公开(公告)号：US20240287018A1

公开(公告)日：2024-08-29

申请号：US18438838

申请日：2024-02-12

申请人： Corsair Pharma, Inc.

发明人： Cyrus K. BECKER ,  Meenakshi S. VENKATRAMAN ,  Xiaoming ZHANG ,  Jürg R. Pfister ,  Gwenaella Rescourio

IPC分类号： C07D321/00 ,  A61K9/00 ,  A61K9/70 ,  A61K31/165 ,  A61K31/216 ,  A61K31/341 ,  A61K31/365 ,  A61K45/06 ,  C07C59/72 ,  C07C69/712 ,  C07C69/734 ,  C07C69/74 ,  C07C69/96 ,  C07C219/16 ,  C07C235/20 ,  C07D207/08 ,  C07D211/60 ,  C07D257/06 ,  C07D263/24 ,  C07D263/26 ,  C07D265/30 ,  C07D295/088 ,  C07D295/145 ,  C07D307/20 ,  C07D317/34 ,  C07D317/40 ,  C07D453/02

CPC分类号： C07D321/00 ,  A61K9/0014 ,  A61K9/7023 ,  A61K31/165 ,  A61K31/216 ,  A61K31/341 ,  A61K31/365 ,  A61K45/06 ,  C07C59/72 ,  C07C69/712 ,  C07C69/734 ,  C07C69/74 ,  C07C69/96 ,  C07C219/16 ,  C07C235/20 ,  C07D207/08 ,  C07D211/60 ,  C07D257/06 ,  C07D263/24 ,  C07D263/26 ,  C07D265/30 ,  C07D295/088 ,  C07D295/145 ,  C07D307/20 ,  C07D317/34 ,  C07D317/40 ,  C07D453/02 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/42 ,  C07C2603/14

摘要： Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.

公开(公告)号：US11738010B2

公开(公告)日：2023-08-29

申请号：US17385258

申请日：2021-07-26

申请人： MERCK SHARP & DOHME CORP.

发明人： John P. Caldwell ,  Reynalda De Jesus ,  Fa-Xiang Ding ,  Charles J. Gill ,  Ginny Dai Ho ,  Sookhee N. Ha ,  Sandra J. Koseoglu ,  Marc A. Labroli ,  Sang Ho Lee ,  Christina Madsen-Duggan ,  Mihir Mandal ,  Terry Roemer ,  Jing Su ,  Christopher Michael Tan ,  Zheng Tan ,  Haifeng Tang ,  Hao Wang ,  Christine Yang ,  Shu-Wei Yang

IPC分类号： A61K31/4439 ,  A61P31/04 ,  A61K31/407 ,  A61K31/421 ,  A61K31/422 ,  A61K31/427 ,  A61K31/431 ,  A61K31/4375 ,  A61K31/438 ,  A61K31/4709 ,  A61K31/5377 ,  A61K31/5383 ,  C07D263/26 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D491/048 ,  C07D495/04 ,  C07D498/04

CPC分类号： A61K31/4439 ,  A61K31/407 ,  A61K31/421 ,  A61K31/422 ,  A61K31/427 ,  A61K31/431 ,  A61K31/438 ,  A61K31/4375 ,  A61K31/4709 ,  A61K31/5377 ,  A61K31/5383 ,  A61P31/04 ,  C07D263/26 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D491/048 ,  C07D495/04 ,  C07D498/04

摘要： Novel compounds of the structural formula I, and the pharmaceutically acceptable salts thereof, are inhibitors of TarO and may be useful in the prevention, treatment and suppression of diseases mediated by TarO, such as bacterial infections, including gram negative bacterial infections and gram positive bacterial infections such as MRSA and MRSE, alone or in combination with a β-lactam antibiotic.

公开(公告)号：US20230023607A1

公开(公告)日：2023-01-26

申请号：US17790831

申请日：2021-02-04

申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA

发明人： Wei Wang

IPC分类号： C07D493/04 ,  C07D493/14 ,  C07D413/06 ,  C07D263/26

摘要： Disclosed are a deuterated compound of fomula (I), or a salt thereof, and methods for preparation thereof. The present disclosure may provide a mild, versatile organophotoredox method for the preparation of diverse, enantioenriched α-deuterated α-amino acids. In particular, the present disclosure may address the long-standing challenge of installing sterically demanding side chains into α-amino acids, including late-stage modifications on medicinal agents and natural products.

公开(公告)号：US20220204540A1

公开(公告)日：2022-06-30

申请号：US17604892

申请日：2020-04-28

申请人： ISAGRO S.p.A.

发明人： Marilena GUSMEROLI ,  Giuseppe D'ORAZIO ,  Entela SINANI ,  Daniele FORGIA ,  Paolo BELLANDI ,  Chiara SARGIOTTO ,  Daniele BIANCHI ,  Jessica VILLATA ,  Riccardo LIGUORI

IPC分类号： C07F9/6574 ,  C07F9/40 ,  C07D207/16 ,  C07D211/60 ,  C07D211/78 ,  C07D233/02 ,  C07D285/12 ,  C07D279/06 ,  C07D277/14 ,  C07D277/06 ,  C07D277/56 ,  C07D263/06 ,  C07D263/24 ,  C07D263/34 ,  C07D263/26 ,  A01N57/24 ,  A01N47/16 ,  A01N43/76 ,  A01N43/86 ,  A01N43/50 ,  A01N43/82 ,  A01N43/78 ,  A01N43/40 ,  A01N43/36

摘要： Non-aromatic fluoroalkenyl heterocyclic compounds having general formula (I), agronomic compositions containing said compounds having formula (I) and their use for the control of nematodes in agricultural crops, are described.

公开(公告)号：US11178873B2

公开(公告)日：2021-11-23

申请号：US15747180

申请日：2016-07-15

申请人： FMC CORPORATION

发明人： Andrew Duncan Satterfield ,  Thomas Martin Stevenson

IPC分类号： A01N47/38 ,  C07D233/38 ,  C07D207/26 ,  C07D207/27 ,  C07D263/26

摘要： Disclosed are compounds of Formula (1), including all stereoisomers, N-oxides, and salts thereof, (Formula (1)) wherein G, J, Q1, R4, Y2, Q2, R5 and Y1 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula (1) and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of a compound or a composition of the invention.

公开(公告)号：US10752605B2

公开(公告)日：2020-08-25

申请号：US16417664

申请日：2019-05-21

申请人： CORSAIR PHARMA, INC.

发明人： Cyrus K. Becker ,  Meenakshi S. Venkatraman ,  Xiaoming Zhang

IPC分类号： C07D313/00 ,  C07C69/712 ,  C07D317/40 ,  C07D321/00 ,  C07D257/06 ,  C07D263/24 ,  C07D265/30 ,  C07D295/088 ,  C07D211/60 ,  C07D295/145 ,  C07D307/20 ,  C07C219/16 ,  C07C235/20 ,  C07D453/02 ,  C07C59/54 ,  C07C69/734 ,  C07C235/34 ,  C07D207/08 ,  C07D263/26 ,  C07D317/34 ,  A61K9/70 ,  A61K31/165 ,  A61K31/216 ,  A61K31/335 ,  C07C59/31

摘要： Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.

公开(公告)号：US20190330180A1

公开(公告)日：2019-10-31

申请号：US16097106

申请日：2017-04-24

申请人： SYNGENTA PARTICIPATIONS AG

发明人： Helmars SMITS ,  Sujit Kumar GHORAI

IPC分类号： C07D401/04 ,  C07D213/75 ,  C07D263/26

摘要： The present invention relates to a process for the preparation of a compound of formula wherein R1, R2, R3, R4, R5 and R6 are as defined in the specification.

公开(公告)号：US10414736B2

公开(公告)日：2019-09-17

申请号：US16146129

申请日：2018-09-28

申请人： Kangwon National University, University Industry Cooperation Foundation

发明人： Phil Ho Lee ,  Koo Yeon Lee ,  Yonghyeon Baek ,  Kyusik Um ,  Byeong Su Kim

IPC分类号： C07D263/26 ,  C07D205/08 ,  B01J31/38 ,  B01J31/22

摘要： Disclosed is a method of preparing ezetimibe, including cross-metathesis using a Grubbs 2nd catalyst and deprotection using a Pearlman's catalyst, and an intermediate thereof. The method of preparing ezetimibe is useful as an efficient ezetimibe synthesis technique in pharmaceutical fields using ezetimibe as a raw material.

公开(公告)号：US20190031607A1

公开(公告)日：2019-01-31

申请号：US16150070

申请日：2018-10-02

申请人： GENENTECH, INC. ,  XENON PHARMACEUTICALS INC.

发明人： Jean-Christophe ANDREZ ,  Philippe BERGERON ,  Paul Robert BICHLER ,  Sultan CHOWDHURY ,  Christoph Martin DEHNHARDT ,  Thilo FOCKEN ,  Wei GONG ,  Michael Edward GRIMWOOD ,  Abid HASAN ,  Ivan William HEMEON ,  Qi JIA ,  Brian Salvatore SAFINA ,  Shaoyi SUN ,  Michael Scott WILSON ,  Alla Yurevna ZENOVA

IPC分类号： C07D207/16 ,  C07C235/52 ,  C07D209/02 ,  C07D401/10 ,  C07D205/04 ,  C07D207/22 ,  C07D211/20 ,  C07C235/42 ,  C07D211/38 ,  C07D409/06 ,  C07D265/30 ,  C07D413/12 ,  C07D263/26 ,  C07C235/54 ,  C07D417/12 ,  C07D305/08 ,  C07D213/69 ,  C07D403/04 ,  C07D231/06 ,  C07D209/52 ,  C07D221/22 ,  C07D209/54 ,  C07D403/12 ,  C07D211/60 ,  C07D207/10 ,  C07D401/12 ,  C07D471/08 ,  C07D413/14 ,  C07D207/08 ,  C07D405/10 ,  C07D403/14 ,  C07D451/02 ,  C07D401/14 ,  C07D263/04 ,  C07D277/06

CPC分类号： C07D207/16 ,  C07C235/42 ,  C07C235/52 ,  C07C235/54 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2603/74 ,  C07D205/04 ,  C07D207/08 ,  C07D207/10 ,  C07D207/22 ,  C07D209/02 ,  C07D209/52 ,  C07D209/54 ,  C07D211/20 ,  C07D211/38 ,  C07D211/60 ,  C07D213/69 ,  C07D221/22 ,  C07D231/06 ,  C07D263/04 ,  C07D263/26 ,  C07D265/30 ,  C07D277/06 ,  C07D305/08 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/10 ,  C07D409/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D451/02 ,  C07D471/08

摘要： The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables RA, RAA, subscript n, subscript q, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

公开(公告)号：US09845305B2

公开(公告)日：2017-12-19

申请号：US15296164

申请日：2016-10-18

申请人： Corsair Pharma Inc.

发明人： Cyrus K. Becker ,  Jürg R. Pfister ,  Gwenaella Rescourio ,  Meenakshi S. Venkatraman ,  Xiaoming Zhang

IPC分类号： C07D321/00 ,  C07D307/20 ,  C07D317/40 ,  C07C235/20 ,  A61K31/165 ,  C07C69/734 ,  A61K31/216 ,  A61K31/365 ,  A61K31/341 ,  A61K45/06 ,  A61K9/00 ,  C07D317/34 ,  C07C69/712 ,  C07C219/16 ,  C07D453/02 ,  C07D257/06 ,  C07D263/24 ,  C07D263/26 ,  C07D265/30 ,  C07D207/08 ,  C07D295/088 ,  C07D211/60 ,  C07D295/145 ,  C07C59/72 ,  C07C69/74 ,  C07C69/96 ,  A61K9/70

CPC分类号： C07D321/00 ,  A61K9/0014 ,  A61K9/7023 ,  A61K31/165 ,  A61K31/216 ,  A61K31/341 ,  A61K31/365 ,  A61K45/06 ,  C07C59/72 ,  C07C69/712 ,  C07C69/734 ,  C07C69/74 ,  C07C69/96 ,  C07C219/16 ,  C07C235/20 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/42 ,  C07C2603/14 ,  C07D207/08 ,  C07D211/60 ,  C07D257/06 ,  C07D263/24 ,  C07D263/26 ,  C07D265/30 ,  C07D295/088 ,  C07D295/145 ,  C07D307/20 ,  C07D317/34 ,  C07D317/40 ,  C07D453/02

摘要： Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable dosage. Transdermal applications can be used.