27
申请人： OrphoMed LLC
IPC分类号： A61K31/485 , C07D489/12 , C07D489/02 , C07C217/64 , C07C217/70 , C07C233/43 , C07D489/08 , A61K31/137 , A61K31/167 , C07C233/16 , C07D489/00 , C07C233/25
CPC分类号： A61K31/167 , A61K9/0053 , A61K9/20 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K31/137 , A61K31/485 , A61K45/06 , C07C217/64 , C07C217/70 , C07C217/74 , C07C233/16 , C07C233/25 , C07C233/43 , C07C2601/14 , C07D489/00 , C07D489/02 , C07D489/08 , C07D489/12 , C07D519/00
摘要： The present invention provides a buprenorphine dimer compound, wherein the two buprenorphine portions are linked via an ethylene spacer, wherein the spacer is bonded to the two opioid molecules via an ether bond. Pharmaceutical compositions comprising such a buprenorphine dimer drug are also disclosed, and the use of such compounds in the treatment of gastrointestinal hyperalgesia generally and in particular diarrhea-predominant irritable bowel syndrome.
摘要翻译： 本发明提供了一种丁丙诺啡二聚体化合物，其中两个丁丙诺啡部分经由乙烯间隔物连接，其中该间隔基通过醚键与两个阿片样物质分子结合。 还公开了包含这种丁丙诺啡二聚体药物的药物组合物，并且这些化合物在治疗胃肠痛觉过敏中的用途通常特别是腹泻型肠易激综合征。
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公开(公告)号：US09115056B2
公开(公告)日：2015-08-25
申请号：US14523777
申请日：2014-10-24
申请人： Acucela Inc.
发明人： Ian Leslie Scott , Vladimir Aleksandrovich Kuksa , Mark W. Orme , Thomas Little , Anna Gall , Jennifer Gage , Feng Hong
IPC分类号： C07C211/00 , C07C321/00 , C07C215/68 , C07C211/27 , C07C211/30 , C07C215/30 , C07C215/42 , C07C217/14 , C07C217/48 , C07C217/62 , C07C217/72 , C07C235/34 , C07C237/20 , C07C251/40 , C07C255/58 , C07C323/29 , C07C323/36 , C07D209/32 , C07D213/14 , C07D309/10 , C07D333/06 , C07D335/02 , C07C217/64 , C07D213/38 , C07D309/12 , C07C215/28 , C07C317/28 , C07C323/25
CPC分类号： C07C215/68 , C07C211/27 , C07C211/30 , C07C215/28 , C07C215/30 , C07C215/42 , C07C217/14 , C07C217/48 , C07C217/62 , C07C217/64 , C07C217/72 , C07C235/34 , C07C237/20 , C07C251/40 , C07C255/58 , C07C317/28 , C07C323/25 , C07C323/29 , C07C323/36 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D209/32 , C07D213/14 , C07D213/38 , C07D309/06 , C07D309/10 , C07D309/12 , C07D333/06 , C07D333/16 , C07D335/02
摘要： Provided are alkynyl phenyl derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.
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公开(公告)号：US08981153B2
公开(公告)日：2015-03-17
申请号：US13111679
申请日：2011-05-19
申请人： Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas Little , Anna Gall , Feng Hong
发明人： Ian L. Scott , Vladimir A. Kuksa , Mark W. Orme , Thomas Little , Anna Gall , Feng Hong
IPC分类号： C07C211/00 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C317/28 , C07C323/25 , C07D277/24 , C07C309/06
CPC分类号： A61K31/137 , A61K31/165 , A61K31/222 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C217/84 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C309/06 , C07C317/28 , C07C323/25 , C07C323/33 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D277/24 , C07D309/06
摘要： The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.
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公开(公告)号：US08546615B2
公开(公告)日：2013-10-01
申请号：US13509725
申请日：2009-11-13
IPC分类号： C07C217/64 , C07C213/10 , A61K31/085 , A61K31/138
CPC分类号： C07C217/48 , C07B2200/07 , C07C213/10
摘要： The present invention relates to solid racemic dapoxetine, solid dapoxetine S(+)enantiomer, processes for their preparation and their use in the pharmaceutically active compound dapoxetine acid addition salt, and pharmaceutical compositions thereof.
摘要翻译： 本发明涉及固体外消旋多巴西汀，固体达波西汀S（+）对映异构体，其制备方法及其在药物活性化合物达泊西汀酸加成盐中的用途及其药物组合物。
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公开(公告)号：US20130046067A1
公开(公告)日：2013-02-21
申请号：US13643328
申请日：2011-04-21
IPC分类号： C07D303/28 , C07C217/64 , C08G59/02 , C08L63/02 , C07D303/30
CPC分类号： C07D303/30 , C07C2603/68 , C08G59/08 , C08G59/184 , C08G59/3218 , C08G59/5033
摘要： The present disclosure provides for polycyclopentadiene compounds that useful as an epoxide resin and/or as an adduct for a curable composition.
摘要翻译： 本公开提供可用作环氧树脂和/或作为可固化组合物的加合物的聚环戊二烯化合物。
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