DEVICE FOR HIGH THROUGHPUT SINGLE-CELL STUDIES
    84.
    发明申请
    DEVICE FOR HIGH THROUGHPUT SINGLE-CELL STUDIES 审中-公开
    高通量单电池研究设备

    公开(公告)号:WO2018051242A1

    公开(公告)日:2018-03-22

    申请号:PCT/IB2017/055524

    申请日:2017-09-13

    Abstract: The present invention concerns a microfluidic device or chip including at least one inlet for introducing at least one object into the device; an oil inlet for introducing an oil that supports droplet formation into the device or a droplet forming substance inlet for introducing a droplet forming substance into the device; a co-encapsulation area or structure where the at least one object is encapsulated by the droplet; a microfluidic tubing or channel for transporting the at least one object to an entrance of the co-encapsulation area or structure; an oil supporting droplet formation microchannel or droplet forming substance microchannel connected to the microfluidic tubing or channel to place a liquid of the microfluidic tubing or channel in direct contact with the oil that supports droplet formation or the droplet forming substance; and a droplet microchannel or tubing for transporting the droplet.

    Abstract translation: 本发明涉及一种微流体装置或芯片,其包括用于将至少一个物体引入装置中的至少一个入口; 用于将支持液滴形成的油引入到装置中的油入口或用于将液滴形成物质引入到装置中的液滴形成物质入口; 共同封装区域或结构,其中至少一个物体被液滴包封; 微流体管道或通道,用于将所述至少一个物体输送到所述共同封装区域或结构的入口; 与微流体管或通道连接以将微流体管或通道的液体与支持微滴形成的油或微滴形成物质直接接触的油支持微滴形成微通道或微滴形成物质微通道; 以及用于输送液滴的液滴微通道或管道。

    A MICROFLUIDIC ASSAY SYSTEM, A MICROFLUIDIC CARTRIDGE AND A METHOD OF PERFORMING AN ASSAY
    85.
    发明申请
    A MICROFLUIDIC ASSAY SYSTEM, A MICROFLUIDIC CARTRIDGE AND A METHOD OF PERFORMING AN ASSAY 审中-公开
    微流体分析系统,微流体分析盒和实施测定的方法

    公开(公告)号:WO2017133741A1

    公开(公告)日:2017-08-10

    申请号:PCT/DK2017/050020

    申请日:2017-01-31

    Abstract: A microfluidic assay system including a microfluidic cartridge and an associated microfluidic operator system. The microfluidic cartridge comprises a base part, having a first face with a recess and a foil fixed to the base part for covering the recess and providing a microfluidic cartridge foil face. The base part with the recess and the foil forms a flow channel and a sink in fluid communication with each other. The microfluidic cartridge comprises an inlet opening into the flow channel upstream to the reaction section. The operator system includes a piston, a temperature regulating element and an actuator positioned such that the foil face of the microfluidic cartridge can be positioned in contact with the operative system with the reaction section in close proximity to the temperature regulating element while the actuator is associated to the sink section to depress the foil covering the sink section and the piston is associated to the flow channel at an upstream valve section to depress the foil to close off the flow channel upstream to the reaction section.

    Abstract translation: 微流体测定系统包括微流体盒和相关的微流体操作系统。 微流体盒包括基部,基部具有带凹部的第一面和固定到基部的箔,用于覆盖凹部并提供微流体盒箔面。 具有凹部和箔片的底座部分形成彼此流体连通的流动通道和水槽。 微流体盒包括进入反应部分上游的流动通道的入口。 操作员系统包括活塞,温度调节元件和致动器,所述致动器被定位成使得微流体盒的箔面能够定位成与操作系统接触,其中反应部分紧邻温度调节元件,同时致动器关联 到沉降部分以压下覆盖沉降部分的箔片,并且活塞与上游阀部分处的流动通道相关联以压下箔片以关闭反应部分上游的流动通道。

    CHIP DEVICE FOR MONITORING AND REGULATING FLUID FLOW, AND METHODS OF MANUFACTURE THEREOF
    87.
    发明申请
    CHIP DEVICE FOR MONITORING AND REGULATING FLUID FLOW, AND METHODS OF MANUFACTURE THEREOF 审中-公开
    用于监测和调节流体流动的芯片装置及其制造方法

    公开(公告)号:WO2015114635A9

    公开(公告)日:2016-08-11

    申请号:PCT/IL2015050111

    申请日:2015-02-01

    Applicant: EZMEMS LTD

    Abstract: A device for monitoring fluid media, and methods of manufacture thereof are disclosed. The monitoring device may be implemented as a single monolithic unit made from a certain type of material without a separate packaging, and having a base element comprising at least one fluid port and at least one cavity or fluid flow path fluidly coupled to the at least one fluid port for enabling fluid exchange of fluid media therewith. The device comprises at least one sensing element associated with the cavity or fluid flow path and configured and operable for measuring at least one property or condition of fluid media introduced therein to, and generate measurement data or signals indicative thereof. Electrical contacts disposed on the base element of the device, and electrically coupled to the at least one sensing element are used for establishing electrical connection with the at least one sensing element.

    Abstract translation: 公开了一种用于监测流体介质的装置及其制造方法。 监测装置可以被实现为由某种类型的材料制成的单个单片单元,而没有单独的包装,并且具有基座元件,该基座元件包括至少一个流体端口和至少一个流体连接到该至少一个的流体端口 流体端口,用于使流体介质与其流体交换。 该装置包括与空腔或流体流动路径相关联的至少一个感测元件,并且被配置和可操作用于测量在其中引入的流体介质的至少一个属性或状态,并产生指示其的流量介质的测量数据或信号。 设置在设备的基座元件上并且电耦合到至少一个感测元件的电触点用于建立与至少一个感测元件的电连接。

    FLUSSZELLE MIT EINEM SPEICHERBEREICH UND EINEM AN EINER SOLLBRUCHSTELLE AUFSCHLIEßBAREN TRANSPORTKANAL
    89.
    发明申请
    FLUSSZELLE MIT EINEM SPEICHERBEREICH UND EINEM AN EINER SOLLBRUCHSTELLE AUFSCHLIEßBAREN TRANSPORTKANAL 审中-公开
    与存储区域和上破点开运输渠道流CELL

    公开(公告)号:WO2016000998A1

    公开(公告)日:2016-01-07

    申请号:PCT/EP2015/063992

    申请日:2015-06-22

    Inventor: WEBER, Lutz

    Abstract: Die Erfindung betrifft eine Flusszelle, insbesondere zur Analyse oder/und Synthese von Substanzen mit wenigstens einem Speicherbereich (10;19;33), der mit einem Kanal (7-9;20) zum Transport von Fluid aus dem, in den oder/und durch den Speicherbereich verbunden ist, wobei der Kanal einen durch ein Substrat (1) und eine mit dem Substrat verbundene Folie (3) begrenzten Kanalbereich (14) aufweist, in welchem der Kanal verschlossen und an einer Sollbruchstelle unter Auslenkung der Folie aufschließbar ist. Die erfindungsgemäße Flusszelle ist dadurch gekennzeichnet, dass die Folie eine den Kanalbereich bildende Ausnehmung (15) in dem Substrat abdeckt und in der Ausnehmung eine den Kanal verschließende, einstückig mit dem Substrat verbundene Sperrwand (16) angeordnet ist, dass die Sollbruchstelle durch einen aufbrechbaren Verbindungsbereich zwischen der Folie und einem der Folie zugewandten Randabschnitt (17) der Sperrwand gebildet ist und dass für die Flächenausdehnung des Verbindungsbereichs die Abmessungen einer in dem Randabschnitt gebildeten, zu der Folie parallelen Randfläche der Sperrwand maßgebend sind.

    Abstract translation: 本发明涉及一种流通池,特别是用于分析和/或具有至少一个存储区物质的合成(10; 19; 33)与通道(7-9; 20),用于从所述流体的输送,在和/或 通过存储区域,其中该通道包括一个通过一个衬底(1)连接,并连接到基板膜(3)限定沟道区(14),其中所述通道被密封并处于下所述膜的偏转的预定的断裂点解开。 根据本发明的流通池的特征在于,所述膜覆盖的沟道部分形成在所述衬底凹槽(15)和所述通道关闭,一体地连接到在所述凹部的基板阻挡壁(16)被布置成使得通过可断裂连接部的预定的断裂点 在膜和膜边缘部分(17)之间朝向在所述阻挡壁的形成,且形成在所述边缘部分中的孔的尺寸,平行于阻挡壁的片材边缘表面是决定性的连接部分的表面面积。

    SEQUENCING DEVICE
    90.
    发明申请
    SEQUENCING DEVICE 审中-公开
    顺序设备

    公开(公告)号:WO2015195831A1

    公开(公告)日:2015-12-23

    申请号:PCT/US2015/036277

    申请日:2015-06-17

    Abstract: A method of preparing reagents includes inserting a cartridge into an instrument. The cartridge includes a plurality of reagent enclosures disposed in a cavity of the cartridge and exposing a port to an exterior of the cartridge. Each reagent enclosure includes a reagent container including a reagent and an internal cavity defining a compressible volume, an opening defined through the reagent container to the internal cavity. The method further includes connecting a plurality of fluid ports to the openings of the plurality of reagent enclosures; applying a solution through the fluid ports to at least partially fill the plurality of reagent enclosures; and cycling a pressure of the cavity, whereby for each of the reagent enclosures, during increasing pressure, the solution enters the internal cavity of the reagent container, combines with the reagent, and compresses the compressible volume, and during decreasing pressure, the compressible volume decreases and the reagent is ejected through the opening.

    Abstract translation: 制备试剂的方法包括将药筒插入仪器中。 盒包括设置在盒的空腔中并将端口暴露于盒的外部的多个试剂盒。 每个试剂盒包括试剂容器,其包括试剂和限定可压缩体积的内腔,通过试剂容器限定到内腔的开口。 该方法还包括将多个流体端口连接到多个试剂盒的开口; 通过所述流体端口施加溶液以至少部分地填充所述多个试剂外壳; 并且循环空腔的压力,由此对于每个试剂外壳,在增加的压力期间,溶液进入试剂容器的内腔,与试剂结合,并压缩可压缩体积,并且在减压期间,可压缩体积 减少,试剂通过开口排出。

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