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    DICATIONIC FLUORESCENT DYES
    1.
    发明申请
    DICATIONIC FLUORESCENT DYES 有权

    公开(公告)号：US20230050863A1

    公开(公告)日：2023-02-16

    申请号：US17756810

    申请日：2020-12-07

    申请人： Roche Molecular Systems, Inc.

    发明人： Alexander Nierth

    IPC分类号： C09K11/06 ,  C09B11/28 ,  C12Q1/6851 ,  G01N33/533

    摘要： The present invention provides for water-soluble mono- and dicationic fluorescent dyes with the latter exhibiting stable fluorescence at elevated temperatures. The present invention also provides for methods for the production of the fluorescent dyes and for using these dyes in biological assays such as multiplexing qPCR and tissue staining.

    Glutathione-detecting fluorescent probe
    6.
    发明授权
    Glutathione-detecting fluorescent probe 有权

    公开(公告)号：US10261090B2

    公开(公告)日：2019-04-16

    申请号：US15116661

    申请日：2015-02-24

    申请人： THE UNIVERSITY OF TOKYO

    发明人： Yasuteru Urano ,  Mako Kamiya ,  Keitaro Umezawa ,  Masafumi Yoshida

    IPC分类号： G01N33/68 ,  C09B11/08 ,  C09B11/24 ,  C09B11/28 ,  C09B19/00 ,  C09K11/07 ,  G01N21/64 ,  C07F7/08 ,  G01N33/58 ,  C09K11/06

    摘要： [Problem] To provide the following: a novel fluorescent probe for detecting a compound, such as glutathione, that contains a —SH group; a detection method using said fluorescent probe; and a detection kit containing said probe.[Solution] A fluorescent probe for detecting a compound containing an —SH group, wherein the fluorescent probe comprises a compound represented by formula (I) or a salt thereof (In the formula, X represents Si(Ra)(Rb), Ge(Ra)(Rb), Sn(Ra)(Rb), C(Ra)(Rb), or O (wherein Ra and Rb each independently represent a hydrogen atom or alkyl group); R1 represents a hydrogen atom, or 1-4 identical or different substituents independently selected from the group consisting of a cyano group, alkyl group, carboxyl group, ester group, alkoxy group, amide group, and azide group, each of which may be optionally substituted; R2 represents a hydrogen atom, halogen atom, hydroxyl group, cyano group, or an alkyl group, alkynyl group, alkoxy group, aryl, or heteroaryl, each of which may be optionally substituted; R3 and R4 each independently represent a hydrogen atom or 1-3 identical or different substituents independently selected from the group consisting of a hydroxyl group, halogen atom, or an alkyl group, sulfo group, carboxyl group, ester group, amide group and azide group, each of which may be optionally substituted; R5, R6, R7 and R8 each independently represent a hydrogen atom or alkyl group, wherein, R5 or R6, respectively together with R3, may form a ring structure including the nitrogen atoms bonded thereto, or R7 or R8, respectively together with R4, may form a ring structure including the nitrogen atoms bonded thereto).