公开(公告)号：WO2004008953A1

公开(公告)日：2004-01-29

申请号：PCT/GB2003/003246

申请日：2003-07-18

Applicant: UNIVERSITY OF BRISTOL ,  UNIVERSITY OF WEST OF ENGLAND ,  PROBERT, Christopher, Simon, John ,  RATCLIFFE, Norman, Mark

Inventor： PROBERT, Christopher, Simon, John ,  RATCLIFFE, Norman, Mark

IPC: A61B5/00

CPC classification number: G01N33/497 ,  Y10T436/17 ,  Y10T436/24 ,  Y10T436/25875

Abstract: A method of determining the cause of disease is described, which method uses the detection of “signature” or “fingerprint” volatile compounds in an emission, especially flatus, from a patient.

Abstract translation: 描述了确定疾病原因的方法，哪种方法使用来自患者的排放物，特别是排泄物中的“特征”或“指纹”挥发性化合物的检测。

公开(公告)号：WO2003073076A1

公开(公告)日：2003-09-04

申请号：PCT/JP2003/000147

申请日：2003-01-10

Applicant: 科学技術振興事業団 ,  井上 佳久 ,  ボロフコフ ビクトル ,  リントゥルオト ユハ

Inventor： 井上 佳久 ,  ボロフコフ ビクトル ,  リントゥルオト ユハ

IPC: G01N21/19

CPC classification number: C07D519/00 ,  G01N21/19 ,  Y10T436/14 ,  Y10T436/145555 ,  Y10T436/17 ,  Y10T436/20

Abstract: A reagent for determining the absolute configuration of a chiral compound containing as the active ingredient a metal porphyrin dimer crosslinked via a carbon chain in which, in at least one of the porphyrin rings of the dimer, at least one of the second carbon atoms counted from the carbon attached to the crosslinking carbon chain along the outer periphery of the porphyrin ring has a substituent bulkier than methyl and the central metal is an alkaline earth metal ion and a method of determining the absolute configuration of a chiral compound with the use of this reagent.

Abstract translation: 用于测定含有通过碳链交联的金属卟啉二聚体作为活性成分的手性化合物的绝对构型的试剂，其中在二聚体的至少一个卟啉环中，至少一个第二碳原子从 沿着卟啉环的外周连接到交联碳链上的碳具有比甲基更大的取代基，中心金属是碱土金属离子，并且使用该试剂测定手性化合物的绝对构型的方法 。

公开(公告)号：WO01079827A1

公开(公告)日：2001-10-25

申请号：PCT/US2001/012038

申请日：2001-04-13

IPC: C01G41/00 ,  C04B35/495 ,  G01N27/12 ,  B05D1/40 ,  G01N27/04 ,  H01C7/00

CPC classification number: G01N27/12 ,  C01G41/00 ,  C01P2006/40 ,  C04B35/495 ,  Y10T436/17 ,  Y10T436/177692 ,  Y10T436/20

Abstract: The mixed oxide WxMo1-xO3, where preferably x can be in the range 0.01 to 0.9, is very useful for the detection of oxidizing gases and in particular is superior for the detection of ozone. The preferred composition is in the range of 1 % to 21 % Mo (i.e. 99 % to 79 % W). The present example in which the composition of the sensing material is in the range WxMo1-xO3 with x varying from 0.01 to 0.9, is clearly distinct from the device claimed in applicant's earlier patent. Precipitation of the material as a mixed oxide from an aqueous solution of the ammonium metallates in concentrations of the appropriate stoichiometric proportions yields a powder that can be screen-printed to give an ideal microstructure. Resistivity of the material may be tailored to a desired value by adjusting the Mo/W ratio within the single phase field. Varying this ratio adjusts catalytic properties of the material.

Abstract translation: 混合氧化物WxMo1-xO3，其中优选x可以在0.01至0.9的范围内，对于氧化气体的检测非常有用，特别是对于臭氧的检测而言是优异的。 优选的组成在1％至21％Mo（即99％至79％W）的范围内。 感测材料的组成在x x从0.01到0.9的范围内的本示例与申请人先前专利中要求保护的装置明显不同。 以合适的化学计量比浓度从金属铵的水溶液中析出的作为混合氧化物的材料产生可以丝网印刷以得到理想的微结构的粉末。 可以通过调整单相场内的Mo / W比来将材料的电阻率调整到期望值。 改变该比例调节材料的催化性能。

公开(公告)号：WO00029827A1

公开(公告)日：2000-05-25

申请号：PCT/US1999/025056

申请日：1999-10-25

IPC: G01N1/10 ,  G01N1/02 ,  G01N1/34

CPC classification number: G01N1/34 ,  G01N2001/028 ,  Y10T436/15 ,  Y10T436/153333 ,  Y10T436/156666 ,  Y10T436/16 ,  Y10T436/17 ,  Y10T436/173076 ,  Y10T436/18 ,  Y10T436/19 ,  Y10T436/193333 ,  Y10T436/25125

Abstract: A process and apparatus for extracting inorganic ionic contaminants from a front surface of a silicon wafer for chemical analysis. The wafer is placed in a container upon a support which holds the wafer in a generally level orientation and isolates the wafer to inhibit air circulation over the front surface. Air circulation can introduce contaminants to the extraction fluid, causing a false measurement of contaminants on the wafer. A layer of extraction fluid is deposited upon only the front surface of the wafer and held for a period of time so that contaminants on the front surface are extracted into the layer of fluid. A portion of the layer of fluid is collected by a sampling device for subsequent analysis.

Abstract translation: 一种用于从用于化学分析的硅晶片的前表面提取无机离子污染物的方法和装置。 将晶片放置在容器中，将支撑物保持在大致水准的方向上，并隔离晶片以阻止前表面上的空气循环。 空气循环可能会将污染物引入萃取液中，导致晶片上杂质的错误测量。 提取液层仅沉积在晶片的前表面上并保持一段时间，使得前表面上的污染物被提取到流体层中。 流体层的一部分由采样装置收集用于随后的分析。

公开(公告)号：WO99008114A1

公开(公告)日：1999-02-18

申请号：PCT/IB1998/001180

申请日：1998-08-03

IPC: G01N21/78 ,  G01N31/00 ,  G01N31/22 ,  G01N33/00 ,  G01N33/62

CPC classification number: G01N31/221 ,  G01N31/22 ,  G01N31/223 ,  G01N33/0054 ,  G01N33/62 ,  Y02A50/246 ,  Y10S436/80 ,  Y10T436/17 ,  Y10T436/175383

Abstract: The present invention provides an ammonia sensor comprising a pH sensitive fluorophore immobilized in a hydrophobic polymer, wherein the fluorophore can react quantitatively with ammonia and the transducing moiety of the fluorophore is neutrally charged when deprotonated. The present invention also provides a method for detecting ammonia using the ammonia sensor and optical sensing devices comprising the ammonia sensor.

Abstract translation: 本发明提供一种氨传感器，其包含固定在疏水性聚合物中的pH敏感的荧光团，其中所述荧光团可以与氨定量反应，并且当去质子化时，荧光团的转导部分是中性带电的。 本发明还提供了一种使用氨传感器和包括氨传感器的光学感测装置检测氨的方法。

公开(公告)号：WO99007881A1

公开(公告)日：1999-02-18

申请号：PCT/IB1998/001181

申请日：1998-08-03

IPC: G01N33/52 ,  C12Q1/00 ,  C12Q1/34 ,  G01N33/70

CPC classification number: C12Q1/34 ,  Y10S436/80 ,  Y10T436/147777 ,  Y10T436/17 ,  Y10T436/175383

Abstract: The present invention provides a creatinine sensor material comprising a first layer of a protonated pH sensitive fluorophore immobilized in a hydrophobic polymer, wherein the fluorophore can react quantitatively with ammonia and the transducing moiety of the fluorophore is neutrally charged when deprotonated; a second layer of creatinine deiminase and a polymer; and a third layer of a polymer. The present invention also provides a method for detecting creatinine using the creatinine sensor material and optical sensing devices comprising the creatinine sensor material.

Abstract translation: 本发明提供一种肌酸酐传感器材料，其包含固定在疏水性聚合物中的质子化pH敏感荧光团的第一层，其中所述荧光团可以与氨定量反应，并且当去质子化时，荧光团的转导部分是中性带电的; 第二层肌酐去亚胺酶和聚合物; 和第三层聚合物。 本发明还提供了一种使用肌酸酐传感器材料和包含肌酸酐传感器材料的光学感测装置检测肌酐的方法。

公开(公告)号：WO1994019679A1

公开(公告)日：1994-09-01

申请号：PCT/US1994001590

申请日：1994-02-18

Applicant: THE COCA-COLA COMPANY

Inventor： THE COCA-COLA COMPANY ,  ROUNBEHLER, David, R. ,  FINE, David, H. ,  MACDONALD, Stephen, J. ,  DENNISON, Daniel, B. ,  ACHTER, Eugene, K.

IPC: G01N21/76

CPC classification number: B07C5/34 ,  B07C5/3408 ,  B08B9/46 ,  B08B2203/005 ,  B29B17/00 ,  B29B17/02 ,  B29B2017/0275 ,  G01N1/2202 ,  G01N1/2226 ,  G01N1/24 ,  G01N21/64 ,  G01N21/76 ,  G01N21/766 ,  G01N21/9018 ,  G01N2001/2223 ,  G01N2001/2229 ,  G01N2033/0081 ,  Y02W30/62 ,  Y02W30/622 ,  Y10T436/113332 ,  Y10T436/17 ,  Y10T436/206664 ,  Y10T436/21

Abstract: A system and method are provided for minimizing the effects of background signals in masking signals indicating the presence of substances to be detected such as contaminants in materials moving rapidly along a conveyor. The contaminants detected may include nitrogen containing compounds and hydrocarbons. The system and method of the present invention minimize during detection of the presence or absence of such substances, the number of falsely positive indications of the presence of such substances due to background signals and changes in background signals. The substances detected are divided into first and second sample portions and the respective portions are heated. The first heated portion is mixed with ozone to cause a chemical action therewith in order to generate radiation by chemiluminescence having characteristic weavelengths related to substances in the first portion. The second portion heated is also mixed with ozone to cause a chemical reaction therewith in order to generate radiation by chemiluminescence having characteristic wavelengths related to substances in the second portion. The radiation of the respective first and second portions is selectively detected. The heating and detecting steps are performed in a manner so as to yield a higher level of detected radiation from one of the portions of the sample than the other for at least some of the selected compounds being detected. Electrical signals from the respective first and second portions are generated and compared in order to determine the presence or absence of selected compounds in the sample. Appropriate reject signals for a bottle sorting system are generated accordingly.

Abstract translation: 提供了一种系统和方法，用于最小化背景信号在掩蔽指示待检测物质的存在的信号中的影响，例如沿着传送器快速移动的材料中的污染物。 检测到的污染物可能包括含氮化合物和碳氢化合物。 本发明的系统和方法在检测到这种物质的存在或不存在期间最小化了由于背景信号和背景信号的改变而导致的这种物质的存在的错误的阳性迹象的数量。 所检测的物质被分成第一和第二样品部分，并且各个部分被加热。 将第一加热部分与臭氧混合以引起化学作用，以通过具有与第一部分中的物质相关的特征波长的化学发光产生辐射。 加热的第二部分也与臭氧混合以引起与其的化学反应，以通过具有与第二部分中的物质相关的特征波长的化学发光产生辐射。 选择性地检测相应的第一和第二部分的辐射。 加热和检测步骤以这样一种方式进行，以便对于所检测的至少一些所选择的化合物，从样品的一个部分获得比其他部分更高水平的检测到的辐射。 产生并比较来自相应的第一和第二部分的电信号，以确定样品中选定化合物的存在或不存在。 相应地生成用于瓶分选系统的适当拒绝信号。

公开(公告)号：WO1994014058A1

公开(公告)日：1994-06-23

申请号：PCT/US1993011823

申请日：1993-12-06

Applicant: BOEHRINGER MANNHEIM CORPORATION

Inventor： BOEHRINGER MANNHEIM CORPORATION ,  RAPKIN, Myron ,  TABB, David ,  DIEBOLD, Eric

IPC: G01N31/00

CPC classification number: G01N33/96 ,  C12Q1/54 ,  C12Q1/60 ,  G01N33/66 ,  G01N33/92 ,  G01N2496/80 ,  Y10T436/104165 ,  Y10T436/104998 ,  Y10T436/106664 ,  Y10T436/108331 ,  Y10T436/144444 ,  Y10T436/17

Abstract: The invention relates to improved control reagents. These materials contain an antioxidant or a hydroxylamine compound together with other ingredients, the most important of which is a known amount of the analyte for which the reagent acts as a control.

Abstract translation: 本发明涉及改进的对照试剂。 这些材料与其他成分一起含有抗氧化剂或羟胺化合物，其中最重要的是试剂作为对照物的已知量的分析物。

公开(公告)号：WO1994011466A1

公开(公告)日：1994-05-26

申请号：PCT/EP1993003133

申请日：1993-11-09

Applicant: BASF AKTIENGESELLSCHAFT ,  DYLLICK-BRENZINGER, Rainer ,  RAULFS, Friedrich-Wilhelm ,  SCHLOESSER, Ulrike

Inventor： BASF AKTIENGESELLSCHAFT

IPC: C10L01/00

CPC classification number: C10L1/003 ,  C07D209/08 ,  C07D295/096 ,  C10L1/14 ,  C10L1/143 ,  C10L1/1608 ,  C10L1/1616 ,  C10L1/22 ,  C10L1/2227 ,  C10L1/223 ,  C10L1/2235 ,  C10L1/224 ,  C10L1/2286 ,  C10L1/231 ,  C10L1/232 ,  C10L1/2335 ,  C10L1/2412 ,  C10L1/2418 ,  C10L1/2431 ,  C10L1/2437 ,  C10M171/007 ,  G01N33/2882 ,  Y10T436/13 ,  Y10T436/17 ,  Y10T436/255

Abstract: The use of anilines of the formula (I) in which R and R are hydrogen, possibly substituted alkyl, alkenyl, possibly substituted phenyl or R and R together with the nitrogen atoms bonding them are a hetercocyclic residue or R is also a possibly substituted hydroxy or possibly substituted amino; R and R are hydrogen, possibily substituted alkyl, alkenyl, cyano, nitro, acyl, acylamino possibly substituted hydroxy, possibly substituted carboxy methyl, possibly substituted amino, possibly substituted mercapto or possibly substituted sulphamoyl or together with R are alkylene or alkenylene or phenyl alkenylene; R is hydrogen, possibly substituted alkyl, alkenyl, possibly substituted hydroxy, possibly substituted amino, possibly substituted carboxyl or possibly substituted sulphamoyl; and R and R are hydrogen possibly substituted alkyl, alkenyl, possibly substituted phenyl, nitro, acylamino, possibly substituted hydroxy, possibly substituted amino, possibly substituted sulphamoyl, alkyl, sulphonyl, alkenyl, sulphonyl or aryl sulphonyl, acyl or possibly substituted carboxyl; provided that at least one of the residues R , R or R is hydrogen, for marking mineral oils, mineral oils marked with the above anilines and a process for detecting the above anilines in mineral oils are disclosed.

公开(公告)号：WO1990004781A1

公开(公告)日：1990-05-03

申请号：PCT/US1989004161

申请日：1989-09-25

Applicant: CRYSTAL DIAGNOSTICS, INC.

Inventor： CRYSTAL DIAGNOSTICS, INC. ,  KOOCHER, Martin

IPC: G01N31/00

CPC classification number: G01N25/147 ,  Y10T436/14 ,  Y10T436/15 ,  Y10T436/16 ,  Y10T436/17 ,  Y10T436/173845 ,  Y10T436/18 ,  Y10T436/182 ,  Y10T436/19 ,  Y10T436/20 ,  Y10T436/201666 ,  Y10T436/203332 ,  Y10T436/204165 ,  Y10T436/21 ,  Y10T436/212 ,  Y10T436/23

Abstract: The present invention provides a general assay methodology suitable for the detection of organic analytes which are neither aldehydes nor ketones and for inorganic substances. The methodology utilizes prepared sensitized films of derivatizing agents and specific developer solutions for the selective and controlled formation of light scattering crystals whose presence serves as a qualitative and/or quantitative measure of the individual analyte of interest in the sample.