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    SULFONATED [8,9]BENZOPHENOXAZINE DYES AND THE USE OF THEIR LABELLED CONJUGATES
    41.
    发明申请
    SULFONATED [8,9]BENZOPHENOXAZINE DYES AND THE USE OF THEIR LABELLED CONJUGATES 审中-公开
    磺化[8,9]苯并噻唑染色体及其标记结合物的使用

    公开(公告)号：WO0183621A3

    公开(公告)日：2002-05-23

    申请号：PCT/US0114110

    申请日：2001-05-01

    申请人： APPLERA CORP

    发明人： YAN XIONGWEI ,  YUAN PAU MIAU

    IPC分类号： G01N33/53 ,  C07D265/38 ,  C07H21/00 ,  C09B19/00 ,  C09K11/06 ,  C12N15/09 ,  C12Q1/02 ,  C12Q1/68 ,  G01N21/78 ,  G01N33/533 ,  G01N33/542 ,  G01N33/566 ,  G01N33/58

    CPC分类号： C09B19/00 ,  G01N33/533 ,  G01N33/582

    摘要： Fluorescent, sulfonated 3,7-diamino-[8,9]benzophenoxazine dyes are provided that are especially useful for labelling biopolymers and other substrates. The dye-labelled conjugates can be used in a variety of contexts, including cell surface assays employing intact, live cells and in nucleic acid detection methods. The new dyes are water soluble and can be conjugated to a variety of substrates, such as polynucleotides, nucleosides, nucleotides, peptides, proteins, antibodies, carbohydrates, ligands, particles and surfaces.

    摘要翻译： 提供荧光，磺化的3,7-二氨基 - [8,9]苯并吩恶嗪染料，其特别可用于标记生物聚合物和其它底物。 染料标记的缀合物可以用于各种情况，包括使用完整的活细胞和核酸检测方法的细胞表面测定。 新染料是水溶性的并且可以与各种底物缀合，例如多核苷酸，核苷，核苷酸，肽，蛋白质，抗体，碳水化合物，配体，颗粒和表面。

    SACCHARIDE SENSING MOLECULES HAVING ENHANCED FLUORESCENT PROPERTIES
    43.
    发明申请
    SACCHARIDE SENSING MOLECULES HAVING ENHANCED FLUORESCENT PROPERTIES 审中-公开
    具有增强的荧光性质的糖敏感性分子

    公开(公告)号：WO0174968A2

    公开(公告)日：2001-10-11

    申请号：PCT/US0110541

    申请日：2001-03-30

    申请人： UNIV CALIFORNIA ,  MINIMED INC

    发明人： SATCHER JOE H JR ,  LANE STEPHEN M ,  DARROW CHRISTOPHER B ,  CARY DOUGLAS R ,  TRAN JOE ANH

    IPC分类号： C07F5/02 ,  C09B19/00 ,  C09B57/08 ,  C09B57/10 ,  C09K11/00

    CPC分类号： C07F5/025 ,  C09B19/00 ,  C09B57/08 ,  C09B57/10

    摘要： The present invention provides formulae for fluorescent compounds that have a number of properties which make them uniquely suited for use in sensors of analytes such as saccharides. The advantageous fluorescent properties include favorable excitation wavelengths, emission wavelengths, fluorescence lifetimes, and photostability. Additional advantageous properties include enhanced aqueous solubility, as well as temperature and pH sensitivity. The compound comprises an aryl or a substituted phenyl boronic acid that acts as a substrate recognition component, a fluorescent switch component, and a fluorophore. Fluorescent compounds are described that are excited at wavelengths greater than 400 nm and emit at wavelengths greater than 450 nm, which is advantageous for optical transmission through skin. The fluorophore is typically selected from transition metal-ligand complexes and thiazone, oxazine, oxazone, or oxazine-one as well as anthracene compounds. The fluorescent compound can be immobilized in a glucose permeable biocompatible polymer matrix that is implantable below the skin.

    摘要翻译： 本发明提供了具有多种性质的荧光化合物的配方，这些性质使得它们特别适用于分析物如糖类的传感器。 有利的荧光性质包括有利的激发波长，发射波长，荧光寿命和光稳定性。 其它有利的性质包括增强的水溶性以及温度和pH敏感性。 该化合物包含充当底物识别组分，荧光开关组分和荧光团的芳基或取代的苯基硼酸。 描述了在大于400nm的波长处被激发并在大于450nm的波长处发射的荧光化合物，这对于透过皮肤的光学透射是有利的。 荧光团通常选自过渡金属 - 配体络合物和噻唑，恶嗪，恶嗪酮或恶嗪 - 酮以及蒽化合物。 荧光化合物可以固定在可植入皮肤下的葡萄糖渗透性生物相容性聚合物基质中。