公开(公告)号：WO2006022920A1

公开(公告)日：2006-03-02

申请号：PCT/US2005/015693

申请日：2005-05-04

Applicant: SURMODICS, INC. ,  TATON, Kristin, S. ,  GUIRE, Patrick, E.

Inventor： TATON, Kristin, S. ,  GUIRE, Patrick, E.

IPC: C09D201/06

CPC classification number: A61L31/14 ,  A61L31/10 ,  C08F220/54 ,  C08F220/60 ,  C08F226/10 ,  C08L2312/00 ,  C09D133/26 ,  C08L77/10

Abstract: A thermally-reactive polymer that forms a polymer-coupled reactive species upon heating is described and useful for forming coated surfaces. The polymer-coated surface has improved lubricity and passivity. A thermally-reactive quaternary amine-containing polymer was produced that provides passivity and anti-microbial activity.

Abstract translation: 描述了在加热时形成聚合物偶联反应性物质的热反应性聚合物，并且可用于形成涂覆表面。 聚合物涂覆的表面具有改善的润滑性和被动性。 制备了一种提供无源和抗微生物活性的热反应性含季胺的聚合物。

公开(公告)号：WO2006002399A2

公开(公告)日：2006-01-05

申请号：PCT/US2005022582

申请日：2005-06-24

Applicant: SURMODICS INC ,  GUIRE PATRICK E ,  TATON KRISTIN S ,  WEN JIE ,  DE WITT DAVID M ,  HERGENROTHER BOB ,  ANDERSON ARON B

Inventor： GUIRE PATRICK E ,  TATON KRISTIN S ,  WEN JIE ,  DE WITT DAVID M ,  HERGENROTHER BOB ,  ANDERSON ARON B

IPC: A61L31/06

CPC classification number: A61L31/06 ,  A61L31/148 ,  C08L67/025 ,  C08L71/02

Abstract: The invention provides implantable intraluminal medical devices that are fabricated of biodegradable materials. The invention further provides methods of treatment utilizing the devices.

Abstract translation: 本发明提供了由生物可降解材料制成的可植入腔内医疗装置。 本发明进一步提供了利用这些装置的治疗方法。

公开(公告)号：WO2004098565A2

公开(公告)日：2004-11-18

申请号：PCT/US2004/013327

申请日：2004-04-29

Applicant: SURMODICS, INC. ,  ANDERSON, Aron, B. ,  LAWIN, Laurie, R. ,  SHEN, Byron, C. ,  DE JUAN, Eugene ,  VARNER, Signe, E. ,  CHAPPA, Ralph, A.

Inventor： ANDERSON, Aron, B. ,  LAWIN, Laurie, R. ,  SHEN, Byron, C. ,  DE JUAN, Eugene ,  VARNER, Signe, E. ,  CHAPPA, Ralph, A.

IPC: A61K9/00

CPC classification number: A61K31/58 ,  A61F2310/00353 ,  A61K9/0051

Abstract: The invention provides a controlled release bioactive agent delivery device that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent, wherein the first polymer comprises polyalkyl(meth)acrylate, aromatic poly(meth)acrylate, or a combination of polyalkyl(meth)acrylate and aromatic poly(meth)acrylate, and wherein the second polymer comprises poly(ethylene-co-vinyl acetate). The invention also provides methods of delivering a bioactive agent to a patient in a controlled release manner, as well as methods of making a controlled release bioactive agent delivery device.

Abstract translation: 本发明提供一种控制释放的生物活性剂递送装置，其包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中，身体构件的至少一部分偏离 所述聚合物涂覆组合物包括第一聚合物，第二聚合物和生物活性剂，其中所述第一聚合物包含（甲基）丙烯酸烷基酯，（甲基）丙烯酸烷基酯，芳族聚（甲基）丙烯酸酯， ）丙烯酸酯或聚（甲基）丙烯酸烷基酯和芳族聚（甲基）丙烯酸酯的组合，其中第二聚合物包括聚（乙烯 - 共 - 乙酸乙烯酯）。 本发明还提供了以受控释放方式将生物活性剂递送到患者的方法，以及制备受控释放的生物活性剂递送装置的方法。

公开(公告)号：WO2004093846A2

公开(公告)日：2004-11-04

申请号：PCT/US2004/007809

申请日：2004-03-12

Applicant: SURMODICS, INC. ,  CHUDZIK, Stephen, J. ,  OFSTEAD, Ronald, F. ,  SWAN, Dale, G.

Inventor： CHUDZIK, Stephen, J. ,  OFSTEAD, Ronald, F. ,  SWAN, Dale, G.

IPC: A61K9/00

CPC classification number: C12N11/08 ,  A61K2035/126

Abstract: Positively-charged initiator polymers having a polymerization initiator group and a cationic portion are provided. The initiator polymers can be used with a polymerizable material for the formation of a polymeric matrix on a surface. The initiator polymers are particularly useful for cell encapsulation using macromers.

公开(公告)号：WO2004093845A3

公开(公告)日：2004-11-04

申请号：PCT/US2004/007458

申请日：2004-03-11

Applicant: SURMODICS, INC. ,  CHUDZIK, Stephen, J. ,  SWAN, Dale, G.

Inventor： CHUDZIK, Stephen, J. ,  SWAN, Dale, G.

IPC: C12N11/08

Abstract: Initiator polymers having an initiator group and a ligand group are provided. The initiator polymers are capable of specifically binding to a receptor on a surface. Using a macromer system, the initiator polymers are useful for the formation of a polymeric matrix on the surface of a material. In particular, initiator polymers are provided that have specificity to pancreatic β cells and can be used to encapsulate cells for transplantation and the treatment of diabetes.

公开(公告)号：WO2004052420A2

公开(公告)日：2004-06-24

申请号：PCT/US2003/038788

申请日：2003-12-05

Applicant: SURMODICS, INC. ,  LAWIN, Laurie, R. ,  BOUCHA-RAYLE, Michelle, C. ,  KLOKE, Timothy, M.

Inventor： LAWIN, Laurie, R. ,  BOUCHA-RAYLE, Michelle, C. ,  KLOKE, Timothy, M.

IPC: A61L31/00

CPC classification number: A61L31/16 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/606

Abstract: A barrier adapted to be positioned between a first surface provided in the form of a polymeric, bioactive agent-containing coating upon a medical device, and a second surface provided by another material positioned in apposition, and preferably moveable apposition, to the first surface. The barrier, as provided by block copolymers or photoderivatized polymers, provides protection to the polymeric composition from mechanical damage and/or delamination during fabrication, storage, delivery or deployment, and/or residence of the device within the body. A combination that includes a medical device, such as a stent, and another device, such as a surrounding sheath or internal expandable balloon, between which is positioned a barrier of the type described.

Abstract translation: 适于定位在以医疗装置的聚合物，含生物活性剂的涂层形式提供的第一表面之间的屏障，以及由位于第一表面上并且优选地可移动地配置的另一材料提供的第二表面。 通过嵌段共聚物或光衍生化聚合物提供的屏障为聚合物组合物在制造，储存，递送或部署过程中的机械损伤和/或分层提供了保护，并且/或者该装置在体内的停留。 包括诸如支架的医疗装置和诸如周围护套或内部可膨胀气囊的另一装置的组合，其间位于所述类型的屏障之间。

公开(公告)号：WO2004028699A3

公开(公告)日：2004-05-27

申请号：PCT/US0322632

申请日：2003-07-17

Applicant: SURMODICS INC ,  CHAPPA RALPH A ,  CARLSON MARK F

Inventor： CHAPPA RALPH A ,  CARLSON MARK F

IPC: B05B13/02 ,  B05B13/04

CPC classification number: B05B7/0807 ,  B05B7/0861 ,  B05B7/0869 ,  B05B13/0207 ,  B05B13/0228 ,  B05B13/0436 ,  B05B13/0442 ,  B05D1/002 ,  B05D1/02

Abstract: A coating apparatus for coating a rollable device including a device rotator having a pair of rollers and spray nozzle is described. The spray nozzle produces a spray of coating material that is directed towards a gap that is between the rollers of the pair. The majority of any spray not deposited on the rollable device during a coating process passes through the gap between the rollers.

Abstract translation: 描述了一种用于涂覆可卷绕装置的涂覆装置，其包括具有一对辊和喷嘴的装置旋转体。 喷嘴产生喷涂的涂料，该喷涂材料指向一对间的间隙。 在涂布过程中，大部分没有沉积在可滚动装置上的喷雾通过辊之间的间隙。

公开(公告)号：WO0210450A3

公开(公告)日：2003-07-31

申请号：PCT/US0121607

申请日：2001-07-09

Applicant: SURMODICS INC

Inventor： GUIRE PATRICK E ,  SWANSON MELVIN J

IPC: G01N33/53 ,  B01J19/00 ,  C12N15/09 ,  C12Q1/68 ,  C40B40/06 ,  C40B60/14 ,  G01N33/543 ,  G01N37/00

CPC classification number: B82Y30/00 ,  B01J19/0046 ,  B01J2219/00378 ,  B01J2219/00387 ,  B01J2219/00466 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00504 ,  B01J2219/00524 ,  B01J2219/00527 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00648 ,  B01J2219/00711 ,  B01J2219/00722 ,  B01J2219/00729 ,  C12Q1/6837 ,  C40B40/06 ,  C40B60/14 ,  C12Q2525/179 ,  C12Q2525/161 ,  C12Q2565/515

Abstract: A system for producing substantially identical specific binding ligand probe arrays, for instance, by preparing and replicating an original master array and/or by providing a reusable assay array that is capable of being regenerated. In one embodiment the system includes the preparation and use of a) a master array surface having address ligands immobilized thereon, b) a multi-ligand conjugate having a binding domain complementary to an address ligand, a binding domain complementary to a target ligand, and a third ligand for use in transferring the conjugates into or onto the surface of assay array, which can be used with or upon disassociation of the address and its complementary ligands.

Abstract translation: 用于制备基本上相同的特异性结合配体探针阵列的系统，例如通过制备和复制原始主阵列和/或通过提供能够再生的可重复使用的分析阵列。 在一个实施方案中，该系统包括a）具有固定在其上的地址配体的主阵列表面的制备和用途，b）具有与地址配体互补的结合结构域的多配体缀合物，与靶配体互补的结合结构域，以及 用于将缀合物转移到测定阵列表面中或其上的第三配体，其可以与解离地址及其互补配体一起使用或分离。

公开(公告)号：WO2003031979A1

公开(公告)日：2003-04-17

申请号：PCT/US2002/031740

申请日：2002-10-04

Applicant: SURMODICS, INC.

Inventor： GUIRE, Patrick, E. ,  TATON, Kristin, S. ,  WALL, John, V.

IPC: G01N33/543

CPC classification number: B82Y30/00 ,  B01J19/0046 ,  B01J2219/00466 ,  B01J2219/005 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00637 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00725 ,  B82Y5/00 ,  B82Y10/00 ,  C12Q1/6837 ,  G01N33/54366 ,  Y10S530/81 ,  Y10S530/811 ,  Y10S530/815 ,  Y10S530/816 ,  C12Q2563/149

Abstract: Arrays including microparticles having probe and marker moieties are used for the detection of a target in a sample. Microparticles are randomly immobilized on at least a portion of a substrate. A detection scheme is performed to detect the marker associated with the microparticle and the identity of the probe, and any target bound to the probe.

Abstract translation: 包括具有探针和标记物部分的微粒的阵列用于检测样品中的靶。 微粒随机固定在底物的至少一部分上。 执行检测方案以检测与微粒相关的标记和探针的身份以及与探针结合的任何靶标。

公开(公告)号：WO0213871A3

公开(公告)日：2002-05-30

申请号：PCT/US0141309

申请日：2001-07-09

Applicant: SURMODICS INC

Inventor： CHUDZIK STEPHEN J ,  EVERSON TERRENCE P ,  AMOS RICHARD A

IPC: A61B17/00 ,  A61F2/06 ,  A61F2/24 ,  A61L27/00 ,  A61L27/34 ,  A61L27/52 ,  A61L27/54 ,  A61L29/00 ,  A61L29/08 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61M1/02 ,  A61M1/36 ,  A61M5/14 ,  A61M25/00 ,  A61M37/00

CPC classification number: A61L31/145 ,  A61L27/34 ,  A61L27/52 ,  A61L27/54 ,  A61L29/085 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/22 ,  A61L2300/232 ,  A61L2300/252 ,  A61L2300/258 ,  A61L2300/404 ,  A61L2300/406 ,  A61L2300/606 ,  Y10S514/944 ,  C08L71/02

Abstract: A coating composition, in both its uncrosslinked and crosslinked forms, for use in delivering a medicament from the surface of a medical device positioned in vivo . Once crosslinked, the coating composition provides a gel matrix adapted to contain the medicament in a form that permits the medicament to be released from the matrix in a prolonged, controlled, predictable and effective manner in vivo . A composition includes a polyether monomer, such as an alkoxy poly(alkylene glycol), a carboxylic acid-containing monomer, such as (meth)acrylic acid, a photoderivatized monomer, and a hydrophilic monomer such as acrylamide.

Abstract translation: 未交联和交联形式的涂料组合物用于从位于体内的医疗装置的表面输送药物。 一旦交联，涂料组合物就提供了凝胶基质，该凝胶基质适合于以允许药物以延长，控制，可预测和有效的方式从体内释放的形式包含药物。 组合物包括聚醚单体如烷氧基聚（亚烷基二醇），含羧酸单体如（甲基）丙烯酸，光衍生单体和亲水单体如丙烯酰胺。