公开(公告)号：US20240327877A1

公开(公告)日：2024-10-03

申请号：US18625942

申请日：2024-04-03

申请人： Alliance for Sustainable Energy, LLC ,  Massachusetts Institute of Technology ,  Wisconsin Alumni Research Foundation ,  UT-Battelle, LLC

发明人： Gregg Tyler BECKHAM ,  Chad Thomas PALUMBO ,  Allison Jean ZIMONT WERNER ,  Kevin P. SULLIVAN ,  Yuriy ROMÁN ,  Shannon Scot STAHL ,  Adam Michael GUSS ,  Jay D. HUENEMANN ,  Thomas David MAND ,  Kathryn MAINS ,  Austin Lee CARROLL

IPC分类号： C12P7/18 ,  C12N1/20 ,  C12R1/40

CPC分类号： C12P7/18 ,  C12N1/205 ,  C12P2201/00 ,  C12R2001/40

摘要： Described herein is a chemical process for the conversion of lignocellulosic biomass into muconic acid which is useful for the generation of plastics and polymers. The described methods utilize catalytic chemical reactions and biological processes to facilitate the conversion, while increasing yields and reducing energy requirements.

公开(公告)号：US12104160B2

公开(公告)日：2024-10-01

申请号：US17307850

申请日：2021-05-04

申请人： ZYMOCHEM, INC.

发明人： Harshal Chokhawala

IPC分类号： C12P7/42 ,  C12N9/00 ,  C12N9/02 ,  C12N9/04 ,  C12N9/06 ,  C12N9/10 ,  C12N9/12 ,  C12N9/16 ,  C12N9/24 ,  C12N9/88 ,  C12N15/52 ,  C12P7/04 ,  C12P7/18 ,  C12P7/24 ,  C12P7/40 ,  C12P7/44 ,  C12P7/6409 ,  C12P13/00 ,  C12P17/08 ,  C12P17/10

CPC分类号： C12N15/52 ,  C12N9/00 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/001 ,  C12N9/0016 ,  C12N9/1029 ,  C12N9/1096 ,  C12N9/1205 ,  C12N9/13 ,  C12N9/16 ,  C12N9/2402 ,  C12N9/88 ,  C12N9/93 ,  C12P7/04 ,  C12P7/18 ,  C12P7/24 ,  C12P7/40 ,  C12P7/42 ,  C12P7/44 ,  C12P7/6409 ,  C12P13/001 ,  C12P13/005 ,  C12P17/08 ,  C12P17/10 ,  C12Y101/01001 ,  C12Y101/01002 ,  C12Y101/01035 ,  C12Y101/01078 ,  C12Y101/01268 ,  C12Y101/01269 ,  C12Y102/01003 ,  C12Y102/01005 ,  C12Y102/01022 ,  C12Y102/01024 ,  C12Y102/01026 ,  C12Y102/01048 ,  C12Y102/01063 ,  C12Y102/07005 ,  C12Y102/99006 ,  C12Y103/01044 ,  C12Y103/01045 ,  C12Y103/01086 ,  C12Y104/01 ,  C12Y203/01001 ,  C12Y203/01032 ,  C12Y203/01035 ,  C12Y203/01057 ,  C12Y206/01008 ,  C12Y206/01009 ,  C12Y206/01036 ,  C12Y206/01043 ,  C12Y206/01048 ,  C12Y206/01076 ,  C12Y206/01082 ,  C12Y207/01031 ,  C12Y207/01165 ,  C12Y208/03 ,  C12Y301/03 ,  C12Y301/03002 ,  C12Y301/03008 ,  C12Y301/03019 ,  C12Y301/0302 ,  C12Y302/01 ,  C12Y401/01001 ,  C12Y401/02 ,  C12Y401/02014 ,  C12Y401/0202 ,  C12Y401/02021 ,  C12Y401/03016 ,  C12Y401/03017 ,  C12Y402/01002 ,  C12Y402/01003 ,  C12Y402/01028 ,  C12Y402/0103 ,  C12Y402/01079 ,  C12Y402/0112 ,  C12Y602/01 ,  Y02E50/30

摘要： Provided herein are methods, compositions, and non-naturally occurring microbial organism for preparing compounds such as1-butanol, butyric acid, succinic acid, 1,4-butanediol, 1-pentanol, pentanoic acid, glutaric acid, 1,5-pentanediol, 1-hexanol, hexanoic acid, adipic acid, 1,6-hexanediol, 6-hydroxy hexanoic acid, ε-Caprolactone, 6-amino-hexanoic acid, ε-Caprolactam, hexamethylenediamine, linear fatty acids and linear fatty alcohols that are between 7-25 carbons long, linear alkanes and linear α-alkenes that are between 6-24 carbons long, sebacic acid and dodecanedioic acid comprising: a) converting a CN aldehyde and pyruvate to a CN+3 β-hydroxyketone intermediate through an aldol addition; and b) converting the CN+3 β-hydroxyketone intermediate to the compounds through enzymatic steps, or a combination of enzymatic and chemical steps.

公开(公告)号：US20240309405A1

公开(公告)日：2024-09-19

申请号：US18339397

申请日：2023-06-22

申请人： Genomatica, Inc.

发明人： Andreas W. SCHIRMER ,  Risha Lindig Bond ,  Erin Frances Perry

IPC分类号： C12P7/18 ,  C07C68/00 ,  C07C69/22 ,  C07C69/30 ,  C12N15/52

CPC分类号： C12P7/18 ,  C07C68/00 ,  C07C69/22 ,  C07C69/30 ,  C12N15/52

摘要： The disclosure relates to the field of specialty chemicals and methods for their synthesis. In embodiments, the disclosure provides novel multifunctional fatty acid derivative molecules such as e.g., fatty triols, fatty tetrols, dihydroxy fatty acids, etc. The disclosure further provides derivatives of the disclosed multifunctional molecules which are useful e.g., in the production of personal care products, surfactants, detergents, polymers, paints, coatings, and as emulsifiers, emollients, and thickeners in cosmetics and foods, as industrial solvents and plasticizers, etc. The disclosure further provides biochemical pathways, recombinant microorganisms and methods for the biological production of various multifuctional fatty acid derivatives.

公开(公告)号：US20240229052A1

公开(公告)日：2024-07-11

申请号：US18558872

申请日：2022-05-06

申请人： David BECKER ,  Canisius University

发明人： David W. Becker ,  Robert J. Grebenok

IPC分类号： C12N15/82 ,  A01G7/06 ,  C12N9/04 ,  C12P7/18

CPC分类号： C12N15/8241 ,  A01G7/06 ,  C12N9/0006 ,  C12P7/18 ,  C12Y101/03006

摘要： Disclosed herein are methods for decreasing plant generation time and increasing certain characteristics of plants including starch accumulation, root biomass, leaf biomass, stem biomass, and seed biomass. The description also includes methods for growing plants with less light increasing and/or shifting the latitude range of a plant so that the plant can be grown at higher latitudes. The improved plants can be used as food, or feedstock for making chemicals such as biofuels.

公开(公告)号：US12031171B2

公开(公告)日：2024-07-09

申请号：US16329910

申请日：2017-09-05

申请人： PURAC BIOCHEM BV

发明人： Roel Otto ,  Aldana Mariel Ramirez ,  Jenny Eelderink

IPC分类号： C12P7/44 ,  C12N1/16 ,  C12N1/20 ,  C12P7/06 ,  C12P7/16 ,  C12P7/18 ,  C12P7/52 ,  C12P7/56

CPC分类号： C12P7/44 ,  C12N1/16 ,  C12N1/20 ,  C12P7/06 ,  C12P7/16 ,  C12P7/18 ,  C12P7/52 ,  C12P7/56

摘要： An antibacterial agent suppresses the growth of gram-positive contaminating bacteria. The antibacterial agent is selected from: a lactylate in accordance with the general formula (R—(O—CH(CH3)—CO)aO)bM; a glycerol ester in accordance with the general formula CH2OR1—CHOR2—CH2OR3; and, mixtures thereof. In the general formulae: R represents a C4-C18 acyl group, R1, R2 and R3 are each independently selected from H or a C4-C18 acyl group, the acyl group having an alkyl or alkenyl chain which may be branched or unbranched, with the proviso that at least one of R1, R2 or R3 is H and at least one of R1, R2, or R3 is an acyl group; M represents a proton (H+) or a counter-cation chosen from the group Li, Na, K, Ca, Mg, Zn, Fe(II), Cu, Mn, Ag, ammonium or substituted ammonium having one or more (C1-4)alkyl optionally substituted with one or more hydroxyl.

公开(公告)号：US20240052378A1

公开(公告)日：2024-02-15

申请号：US18256012

申请日：2021-12-06

申请人： COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH

发明人： Diptarka DASGUPTA ,  Asmita Ashutosh PRABHUNE ,  Snehal Vijay MORE ,  Debashish GHOSH ,  Bhaskar THALLADA ,  Anjan RAY ,  Arushdeep SIDANA

IPC分类号： C12P7/18

CPC分类号： C12P7/18 ,  C12P2203/00

摘要： The present invention realtes to a process for the detoxification and concentration of xylose rich biomass derived liquid hydrolysate and its application as a substrate for the synthesis of crystalline and pure xylitol.

公开(公告)号：US11898188B2

公开(公告)日：2024-02-13

申请号：US16962213

申请日：2019-01-15

申请人： KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY ,  HANWHA SOLUTIONS CORPORATION

发明人： Sang Yup Lee ,  Jae Sung Cho ,  Je Woong Kim ,  Yoo Sung Ko ,  Cindy Pricilia Surya Prabowo ,  Taehee Han ,  Euiduk Kim ,  Jae Won Choi ,  Changhee Cho ,  Jun Kyu Lee

IPC分类号： C12P7/18 ,  C12N9/04 ,  C12N9/12 ,  C12N9/88 ,  C12N15/77 ,  C12N1/21

CPC分类号： C12P7/18 ,  C12N9/0006 ,  C12N9/1205 ,  C12N9/88 ,  C12N15/77 ,  C12Y101/01006 ,  C12Y101/01202 ,  C12Y207/0103 ,  C12Y402/0103

摘要： The present disclosure relates to a mutant microorganism in which a glycerol catabolic pathway and a 1,3-PDO biosynthetic pathway are introduced into a microorganism incapable of using glycerol as a carbon source, and a method of producing 1,3-PDO using the same. According to the present disclosure, it is possible to produce 1,3-PDO while growing a mutant microorganism having 1,3-PDO production ability by using the inexpensive raw material glycerol as a single carbon source. Thus, the present disclosure is useful for the economical production of 1,3-PDO.

公开(公告)号：US20240018527A1

公开(公告)日：2024-01-18

申请号：US18457299

申请日：2023-08-28

申请人： LanzaTech, Inc.

发明人： Fungmin Liew ,  Michael Koepke

IPC分类号： C12N15/52 ,  C12N15/74 ,  C12P7/42 ,  C12P7/18 ,  C12N9/00 ,  C12N9/02 ,  C12N9/04 ,  C12N9/10

CPC分类号： C12N15/52 ,  C12N15/74 ,  C12P7/42 ,  C12P7/18 ,  C12N9/93 ,  C12N9/0008 ,  C12N9/0006 ,  C12N9/1096 ,  C12Y101/01001 ,  C12Y604/01002 ,  C12Y206/01018 ,  C12Y102/01075 ,  C12Y102/07005

摘要： Microorganisms are genetically engineered to produce 3-hydroxypropionate (3-HP). The microorganisms are carboxydotrophic acetogens. The microorganisms produce acetyl-coA using the Wood-Ljungdahl pathway for fixing CO/CO2. A β-alanine pyruvate aminotransferase from a microorganism that contains such an enzyme is introduced. Additionally, an acetyl-coA carboxylase may also be introduced. The production of 3-HP can be improved. This can be effected by improved promoters or higher copy number or enzymes that are catalytically more efficient.

公开(公告)号：US20230407242A1

公开(公告)日：2023-12-21

申请号：US18146506

申请日：2022-12-27

申请人： Hubei University

发明人： Shihui YANG ,  Qiaoning HE ,  Yang LI

IPC分类号： C12N1/20 ,  C12P7/06 ,  C12P7/18

CPC分类号： C12N1/205 ,  C12P7/06 ,  C12P7/18 ,  C12R2001/01

摘要： The disclosure relates to a genetically engineered Z. mobilis ZM4 for producing PHB and uses thereof. A variety of strains capable of producing both PHB and ethanol that are constructed by integrating three codon-optimized essential genes for exogenous PUB biosynthesis, phaA, phaB and phaC, together with a tetracycline-inducible promoter Ptet into the genome of ZM4.

公开(公告)号：US20230348886A1

公开(公告)日：2023-11-02

申请号：US18310636

申请日：2023-05-02

申请人： LanzaTech, Inc.

发明人： Ching Leang

IPC分类号： C12N9/88 ,  C12N9/10 ,  C12P7/6409 ,  C12P7/30 ,  C12P7/04 ,  C12P5/02 ,  C12P7/42 ,  C12P7/26 ,  C12P5/00 ,  C12P7/18

CPC分类号： C12N9/88 ,  C12Y401/01005 ,  C12N9/1029 ,  C12N9/13 ,  C12Y208/03 ,  C12Y401/01001 ,  C12P7/6409 ,  C12P7/30 ,  C12P7/04 ,  C12P5/026 ,  C12P7/42 ,  C12P7/26 ,  C12P5/007 ,  C12P7/18

摘要： Provided herein is a genetically engineered microorganism comprising knock-in of DNA at an acetolactate decarboxylase gene locus. Replacement of the acetolactate decarboxylase gene with DNA encoding one or more native or nonnative enzymes confers certain advantages, including fermentation stability and increased production of native and nonnative products from gaseous substrates.