公开(公告)号：US12012418B2

公开(公告)日：2024-06-18

申请号：US17859505

申请日：2022-07-07

申请人： Nogra Pharma Limited

发明人： Francesca Viti ,  Salvatore Bellinvia ,  Salvatore Demartis

IPC分类号： C07D495/14 ,  C07C233/29 ,  C07C233/73 ,  C07C235/38 ,  C07C235/46 ,  C07D209/08 ,  C07D209/14 ,  C07D209/86 ,  C07D209/94 ,  C07D213/75 ,  C07D235/30 ,  C07D277/64 ,  C07D277/82 ,  C07D333/36 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04

CPC分类号： C07D495/14 ,  C07C233/29 ,  C07C233/73 ,  C07C235/38 ,  C07C235/46 ,  C07D209/08 ,  C07D209/14 ,  C07D209/86 ,  C07D209/94 ,  C07D213/75 ,  C07D235/30 ,  C07D277/64 ,  C07D277/82 ,  C07D333/36 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04

摘要： The present invention is generally directed towards compounds capable of binding the aryl hydrocarbon receptor and modulating its activity, methods of treating inflammatory conditions such as Crohn's disease using such compounds, and pharmaceutical compositions comprising such compounds. Also provided are methods of increasing levels of IL-22 in a subject and/or decreasing levels of IFN-γ in a subject.

公开(公告)号：US11845724B2

公开(公告)日：2023-12-19

申请号：US17019097

申请日：2020-09-11

申请人： Vincere Biosciences, Inc.

发明人： Donna L. Romero ,  Michael Garrett Johnson ,  Andrew David Lee ,  Bahareh Behrouz ,  Edward Lawrence Fritzen, Jr.

IPC分类号： C07D205/04 ,  C07D209/20 ,  C07C317/36 ,  C07D309/14 ,  C07D309/12 ,  C07D217/26 ,  C07D471/04 ,  C07D213/72 ,  C07D333/36 ,  C07D305/08 ,  C07D405/12 ,  C07D211/58 ,  C07D307/22

CPC分类号： C07D205/04 ,  C07C317/36 ,  C07D209/20 ,  C07D211/58 ,  C07D213/72 ,  C07D217/26 ,  C07D305/08 ,  C07D307/22 ,  C07D309/12 ,  C07D309/14 ,  C07D333/36 ,  C07D405/12 ,  C07D471/04

摘要： The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of USP30, and the treatment of USP30-mediated disorders.

公开(公告)号：US20230357139A1

公开(公告)日：2023-11-09

申请号：US18025818

申请日：2021-09-13

申请人： Artizan Biosciences, Inc.

发明人： William HOEKSTRA ,  Hyunji RYU ,  Priyanka CHINTHA

IPC分类号： C07C311/29 ,  C07D333/34 ,  C07D213/42 ,  C07D213/71 ,  C07D231/12 ,  C07D401/12 ,  C07D209/08 ,  C07D333/36 ,  C07D409/12 ,  C07D401/08 ,  C07D231/56 ,  C07D413/12 ,  C07D277/28

CPC分类号： C07C311/29 ,  C07D333/34 ,  C07D213/42 ,  C07D213/71 ,  C07D231/12 ,  C07D401/12 ,  C07D209/08 ,  C07D333/36 ,  C07D409/12 ,  C07D401/08 ,  C07D231/56 ,  C07D413/12 ,  C07D277/28

摘要： Described herein are compounds and compositions for use in treatment or prevention of an inflammatory bowel disease, gastrointestinal cancer, or a systemic bacterial infection in a subject in need thereof. The subject may be colonized by one or more pathogenic bacterial strains such as B. fragilis, E. faecalis, or C. perfringens. In certain aspects, the disclosure provides a method of diminishing the pathogenic effects of these bacterial strains by administering a compound that binds to and/or inhibits one or more toxins produced thereby.

公开(公告)号：US11632957B2

公开(公告)日：2023-04-25

申请号：US16794955

申请日：2020-02-19

申请人： CORTEVA AGRISCIENCE LLC

发明人： Ronald J. Heemstra ,  Ronald Ross, Jr. ,  Kyle A. DeKorver ,  Kaitlyn Gray ,  Daniel I. Knueppel ,  Peter Vednor ,  Timothy P. Martin ,  Joseph D. Eckelbarger ,  John F. Daeuble, Sr. ,  Ricky Hunter ,  David A. Demeter ,  Tony K. Trullinger ,  Erich W. Baum ,  Zoltan L. Benko ,  Nakyen Choy ,  Gary D. Crouse ,  Fangzheng Li ,  Jeffrey Nissen ,  Monica B. Olson ,  Michelle Riener ,  Thomas C. Sparks ,  Frank J. Wessels ,  Maurice C. Yap

IPC分类号： A01N53/00 ,  C07C255/46 ,  C07C255/57 ,  C07C255/60 ,  C07C259/10 ,  C07D213/84 ,  C07D213/89 ,  C07D215/227 ,  C07C271/28 ,  C07C271/66 ,  C07D215/38 ,  C07D231/56 ,  C07D233/36 ,  C07C311/08 ,  C07C311/46 ,  C07D235/30 ,  C07C317/28 ,  C07C317/40 ,  C07C317/50 ,  C07C323/41 ,  C07C323/42 ,  C07C323/59 ,  C07C331/12 ,  C07C381/10 ,  C07D205/04 ,  C07C237/42 ,  C07D207/452 ,  C07C255/29 ,  C07D209/49 ,  C07D213/75 ,  C07D213/81 ,  C07D309/14 ,  C07D231/12 ,  C07D331/04 ,  C07D333/36 ,  C07D249/08 ,  C07D207/10 ,  C07D285/06 ,  C07D295/32 ,  C07D305/08 ,  C07D207/273 ,  C07D233/80 ,  C07D261/12 ,  C07D263/26 ,  C07D277/36 ,  C07D307/33 ,  C07D333/48 ,  C07C237/22 ,  C07D213/56 ,  C07D277/30 ,  C07D307/52 ,  C07D333/60 ,  A01N37/22 ,  A01N37/34 ,  A01N41/10 ,  A01N43/40 ,  A01N43/60 ,  A01N43/653 ,  A01N43/707 ,  A01N43/82 ,  A01N43/90 ,  C07C233/63 ,  C07C233/65 ,  C07C317/14 ,  C07D241/20 ,  C07D253/07 ,  C07D487/04

摘要： This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).

公开(公告)号：US11608329B2

公开(公告)日：2023-03-21

申请号：US17126279

申请日：2020-12-18

申请人： Ikena Oncology, Inc.

发明人： Alfredo C. Castro ,  Karen J. McGovern ,  Michael Burke

IPC分类号： C07D277/42 ,  C07D417/04 ,  A61P1/00 ,  A61P29/00 ,  C07D235/00 ,  C07D249/14 ,  C07D263/48 ,  C07D271/07 ,  C07D271/113 ,  C07D277/48 ,  C07D285/135 ,  C07D333/36 ,  C07D417/12

摘要： The present invention provides AHR agonists, compositions thereof, and methods of using the same.

公开(公告)号：US20220332695A1

公开(公告)日：2022-10-20

申请号：US17621002

申请日：2020-06-25

申请人： RTI INTERNATIONAL

发明人： Yanan ZHANG ,  Thuy T. NGUYEN

IPC分类号： C07D333/36 ,  C07C275/30 ,  A61P25/30

摘要： Heteroaryl and aliphatic analogs of diarylurea-based cannabinoid 1 receptor (CB1R) allosteric modulators are described. Exemplary analogs can provide improved potencies and pharmacokinetic properties. Methods of using the analogs to treat diseases mediated by CB1R, such as substance abuse and obesity, are described.

公开(公告)号：US11453678B2

公开(公告)日：2022-09-27

申请号：US17287423

申请日：2019-10-23

申请人： NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY

发明人： Hajime Ito ,  Koji Kubota

IPC分类号： C07D487/22 ,  B01J23/44 ,  C07C17/275 ,  C07C41/22 ,  C07C45/68 ,  C07C67/343 ,  C07C209/10 ,  C07D209/88 ,  C07D333/28 ,  C07D333/36 ,  C07F5/02

摘要： Disclosed is a cross-coupling reaction method which forms a chemical bond selected from C—N, C—B, C—C, C—O and C—S bonds, the method comprising: preparing an aromatic compound (1) having a leaving group; preparing a compound (2) capable of undergoing a cross-coupling reaction selected from an aromatic amino compound (2-1), a diboronic acid ester or the like (2-2), an aromatic boronic acid or the like (2-3), an aromatic compound (2-4) having a hydroxyl group and an aromatic compound (2-5) having a thiol group; and performing a cross-coupling reaction of the compound (1) with the compound (2) in the presence of a palladium catalyst, a base and a compound (4) having a carbon-carbon double bond or a carbon-carbon triple bond, in the absence of a solvent.

公开(公告)号：US11427600B2

公开(公告)日：2022-08-30

申请号：US15321967

申请日：2015-06-26

申请人： Nogra Pharma Limited

发明人： Francesca Viti ,  Salvatore Bellinvia ,  Salvatore Demartis

IPC分类号： C07D495/14 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07C233/29 ,  C07C233/73 ,  C07C235/38 ,  C07C235/46 ,  C07D209/08 ,  C07D209/14 ,  C07D209/86 ,  C07D209/94 ,  C07D213/75 ,  C07D235/30 ,  C07D277/64 ,  C07D277/82 ,  C07D333/36

摘要： The present invention is generally directed towards compounds capable of binding the aryl hydrocarbon receptor and modulating its activity, methods of treating inflammatory conditions such as Crohn's disease using such compounds, and pharmaceutical compositions comprising such compounds. Also provided are methods of increasing levels of IL-22 in a subject and/or decreasing levels of IFN-γ in a subject.

公开(公告)号：US11306067B2

公开(公告)日：2022-04-19

申请号：US16975472

申请日：2019-03-01

申请人： DENOVAMED INC.

发明人： Fan Wu ,  Erhu Lu ,  Shengguo Sun ,  Christopher J. Barden

IPC分类号： C07D333/38 ,  C07D333/34 ,  C07D333/36 ,  A61K31/43 ,  A61K31/7048 ,  A61K38/12

摘要： Compounds or pharmaceutical acceptable salts thereof of Formula (I), in which RM have the meaning described herein and pharmaceutical compositions thereof useful as antimicrobial and/or adjuvant:

公开(公告)号：US11261378B2

公开(公告)日：2022-03-01

申请号：US15539666

申请日：2015-12-17

申请人： DIC CORPORATION

发明人： Masahiro Horiguchi ,  Sayaka Nose ,  Akihiro Koiso

IPC分类号： C09K19/54 ,  C07C69/753 ,  C07C69/76 ,  C07D333/22 ,  C07D339/06 ,  C07D339/08 ,  C07D407/12 ,  C07D409/12 ,  C07C323/21 ,  C07D413/12 ,  C07D417/04 ,  C07D417/06 ,  C07D249/06 ,  C07C327/48 ,  C07C251/24 ,  C07D207/452 ,  C07C251/86 ,  C07C251/88 ,  C07D209/12 ,  C07D277/82 ,  C07D513/04 ,  C08F20/10 ,  G02B5/30 ,  C07C69/94 ,  C07C69/75 ,  C09K19/34 ,  C07D409/14 ,  C07D305/06 ,  C07C251/78 ,  C07D403/04 ,  C07D209/40 ,  C07D303/48 ,  C09K19/32 ,  C07D495/04 ,  C07C69/757 ,  C07C245/08 ,  C07D333/36 ,  C07D307/66 ,  C07D403/12 ,  C07D417/12 ,  C07D265/16 ,  C07D249/04 ,  C07D213/74 ,  C07C251/18 ,  C07D409/06 ,  C07D333/76 ,  C07D277/64 ,  C07D209/88 ,  C09K19/38 ,  G02F1/13363 ,  C09K19/04 ,  C08F220/30

摘要： The present invention aims to provide a polymerizable compound that has high storage stability without causing crystal precipitation when added to a polymerizable composition and to provide a polymerizable composition containing the polymerizable compound. A polymer film produced by polymerization of the polymerizable composition has a low haze, high thickness uniformity, low occurrence of nonuniform orientation, high surface hardness, high adhesiveness, and good appearances and fewer orientation defects even after ultraviolet irradiation. The present invention also aims to provide a polymer produced by polymerization of the polymerizable composition and an optically anisotropic body produced from the polymer.