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公开(公告)号：US12018304B2
公开(公告)日：2024-06-25
申请号：US17386204
申请日：2021-07-27
IPC分类号： C12P17/12 , C12N1/20 , C12N9/00 , C12N9/02 , C12N9/04 , C12N9/10 , C12N9/14 , C12N9/88 , C12N9/90 , C12N15/00 , C12N15/52 , C12P7/24 , C12P13/00 , C12P13/22
CPC分类号： C12P17/12 , C12N9/0006 , C12N9/0008 , C12N9/0071 , C12N9/1085 , C12N9/90 , C12N15/52 , C12P7/24 , C12P13/001 , C12P13/225
摘要： Host cells that are engineered to produce benzylisoquinoline alkaloid (BIAS) precursors, such as norcoclaurine (NC) and norlaudanosoline (NL), are provided. The host cells may have one or more engineered modifications selected from: a feedback inhibition alleviating mutation in a enzyme gene; a transcriptional modulation modification of a biosynthetic enzyme gene; an inactivating mutation in an enzyme; and a heterologous coding sequence. Also provided are methods of producing a BIA of interest or a precursor thereof using the host cells and compositions, e.g., kits, systems etc., that find use in methods of the invention.
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2.发明公开公开(公告)号：US20240043886A1
公开(公告)日：2024-02-08
申请号：US18464158
申请日：2023-09-08
发明人： Han Hyoung LEE , Hyo Jeong BYUN , Byeong Soo KIM , Hee Ju KIM , Moo Young JUNG , Hyung Joon KIM , Seul-Gi PARK
CPC分类号： C12P13/227 , C12P13/08 , C12N9/0006 , C12Y101/01049 , C12N9/1205 , C12Y207/01004
摘要： The present disclosure relates to a microorganism of the genus Corynebacterium producing L-amino acid, a method for producing L-amino acid using the same, use of L-amino acid production, and a composition for producing L-amino acid.
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公开(公告)号：US11879144B2
公开(公告)日：2024-01-23
申请号：US18152329
申请日：2023-01-10
发明人： Yousong Ding , Ran Zuo
CPC分类号： C12P13/227 , C12N9/0006 , C12N9/0042 , C12N9/0075 , C12N15/62 , C12Y101/9901 , C12Y106/02004 , C12Y114/13039
摘要： The disclosure relates, in some aspects, to compositions and methods useful for production of nitrated aromatic molecules. The disclosure is based, in part, on whole cell systems expressing artificial fusion proteins comprising cytochrome P450 enzymes linked to reductase enzymes. In some aspects, the disclosure relates to methods of producing nitrated aromatic molecules in whole cell systems having artificial fusion proteins comprising cytochrome P450 enzymes linked to reductase enzymes.
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4.发明授权公开(公告)号：US11879143B2
公开(公告)日：2024-01-23
申请号：US16691452
申请日：2019-11-21
发明人： Andrew Richard Buller , Sabine Brinkmann-Chen , Michael Herger , David K. Romney , Javier Murciano Calles , Paul van Roye
CPC分类号： C12P13/227 , C12N9/88 , C12P13/04 , C12Y402/0102
摘要： This disclosure relates to modified tryptophan synthase and more particularly to modified beta-subunits of tryptophan synthase. The disclosure further relates to cells expressing such modified subunits and methods of producing non-canonical amino acids.
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公开(公告)号：US20230313245A1
公开(公告)日：2023-10-05
申请号：US17985033
申请日：2022-11-10
CPC分类号： C12P13/225 , C12Y402/0102 , C12N9/88
摘要： The present disclosure provides engineered enzymes and methods for preparing tyrosine and tyrosine analogs from a donor amino acid and phenols in a single step. Also disclosed are methods to engineer enzymes having such ‘tyrosine synthase’ activity, starting from the beta-subunit of a tryptophan synthase (TrpB).
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公开(公告)号：US20230287466A1
公开(公告)日：2023-09-14
申请号：US18152329
申请日：2023-01-10
发明人： Yousong Ding , Ran Zuo
CPC分类号： C12P13/227 , C12N9/0006 , C12N9/0042 , C12N9/0075 , C12N15/62 , C12Y101/9901 , C12Y106/02004 , C12Y114/13039
摘要： The disclosure relates, in some aspects, to compositions and methods useful for production of nitrated aromatic molecules. The disclosure is based, in part, on whole cell systems expressing artificial fusion proteins comprising cytochrome P450 enzymes linked to reductase enzymes. In some aspects, the disclosure relates to methods of producing nitrated aromatic molecules in whole cell systems having artificial fusion proteins comprising cytochrome P450 enzymes linked to reductase enzymes.
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公开(公告)号：US11746345B2
公开(公告)日：2023-09-05
申请号：US15165606
申请日：2016-05-26
申请人： AJINOMOTO CO., INC.
IPC分类号： C12N9/00 , C12P13/08 , C12P13/04 , C12N15/52 , C12P13/06 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/22 , C12P13/24
CPC分类号： C12N9/93 , C12N15/52 , C12P13/04 , C12P13/06 , C12P13/08 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/222 , C12P13/227 , C12P13/24 , C12Y603/02002
摘要： The present invention provides a method for producing an L-amino acid such as a branched-chain L-amino acid by fermentation using a bacterium of the family Enterobacteriaceae, particularly a bacterium belonging to the genus Escherichia, which has been modified to attenuate expression of the gshA gene.
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公开(公告)号：US20230134555A1
公开(公告)日：2023-05-04
申请号：US17911083
申请日：2021-03-05
发明人： Chang Il SEO , Hyun Ah KIM , Sung Kwang SON , Ki Yong CHEONG , Moo Young JUNG , Tae Yeon KIM
摘要： The present disclosure relates to a method for producing L-tryptophan through the enhancement of prephenate dehydratase (PheA) activity.
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公开(公告)号：US20230050643A1
公开(公告)日：2023-02-16
申请号：US17772825
申请日：2020-06-26
申请人： DAESANG CORPORATION
发明人： Won Joo SHIN , Young Il JO , Sun Hee LEE , Hyun Young KIM , Yong Soo KIM , Cheol Min YANG
摘要： Provided is a mutant strain having improved aromatic amino acid production capability as a result of inactivation or weakening of activity of glutaminase which is expressed by glutaminase B (glsB) gene.
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公开(公告)号：US20220403428A1
公开(公告)日：2022-12-22
申请号：US17642815
申请日：2020-09-16
发明人： Irina Borodina , Nicholas Milne , Steven van der Hoek , Morten Otto Alexander Sommer , Jérémy Christophe Daniel Armetta , Philip Tinggaard Thomsen
摘要： The present disclosure relates to methods for production of 4-hydroxytryptamine and derivatives thereof in a yeast cell. Herein are also disclosed methods for production of halogenated tryptophans and derivatives thereof in a cell. Herein are also disclosed methods for production of methylated tryptamine. The disclosure also provides nucleic acid constructs and cells useful for performing the present methods.
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