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    DEVICES, METHODS AND KITS FOR BIOLOGICAL SAMPLE CAPTURE AND PROCESSING
    2.
    发明公开
    DEVICES, METHODS AND KITS FOR BIOLOGICAL SAMPLE CAPTURE AND PROCESSING 审中-公开

    公开(公告)号：US20240301491A1

    公开(公告)日：2024-09-12

    申请号：US18180400

    申请日：2023-03-08

    申请人： VosBio, Inc.

    发明人： Douglas T. GJERDE ,  Daniel Robert BOLLINGER

    IPC分类号： C12Q1/6881 ,  A61B5/097 ,  C12Q1/6844

    CPC分类号： C12Q1/6881 ,  A61B5/097 ,  C12Q1/6844

    摘要： Breath liquid particles and vapor are captured in a device presenting a surface and chamber space that condenses or freezes the vapor and aerosol particulates. One or more breaths are exhaled through the device. Capture can be performed on the freezing surface immobilizing water upon contact. The chamber space within the device may freeze or condense liquid breath particles and vapor to collect them. After collection, the liquid is gathered and collected either by draining, scraping, pushing, or centrifugal force. The liquid may be collected and combined with a sample preparation reagent such as a virus lysing reagent, an internal standard, etc. After collection, the sample is separated into a plurality of independently analyzable units for detection and quantification of a target. Analysis may be performed by PCR, qPCR RT-PCR, RT-qPCR, LAMP, RPA or any nucleic acid detection method, lateral antigen mass spectrometry, spectrophotometry or any analytical tool or method. Nucleic acid amplification reagents may contain a lysing reagent such as acetonitrile.

    USE OF GENETIC AND EPIGENETIC MARKERS TO DETECT CELL DEATH
    5.
    发明公开
    USE OF GENETIC AND EPIGENETIC MARKERS TO DETECT CELL DEATH 审中-公开

    公开(公告)号：US20240279720A1

    公开(公告)日：2024-08-22

    申请号：US18291091

    申请日：2022-07-25

    申请人： Georgetown University

    发明人： Anton Wellstein ,  Megan E. McNamara ,  Alexander H.K. Kroemer

    IPC分类号： C12Q1/6827 ,  A61K45/06 ,  C12Q1/6881

    CPC分类号： C12Q1/6827 ,  A61K45/06 ,  C12Q1/6881 ,  C12Q2600/154 ,  C12Q2600/156

    摘要： A method of detecting donor cell death in a subject receiving foreign biological material from a donor. The method comprises sequencing cfDNA in a biospecimen from the subject; determining cellular origin of the cfDNA by identifying methylation patterns in the sequence of the cfDNA and comparing the methylation patterns in the sequence of the cfDNA to known methylation patterns associated with different cell types; and determining source origin of the cfDNA by genotyping the cfDNA and identifying whether the cfDNA originates from the foreign biological material or from the subject. Cell death is detected when the cfDNA has both a cellular origin of the type of foreign biological material that was received from the donor, and a source origin of the donor.