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公开(公告)号：US12018094B2
公开(公告)日：2024-06-25
申请号：US18086203
申请日：2022-12-21
发明人： Scott M. Duncan , Martin P. Redmon
IPC分类号： C07K5/072 , C07C237/20 , C07K5/068
CPC分类号： C07K5/06095 , C07C237/20 , C07K5/06086 , C07B2200/13
摘要： Disclosed are crystalline forms of L-Lys(Boc)-Phe-NH2 and Boc-D-Arg-DMT. The crystalline forms may be used in the synthesis of elamipretide.
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公开(公告)号：US11919836B2
公开(公告)日：2024-03-05
申请号：US16847988
申请日：2020-04-14
发明人： Sandeep Patil , Ron Bihovsky , Steven A Smith , Yuhua Ji , Valentino Stella , Daniel D. Long , Daniel Marquess
IPC分类号： C07C271/24 , A61K9/00 , A61K47/10 , A61K47/26 , A61K47/38 , A61K47/54 , A61K47/64 , C07C233/06 , C07C237/04 , C07C237/20 , C07C237/22 , C07C271/56 , C07K5/062
CPC分类号： C07C237/04 , A61K9/0019 , A61K9/0053 , A61K9/0095 , A61K47/10 , A61K47/26 , A61K47/38 , A61K47/542 , A61K47/64 , C07C233/06 , C07C237/20 , C07C237/22 , C07C271/24 , C07C271/56 , C07K5/06026 , C07K5/06052 , C07B2200/07 , C07C2602/42
摘要： Disclosed herein are pharmaceutical compositions comprising fencamfamine or fencamfamine related prodrug derivatives for targeted therapeutic applications and methods of synthesizing the compositions.
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公开(公告)号：US20230391779A1
公开(公告)日：2023-12-07
申请号：US18021784
申请日：2021-08-17
发明人： Xiaofeng XU , Jinheng GAO , Hongfei RONG , Xizhen SONG , Jie CHEN , Xiangyong LIU , Hongling SHEN , Jing GUO , Dan YAN , Hong LAN , Lieming DING , Jiabing WANG
IPC分类号： C07D487/04 , C07D403/04 , C07D471/04 , C07D403/06 , C07D231/56 , C07D401/14 , C07D401/04 , C07D405/04 , C07D413/04 , C07D413/14 , C07D405/14 , C07D493/04 , C07C237/20 , C07D205/04 , A61P35/00
CPC分类号： C07D487/04 , A61P35/00 , C07D471/04 , C07D403/06 , C07D231/56 , C07D401/14 , C07D401/04 , C07D405/04 , C07D413/04 , C07D413/14 , C07D405/14 , C07D493/04 , C07C237/20 , C07D205/04 , C07D403/04
摘要： The present invention relates to compounds of Formula (I), pharmaceutical compositions comprising such compounds and use thereof. The compounds are useful in treating, preventing or ameliorating diseases or disorders such as cancer.
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公开(公告)号：US11427531B2
公开(公告)日：2022-08-30
申请号：US16754386
申请日：2018-10-09
发明人： Asher Peretz , Bernard Attali
IPC分类号： C07C233/22 , C07C237/20 , A61K31/165 , A61P25/02 , A61P43/00
摘要： Novel compounds usable in modulating an activity or function of a voltage-dependent potassium channel and/or of TRPV1 are provided. The compounds are represented by Formula I as described and defined in the specification.
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公开(公告)号：US20220267255A1
公开(公告)日：2022-08-25
申请号：US17597550
申请日：2020-07-13
发明人： Hoang Van LE , Md. Imran HOSSAIN
IPC分类号： C07C237/20 , A61P35/00
摘要： Disclosed are substantially pure L-y-methyleneglutamine, L-y-methyleneglutamic acid, and/or amide derivatives, and methods of use thereof. In particular, the presently disclosed subject matter relates to L-y-methyleneglutamine, L-y-methyleneglutamic acid, and/or amide derivatives thereof, and methods of treating cancer. The method comprises administering one or more substantially pure L-y-methyleneglutamine, L-y-methyleneglutamic acid, and/or amide derivatives to a subject in need thereof.
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公开(公告)号：US11230524B2
公开(公告)日：2022-01-25
申请号：US15999268
申请日：2018-08-17
申请人： STANDARD LLC
发明人： Junhu Zhang
IPC分类号： C07C237/20 , C07D213/30 , C07D417/04 , C07D263/48 , C07C233/44 , C07C259/06 , C07C323/36 , C07D215/38 , C07D277/82 , C07D305/08 , C07D285/135 , C07D271/113 , C07D213/56 , C07D209/14 , C07D295/135 , C07D213/74 , C07D401/04
摘要： The present disclosure provides novel compounds capable of functioning as Myocyte Enhancer Factor 2 (MEF2) modulators, as well as compositions, pharmaceutical formulations, methods of synthesis and kits.
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公开(公告)号：US11198679B2
公开(公告)日：2021-12-14
申请号：US16837757
申请日：2020-04-01
发明人： Gary A. Piazza , Xi Chen , Adam B. Keeton , Michael R. Boyd
IPC分类号： C07C235/34 , A61K31/165 , C07D317/64 , C07D307/52 , C07D213/75 , C07D207/14 , C07D213/40 , C07D207/335 , C07C311/29 , A61K31/216 , A61K31/421 , A61K31/4402 , A61K31/4406 , A61K31/496 , A61K31/5375 , A61K31/5377 , C07C235/32 , C07C237/20 , C07D213/24 , C07D235/30 , C07D307/38 , C07D405/12 , A61K31/401 , A61K31/167 , A61K31/341 , A61K31/40 , A61K45/06 , G01N33/574 , A61K31/36 , A61K31/44 , A61K31/445 , C07C233/58 , C07D207/337 , C07D211/56 , C07D307/54
摘要： Disclosed are compounds, for example, a compound of formula I, wherein R, R0, R1-R8, n, X, Y, Y′, and E are as described herein, pharmaceutical compositions containing such compounds, and methods of treating or preventing a disease or condition for example, cancer, mediated by the ras gene.
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公开(公告)号：US11124498B2
公开(公告)日：2021-09-21
申请号：US16462460
申请日：2017-11-15
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： Michael A. Fischbach , Chun-Jun Guo , Christopher A. Voigt , Fang-Yuan Chang , Jon Clardy , Thomas Wyche
IPC分类号： C07D403/14 , C07C237/20 , C07D403/12 , C07C323/60 , C07D241/18 , C07D241/12 , C07D403/06
摘要： Disclosed herein, inter alia, are compositions for modulating protease activity and treating cancer.
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公开(公告)号：US11104658B2
公开(公告)日：2021-08-31
申请号：US15537283
申请日：2015-12-16
发明人： Gary A. Piazza , Xi Chen , Adam B. Keeton , Michael R. Boyd
IPC分类号： A61K31/341 , A61K31/40 , A61K31/44 , A61K31/445 , A61K31/495 , A61K31/5375 , C07D317/64 , C07D307/52 , C07C235/34 , C07D213/75 , C07D207/14 , C07D213/40 , C07D207/335 , C07C311/29 , A61K31/165 , A61K31/216 , A61K31/421 , A61K31/4402 , A61K31/4406 , A61K31/496 , A61K31/5377 , C07C235/32 , C07C237/20 , C07D213/24 , C07D235/30 , C07D307/38 , C07D405/12 , A61K31/401 , A61K31/167 , A61K45/06 , G01N33/574 , A61K31/36 , C07C233/58 , C07D207/337 , C07D211/56 , C07D307/54
摘要： Disclosed are compounds, for example, a compound of formula I, wherein R, R0, R1-R8, n, X, Y, Y′, and E are as described herein, pharmaceutical compositions containing such compounds, and methods of treating or preventing a disease or condition for example, cancer, mediated by the ras gene.
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公开(公告)号：US10975096B2
公开(公告)日：2021-04-13
申请号：US16686912
申请日：2019-11-18
发明人： Anna Chiu , John Enquist, Jr. , Nolan Griggs , Christopher Hale , Norihiro Ikemoto , Katie Ann Keaton , Matt Kraft , Scott E. Lazerwith , Michel Leeman , Zhihui Peng , Kate Schrier , Jonathan Trinidad , Jochem Van Herpt , Andrew W. Waltman
IPC分类号： C07D498/14 , C07D498/22 , C07D319/06 , C07D309/40 , C07C237/20 , C07D213/82 , C07C235/80 , C07C231/02 , C07C231/12
摘要： Methods of making compounds of Formula I are disclosed:
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