公开(公告)号：WO2016106094A3

公开(公告)日：2016-09-29

申请号：PCT/US2015066474

申请日：2015-12-17

Applicant: UNIV CALIFORNIA ,  SANDIA CORP ,  VIRDIA INC

Inventor： SATHITSUKSANOH NOPPADON ,  ALLENDORF MARK D ,  GEORGE ANTHE ,  JANSEN ROBERT ,  LEONG KIRSTY ,  SIMMONS BLAKE A ,  SINGH SEEMA ,  TRAVISANO III PHILIP

IPC: C07D307/50 ,  C07D307/48 ,  C08B1/00

CPC classification number: C07D307/46

Abstract: Methods of processing lignocellulose using metal-organic frameworks (MOFs) to form renewable platform chemicals that may be used as initial feedstock are provided. Metal -organic frameworks react with lignocellulosic derivatives such as glucose and fructose to form 5-hydroxymethyl furfural (HMF) with high yield and high selectivity for FIMF production.

Abstract translation: 提供了使用金属有机骨架（MOF）处理木质纤维素以形成可用作初始原料的可再生平台化学品的方法。 金属 - 有机骨架与木质纤维素衍生物如葡萄糖和果糖反应形成5-羟甲基糠醛（HMF），其对FIMF生产具有高产率和高选择性。

公开(公告)号：WO2016073055A3

公开(公告)日：2016-07-14

申请号：PCT/US2015045762

申请日：2015-08-18

Applicant: STC UNM ,  ARROWHEAD CT INC ,  SANDIA CORP ,  UNIV INDIANA RES & TECH CORP

Inventor： BUSANI TITO ,  LAVROVA OLGA ,  MARTINEZ JULIO ,  SHELNUTT JOHN A ,  ZHANG SHIXIONG

IPC: H02S10/30 ,  H02S40/40 ,  H02S40/44

CPC classification number: H02S10/30 ,  H01G9/0029 ,  H01G9/2013 ,  H01G9/2022 ,  H01G9/204 ,  H01G9/2059 ,  H01L31/0547 ,  H01L35/00 ,  H01L51/0036 ,  H01L51/0048 ,  H01L51/0049 ,  H01L51/0056 ,  H01L51/006 ,  H01L51/0092 ,  H01L51/4233 ,  H02S40/38 ,  Y02B10/10 ,  Y02B10/70 ,  Y02E10/52 ,  Y02E10/549 ,  Y02P70/521

Abstract: The present invention is a photovoltaic-thermoelectric solar cell and a method of manufacturing a photovoltaic-thermoelectric solar cell. The solar cell includes a substantially transparent electrode, an organometallic photovoltaic material disposed on the transparent electrode, and a cathode disposed on the organometallic photovoltaic material. The organometallic photovoltaic material may be a porphyrin nanomaterial.

Abstract translation: 本发明是一种光电热电太阳能电池及其制造方法。 太阳能电池包括基本上透明的电极，设置在透明电极上的有机金属光伏材料和设置在有机金属光伏材料上的阴极。 有机金属光伏材料可以是卟啉纳米材料。

公开(公告)号：WO2014105233A3

公开(公告)日：2014-08-21

申请号：PCT/US2013061641

申请日：2013-09-25

Applicant: SANDIA CORP

Inventor： NIELSON GREGORY N ,  KIM BONGSANG ,  CRUZ-CAMPA JOSE LUIS ,  TAUKE-PEDRETTI ANNA ,  CEDERBERG JEFFREY ,  RESNICK PAUL J ,  SANCHEZ CARLOS ANTHONY ,  OKANDAN MURAT

IPC: H01L21/20

CPC classification number: H01L25/50 ,  B81C1/00373 ,  B81C2201/0194 ,  H01L21/283 ,  H01L21/31111 ,  H01L21/561 ,  H01L21/568 ,  H01L21/6835 ,  H01L21/6836 ,  H01L24/13 ,  H01L24/80 ,  H01L24/97 ,  H01L25/0657 ,  H01L2221/68327 ,  H01L2221/68354 ,  H01L2221/68368 ,  H01L2221/68381 ,  H01L2224/0401 ,  H01L2224/08145 ,  H01L2224/13005 ,  H01L2224/131 ,  H01L2224/14135 ,  H01L2224/80006 ,  H01L2224/80896 ,  H01L2224/9202 ,  H01L2224/97 ,  H01L2225/06517 ,  H01L2225/06568 ,  H01L2224/11 ,  H01L2224/80001 ,  H01L2924/00012 ,  H01L2924/014

Abstract: A method includes forming a release layer over a donor substrate. A plurality of devices made of a first semiconductor material are formed over the release layer. A first dielectric layer is formed over the plurality of devices such that all exposed surfaces of the plurality of devices are covered by the first dielectric layer. The plurality of devices are chemically attached to a receiving device made of a second semiconductor material different than the first semiconductor material, the receiving device having a receiving substrate attached to a surface of the receiving device opposite the plurality of devices. The release layer is etched to release the donor substrate from the plurality of devices. A second dielectric layer is applied over the plurality of devices and the receiving device to mechanically attach the plurality of devices to the receiving device.

Abstract translation: 一种方法包括在供体衬底上形成释放层。 在释放层上形成由第一半导体材料制成的多个器件。 第一电介质层形成在多个器件上，使得多个器件的所有暴露表面被第一电介质层覆盖。 所述多个装置化学附着到由不同于所述第一半导体材料的第二半导体材料制成的接收装置，所述接收装置具有附接到与所述多个装置相对的所述接收装置的表面的接收基底。 蚀刻释放层以从多个器件释放供体衬底。 第二电介质层被施加在多个装置和接收装置上以机械地将多个装置附接到接收装置。

公开(公告)号：WO2012149376A3

公开(公告)日：2013-01-17

申请号：PCT/US2012035529

申请日：2012-04-27

Applicant: STC UNM ,  SANDIA CORP ,  BRINKER JEFFREY C ,  CARNES ERIC C ,  ASHLEY CARLEE ERIN

Inventor： BRINKER JEFFREY C ,  CARNES ERIC C ,  ASHLEY CARLEE ERIN

IPC: A61K9/16 ,  A61K38/17 ,  A61K47/30 ,  A61K47/48 ,  A61K48/00

CPC classification number: A61K9/1271 ,  A61K31/704 ,  A61K31/711 ,  A61K33/24 ,  A61K38/00 ,  A61K39/05 ,  A61K45/06 ,  A61K47/62 ,  A61K47/6901 ,  A61K48/0016 ,  C07K14/47 ,  C12N15/1135 ,  C12N15/88 ,  C12N2310/14 ,  C12N2320/32 ,  C12N2810/40

Abstract: The present invention is directed to protocells for specific targeting of hepatocellular and other cancer cells which comprise a nanoporous silica core with a supported lipid bilayer; at least one agent which facilitates cancer cell death (such as a traditional small molecule, a macromolecular cargo (e.g. siRNA or a protein toxin such as ricin toxin A-chain or diphtheria toxin A-chain) and/or a histone-packaged plasmid DNA disposed within the nanoporous silica core (preferably supercoiled in order to more efficiently package the DNA into protocells) which is optionally modified with a nuclear localization sequence to assist in localizing protocells within the nucleus of the cancer cell and the ability to express peptides involved in therapy (apoptosis/cell death) of the cancer cell or as a reporter, a targeting peptide which targets cancer cells in tissue to be treated such that binding of the protocell to the targeted cells is specific and enhanced and a fusogenic peptide that promotes endosomal escape of protocells and encapsulated DNA. Protocells according to the present invention may be used to treat cancer, especially including hepatocellular (liver) cancer using novel binding peptides (c-MET peptides) which selectively bind to hepatocellular tissue or to function in diagnosis of cancer, including cancer treatment and drug discovery.

Abstract translation: 本发明涉及用于特异性靶向肝细胞和其它癌细胞的原细胞，其包含具有支持的脂质双层的纳米多孔二氧化硅核心; 至少一种促进癌细胞死亡的药物（例如传统的小分子，大分子货物（例如siRNA或蛋白质毒素如蓖麻毒素A链或白喉毒素A链）和/或组蛋白包装的质粒DNA 设置在纳米多孔硅芯内（优选超螺旋以更有效地将DNA包装到原细胞中），其任选地用核定位序列修饰以帮助定位癌细胞核内的原细胞，以及表达参与治疗的肽的能力 （凋亡/细胞死亡）或作为报告物，靶向肽靶向待治疗的组织中的癌细胞，使得原细胞与靶细胞的结合是特异性和增强的，并且促进内源性逃逸的融合肽 原细胞和包封的DNA。根据本发明的原细胞可用于治疗癌症，特别是包括肝细胞（肝）癌症 选择性结合肝细胞组织或在癌症诊断中起作用的新型结合肽（c-MET肽），包括癌症治疗和药物发现。

公开(公告)号：WO2009005542A3

公开(公告)日：2009-04-16

申请号：PCT/US2008001721

申请日：2008-02-08

Applicant: STC UNM ,  SANDIA CORP ,  LARSON RICHARD S ,  HJELLE BRIAN ,  HALL PAM R ,  BROWN DAVID C ,  BISOFFI MARCO ,  BROZIK SUSAN M ,  BRANCH DARREN W ,  EDWARDS THAYNE L ,  WHEELER DAVID

Inventor： LARSON RICHARD S ,  HJELLE BRIAN ,  HALL PAM R ,  BROWN DAVID C ,  BISOFFI MARCO ,  BROZIK SUSAN M ,  BRANCH DARREN W ,  EDWARDS THAYNE L ,  WHEELER DAVID

IPC: C12Q1/34 ,  C12M3/00

CPC classification number: G01N33/54373 ,  C12Q1/6825 ,  G01N29/032 ,  G01N33/553 ,  G01N2291/0422

Abstract: Viruses and other bioagents are of high medical and biodefense concern and their detection at concentrations well below the threshold necessary to cause health hazards continues to be a challenge with respect to sensitivity, specificity, and selectivity. Ideally, assays for accurate and real time detection of viral agents and other bioagents would not necessitate any pre-processing of the analyte, which would make them applicable for example to bodily fluids (blood, sputum) and man-made as well as naturally occurring bodies of water (pools, rivers). We describe herein a robust biosensor that combines the sensitivity of surface acoustic waves (SAW) generated at a frequency of 325 MHz with the specificity provided by antibodies and other ligands for the detection of viral agents. In preferred embodiments, a lithium tantalate based SAW transducer with silicon dioxide waveguide sensor platform featuring three test and one reference delay lines was used to adsorb antibodies directed against Coxsackie virus B4 or the negative-stranded category A bioagent Sin Nombre virus (SNV), a member of the genus Hantavirus, family Bunyaviridae, negative-stranded RNA viruses. Rapid detection (within seconds) of increasing concentrations of viral particles was linear over a range of order of magnitude for both viruses, although the sensor was approximately 50x104 -fold more sensitive for the detection of SNV. For both pathogens, the sensor's selectivity for its target was not compromised by the presence of confounding Herpes Simplex virus type 1. The biosensor was able to detect SNV at doses lower than the load of virus typically found in a human patient suffering from hantavirus cardiopulmonary syndrome (HCPS). Further, in a proof-of-principle real world application, the SAW biosensor was capable of selectively detecting SNV agents in complex solutions, such as naturally occurring bodies of water (river, sewage effluent) without analyte pre-processing.

Abstract translation: 病毒和其他生物制剂对医学和生物防御有很高的关注度，并且它们的检测浓度远低于引起健康危害所必需的阈值，这仍然是灵敏度，特异性和选择性方面的挑战。 理想情况下，准确和实时检测病毒剂和其他生物剂的分析不需要对分析物进行任何预处理，这将使其适用于例如体液（血液，痰液）和人造以及自然发生的 水体（水池，河流）。 我们在此描述了一种鲁棒的生物传感器，其将频率为325MHz的表面声波（SAW）的灵敏度与由抗体和其他配体提供的用于检测病毒剂的特异性相结合。 在优选的实施方案中，具有三个测试和一个参考延迟线的具有二氧化硅波导传感器平台的基于钽酸锂的SAW换能器被用于吸附针对柯萨奇病毒B4或负链A类生物因子Sin Nombre病毒（SNV）的抗体，a 汉坦病毒属，布尼亚病毒科，负链RNA病毒成员。 对于两种病毒，增加浓度的病毒颗粒的快速检测（数秒内）在一定数量级范围内是线性的，尽管对于检测SNV而言传感器的灵敏度约为50×10 4倍。 对于这两种病原体而言，传感器对其靶标的选择性不会由于混杂的1型单纯性疱疹病毒的存在而受到损害。生物传感器能够以比通常在患有汉坦病毒心肺综合征的人类患者中发现的病毒载量低的剂量检测SNV （HCPS）。 此外，在原理验证的实际应用中，SAW生物传感器能够选择性检测复杂溶液中的SNV试剂，例如没有分析物预处理的天然存在的水体（河流，污水流出物）。

公开(公告)号：WO03036688A3

公开(公告)日：2003-10-16

申请号：PCT/US0234368

申请日：2002-10-25

Applicant: SANDIA CORP ,  BOWER WARD ISSAC ,  THOMAS MICHAEL G ,  RUBY DOUGLAS S

Inventor： BOWER WARD ISSAC ,  THOMAS MICHAEL G ,  RUBY DOUGLAS S

IPC: H01L31/00 ,  H01L31/042 ,  H01L31/048 ,  H01L31/05 ,  H02J3/38

CPC classification number: H02J3/383 ,  H02S20/23 ,  H02S40/32 ,  Y02B10/12 ,  Y02B10/14 ,  Y02E10/563 ,  Y10S136/291 ,  Y10S136/293 ,  Y10S323/906

Abstract: A modular apparatus for and method of alternating current photovoltaic power generation comprising: via a photovoltaic module (12), generating power in the form of direct current; and converting direct current to alternating current and exporting power via one or more power conversion and transfer units attached to the module, each unit comprising a unitary housing extending a length or width of the module, which housing comprises: contact means for receiving direct current from the module; one or more direct current-to-alternating current inverters (216); an alternating current bus (212); and contact means for receiving alternating current from the one or more inverters

Abstract translation: 一种用于交流光伏发电的模块化装置和方法，包括：经由光伏模块（12），以直流形式发电; 并且通过经由连接到所述模块的一个或多个功率转换和传送单元将直流电流转换成交流电和输出功率，每个单元包括延伸所述模块的长度或宽度的整体外壳，所述壳体包括：接触装置， 模块; 一个或多个直流电流 - 交流逆变器（216）; 交流母线（212）; 以及用于从一个或多个逆变器接收交流电的接触装置

公开(公告)号：WO2013056132A3

公开(公告)日：2013-06-13

申请号：PCT/US2012060072

申请日：2012-10-12

Applicant: STC UNM ,  SANDIA CORP

Inventor： ASHLEY CARLEE ERIN ,  BRINKER C JEFFREY ,  CARNES ERIC C ,  FEKRAZAD MOHAMMAD HOUMAN ,  FELTON LINDA A ,  NEGRETE OSCAR ,  PADILLA DAVID PATRICK ,  WILKINSON BRIAN S ,  WILKINSON DAN C ,  WILLMAN CHERYL L

IPC: A61K9/16 ,  A61K31/7088 ,  A61K31/7105 ,  A61K38/17 ,  A61K47/48 ,  A61K48/00 ,  A61K49/08

CPC classification number: A61K47/48823 ,  A61K9/0014 ,  A61K9/107 ,  A61K9/1271 ,  A61K9/5078 ,  A61K31/192 ,  A61K31/465 ,  A61K31/506 ,  A61K31/513 ,  A61K31/704 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/713 ,  A61K33/24 ,  A61K38/00 ,  A61K38/17 ,  A61K38/45 ,  A61K38/47 ,  A61K45/06 ,  A61K47/483 ,  A61K47/48561 ,  A61K47/48815 ,  A61K47/48861 ,  A61K47/6923 ,  A61K48/0008 ,  A61K49/0082 ,  A61K49/0423 ,  B82Y5/00 ,  C07K7/06 ,  C07K2319/00 ,  C12N15/113 ,  C12N15/1131 ,  C12N15/88 ,  C12N2310/14 ,  C12N2320/32 ,  C12N2810/40 ,  C12Y204/02036 ,  C12Y302/02022 ,  A61K2300/00

Abstract: The present invention is directed to protocells for specific targeting of hepatocellular and other cancer cells which comprise a nanoporous silica core with a supported lipid bilayer; at least one agent which facilitates cancer cell death (such as a traditional small molecule, a macromolecular cargo (e.g. siRNA or a protein toxin such as ricin toxin A-chain or diphtheria toxin A-chain) and/or a histone-packaged plasmid DNA disposed within the nanoporous silica core (preferably supercoiled in order to more efficiently package the DNA into protocells) which is optionally modified with a nuclear localization sequence to assist in localizing protocells within the nucleus of the cancer cell and the ability to express peptides involved in therapy (apoptosis/cell death) of the cancer cell or as a reporter, a targeting peptide which targets cancer cells in tissue to be treated such that binding of the protocell to the targeted cells is specific and enhanced and a fusogenic peptide that promotes endosomal escape of protocells and encapsulated DNA. Protocells according to the present invention may be used to treat cancer, especially including hepatocellular (liver) cancer using novel binding peptides (c-MET peptides) which selectively bind to hepatocellular tissue or to function in diagnosis of cancer, including cancer treatment and drug discovery.

Abstract translation: 本发明涉及用于特异性靶向肝细胞和其它癌细胞的原细胞，其包含具有支持的脂质双层的纳米多孔二氧化硅核心; 至少一种促进癌细胞死亡的药物（例如传统的小分子，大分子货物（例如siRNA或蛋白质毒素如蓖麻毒素A链或白喉毒素A链）和/或组蛋白包装的质粒DNA 设置在纳米多孔硅芯内（优选超螺旋以更有效地将DNA包装到原细胞中），其任选地用核定位序列修饰以帮助定位癌细胞核内的原细胞，以及表达参与治疗的肽的能力 （凋亡/细胞死亡）或作为报告物，靶向肽靶向待治疗的组织中的癌细胞，使得原细胞与靶细胞的结合是特异性和增强的，并且促进内源性逃逸的融合肽 原细胞和包封的DNA。根据本发明的原细胞可用于治疗癌症，特别是包括肝细胞（肝）癌症 选择性结合肝细胞组织或在癌症诊断中起作用的新型结合肽（c-MET肽），包括癌症治疗和药物发现。

公开(公告)号：WO2013022664A3

公开(公告)日：2013-05-02

申请号：PCT/US2012049127

申请日：2012-08-02

Applicant: SANDIA CORP ,  WRIGHT STEVEN A ,  PICKARD PAUL S ,  VERNON MILTON E ,  RADEL ROSS F

Inventor： WRIGHT STEVEN A ,  PICKARD PAUL S ,  VERNON MILTON E ,  RADEL ROSS F

IPC: F01K23/08 ,  F01D15/10 ,  F01K25/02 ,  F25B27/00

CPC classification number: F02C9/00 ,  F01K7/32 ,  F01K25/08 ,  F01K25/103 ,  F02C1/10 ,  F22B3/08 ,  F22B29/026 ,  F22B35/086 ,  Y02E10/46

Abstract: Various technologies pertaining to tuning composition of a fluid mixture in a supercritical Brayton cycle power generation system are described herein. Compounds, such as Alkanes, are selectively added or removed from an operating fluid of the supercritical Brayton cycle power generation system to cause the critical temperature of the fluid to move up or down, depending upon environmental conditions. As efficiency of the supercritical Brayton cycle power generation system is substantially optimized when heat is rejected near the critical temperature of the fluid, dynamically modifying the critical temperature of the fluid based upon sensed environmental conditions improves efficiency of such a system.

Abstract translation: 本文描述了关于调节超临界布雷顿循环发电系统中的流体混合物的组成的各种技术。 取决于环境条件，化合物例如烷烃被选择性地添加到超临界布雷顿循环发电系统的工作流体中或从超临界布雷顿循环发电系统的工作流体中除去以引起流体的临界温度向上或向下移动。 由于超临界布雷顿循环发电系统的效率在靠近流体的临界温度时拒绝热量时基本上被优化，所以基于感测到的环境条件动态地改变流体的临界温度提高了这种系统的效率。

公开(公告)号：WO2007041527A3

公开(公告)日：2007-08-02

申请号：PCT/US2006038511

申请日：2006-10-02

Applicant: SANDIA CORP ,  KHOLWADWALA DEEPESH K ,  SLEPOVA LUBOV V ,  WHEELER JASON W ,  RAHIMIAN KAMYAR ,  ROHRER BRANDON R ,  JOHNSTON GABRIEL A ,  COLEMAN JENNIFER L ,  VAUGHN MARK R ,  PERVUSHIN VLADIMIR I ,  IVANOV ANATOLI S

Inventor： KHOLWADWALA DEEPESH K ,  SLEPOVA LUBOV V ,  WHEELER JASON W ,  RAHIMIAN KAMYAR ,  ROHRER BRANDON R ,  JOHNSTON GABRIEL A ,  COLEMAN JENNIFER L ,  VAUGHN MARK R ,  PERVUSHIN VLADIMIR I ,  IVANOV ANATOLI S

IPC: A61F2/80

CPC classification number: A61F2/60 ,  A61F2/6607 ,  A61F2/76 ,  A61F2/78 ,  A61F2/80 ,  A61F2002/30433 ,  A61F2002/5007 ,  A61F2002/5018 ,  A61F2002/502 ,  A61F2002/5023 ,  A61F2002/5043 ,  A61F2002/6621 ,  A61F2002/6642 ,  A61F2002/6671 ,  A61F2002/7862 ,  A61F2220/0041

Abstract: A lower limb prosthesis comprising a foot, a pylon, a socket, a connector between the socket and the pylon, an adapter between the foot and the pylon, and a liner in the socket, the liner being substantially rigid at room temperatures and moldable at a temperature between approximately 50 degrees C and approximately 100 degrees C. Also a support for a residual lower limb, the support being sized to receive the residual lower limb and comprising a socket and a liner in the socket, the liner being substantially rigid at room temperatures and moldable at a temperature between approximately 50 degrees C and approximately 100 degrees C.

Abstract translation: 一种下肢假体，其包括足部，塔架，套筒，位于套筒和塔架之间的连接器，位于足部和塔架之间的适配器以及套筒中的衬里，该衬里在室温下基本上是刚性的并且可在 大约50摄氏度到大约100摄氏度之间的温度。还有用于残余下肢的支撑件，所述支撑件的尺寸被设计成接收残余下肢并且包括插座和插座中的内衬，所述内衬在室 温度并且可以在约50℃和约100℃之间的温度下模塑

公开(公告)号：WO2005057588A3

公开(公告)日：2005-08-11

申请号：PCT/US2004022956

申请日：2004-07-16

Applicant: SANDIA CORP ,  TUCKER MARK D

Inventor： TUCKER MARK D

IPC: A61K31/14 ,  A61K31/327 ,  A61K33/00 ,  A61K33/22 ,  A61K33/40 ,  A61K33/42 ,  A61K45/06 ,  G21F20060101 ,  A61K7/00

CPC classification number: A62D3/38 ,  A61K31/14 ,  A61K31/327 ,  A61K33/00 ,  A61K33/22 ,  A61K33/40 ,  A61K33/42 ,  A61K45/06 ,  A61L2/186 ,  A61L2202/24 ,  A62D2101/02 ,  Y10S588/901 ,  A61K2300/00

Abstract: A decontamination formulation and method of making that neutralizes the adverse health effects of both chemical and biological compounds, especially chemical warfare (CW) and biological warfare (BW) agents, and toxic industrial chemicals. The formulation provides solubilizing compounds that serve to effectively render the chemical and biological compounds, particularly CW and BW compounds, susceptible to attack, and at least one reactive compound that serves to attack (and detoxify or kill) the compound. The formulation includes at least one solubilizing agent, a reactive compound, a sorbent additive, and water. A highly adsorbent sorbent additive (e.g., amorphous silica, sorbitol, mannitol, etc.) is used to "dry out" one or more liquid ingredients into a dry, free-flowing powder that has an extended shelf life, and is more convenient to handle and mix in the field.

Abstract translation: 一种净化配方和中和化学和生物化合物，特别是化学战（CW）和生物战剂（BW）剂以及有毒工业化学品的不利健康影响的方法。 该制剂提供增溶化合物，其用于有效地使化学和生物化合物，特别是CW和BW化合物易于发生攻击，以及至少一种用于攻击（和解毒或杀死）化合物的活性化合物。 制剂包括至少一种增溶剂，反应性化合物，吸附剂添加剂和水。 使用高吸附剂吸附剂添加剂（例如无定形二氧化硅，山梨糖醇，甘露糖醇等）将一种或多种液体成分“干燥”成具有延长保质期的干燥，自由流动的粉末，并且更方便 处理和混合在现场。