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公开(公告)号：WO2012094459A2
公开(公告)日：2012-07-12
申请号：PCT/US2012/020278
申请日：2012-01-05
Applicant: GLEZER, Eli N. , HIGGINS, Stephen , KOVACS, Sandor , KUMAR, Sudeep , PAGE, Kenneth , ROTH, Kristian , SIGAL, George
Inventor： GLEZER, Eli N. , HIGGINS, Stephen , KOVACS, Sandor , KUMAR, Sudeep , PAGE, Kenneth , ROTH, Kristian , SIGAL, George
CPC classification number: B01L7/525 , B01L3/5027 , B01L2200/027 , B01L2200/0605 , B01L2200/0621 , B01L2200/0631 , B01L2200/10 , B01L2200/146 , B01L2200/16 , B01L2300/0645 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0883 , B01L2400/0487 , B01L2400/0688 , B01L2400/0694 , C12Q1/686
Abstract: Assay cartridges are described that have purification, reaction, and detection zones and other fluidic components which can include sample chambers, waste chambers, conduits, vents, reagent chambers, reconstitution chambers and the like. The assay cartridges are used to conduct multiplexed nucleic acid measurements. Also described are kits including such cartridges, methods of using the same, and a reader configured to analyze an assay conducted using an assay cartridge.
Abstract translation: 描述了具有净化，反应和检测区域以及可以包括样品室，废物室，导管，通风口，试剂室，重构室等的流体组分的测定盒。 测定盒用于进行多重核酸测量。 还描述了包括这种盒的试剂盒，使用它们的方法，以及配置成分析使用测定盒进行的分析的读取器。
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公开(公告)号：WO2011071772A2
公开(公告)日：2011-06-16
申请号：PCT/US2010/058913
申请日：2010-12-03
Applicant: MESO SCALE TECHNOLOGIES, LLC. , ANDERSON, Nicholas , DEBAD, Jeffrey , GLEZER, Eli, N. , KUMAR, Sudeep , LAWRENCE, Noel , PAGE, Kenneth , SIGAL, George , WEST, Sharon
Inventor： ANDERSON, Nicholas , DEBAD, Jeffrey , GLEZER, Eli, N. , KUMAR, Sudeep , LAWRENCE, Noel , PAGE, Kenneth , SIGAL, George , WEST, Sharon
IPC: G01N21/03
CPC classification number: G01N21/05 , B01L3/5027 , B01L3/502723 , B01L3/502746 , B01L3/502784 , B01L7/00 , B01L9/527 , B01L2200/025 , B01L2200/04 , B01L2200/0605 , B01L2200/0684 , B01L2200/0689 , B01L2200/12 , B01L2200/141 , B01L2200/147 , B01L2200/16 , B01L2300/021 , B01L2300/024 , B01L2300/027 , B01L2300/044 , B01L2300/0645 , B01L2300/0654 , B01L2300/0809 , B01L2300/0874 , B01L2300/0877 , B01L2300/0887 , B01L2300/126 , B01L2300/161 , B01L2400/0487 , B01L2400/0672 , B01L2400/0683 , B01L2400/0688 , G01F23/02 , G01F23/292 , G01N21/03 , G01N21/0303 , G01N21/69 , G01N21/76 , G01N2021/0346 , Y10T137/0396 , Y10T137/8593
Abstract: Assay cartridges are described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain embodiments, these cartridges are adapted to receive and analyze a sample collected on an applicator stick. Also described are kits including such cartridges and a cartridge reader configured to analyze an assay conducted using an assay cartridge.
Abstract translation: 描述了具有检测室，优选具有集成电极的测定盒，以及可包括样品室，废物室，导管，通气口，气泡阱，试剂室，干试剂药片区等的其它流体组分。 在某些实施例中，这些盒适于接收和分析在施用器棒上收集的样品。 还描述了包括这种盒的试剂盒和盒读取器，其被配置为分析使用分析盒进行的分析。
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公开(公告)号：WO2009126303A3
公开(公告)日：2010-01-28
申请号：PCT/US2009002244
申请日：2009-04-10
Applicant: MESO SCALE TECHNOLOGIES LLC , CLINTON CHARLES M , GLEZER ELI N , WEST SHARON , SIGAL GEORGE , STEVENS CARL , VOCK MICHAEL
Inventor： CLINTON CHARLES M , GLEZER ELI N , WEST SHARON , SIGAL GEORGE , STEVENS CARL , VOCK MICHAEL
CPC classification number: G01N21/76 , G01N21/69 , G01N35/0092 , G01N35/028 , G01N35/1079 , G01N2035/0425 , Y10T436/114165
Abstract: We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.
Abstract translation: 我们描述用于进行测定的装置，系统，方法，试剂和试剂盒以及其制备方法。 它们特别适合进行多孔板测定格式的自动采样，样品制备和分析。 例如，它们可用于在环境监测中对其中衍生的空气和/或液体样品中的颗粒进行自动分析。
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公开(公告)号：WO2009126303A2
公开(公告)日：2009-10-15
申请号：PCT/US2009/002244
申请日：2009-04-10
Applicant: MESO SCALE TECHNOLOGIES, LLC , CLINTON, Charles, M. , GLEZER, Eli, N. , WEST, Sharon , SIGAL, George , STEVENS, Carl , VOCK, Michael
Inventor： CLINTON, Charles, M. , GLEZER, Eli, N. , WEST, Sharon , SIGAL, George , STEVENS, Carl , VOCK, Michael
CPC classification number: G01N21/76 , G01N21/69 , G01N35/0092 , G01N35/028 , G01N35/1079 , G01N2035/0425 , Y10T436/114165
Abstract: We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.
Abstract translation: 我们描述了用于进行测定的装置，系统，方法，试剂和试剂盒以及它们的制备方法。 它们特别适合于以多孔板分析方式进行自动取样，样品制备和分析。 例如，它们可以用于自动分析空气中的微粒和/或从环境监测中得到的液体样品。
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5.发明申请ASSAY PLATES READER SYSTEMS AND METHODS FOR LUMINESCENCE TEST MEASUREMENTS 审中-公开测定板读取器系统和用于发光测试测量的方法
公开(公告)号：WO2003001889A2
公开(公告)日：2003-01-09
申请号：PCT/US2002/020570
申请日：2002-06-28
Applicant: MESO SCALE TECHNOLOGIES, LLC. , WOHLSTADTER, Jacob, N. , WILBUR, James, L. , SIGAL, George , GLEZER, Eli , JOHNSON, Kent , JEFFREY-COKER, Bandele , KISHBAUGH, Alan , CLINTON, Charles , DEBAD, Jeff, D. , FISCHER, Alan, B.
Inventor： WOHLSTADTER, Jacob, N. , WILBUR, James, L. , SIGAL, George , GLEZER, Eli , JOHNSON, Kent , JEFFREY-COKER, Bandele , KISHBAUGH, Alan , CLINTON, Charles , DEBAD, Jeff, D. , FISCHER, Alan, B.
IPC: G01N21/76 , B01L3/00 , G01J3/30 , G01N1/00 , G01N1/10 , G01N21/64 , G01N21/66 , G01N27/26 , G01N27/30 , G01N35/04 , G06K7/00
CPC classification number: G01N21/253 , B01L3/5085 , B01L9/50 , B01L2300/021 , B01L2300/0645 , B01L2300/0829 , B01L2300/0851 , B01L2300/12 , G01N21/645 , G01N21/66 , G01N21/76 , G01N2035/042 , G01N2035/0425 , G01N2035/0494 , Y10T29/49155 , Y10T83/04
Abstract: Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
Abstract translation: 使用具有集成电极的测定模块进行发光测试测量，所述测试模块具有适于接收测定模块的读取器设备，在测定模块的孔或测定区域中诱导发光，优选电极诱导的发光，并且测量 诱导发光。
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Patent Agency Ranking
公开(公告)号：WO2014107576A2
公开(公告)日：2014-07-10
申请号：PCT/US2014/010182
申请日：2014-01-03
Applicant: MESO SCALE TECHNOLOGIES, LLC , CHAMBERLIN, Ian , CLINTON, Charles, M. , GLEZER, Eli, N. , JEFFREY-COKER, Bandele , KOCHAR, Manish , KOVACS, Sandor , LE, D.T. , LEIMKUEHLER, Aaron , SIGAL, George , TABAKIN, Leo , WILLOUGHBY, Jon
Inventor： CHAMBERLIN, Ian , CLINTON, Charles, M. , GLEZER, Eli, N. , JEFFREY-COKER, Bandele , KOCHAR, Manish , KOVACS, Sandor , LE, D.T. , LEIMKUEHLER, Aaron , SIGAL, George , TABAKIN, Leo , WILLOUGHBY, Jon
CPC classification number: G02B7/36 , G01N21/253 , G01N21/6452 , G01N35/028
Abstract: Apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation are described. They are particularly well suited for conducting automated analysis in a multi-well plate assay format.
Abstract translation: 描述了用于进行测定的装置，系统，方法，试剂和试剂盒及其制备方法。 它们特别适用于以多孔板测定方式进行自动化分析。
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公开(公告)号：WO2011017094A2
公开(公告)日：2011-02-10
申请号：PCT/US2010043375
申请日：2010-07-27
Applicant: CHAMBERLIN IAN , CLINTON CHARLES M , GLEZER ELI N , JEFFREY-COKER BANDELE , KOCHAR MANISH , KOVACS SANDOR , LE DT , LEIMKUEHLER AARON , PINCKNEY GREG , ROTH KRISTIAN , SIGAL GEORGE , YIN FEI
Inventor： CHAMBERLIN IAN , CLINTON CHARLES M , GLEZER ELI N , JEFFREY-COKER BANDELE , KOCHAR MANISH , KOVACS SANDOR , LE DT , LEIMKUEHLER AARON , PINCKNEY GREG , ROTH KRISTIAN , SIGAL GEORGE , YIN FEI
CPC classification number: G01N33/5304 , B01L3/5085 , B01L2200/16 , B01L2300/021 , B01L2300/022 , B01L2300/0829 , B01L2300/105 , G01N21/6452 , G01N21/66 , G01N21/76 , G01N33/54326 , G01N33/54366 , G01N33/56983 , G01N2035/0425 , Y02A90/26
Abstract: We describe apparatuses, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of liquid samples in a clinical point of care setting.
Abstract translation: 我们描述了用于进行测定的装置，方法，试剂和试剂盒以及它们的制备方法。 它们特别适合于以多孔板分析方式进行自动取样，样品制备和分析。 例如，它们可用于临床护理场所中的液体样品的自动分析。
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公开(公告)号：WO2008057111A2
公开(公告)日：2008-05-15
申请号：PCT/US2006049049
申请日：2006-12-21
Applicant: MESO SCALE TECHNOLOGIES LLC , CLINTON CHARLES M , GLEZER ELI N , JEFFREY-COKER BANDELE , KOVACS SANDOR , KUMAR SUDEEP M , SIGAL GEORGE , STEVENS CARL , VOCK MICHAEL
Inventor： CLINTON CHARLES M , GLEZER ELI N , JEFFREY-COKER BANDELE , KOVACS SANDOR , KUMAR SUDEEP M , SIGAL GEORGE , STEVENS CARL , VOCK MICHAEL
CPC classification number: G01N33/582 , G01N21/6452 , G01N21/66 , G01N33/5302 , G01N35/028 , G01N35/1002 , G01N35/1079 , G01N35/109 , G01N2035/0405 , G01N2035/0425 , G01N2035/1025
Abstract: We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.
Abstract translation: 我们描述用于进行测定的装置，系统，方法，试剂和试剂盒以及其制备方法。 它们特别适用于以多孔板测定形式进行自动取样，样品制备和分析。 例如，它们可用于在环境监测中对其中衍生的空气和/或液体样品中的颗粒进行自动分析。
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公开(公告)号：WO2007076023A3
公开(公告)日：2007-07-05
申请号：PCT/US2006/049048
申请日：2006-12-21
Applicant: MESO SCALE TECHNOLOGIES, LLC , GLEZER, Eli, N. , JEFFREY-COKER, Bandele , DEBAD, Jeff, D. , KUMAR, Sudeep, M. , SIGAL, George , SPIELES, Gisbert , TSIONKSY, Michael , WARNOCK, Michael
Inventor： GLEZER, Eli, N. , JEFFREY-COKER, Bandele , DEBAD, Jeff, D. , KUMAR, Sudeep, M. , SIGAL, George , SPIELES, Gisbert , TSIONKSY, Michael , WARNOCK, Michael
IPC: G01N33/53
Abstract: We describe assay modules (e.g., assay plates, cartridges, multi-well assay plates, reaction vessels, etc.), processes for their preparation, and method of their use for conducting assays. Reagents may be present in free form or supported on solid phases including the surfaces of compartments (e.g., chambers, channels, flow cells, wells, etc.) in the assay modules or the surface of colloids, beads, or other particulate supports. In particular, dry reagents can be incorporated into the compartments of these assay modules and reconstituted prior to their use in accordance with the assay methods. A desiccant material may be used to maintain and stabilize these reagents in a dry state.
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公开(公告)号：WO2017015636A1
公开(公告)日：2017-01-26
申请号：PCT/US2016/043755
申请日：2016-07-22
Applicant: MESO SCALE TECHNOLOGIES, LLC. , KOCHAR, Manish , BOSCO, Peter, J. , CHAMBERLIN, Ian, D. , JEFFREY-COKER, Bandele , JONES, Eric, M. , KRIVOY, Gary, I. , KRUEGER, Don, E. , LEIMKUEHLER, Aaron, H. , WU, Pei-Ming , NGUYEN, Kim-Xuan , OBEROI, Pankaj , PANG, Louis, W. , PARKER, Jennifer , PELLICIER, Victor , SAMMONS, Nick , SIGAL, George , WOHLSTADTER, Jacob , VOCK, Mike , SMITH, Stanley, T. , STEVENS, Carl, C. , OSBORNE, Roger, D. , PAGE, Kenneth , WADE, Michael, T. , WILLOUGHBY, Jon , WANG, Lei
Inventor： KOCHAR, Manish , BOSCO, Peter, J. , CHAMBERLIN, Ian, D. , JEFFREY-COKER, Bandele , JONES, Eric, M. , KRIVOY, Gary, I. , KRUEGER, Don, E. , LEIMKUEHLER, Aaron, H. , WU, Pei-Ming , NGUYEN, Kim-Xuan , OBEROI, Pankaj , PANG, Louis, W. , PARKER, Jennifer , PELLICIER, Victor , SAMMONS, Nick , SIGAL, George , WOHLSTADTER, Jacob , VOCK, Mike , SMITH, Stanley, T. , STEVENS, Carl, C. , OSBORNE, Roger, D. , PAGE, Kenneth , WADE, Michael, T. , WILLOUGHBY, Jon , WANG, Lei
IPC: G01N33/53 , G01N33/543 , G06F17/30 , C40B60/12
CPC classification number: G06Q10/10 , G06F19/00 , G06Q10/087 , G16H10/40
Abstract: The present invention relates to methods, devices and systems for associating consumable data with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system adjusts one or more steps of an assay protocol based on consumable data specific for that consumable. Various types of consumable data are described, as well as methods of using such data in the conduct of an assay by an assay system. The present invention also relates to consumables (e.g., kits and reagent containers), software, data deployable bundles, computer-readable media, loading carts, instruments, systems, and methods, for performing automated biological assays.
Abstract translation: 本发明涉及将消耗品数据与生物测定中使用的测定消耗品相关联的方法，装置和系统。 提供了测定系统和相关的消耗品，其中测定系统基于该消耗品特有的消耗性数据来调整测定方案的一个或多个步骤。 描述了各种类型的消耗品数据，以及在通过测定系统进行测定时使用这些数据的方法。 本发明还涉及用于进行自动生物测定的消耗品（例如，试剂盒和试剂容器），软件，可部署数据的捆，计算机可读介质，装载车，仪器，系统和方法。
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