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    SUBSTITUTED (ARYLALKOXYBENZYL)AMINOPROPANAMIDE DERIVATIVES, THEIR PREPARATION AND USE AS ANTI-EPILEPTIC, NEUROPROTECTIVE AND ANTIDEPRESSANT AGENTS
    1.
    发明申请
    SUBSTITUTED (ARYLALKOXYBENZYL)AMINOPROPANAMIDE DERIVATIVES, THEIR PREPARATION AND USE AS ANTI-EPILEPTIC, NEUROPROTECTIVE AND ANTIDEPRESSANT AGENTS 审中-公开
    取代（芳基烷氧基）氨基丙酰胺衍生物，其制备和用作抗真菌，神经保护和抗原剂

    公开(公告)号：WO1994022808A1

    公开(公告)日：1994-10-13

    申请号：PCT/EP1994000802

    申请日：1994-03-15

    Applicant: FARMITALIA CARLO ERBA Srl

    Inventor： FARMITALIA CARLO ERBA Srl ,  VARASI, Mario ,  DOSTERT, Philippe ,  PEVARELLO, Paolo ,  BONSIGNORI, Alberto

    IPC: C07C237/06

    CPC classification number: C07C237/00

    Abstract: The invention provides new compounds of formula (I) wherein, subject to a proviso, n is zero or an integer of 1 to 3; each of R and R1, which may be the same or different, is hydrogen, halogen, trifluoromethyl or C1-C4 alkoxy; R2 is hydrogen or C1-C4 alkyl optionally substituted by hydroxy; each of R3 and R4 independently is hydrogen or C1-C4 alkyl; or a pharmaceutically acceptable salt thereof; and of formula (IA), wherein R5 is hydrogen, halogen, trifluoromethyl or C1-C4 alkoxy, or a pharmaceutically acceptable salt thereof, which are active on the central nervous system (CNS) and can be used in therapy as anti-epileptics, anti-Parkinson, neuroprotective, antidepressant, anti-spastic and hypnotic agents.

    Abstract translation: 本发明提供新的式（I）化合物，其中，条件是n为0或1至3的整数; R和R 1可以相同或不同，为氢，卤素，三氟甲基或C 1 -C 4烷氧基; R2是氢或任选被羟基取代的C 1 -C 4烷基; R 3和R 4各自独立地是氢或C 1 -C 4烷基; 或其药学上可接受的盐; 和式（IA）的化合物，其中R5是氢，卤素，三氟甲基或C1-C4烷氧基，或其药学上可接受的盐，它们在中枢神经系统（CNS）上有活性，可用作抗癫痫药， 抗帕金森，神经保护，抗抑郁药，抗痉挛和催眠药。

    DERIVATIVES OF (R) 5-PENTYLAMINO-5-OXOPENTANOIC ACID WITH ANTICHOLECYSTOKININ ACTIVITY
    6.
    发明申请
    DERIVATIVES OF (R) 5-PENTYLAMINO-5-OXOPENTANOIC ACID WITH ANTICHOLECYSTOKININ ACTIVITY 审中-公开
    （R）5-戊基氨基-5-氧代戊酸与抗转氨酶活性的衍生物

    公开(公告)号：WO1988005774A1

    公开(公告)日：1988-08-11

    申请号：PCT/EP1988000061

    申请日：1988-01-28

    Applicant: ROTTA RESEARCH LABORATORIUM S.P.A.

    Inventor： ROTTA RESEARCH LABORATORIUM S.P.A. ,  MAKOVEC, Francesco ,  CHISTE', Rolando ,  PERIS, Walter ,  ROVATI, Luigi

    IPC: C07C103/50

    CPC classification number: A61K31/195 ,  C07C231/02 ,  C07C233/12 ,  C07C233/83 ,  C07C237/00

    Abstract: Optically active derivatives of (R) 5-pentylamino-5-oxopentanoic acid and their pharmaceutically acceptable salts, having antagonistic activity towards cholecystokinin, and with formula (I), in which R1 is selected from the groups 2-naphthyl, 3,4-dichlorobenzoyl and 3,4-dimethylbenzoyl and R2 is a pentyl group or an alkoxyalkyl group with 4 carbon atoms, and in which the substituents on the central chiral group (marked with an asterisk in Formula (I)), have the R (rectus) conformation.

    Abstract translation: （R）5-戊基氨基-5-氧代戊酸及其药学上可接受的盐，对缩胆囊素具有拮抗作用并且具有式（I）的光学活性衍生物，其中R 1选自2-萘基，3,4- 二氯苯甲酰基和3,4-二甲基苯甲酰基，R 2是具有4个碳原子的戊基或烷氧基烷基，其中中心手性基团上的取代基（在式（I）中用星号标记））具有R（直角） 构象。

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