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公开(公告)号：WO2007076070A2
公开(公告)日：2007-07-05
申请号：PCT/US2006049141
申请日：2006-12-22
Applicant: VERTEX PHARMA , MAKINGS LEWIS R , GARCIA-GUZMAN BLANCO MIGUEL , HURLEY DENNIS J , DRUTU IOANA , RAFFAI GABRIEL , BERGERON DANIELE M , NAKATANI AKIKO , TERMIN ANDREAS P , SILINA ALINA
Inventor： MAKINGS LEWIS R , GARCIA-GUZMAN BLANCO MIGUEL , HURLEY DENNIS J , DRUTU IOANA , RAFFAI GABRIEL , BERGERON DANIELE M , NAKATANI AKIKO , TERMIN ANDREAS P , SILINA ALINA
CPC classification number: A61K31/4545 , A61K31/438 , A61K31/46 , A61K31/497 , A61K31/498 , A61K31/501 , A61K31/506 , C07D221/20 , C07D401/04 , C07D401/06 , C07D405/04 , C07D417/14 , C07D471/10 , C07D487/08 , C07D491/10
Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
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公开(公告)号：WO2007050522A1
公开(公告)日：2007-05-03
申请号：PCT/US2006/041304
申请日：2006-10-23
Applicant: VERTEX PHARMACEUTICALS INCORPORATED , MARTINBOROUGH, Esther , TERMIN, Andreas, P. , NEUBERT, Timothy, D. , ZIMMERMANN, Nicole , GUTIERREZ, Corey, Don
Inventor： MARTINBOROUGH, Esther , TERMIN, Andreas, P. , NEUBERT, Timothy, D. , ZIMMERMANN, Nicole , GUTIERREZ, Corey, Don
IPC: C07D207/12 , C07D211/54 , C07D401/08 , C07D401/12 , C07D403/08 , A61K31/40 , A61K31/4025 , A61K31/445 , A61K31/4523 , A61P25/00
CPC classification number: C07D401/08 , C07D207/10 , C07D207/12 , C07D211/54 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/08
Abstract: Sulfonamide derivatives act as ion channel antagonists. These compounds have the general Formula (I): Formula (I) compositions are useful for treating or relieving pain-related conditions.
Abstract translation: 磺酰胺衍生物作为离子通道拮抗剂。 这些化合物具有通式（I）：式（I）组合物可用于治疗或缓解疼痛相关病症。
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公开(公告)号：WO2006122014A2
公开(公告)日：2006-11-16
申请号：PCT/US2006/017699
申请日：2006-05-08
Applicant: VERTEX PHARMACEUTICALS INCORPORATED , KAWATKAR, Aarti, S. , WHITNEY, Tara , NEUBERT, Timothy, D. , ZIMMERMANN, Nicole , TERMIN, Andreas, P. , MARTINBOROUGH, Esther
Inventor： KAWATKAR, Aarti, S. , WHITNEY, Tara , NEUBERT, Timothy, D. , ZIMMERMANN, Nicole , TERMIN, Andreas, P. , MARTINBOROUGH, Esther
IPC: C07D417/12 , C07D417/14 , C07D413/14 , C07D413/12 , C07D403/14 , C07D403/12 , A61K31/404 , A61K31/4725 , A61K31/4709 , A61P23/00
CPC classification number: C07D417/14 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12
Abstract: Bicyclic derivatives having formula (I) and a composition thereof are useful as ion channel antagonists: (I).
Abstract translation: 具有式（I）的双环衍生物及其组合物可用作离子通道拮抗剂：（I）。
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4.发明申请HETEROARYLAMINOSULFONYLPHENYL DERIVATIVES FOR USE AS SODIUM OR CALCIUM CHANNEL BLOCKERS IN THE TREATMENT OF PAIN 审中-公开用于治疗疼痛的钠或钙通道阻断剂的异喹啉基苯基衍生物
公开(公告)号：WO2005013914A8
公开(公告)日：2006-09-28
申请号：PCT/US2004025827
申请日：2004-08-09
Applicant: VERTEX PHARMA , GONZALES JESUS E III , TERMIN ANDREAS P , MARTINBOROUGH ESTHER , ZIMMERMAN NICOLE
Inventor： GONZALES JESUS E III , TERMIN ANDREAS P , MARTINBOROUGH ESTHER , ZIMMERMAN NICOLE
IPC: C07C311/46 , A61K31/513 , A61K31/517 , A61K31/522 , A61K31/5377 , A61K31/5415 , C07C311/51 , C07D209/80 , C07D209/92 , C07D213/76 , C07D231/38 , C07D231/42 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/46 , C07D239/52 , C07D239/54 , C07D239/545 , C07D239/69 , C07D241/22 , C07D261/16 , C07D263/50 , C07D277/52 , C07D277/82 , C07D285/12 , C07D285/125 , C07D285/135 , C07D295/26 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D513/04
CPC classification number: C07D417/14 , C04B35/632 , C07C311/46 , C07C311/51 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D209/80 , C07D209/92 , C07D213/76 , C07D231/38 , C07D231/42 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/47 , C07D239/52 , C07D239/545 , C07D239/69 , C07D241/22 , C07D261/16 , C07D263/50 , C07D277/52 , C07D277/82 , C07D285/125 , C07D285/135 , C07D295/26 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D513/04
Abstract: The present invention relates to compounds such as those of formula (I-A) inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, such as pain.
Abstract translation: 本发明涉及电压门控钠通道抑制剂的式（I-A）化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病如疼痛的方法。
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5.发明申请MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR 审中-公开CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR的调节剂
公开(公告)号：WO2016057572A1
公开(公告)日：2016-04-14
申请号：PCT/US2015/054316
申请日：2015-10-06
Applicant: MILLER, Mark Thomas , ANDERSON, Corey , ARUMUGAM, Vijayalaksmi , BEAR, Brian Richard , BINCH, Hayley Marie , CLEMENS, Jeremy J. , CLEVELAND, Thomas , CONROY, Erica , COON, Timothy Richard , FRIEMAN, Bryan A. , GROOTENHUIS, Peter Diederik Jan , GROSS, Raymond Stanley , HADIDA-RUAH, Sara Sabina , HARIPADA, Khatuya , JOSHI, Pramod Virupax , KRENITSKY, Paul John , LIN, Chun-Chieh , MARELIUS, Gulin Erdgogan , MELILLO, Vito , MCCARTNEY, Jason , NICHOLLS, Georgia McGaughey , PIERRE, Fabrice Jean Denis , SILINA, Alina , TERMIN, Andreas P. , UY, Johnny , ZHOU, Jinglan
Inventor： MILLER, Mark Thomas , ANDERSON, Corey , ARUMUGAM, Vijayalaksmi , BEAR, Brian Richard , BINCH, Hayley Marie , CLEMENS, Jeremy J. , CLEVELAND, Thomas , CONROY, Erica , COON, Timothy Richard , FRIEMAN, Bryan A. , GROOTENHUIS, Peter Diederik Jan , GROSS, Raymond Stanley , HADIDA-RUAH, Sara Sabina , HARIPADA, Khatuya , JOSHI, Pramod Virupax , KRENITSKY, Paul John , LIN, Chun-Chieh , MARELIUS, Gulin Erdgogan , MELILLO, Vito , MCCARTNEY, Jason , NICHOLLS, Georgia McGaughey , PIERRE, Fabrice Jean Denis , SILINA, Alina , TERMIN, Andreas P. , UY, Johnny , ZHOU, Jinglan
CPC classification number: A61K31/506 , A61J1/035 , A61K31/404 , A61K31/415 , A61K31/44 , A61K31/4418 , A61K31/4439 , A61K31/444 , A61K31/4525 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/497 , C07D209/18 , C07D209/42 , C07D209/49 , C07D213/64 , C07D213/73 , C07D213/82 , C07D213/84 , C07D231/12 , C07D231/14 , C07D231/20 , C07D235/24 , C07D239/34 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D405/14 , C07D407/12 , C07D413/14 , C07D417/12
Abstract: The present invention features a compound of formula (I): (I) or a pharmaceutically acceptable salt thereof, where R 1 , R 2 , R 3 , W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.
Abstract translation: 本发明的特征在于式（I）化合物：（I）或其药学上可接受的盐，其中R1，R2，R3，W，X，Y，Z，n，o，p和q如本文所定义， 治疗CFTR介导的疾病，如囊性纤维化。 本发明还特征在于药物组合物，治疗方法及其试剂盒。
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Patent Agency Ranking
公开(公告)号：WO2006023852A2
公开(公告)日：2006-03-02
申请号：PCT/US2005/029780
申请日：2005-08-19
Applicant: VERTEX PHARMACEUTICALS, INCORPORATED , MAKINGS, Lewis, R. , GARCIA-GUZMAN BLANCO, Miguel , HURLEY, Dennis, J. , DRUTU, Ioana , RAFFAI, Gabriel , BERGERON, Daniele, J. , NAKATANI, Akiko , TERMIN, Andreas, P. , SILINAS, Alina
Inventor： MAKINGS, Lewis, R. , GARCIA-GUZMAN BLANCO, Miguel , HURLEY, Dennis, J. , DRUTU, Ioana , RAFFAI, Gabriel , BERGERON, Daniele, J. , NAKATANI, Akiko , TERMIN, Andreas, P. , SILINAS, Alina
IPC: A61K31/435 , A61K31/438 , A61P43/00 , A61P25/00
CPC classification number: C07D401/06 , A61K31/435 , A61K31/438 , A61K31/4747 , A61K31/55 , C07D221/20 , C07D223/32 , C07D405/04 , C07D405/06 , C07D405/12 , C07D451/02 , C07D451/04 , C07D471/10 , C07D491/10
Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
Abstract translation: 本发明涉及毒蕈碱受体的调节剂。 本发明还提供包含这种调节剂的组合物，及其用于治疗毒蕈碱受体介导的疾病的方法。
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公开(公告)号：WO2006130493A8
公开(公告)日：2008-02-21
申请号：PCT/US2006020521
申请日：2006-05-26
Applicant: VERTEX PHARMA , WILSON DEAN M , TERMIN ANDREAS P , FANNING LEV T D , KRENITSKY PAUL , JOSHI PRAMOD
Inventor： WILSON DEAN M , TERMIN ANDREAS P , FANNING LEV T D , KRENITSKY PAUL , JOSHI PRAMOD
IPC: C07D417/04 , A61K31/44 , A61K31/496
CPC classification number: C07D277/38 , C07D285/08 , C07D417/04
Abstract: The present invention relates to compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
Abstract translation: 本发明涉及可用作离子通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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8.发明申请SPIRO CONDENSED PIPERIDNES AS MODULATORS OF MUSCARINIC RECEPTORS 审中-公开SPIRO CONDENSED PIPERIDNES as MODULATORS OF MUSCARINIC RECEPTORS
公开(公告)号：WO2007100670A1
公开(公告)日：2007-09-07
申请号：PCT/US2007/004745
申请日：2007-02-22
Applicant: VERTEX PHARMACEUTICALS INCORPORATED , MAKINGS, Lewis, R. , GARCIA-GUZMAN BLANCO, Miguel , HURLEY, Dennis, J. , DRUTU, Ioana , RAFFAI, Gabriel , BERGERON, Daniele, M. , NAKATANI, Akiko , TERMIN, Andreas, P. , SILINA, Alina
Inventor： MAKINGS, Lewis, R. , GARCIA-GUZMAN BLANCO, Miguel , HURLEY, Dennis, J. , DRUTU, Ioana , RAFFAI, Gabriel , BERGERON, Daniele, M. , NAKATANI, Akiko , TERMIN, Andreas, P. , SILINA, Alina
IPC: C07D471/10 , C07D519/00 , A61K31/438 , A61K31/46 , A61K31/4747 , A61P25/00
CPC classification number: C07D471/10
Abstract: The present invention relates to modulators of muscarnic receptors of formula (I). The present invention also provides impositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
Abstract translation: 本发明涉及式（I）的毒蕈碱受体的调节剂。 本发明还提供包含这种调节剂的作用，以及其用于治疗毒蕈碱受体介导的疾病的方法。
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公开(公告)号：WO2006130493A3
公开(公告)日：2007-03-01
申请号：PCT/US2006020521
申请日：2006-05-26
Applicant: VERTEX PHARMA , KRENITSKY PAUL , JOSHI PRAMOD , WILSON DEAN M , TERMIN ANDREAS P , FANNING LEV T D
Inventor： KRENITSKY PAUL , JOSHI PRAMOD , WILSON DEAN M , TERMIN ANDREAS P , FANNING LEV T D
IPC: C07D417/04 , A61K31/44 , A61K31/496
CPC classification number: C07D277/38 , C07D285/08 , C07D417/04
Abstract: The present invention relates to compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
Abstract translation: 本发明涉及可用作离子通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：WO2006124744A1
公开(公告)日：2006-11-23
申请号：PCT/US2006/018669
申请日：2006-05-12
Applicant: VERTEX PHARMACEUTICALS INCORPORATED , TERMIN, Andreas, P. , ZIMMERMANN, Nicole , KNOLL, Tara, Leanne , MARTINEZ-BOTELLA, Gabriel , MARTINBOROUGH, Esther
Inventor： TERMIN, Andreas, P. , ZIMMERMANN, Nicole , KNOLL, Tara, Leanne , MARTINEZ-BOTELLA, Gabriel , MARTINBOROUGH, Esther
IPC: C07D401/12 , C07D417/12 , A61K31/4709 , A61K31/55 , A61P23/00
CPC classification number: C07D417/12 , C07D401/12
Abstract: The present invention relates to bicyclic compounds of formula (I); wherein Z,R N ,q,R M ,Q,R Q are as defined in claim 1 , useful as inhibitors of ion channels.The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
Abstract translation: 本发明涉及式（I）的双环化合物; 其中Z，R N，Q，R M，Q，R Q如权利要求1中所定义，可用作离子通道的抑制剂。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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