公开(公告)号：US20190047939A1

公开(公告)日：2019-02-14

申请号：US16080358

申请日：2017-03-01

申请人： Patheon Austria GmbH & Co KG

发明人： George Petros YIANNIKOUROS ,  Panos KALARITIS ,  Denis Viktorovich AREFYEV

IPC分类号： C07C213/08 ,  C07C45/29 ,  C07C41/01 ,  C07C249/02 ,  C07J21/00 ,  C07C62/26 ,  C07C251/06 ,  C07C217/52

摘要： The invention pertains to a process for producing a compound of formula (11) wherein R7 and R8 are each independently selected from H, halogen, alkyl, aryl, or alkylaryl, R42 is H or a protective group, R43 is H or R3, wherein R3 is a protective group, by contacting a compound of formula (10) with an olefmation reagent, wherein compound of formula (10) comprises a counter acid X1 when R42═H and R43═H.

公开(公告)号：US5811569A

公开(公告)日：1998-09-22

申请号：US742729

申请日：1996-11-01

申请人： Erwin Waldvogel ,  Eugen Eichenberger

发明人： Erwin Waldvogel ,  Eugen Eichenberger

IPC分类号： C07C243/14 ,  C07C251/76 ,  C07D231/18 ,  C07C327/22 ,  C07C251/06

CPC分类号： C07D231/18 ,  C07C243/14 ,  C07C251/76

摘要： The invention discloses a novel process for the preparation of a compound of formula II ##STR1## wherein R.sub.1 is C.sub.1-5 alkyl, R.sub.2 is hydrogen or C.sub.1-5 alkyl, and R.sub.3 is optionally substituted phenyl, comprising the reaction of a 4-hydroxypyrazole of formula III ##STR2## wherein R.sub.1 and R.sub.2 are as defined for formula II, with a benzylhalide of formula IV Hal--CH.sub.2 --R.sub.3 (IV) wherein Hal is halogen, preferably bromine or chlorine, and R.sub.3 is as defined for formula II, in the presence of a base. The invention further comprises a novel process for the preparation of the 4-hydroxypyrazole of formula III. The compounds of formulae II and III are intermediates for highly effective systemic fungicides of the class of pyrazolyl acetic acid derivatives.

摘要翻译： 本发明公开了一种制备式II化合物（II）的新方法，其中R 1是C 1-5烷基，R 2是氢或C 1-5烷基，R 3是任选取代的苯基，包括4- （III）的羟基吡唑其中R 1和R 2如式II所定义，与式IV的卤代卤化物Hal-CH 2 -R 3（Ⅳ）其中Hal是卤素，优选溴或氯，R3如上定义） 对于式II，在碱的存在下。 本发明还包括用于制备式III的4-羟基吡唑的新方法。 式II和III的化合物是用于吡唑基乙酸衍生物类的高效全身性杀真菌剂的中间体。

公开(公告)号：US4093656A

公开(公告)日：1978-06-06

申请号：US722232

申请日：1976-09-10

申请人： Jean Pierre Schirmann ,  Jean Combroux ,  Serge Yvon Delavarenne

发明人： Jean Pierre Schirmann ,  Jean Combroux ,  Serge Yvon Delavarenne

IPC分类号： C07C251/02 ,  B01J20060101 ,  C07C20060101 ,  C07C67/00 ,  C07C241/00 ,  C07C241/02 ,  C07C251/06 ,  C07C251/08 ,  C07C251/10 ,  C07C251/12 ,  C07C251/14 ,  C07C251/22 ,  C07C251/88 ,  C07C265/02 ,  C07C265/04 ,  C07C265/06 ,  C07C265/08 ,  C07C265/14 ,  C07C119/00

CPC分类号： C07C251/88

摘要： A process is described for the production of azines by contacting in the liquid phase ammonia, hydrogen peroxide and a carbonyl compound, either an aldehyde or a ketone. The reaction takes place in the presence of an amide (I) of a monocarboxylic or dicarboxylic acid, wherein at least one of the ionization constants is below 5 .times. 10.sup.-5, and further in the presence of an inorganic or organic catalyst (II), having the atomic structure H--X--Y.dbd.Z, H representing hydrogen, X and Z representing oxygen or nitrogen and Y representing carbon, nitrogen, phosphorus, arsenic, antimony, sulphur, selenium or tellurium. It is possible for X, Y or Z to carry other substituents, providing valency rules are obeyed. The process is carried out in the presence of the ammonium salt (III) of the carboxylic acid corresponding to the amide (I), at the rate of at least 0.1 mole of the ammonium salt (III) per mole of hydrogen peroxide employed.

摘要翻译： 描述了通过在液相氨，过氧化氢和羰基化合物（醛或酮）中接触来制备吖嗪的方法。 反应在一元羧酸或二羧酸的酰胺（I）存在下进行，其中至少一种电离常数低于5×10-5，进一步在无机或有机催化剂（II）的存在下， 原子结构为HXY = Z，H代表氢，X和Z表示氧或氮，Y表示碳，氮，磷，砷，锑，硫，硒或碲。 X，Y或Z可以携带其他取代基，提供价格规则。 该方法在对应于酰胺（I）的羧酸的铵盐（III）存在下，以每摩尔过氧化氢至少0.1摩尔铵盐（III）的速率进行。

公开(公告)号：US20240190805A1

公开(公告)日：2024-06-13

申请号：US18546735

申请日：2022-02-25

申请人： SUMITOMO CHEMICAL COMPANY, LIMITED

发明人： Keisuke ARAI

IPC分类号： C07C69/63 ,  A01N37/50 ,  A01N43/10 ,  A01N43/40 ,  A01N43/56 ,  A01N43/78 ,  A01P3/00 ,  A01P7/02 ,  A01P7/04 ,  C07C251/06 ,  C07D213/55 ,  C07D231/12 ,  C07D277/30 ,  C07D333/24

CPC分类号： C07C69/63 ,  A01N37/50 ,  A01N43/10 ,  A01N43/40 ,  A01N43/56 ,  A01N43/78 ,  A01P3/00 ,  A01P7/02 ,  A01P7/04 ,  C07C251/06 ,  C07D213/55 ,  C07D231/12 ,  C07D277/30 ,  C07D333/24

摘要： The present invention provides a compound represented by formula (I) wherein a combination of X and L represents a combination wherein X represents a nitrogen atom and L represents an oxygen atom or NH, etc., n is 1 or 2, E represents a C6-C10 aryl group, etc., R1 and R2 are identical to or different from each other and each represents a C1-C3 chain hydrocarbon group which may be optionally substituted with one or more halogens, etc.]
which has an excellent control efficacy against pests, or its N-oxide or salts of the same.

公开(公告)号：US06090982A

公开(公告)日：2000-07-18

申请号：US441235

申请日：1999-11-16

申请人： Daniel John Bayston ,  Jonathan Luke William Griffin ,  Arne Gruman ,  Mario Eugenio Cosimino Polywka ,  Ronald Michael Scott

发明人： Daniel John Bayston ,  Jonathan Luke William Griffin ,  Arne Gruman ,  Mario Eugenio Cosimino Polywka ,  Ronald Michael Scott

IPC分类号： C07C227/18 ,  C07C229/28 ,  C07C251/18 ,  C07C253/00 ,  C07C255/31 ,  C07C229/36 ,  C07C251/06

CPC分类号： C07C255/31 ,  C07C227/18 ,  C07C229/28 ,  C07C251/18 ,  C07C253/00 ,  C07B2200/07 ,  C07C2101/02

摘要： Disclosed is a process for the preparation of cyclopropylglycine by a 5-step process wherein cyclopropanecarboxaldehyde is reacted with an .alpha.-aminoalkylaromatic compound to obtain an imine which is reacted with a cyanide to produce an aminonitrile compound; the aminonitrile compound is hydrolyzed to the corresponding aminocarboxylic acid and finally the arylalkyl residue is removed from the amino group by hydrogenolysis.

公开(公告)号：US4816038A

公开(公告)日：1989-03-28

申请号：US159100

申请日：1988-02-23

申请人： Frederick W. Koch ,  Gail A. Evans ,  Casper J. Dorer, Jr. ,  Alan A. Del Paggio

发明人： Frederick W. Koch ,  Gail A. Evans ,  Casper J. Dorer, Jr. ,  Alan A. Del Paggio

IPC分类号： C10L1/22 ,  C07C20060101 ,  C07C251/06 ,  C07F1/00 ,  C07F1/08 ,  C07F3/06 ,  C07F13/00 ,  C07F15/02 ,  C10L20060101 ,  C10L1/222 ,  C10L1/24 ,  C10L1/30 ,  C10L1/32 ,  C10L10/06 ,  F01N3/023 ,  F02B3/06 ,  C10L1/18

CPC分类号： F01N3/023 ,  C10L1/305 ,  C10L10/06 ,  F01N2430/04 ,  F02B3/06

摘要： Metal complexes of hydroxyl- and/or thiol-containing Mannich are prepared by reacting a transition metal-containing agent with an aromatic Mannich. The Mannich is prepared from a substituted hydroxyl- and/or thiol-containing aromatic, an aldehyde or ketone, and a hydroxyl- and/or thiol-containing amine compound. A Schiff base is then reacted therewith. The products are useful in reducing soot ignition temperatures in diesel particulate traps.

摘要翻译： 通过使含过渡金属的试剂与芳族Mannich反应制备含羟基和/或硫醇的曼尼希的金属络合物。 Mannich由取代的含羟基和/或硫醇的芳族化合物，醛或酮以及含羟基和/或硫醇的胺化合物制备。 然后将席夫碱与其反应。 该产品可用于降低柴油颗粒捕集器中的烟灰点燃温度。

公开(公告)号：US20220144746A1

公开(公告)日：2022-05-12

申请号：US17605681

申请日：2020-05-14

申请人： SIKA TECHNOLOGY AG

发明人： Urs BURCKHARDT ,  Andreas KRAMER ,  Michael GEYER ,  John BARRATT

IPC分类号： C07C67/08 ,  C07C251/06 ,  C07C45/75 ,  C08G18/32

摘要： A process for preparing an aldol ester of the formula (I), wherein at least one carboxylic anhydride of the formula (II) is reacted with at least one aldol of the formula (III) with heating in the presence of a basic catalyst with a pKa of the conjugate acid of at least 8, and the reaction product obtained from the process. The process provides a light-coloured and low-odour reaction product which has a high content of aldol ester content of the formula (I) and can be used, without elaborate purification steps, particularly without overhead distillation of the aldol ester, as a blocking agent for primary amines. The resultant blocked amines have a long storage life together with polymers containing isocyanate groups, and cure rapidly and reliably on contact with moisture to form mechanically high-grade and robust elastomers.

公开(公告)号：US08969623B2

公开(公告)日：2015-03-03

申请号：US14052116

申请日：2013-10-11

申请人： Amneal Pharmaceuticals, LLC ,  Megafine Pharma (P) Ltd.

发明人： Vijayavitthal Thippannachar Mathad ,  Navnath Chintaman Niphade ,  Gorakshanath Balasaheb Shinde ,  Sharad Subhash Ippar ,  Shrikant Prataprao Deshmukh ,  Raghavendra Kumar Panchangam

IPC分类号： C07C209/00 ,  C07C209/62 ,  C07C209/86 ,  C07C211/08 ,  C07C249/02 ,  C07C251/30 ,  C07C211/30 ,  C07C251/16 ,  C07C251/24 ,  C07C251/06

CPC分类号： C07C209/62 ,  C07B2200/07 ,  C07B2200/13 ,  C07C211/30 ,  C07C249/02 ,  C07C251/06 ,  C07C251/16 ,  C07C251/24 ,  C07C251/30

摘要： A method for the preparation of Cinacalcet is disclosed comprising treating (R)-1-naphthyl ethylamine with an aromatic aldehyde to form (1R)-1-(2-naphthyl)-N-(aryl methylene)ethanamine derivative of Formula (IV), which is further treated with 1-(3-halopropyl)-3-(trifluoromethyl)benzene of Formula (V) to obtain an iminium salt of Formula (VI), followed by hydrolysis to obtain Cinacalcet free base.

摘要翻译： 公开了制备西那卡塞的方法，其包括用芳族醛处理（R）-1-萘基乙胺以形成式（IV）的（1R）-1-（2-萘基）-N-（芳基亚甲基）乙胺衍生物 ，其进一步用式（V）的1-（3-卤代丙基）-3-（三氟甲基）苯处理，得到式（VI）的亚铵盐，随后水解得到西那卡塞游离碱。

公开(公告)号：US20080194877A1

公开(公告)日：2008-08-14

申请号：US11909287

申请日：2006-03-16

申请人： Ornella Letari ,  Massimo Maria D'Amato ,  Simona Zanzola ,  Roberto Artusi ,  Lucio Claudio Rovati ,  Gianfranco Caselli ,  Antonio Giordani

发明人： Ornella Letari ,  Massimo Maria D'Amato ,  Simona Zanzola ,  Roberto Artusi ,  Lucio Claudio Rovati ,  Gianfranco Caselli ,  Antonio Giordani

IPC分类号： C07C251/06

CPC分类号： A61K31/17

摘要： Mucositis is the result of a complex process of interactive biologic phenomena that take place in both the epitelium and the submucosa, often leading to severe pain and increased risk of dangerous syste f48 mic infections. Mucositis is often a side effect during chemotherapy and radiation therapy. The benzamidine derivatives herein described are particularly effective for treating and preventing mucositis since they are acting simultaneously at the several phases that characterize this disease. Data supplied from the esp@cenet database

摘要翻译： 粘膜炎是由上皮和粘膜下层发生的交互式生物学现象的复杂过程的结果，常常导致严重的疼痛，并增加危险的系统性f48 mic感染的风险。 在化学疗法和放射治疗中，粘膜炎往往是副作用的。 本文所述的苄脒衍生物对于治疗和预防粘膜炎是特别有效的，因为它们在表征该疾病的几个阶段同时作用。 从esp @ cenet数据库提供的数据

公开(公告)号：US5554582A

公开(公告)日：1996-09-10

申请号：US983604

申请日：1992-11-30

申请人： Michael Keil ,  Ulrich Schirmer ,  Dieter Kolassa ,  Juergen Kast ,  Bruno Wuerzer ,  Norbert Meyer

发明人： Michael Keil ,  Ulrich Schirmer ,  Dieter Kolassa ,  Juergen Kast ,  Bruno Wuerzer ,  Norbert Meyer

IPC分类号： A01N35/10 ,  A01N43/28 ,  A01N43/32 ,  C07C251/06 ,  C07C251/42 ,  C07C251/52 ,  C07C323/46 ,  C07C323/47 ,  C07C323/52 ,  C07D317/26 ,  C07D319/06 ,  C07D327/02 ,  C07D333/28 ,  C07D339/06 ,  C07D339/08 ,  A01N33/24 ,  A01N43/18 ,  C07C251/44

CPC分类号： C07C251/52 ,  A01N35/10 ,  A01N43/28 ,  A01N43/32 ,  C07C251/06 ,  C07C323/46 ,  C07C323/47 ,  C07C323/52 ,  C07D317/26 ,  C07D319/06 ,  C07D327/02 ,  C07D339/06 ,  C07D339/08 ,  C07C2101/16

摘要： Cyclohexenone compounds of the formula ##STR1## where R.sup.1 is alkyl of 1 to 4 carbon atoms, alkenyl or alkynyl of 3 or 4 carbon atoms, haloalkenyl of 3 or 4 carbon atoms and 1 to 3 halogen substituents, or is thenyl which is unsubstituted or substituted by halo and/or alkyl, R.sup.2 is alkyl of 1 to 4 carbon atoms, and R.sup.3 is formyl, a radical of the general formula R.sup.4 XCHXR.sup.5, where X is oxygen or sulfur, and R.sup.4 and R.sup.5 are identical or different alkyl, or together denote alkylene of 1 to 4 carbon atoms and which is unsubstituted or substituted by alkyl, alkoxy, alkylthio, hydroxy, halogen, cyano or N,N-dialkylamino, have a good herbicidal action preferably on species from the grass family.

摘要翻译： 其中R 1为1至4个碳原子的烷基，3或4个碳原子的链烯基或炔基，3或4个碳原子的卤代烯基和1至3个卤素取代基，或其中R 1为 未被取代或被卤素和/或烷基取代，R 2是1至4个碳原子的烷基，R 3是甲酰基，通式为R 4 XCHXR 5的基团，其中X是氧或硫，R 4和R 5是相同或不同的烷基 或一起表示1至4个碳原子的亚烷基，其未被取代或被烷基，烷氧基，烷硫基，羟基，卤素，氰基或N，N-二烷基氨基取代，优选地对来自草类的物种具有良好的除草作用。