公开(公告)号：WO03050290A2

公开(公告)日：2003-06-19

申请号：PCT/US0225049

申请日：2002-08-07

Applicant: UNIV TEXAS

Inventor： GORENSTEIN DAVID NMI ,  LUXON BRUCE A ,  HERZOG NORBERT NMI ,  YANG XIAN BIN

IPC: C12Q1/68 ,  C40B40/06 ,  C40B60/14 ,  G01N33/53 ,  G01N33/543 ,  G01N33/68 ,  C12Q

CPC classification number: C12N15/1048 ,  B01J2219/00378 ,  B01J2219/00387 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00529 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00707 ,  B01J2219/00722 ,  C07B2200/11 ,  C12N15/115 ,  C12N2310/16 ,  C12N2310/313 ,  C12N2310/315 ,  C12N2320/10 ,  C12Q1/6811 ,  C40B20/04 ,  C40B40/06 ,  C40B40/08 ,  C40B60/14 ,  G01N33/6803 ,  G01N33/6851 ,  C12Q2541/101 ,  C12Q2525/113

Abstract: An apparatus and method for monitoring biological interactions is disclosed. The apparatus includes a substrate, a modified nucleotide aptamer attached to the substrate, a target molecule or portion thereof, wherein the interaction between the modified nucleotide aptamer and the target molecule or portion thereof is detected.

Abstract translation: 公开了用于监测生物相互作用的装置和方法。 该装置包括底物，与底物连接的修饰的核苷酸适体，靶分子或其部分，其中检测到修饰的核苷酸适体与靶分子或其部分之间的相互作用。

公开(公告)号：WO02081076A3

公开(公告)日：2003-04-24

申请号：PCT/US0210935

申请日：2002-04-04

Applicant: SYMYX TECHNOLOGIES INC

Inventor： WHEELER TONY H ,  VAN ERDEN LYNN ,  CHANDLER WILLIAM H JR ,  TIEDE RICHARD ,  SAXTON ROBERT J ,  GURAM ANIL

IPC: B01J19/00 ,  C40B60/14 ,  F28F27/00

CPC classification number: F28F27/00 ,  B01J19/0046 ,  B01J2219/00155 ,  B01J2219/00283 ,  B01J2219/00308 ,  B01J2219/00351 ,  B01J2219/00477 ,  B01J2219/00481 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00698 ,  B01J2219/00718 ,  C40B60/14 ,  Y10T436/11 ,  Y10T436/142222

Abstract: A combinatorial chemistry reactor system for the parallel processing of reaction mixtures. The system comprises a frame, a head mounted in fixed position on the frame, and a reactor block having a plurality of wells therein for containing reaction mixtures. The reactor block is movable with respect to the head between a first position in which the reactor block and head are assembled for conducting reactions in the wells and a second position in which the reactor block is removed from the head for providing access to the vessels. Gaps in the reactor block between the wells serve to thermally isolate the wells from one another. Other features relating to pressure relief, reactor block temperature control, and sensor mounting are also disclosed.

Abstract translation: 用于并行处理反应混合物的组合化学反应器系统。 该系统包括框架，安装在框架上的固定位置的头部和反应器块，其中具有用于容纳反应混合物的多个孔。 反应器模块可相对于头部在第一位置和第二位置之间相对于第一位置移动，在第一位置，反应器块和头组装在其中以在井中进行反应，而在第二位置，反应器块从头部移除以提供对容器的通路。 两个井之间的反应器块中的间隙用于将孔彼此热隔离。 还公开了与减压，反应堆块温度控制和传感器安装相关的其它特征。

公开(公告)号：WO03026797A2

公开(公告)日：2003-04-03

申请号：PCT/EP0210280

申请日：2002-09-13

Applicant: SOLVIAS AG ,  BLATTER FRITZ ,  CRON-ECKHARDT BRIGITTE ,  HOFMEIER URS CHRISTOPH ,  KOLLER PETER ,  MARCOLLI CLAUDIA ,  SZELAGIEWICZ MARTIN

Inventor： BLATTER FRITZ ,  CRON-ECKHARDT BRIGITTE ,  HOFMEIER URS CHRISTOPH ,  KOLLER PETER ,  MARCOLLI CLAUDIA ,  SZELAGIEWICZ MARTIN

IPC: B01L3/00 ,  B01L99/00 ,  C40B60/14 ,  G01N1/40 ,  G01N21/11 ,  G01N21/25 ,  G01N21/65

CPC classification number: G01N21/253 ,  B01J2219/00274 ,  B01J2219/00283 ,  B01J2219/00315 ,  B01J2219/00335 ,  B01J2219/00389 ,  B01J2219/00484 ,  B01J2219/00585 ,  B01J2219/00659 ,  B01J2219/00756 ,  B01L3/0293 ,  B01L3/5025 ,  B01L3/50853 ,  B01L2300/046 ,  B01L2300/0829 ,  B01L2400/0487 ,  C40B60/14 ,  G01N1/40 ,  G01N21/11 ,  G01N2001/4027 ,  G01N2021/651

Abstract: Device consisting of a support (1) and at least two seals (2), which are arranged in a row and are hermetically fitted into cavities, and protrude from the support laterally with respect to inlet and outlet openings, one end of the support being provided with an inlet opening (3) and one end being provided with an outlet opening (4), and the seals being provided with a least one inlet opening and one outlet opening, and the support containing at least one first channel (5) which starts at the inlet opening (3) and is continuous, and is arranged in such a way that it opens into the inlet openings in the side walls of the seals arranged in a row, and one second channel (6) which starts at the outlet opening and is continuous, and is arranged in such a way that it opens into the outlet openings in the side walls of the seals arranged in a row. The system is suitable for simultaneous multiple studies, in particular with the use of microtitration plates, and physical measurements of the results directly in the containers, for example of a microtitration plate. The multiple studies may be used to perform screening processes to discover and develop polymorphic and pseudopolymorphic forms, new formulations and suitable crystallisation conditions.

Abstract translation: 装置由一个支承件（1）和至少两个密封件（2）组成，它们排列成一排并密封配合到空腔中，并且相对于入口和出口横向地从支承件伸出，支承件的一端是 设置有入口开口（3）并且一端设有出口开口（4），并且所述密封件设置有至少一个入口开口和一个出口开口，并且所述支撑件包含至少一个第一通道（5），所述第一通道 从入口开口（3）开始并且是连续的，并且以这样的方式布置，使得其通向排成一排的密封件的侧壁中的入口开口和一个第二通道（6），该第二通道在出口 开口并且是连续的，并且以这样的方式布置，即它通向排成一排的密封件的侧壁中的出口开口。 该系统适用于同时进行多项研究，特别是使用微量滴定板，并直接在容器中对结果进行物理测量，例如微量滴定板。 多项研究可用于进行筛选过程以发现和开发多晶型和假多晶型形式，新制剂和合适的结晶条件。

公开(公告)号：WO02092221A8

公开(公告)日：2003-03-13

申请号：PCT/EP0205323

申请日：2002-05-13

Applicant: AVANTIUM INT BV ,  VAN DEN BRINK PETER JOHN ,  BRACHT MAARTEN

Inventor： VAN DEN BRINK PETER JOHN ,  BRACHT MAARTEN

IPC: B01J8/00 ,  B01J8/02 ,  B01J19/00 ,  B01L3/00 ,  C40B30/08 ,  C40B40/18 ,  C40B60/14 ,  G01N31/10

CPC classification number: B01L3/5025 ,  B01J8/0085 ,  B01J8/0285 ,  B01J19/0046 ,  B01J19/0093 ,  B01J2219/00286 ,  B01J2219/00308 ,  B01J2219/00423 ,  B01J2219/00479 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00587 ,  B01J2219/00704 ,  B01J2219/00745 ,  B01J2219/00747 ,  B01J2219/00835 ,  B01J2219/00844 ,  B01J2219/00873 ,  B01L2300/04 ,  B01L2300/18 ,  C40B30/08 ,  C40B40/18 ,  C40B60/14 ,  G01N31/10

Abstract: The system comprises a flow through reaction vessel having an inlet, an outlet and a reaction zone intermediate said inlet and outlet. The system further comprises reagent feed means for introducing one or more reagents into said vessel, said one or more reagents forming one or more reaction products in said reaction zone. Said reagent feed means at least include a liquid feed means for introducing a liquid into said inlet of said vessel. The vessel has a liquid evaporation zone intermediate said inlet and said reaction zone. Said liquid evaporation zone comprises an evaporation structure contacting said liquid and providing a liquid residence time in said liquid evaporation zone improving evaporation of said liquid.

Abstract translation: 该系统包括流过反应容器，其具有在入口和出口之间的入口，出口和反应区。 该系统还包括用于将一种或多种试剂引入所述​​容器的试剂进料装置，所述一种或多种试剂在所述反应区中形成一种或多种反应产物。 所述试剂进料装置至少包括用于将液体引入所述容器的所述入口的液体进料装置。 容器在所述入口和所述反应区之间具有液体蒸发区。 所述液体蒸发区包括与所述液体接触的蒸发结构，并在所述液体蒸发区中提供液体停留时间，从而改善所述液体的蒸发。

公开(公告)号：WO02064812A3

公开(公告)日：2003-02-27

申请号：PCT/US0145446

申请日：2001-10-30

Applicant: ROBODESIGN INTERNATIONAL INC ,  GANZ BRIAN L ,  MICKLEY MANDEL W ,  MOULDS JOHN ANDREW ,  BROVOLD CHRISTOPHER T

Inventor： GANZ BRIAN L ,  MICKLEY MANDEL W ,  MOULDS JOHN ANDREW ,  BROVOLD CHRISTOPHER T

IPC: B01J19/00 ,  B01L3/02 ,  C40B60/14 ,  G01N35/00 ,  G01N35/04 ,  B01L3/00 ,  B01L11/00 ,  B65B1/04 ,  B65B3/04 ,  B65B31/00 ,  B65B43/42 ,  G01N1/00 ,  G01N1/10 ,  G01N15/06 ,  G01N21/00 ,  G01N21/29 ,  G01N21/41 ,  G01N21/47 ,  G01N31/22 ,  G01N33/00 ,  G01N33/48

CPC classification number: B82Y30/00 ,  B01J19/0046 ,  B01J2219/00315 ,  B01J2219/00387 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01L3/0241 ,  C40B60/14 ,  G01N2035/00158 ,  G01N2035/0422

Abstract: A high capacity microarrayer for spotting solution onto slides (4A1-4E10) in an automated microarray dispensing device. A microp late indexing device automatically moves, in sequence, a plurality of microplates (5) to a solution removal area. A dispense head(6) accesses each microplate at the solution removal area to remove solution from the microplate. The dispense head than moves to a slide positioning station to spot slides at the slide positioning station. In a preferred embodiment of the present invention, the microplate indexing station has at least one input stacking chamber for stacking microplates, and at least one output stacking chamber for stacking microplates. A beam walking beam indexer is for moving microplates from the input stacking chamber to the output stacking chamber.

Abstract translation: 用于在自动化微阵列分配装置中将溶液分配到载片（4A1-4E10）上的高容量微阵列器。 微型后期分度装置依次将多个微板（5）自动移动到溶液移除区域。 分配头（6）在溶液去除区域处访问每个微量培养板以从微板中除去溶液。 分配头移动到滑动定位站以在滑动定位站处发现幻灯片。 在本发明的优选实施例中，微板分度站具有用于堆叠微板的至少一个输入堆叠室和用于堆叠微板的至少一个输出堆叠室。 光束步进光束分度器用于将微板从输入堆叠室移动到输出堆叠室。

公开(公告)号：WO03014325A2

公开(公告)日：2003-02-20

申请号：PCT/US0225588

申请日：2002-08-12

Applicant: XENCOR INC ,  BENTZIEN JOERG ,  DAHIYAT BASSIL I ,  DESJARLAIS JOHN ,  HAYES ROBERT J ,  VIELMETTER JOST

Inventor： BENTZIEN JOERG ,  DAHIYAT BASSIL I ,  DESJARLAIS JOHN ,  HAYES ROBERT J ,  VIELMETTER JOST

IPC: C07K1/00 ,  C07K1/04 ,  C12N15/10 ,  C40B40/10 ,  C40B50/02 ,  C40B60/14 ,  G01N33/68 ,  G06F19/16 ,  G06F19/18 ,  G06F19/22 ,  C12N

CPC classification number: C12N15/1089 ,  B01J2219/00315 ,  B01J2219/00695 ,  B01J2219/007 ,  B01J2219/00725 ,  C12N15/1027 ,  C12N15/1093 ,  C40B50/02 ,  C40B60/14 ,  G01N33/6842 ,  G06F19/16 ,  G06F19/18 ,  G06F19/22

Abstract: The invention relates to the use of protein design automation (PDA ) to generate computationally prescreened secondary libraries of proteins, and to methods and compositions utilizing the libraries.

Abstract translation: 本发明涉及使用蛋白质设计自动化（PDA TM）来生成计算预先筛选的蛋白质二级文库，以及利用文库的方法和组合物。

公开(公告)号：WO02075734A3

公开(公告)日：2003-02-13

申请号：PCT/EP0202941

申请日：2002-03-16

Applicant: LIFEBITS AG ,  REXHAUSEN ULRICH ,  WICK MANFRED

Inventor： REXHAUSEN ULRICH ,  WICK MANFRED

IPC: B01L3/00 ,  B01L3/02 ,  C40B60/14 ,  G11B7/26 ,  G03F7/00

CPC classification number: B01L3/5085 ,  B01J2219/00382 ,  B01J2219/00441 ,  B01J2219/00536 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00621 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01L3/0241 ,  C40B60/14

Abstract: The invention relates to a method for producing a carrier for conducting a biochemical analysis. To this end, a carrier is produced with a large number of pits that are arranged along a spiral. Copies are produced starting from a master carrier and they contain subsets of the pits of said master carrier. When producing the copies, the pits of the master carrier are read, and the tracking of the laser is corrected according to the arrangement of the pits of the master carrier.

Abstract translation: 一种生产用于生化分析的支撑方法表明，以产生具有大量沿着螺旋排列的凹坑的载体。 从主载体拷贝的生产，包含主载波的凹坑的子集开始。 在制备主载体的凹坑的拷贝被读取并根据所述主载波的凹坑的校正装置中激光的跟踪。

公开(公告)号：WO0241004A3

公开(公告)日：2003-02-06

申请号：PCT/US0146157

申请日：2001-11-15

Applicant: BURSTEIN TECHNOLOGIES INC

Inventor： ZOVAL JIM V ,  KIDO HORACIO ,  VIRTANEN JORMA ANTERO

IPC: B01J19/00 ,  B01L3/00 ,  B81B1/00 ,  C40B40/06 ,  C40B50/14 ,  C40B60/14 ,  G01N21/07 ,  G01N35/00

CPC classification number: B82Y30/00 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/005 ,  B01J2219/00536 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00637 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/00702 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01L3/5025 ,  B01L3/5027 ,  B01L3/502753 ,  B01L2200/12 ,  B01L2300/021 ,  B01L2300/0636 ,  B01L2300/0806 ,  B01L2300/0887 ,  B01L2300/168 ,  B01L2400/0409 ,  C40B40/06 ,  C40B50/14 ,  C40B60/14 ,  G01N21/07 ,  G01N35/00069

Abstract: An optical biodisc has a substrate, a first reflective layer over the substrate, an opening in the first reflective layer for receiving an investigational feature, and a second reflective layer over the opening for reflecting light transmitted through the substrate.

Abstract translation: 光学生物二极管具有衬底，衬底上的第一反射层，用于接收研究特征的第一反射层中的开口和用于反射透射通过衬底的光的开口上的第二反射层。

公开(公告)号：WO03006153A2

公开(公告)日：2003-01-23

申请号：PCT/FR0202427

申请日：2002-07-10

Applicant: CENTRE NAT RECH SCIENT ,  CABRERA MICHEL ,  JABER MEHDI ,  CLOAREC JEAN-PIERRE ,  BROUTIN JEROME ,  SOUTEYRAND ELIANE ,  MARTIN JEAN-RENE

Inventor： CABRERA MICHEL ,  JABER MEHDI ,  CLOAREC JEAN-PIERRE ,  BROUTIN JEROME ,  SOUTEYRAND ELIANE ,  MARTIN JEAN-RENE

IPC: G01N35/02 ,  B01J4/02 ,  B01J19/00 ,  C12M1/00 ,  C40B40/06 ,  C40B60/14 ,  G01N35/04 ,  G01N35/10 ,  G01N37/00

CPC classification number: B82Y30/00 ,  B01J19/0046 ,  B01J2219/00369 ,  B01J2219/00378 ,  B01J2219/00412 ,  B01J2219/00418 ,  B01J2219/00527 ,  B01J2219/00529 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00689 ,  B01J2219/00693 ,  B01J2219/00702 ,  B01J2219/00722 ,  C40B40/06 ,  C40B60/14

Abstract: A method for ex situ production of at least one biochip consisting in projecting a microvolume of a reagent on a substrate (18), said reagent comprising at least one probe diluted in an appropriate solvent in order to form, after elimination of said solvent, a contact element (20) comprising said probe, characterized in that said method consists in using a microprojection device (D) comprising at least one reservoir (1) wherein the reagent (3) is stored and at least one pressurized gas source (5) communicating with the reservoir (1), in addition to projecting the microvolume of reagent through an ejection nozzle (14) under the effect of pressure exerted by the gas on the reagent.

Abstract translation: 一种异位生产至少一种生物芯片的方法，该方法包括将微量的试剂投射到基底（18）上，所述试剂包含稀释于适当溶剂中的至少一种探针，以便在消除所述溶剂后形成 包括所述探针的接触元件（20），其特征在于，所述方法包括使用包含储存试剂（3）的至少一个储存器（1）和至少一个加压气体源（5）的微喷射装置（D） 与储器（1）一起，除了在气体施加在试剂上的压力的作用下将微量的试剂投射通过喷射喷嘴（14）之外。

公开(公告)号：WO03004690A2

公开(公告)日：2003-01-16

申请号：PCT/US0221579

申请日：2002-07-08

Applicant: 4543 CORP ,  WEINER MICHAEL ,  ATTIYA SAID ,  CRENSHAW HUGH ,  ROTHBERG JONATHAN M ,  MATSON STEVE

Inventor： WEINER MICHAEL ,  ATTIYA SAID ,  CRENSHAW HUGH ,  ROTHBERG JONATHAN M ,  MATSON STEVE

IPC: C12N15/09 ,  B01D61/14 ,  B01D71/56 ,  B01J19/00 ,  C12M1/34 ,  C12M1/40 ,  C12Q1/68 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  C12Q

CPC classification number: B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00286 ,  B01J2219/00313 ,  B01J2219/00355 ,  B01J2219/00414 ,  B01J2219/00418 ,  B01J2219/00423 ,  B01J2219/00466 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00524 ,  B01J2219/00576 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00641 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00702 ,  B01J2219/00722 ,  B01J2219/00725 ,  C12Q1/6869 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14

Abstract: The present invention relates to the field of fluid dynamics. More specifically, this invention relates to methods and apparatus for conducting densely packed, independent chemical reactions in parallel in a substantially two-dimensional array. Accordingly, this invention also focuses on the use of this array for applications such as DNA sequencing, most preferably pyrosequencing, and DNA amplification.

Abstract translation: 本发明涉及流体动力学领域。 更具体地说，本发明涉及用于在基本上二维阵列中平行进行密集填充的独立化学反应的方法和装置。 因此，本发明还着重于将该阵列用于诸如DNA测序，最优选焦磷酸测序和DNA扩增的应用。