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    SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION
    15.
    发明申请
    SUBSTITUTED THIAZOLES FOR THE TREATMENT OF INFLAMMATION 审中-公开
    用于治疗炎症的替代治疗的THIAZOLES

    公开(公告)号：WO1996003392A1

    公开(公告)日：1996-02-08

    申请号：PCT/US1995009444

    申请日：1995-07-26

    Applicant: G.D. SEARLE & CO. ,  TALLEY, John, J. ,  CARTER, Jeffery, S. ,  COLLINS, Paul, W. ,  KRAMER, Steven, W. ,  PENNING, Thomas, D. ,  ROGIER, Donald, J., Jr. ,  ROGERS, Roland, S.

    Inventor： G.D. SEARLE & CO.

    IPC: C07D277/26

    CPC classification number: C07D417/04 ,  C07D277/26 ,  C07D277/30 ,  C07D277/42 ,  C07D277/56 ,  C07D417/12

    Abstract: A class of substituted thiazolyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula (II), wherein R is selected from alkyl and amino, wherein R is selected from aryl, cycloalkyl, cycloalkenyl and heterocyclic; wherein R is optionally substituted at a substitutable position with one or more radicals selected from halo, alkylthio, alkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, aminosulfonyl, alkyl, alkenyl, alkynyl, cyano, carboxyl, carboxyalkyl, alkoxycarbonyl, aminocarbonyl, acyl, N-alkylaminocarbonyl, N-arylaminocarbonyl, N,N-dialkylaminocarbonyl, N-alkyl-N-arylaminocarbonyl, haloalkyl, hydroxyl, alkoxy, hydroxyalkyl, haloalkoxy, amino, N-alkylamino, N,N-dialkylamino, heterocyclic and nitro; and wherein R is selected from halo, amino, alkoxy, nitro, hydroxyl, aminocarbonyl, acyl, alkylaminocarbonyl, arylaminocarbonyl, alkenyl, alkynyl, haloalkoxy, alkylamino, arylamino, aralkylamino, alkoxycarbonylalkyl, alkylaminoalkyl, heterocycloalkyl, aralkyl, cyanoalkyl, N-alkylsulfonylamino, heteroarylsulfonylalkyl, heteroarylsulfonylhaloalkyl, aryloxyalkyl, aralkyloxyalkyl, aryl and heterocyclo, wherein the aryl and heterocyclo radicals are optionally substituted at a substitutable position with one or more radicals selected from halo, alkyl, alkoxy, alkylthio, alkylsulfinyl, haloalkyl, haloalkoxy, carboxyalkyl, alkoxycarbonyl, aminocarbonyl, amino, acyl and alkylamino; or a pharmaceutically-acceptable salt thereof.

    Abstract translation: 描述了一类用于治疗炎症和炎症相关疾病的取代的噻唑基化合物。 特别感兴趣的化合物由式（II）定义，其中R 4选自烷基和氨基，其中R 5选自芳基，环烷基，环烯基和杂环; 其中R 5任选在可取代的位置被一个或多个选自卤素，烷硫基，烷基亚磺酰基，烷基磺酰基，卤代烷基磺酰基，氨基磺酰基，烷基，烯基，炔基，氰基，羧基，羧基烷基，烷氧基羰基，氨基羰基，酰基，N 烷基氨基羰基，N-芳基氨基羰基，N，N-二烷基氨基羰基，N-烷基-N-芳基氨基羰基，卤代烷基，羟基，烷氧基，羟基烷基，卤代烷氧基，氨基，N-烷基氨基，N，N-二烷基氨基，杂环和硝基。 其中R 6选自卤素，氨基，烷氧基，硝基，羟基，氨基羰基，酰基，烷基氨基羰基，芳基氨基羰基，烯基，炔基，卤代烷氧基，烷基氨基，芳基氨基，芳烷基氨基，烷氧基羰基烷基，烷基氨基烷基，杂环烷基，芳烷基，氰基烷基，N - 烷基磺酰基氨基，杂芳基磺酰基烷基，杂芳基磺酰基卤代烷基，芳氧基烷基，芳烷氧基烷基，芳基和杂环，其中芳基和杂环基任选在可取代位置与一个或多个选自卤素，烷基，烷氧基，烷硫基，烷基亚磺酰基，卤代烷基，卤代烷氧基， ，烷氧基羰基，氨基羰基，氨基，酰基和烷基氨基; 或其药学上可接受的盐。

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