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    SUBSTITUTED PYRROLIDONE, THIAZOLIDONES OR OXAZOLIDONES AS HERBICIDES
    1.
    发明申请
    SUBSTITUTED PYRROLIDONE, THIAZOLIDONES OR OXAZOLIDONES AS HERBICIDES 审中-公开
    取代的吡咯烷酮，噻唑烷酮或氧杂环己酮作为除草剂

    公开(公告)号：WO1995033719A1

    公开(公告)日：1995-12-14

    申请号：PCT/GB1995001224

    申请日：1995-05-26

    Applicant: ZENECA LIMITED ,  COX, John, Michael ,  CLOUGH, John, Martin ,  BARNES, Nigel, John ,  PEARSON, David, Philip, John ,  MATTHEWS, Ian, Richard ,  VOHRA, Shaheen, Khatoon ,  SMITH, Stephen, Christopher ,  MITCHELL, Glynn ,  BARBER, Richard, Anthony ,  ELLIS, Russell, Martin ,  LANGTON, David, William ,  GILLEN, Kevin, James ,  HATTER, Glenn ,  KOZAKIEWICZ, Anthony, Marian ,  BACON, David, Philip ,  BELLINI, Peter

    Inventor： ZENECA LIMITED

    IPC: C07D207/26

    CPC classification number: C07D207/26 ,  A01N43/36 ,  A01N43/40 ,  A01N43/50 ,  A01N43/54 ,  A01N43/76 ,  A01N43/78 ,  A01N43/80 ,  A01N47/06 ,  A01N47/18 ,  A01N47/24 ,  A01N47/36 ,  A01N51/00 ,  A01N55/00 ,  C07C271/10 ,  C07C271/32 ,  C07C271/40 ,  C07D207/273 ,  C07D263/18 ,  C07D277/14 ,  C07D277/16 ,  C07D277/18 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04

    Abstract: Compounds of general formula (I), wherein X is O, S or CR R ; each R and R is, independently, hydrogen or C1-C4 alkyl; Z is O, S or NR ; n is 0 or 1; Y is O, S, NR or CR R ; R is H, OH, CHO, NR R or C1-C10 hydrocarbyl, 0-(C1-C10 hydrocarbyl), either of which may be substituted with one orm ore substituents chosen from OR , COR , COOR , OCOR , CN, halogen, S(O)pR , NR R , NO2, NR COR , NR CONR R , CONR R or heterocyclyl; R , R and R are each, independently, hydrogen, C1-C6 hydrocarbyl or C1-C6 halohydrocarbyl; p is 0, 1 or 2; alternatively: when Y is NR or CR R , and: a) Z is NR ; or b) n is 0; the substituents of Y and Z or Y and R may together form a bridge represented by the formula -Q -Q - or -Q -Q -Q -, where Q , Q and Q each independently represent CR R , =CR , CO, NR , =N, O or S; each or R and R independently represents hydrogen, C1-C4 alkyl, OH or halogen; R represents hydrogen or C1-C4 alkyl; W is O or S; R is hydrogen or C1-C10 hydrocarbyl or heterocyclyl having 3 to 8 ring atoms; R and R are each independently hydrogen or C1-C4 alkyl; A is an aromatic or heteroaromatic ring system optionally substituted alternatively, two or more substituents of the group A may combine to form a fused 5- or 6-membered saturated or partially saturated carbocyclic or heterocyclic ring in which any carbon or quaternised nitrogen atom may be substituted with any of the groups mentioned above for A or in which a ring carbon atom may be part of a carbonyl group or a nitrogen atom may be oxidised.

    Abstract translation: 通式（I）的化合物，其中X是O，S或CR 4 R 5; 每个R 4和R 5独立地是氢或C 1 -C 4烷基; Z是O，S或NR 4; n为0或1; Y是O，S，NR 6或CR 4 R 5; R 6是H，OH，CHO，NR 16 R 17或C 1 -C 10烃基，O-（C 1 -C 10烃基），其中任一个可以被一个选自OR 16的取代基取代 ，COR 16，OCOR 16，CN，卤素，S（O）p R 16，NR 16 R 17，NO 2，NR 16 COR 17， NR 16 CONR 17 R 18，CONR 16 R 17或杂环基; R 16，R 17和R 18各自独立地为氢，C 1 -C 6烃基或C 1 -C 6卤代烃基; p为0,1或2; 或者：当Y是NR 6或CR 4 R 5时，和：a）Z是NR 4; 或b）n为0; Y和Z或Y和R 1的取代基可以一起形成由式-Q 1 -Q 2 - 或-Q 1 -Q 2 -Q 3 - 其中Q 1，Q 2和Q 3各自独立地表示CR 12 R 13，= CR 12，CO，NR 14，= N，O或S; 每个或R 12和R 13独立地表示氢，C 1 -C 4烷基，OH或卤素; R 14表示氢或C 1 -C 4烷基; W为O或S; R 1是氢或C 1 -C 10烃基或具有3至8个环原子的杂环基; R 2和R 3各自独立地为氢或C 1 -C 4烷基; A是任选地任选取代的芳族或杂芳族环系统，组A中的两个或多个取代基可以结合形成稠合的5或6元饱和或部分饱和的碳环或杂环，其中任何碳或季铵化氮原子可以是 被上述任何A取代或环碳原子可以是羰基或氮原子的一部分被氧化。

    NEUROPROTECTIVE MULTIFUNCTIONAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM
    2.
    发明申请
    NEUROPROTECTIVE MULTIFUNCTIONAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM 审中-公开
    神经保护性多功能化合物和包含它们的药物组合物

    公开(公告)号：WO2010086860A3

    公开(公告)日：2011-02-24

    申请号：PCT/IL2010000080

    申请日：2010-01-31

    Applicant: YEDA RES & DEV ,  TECHNION RES & DEV FOUNDATION ,  YOUDIM MOUSSA B H ,  FRIDKIN MATI ,  ZHENG HAILIN

    Inventor： YOUDIM MOUSSA B H ,  FRIDKIN MATI ,  ZHENG HAILIN

    IPC: C07C211/38 ,  A61K31/131 ,  A61K31/135 ,  A61K31/47 ,  A61P9/00 ,  A61P25/00 ,  A61P29/00 ,  C07C259/10 ,  C07C271/40 ,  C07D215/34 ,  C07D401/12

    CPC classification number: C07C259/10 ,  C07C211/38 ,  C07C271/40 ,  C07C2602/08 ,  C07C2603/74 ,  C07D215/34 ,  C07D401/06 ,  C07D401/12

    Abstract: Multifunctional compounds are provided, comprising two or more functional moieties selected from: (i) a moiety that imparts an iron chelator function; (ii) a moiety that imparts a neuroprotective function; (iii) a moiety that imparts combined antiapoptotic, neuroprotective and/or neurorestorative functions; (iv) a moiety that imparts brain MAO inhibition, preferably with little or no MAO inhibition in liver and small intestine; (v) a moiety that imparts cholinesterase inhibitory function; and (vi) a moiety that imparts an N-methyl-D-aspartic acid receptor (NMDAR) inhibition, and pharmaceutically acceptable salts and optical isomers thereof. The multifunctional compounds are useful in the treatment or prevention of diseases, disorders or conditions that can be prevented and/or treated by iron chelation therapy, and/or neuroprotection and/or neurorestoration, and/or apoptosis inhibition and/or MAO inhibition and/or cholinesterase inhibition and/or NMADR inhibition. The present invention encompasses compounds of the formulas I to Vl.

    Abstract translation: 提供多官能化合物，其包含两个或多个选自以下的官能部分：（i）赋予铁螯合剂功能的部分; （ii）赋予神经保护功能的部分; （iii）赋予组合的抗细胞凋亡，神经保护和/或神经恢复功能的部分; （iv）赋予脑MAO抑制的部分，优选在肝脏和小肠中几乎没有MAO抑制作用; （v）赋予胆碱酯酶抑制功能的部分; 和（vi）赋予N-甲基-D-天冬氨酸受体（NMDAR）抑制的部分及其药学上可接受的盐和旋光异构体。 多官能化合物可用于治疗或预防可通过铁螯合治疗和/或神经保护和/或神经恢复，和/或凋亡抑制和/或MAO抑制和/或MAO抑制和/或治疗的/ 或胆碱酯酶抑制和/或NMADR抑制。 本发明包括式I至VI的化合物。

    NOVEL BENZYLAMINE DERIVATIVES, METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
    3.
    发明申请
    NOVEL BENZYLAMINE DERIVATIVES, METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME 审中-公开
    新型苯甲酰胺衍生物，其制备方法及含有其的药物组合物

    公开(公告)号：WO1995029154A1

    公开(公告)日：1995-11-02

    申请号：PCT/FR1995000525

    申请日：1995-04-21

    Applicant: PIERRE FABRE MEDICAMENT ,  GOTTELAND, Jean-Pierre ,  HALAZY, Serge ,  DELHON, André ,  JUNQUERO, Didier

    Inventor： PIERRE FABRE MEDICAMENT

    IPC: C07C271/20

    CPC classification number: C07C275/24 ,  C07C27/28 ,  C07C271/20 ,  C07C271/32 ,  C07C271/40 ,  C07F7/081

    Abstract: Novel compounds of general formula (I) wherein R1-R7 denote, in particular, a straight or branched hydrocarbon radical comprising 1-6 carbon atoms, Z is a straight or branched hydroxycarbon radical comprising 2-6 carbon atoms, a triple bond, a Z or E stereochemistry double bond (Z'CH=CHZ") in which Z' and Z", which are the same or different, are a hydrogen atom, a fluorine atom or a straight or branched hydrocarbon radical comprising 1-6 carbon atoms; n=0.1 or 2; X and X', which are the same or different, are O or NR'1, where R'1 is a hydrogen atom, a straight or branched hydroxycarbon radical comprising 1-5 carbon atoms, or a cycloalkyl radical comprising 3-7 carbon atoms; and Y = O,S.

    Abstract translation: 通式（I）的新型化合物，其中R 1 -R 7特别表示包含1-6个碳原子的直链或支链烃基，Z是包含2-6个碳原子的直链或支链羟基羰基，三键， Z或E立体化学双键（Z'CH = CHZ“），其中Z'和Z”相同或不同，为氢原子，氟原子或含1-6个碳原子的直链或支链烃基 ; n = 0.1或2; X和X'是相同或不同的，是O或NR'1，其中R'1是氢原子，包含1-5个碳原子的直链或支链羟基烃基或包含3-7碳原子的环烷基 原子; 和Y = O，S。

    POLYMERISABLE PLASTICISER, LIQUID POLYURETHANE RESIN COMPOSITION COMPRISING SAME AND USES THEREOF
    6.
    发明申请
    POLYMERISABLE PLASTICISER, LIQUID POLYURETHANE RESIN COMPOSITION COMPRISING SAME AND USES THEREOF 审中-公开
    聚合物塑化剂，包含它的液体聚氨酯树脂组合物及其用途

    公开(公告)号：WO2013057429A3

    公开(公告)日：2013-10-03

    申请号：PCT/FR2012052369

    申请日：2012-10-18

    Applicant: SOPREMA

    Inventor： DUROT LOUIS ,  BINDSCHEDLER PIERRE-ETIENNE ,  FRANCOIS BARSEGHIAN VIRGINIE ,  PERRIN REMI

    IPC: C08G18/28 ,  C07C271/06 ,  C08G18/64 ,  C08G18/76 ,  C08G18/78 ,  C08G18/79 ,  C08G18/80 ,  C08L95/00 ,  C09D195/00

    CPC classification number: C08F8/30 ,  C07C271/06 ,  C07C271/32 ,  C07C271/40 ,  C08F2810/40 ,  C08G18/2825 ,  C08G18/6476 ,  C08G18/7664 ,  C08G18/7843 ,  C08G18/791 ,  C08G18/8067 ,  C08L95/00 ,  C09D175/08 ,  C09D195/00

    Abstract: The present invention relates to a polymerisable plasticiser formed by a hydrocarbon chain, one end of which bears more than one isocyanate function, said hydrocarbon chain comprising and/or being substituted by an aromatic ring and/or an aliphatic ring and/or said hydrocarbon chain is substituted by at least two hydrocarbon chains that can comprise an unsaturation, and the number of isocyanate functions being strictly greater than 1, preferably greater than 1.2, and, more preferably, grater than 1.5 but less than or equal to 2.2. The invention also relates to liquid polyurethane resin compositions and, in particular, stable, ready-to-use liquid polyurethane resin compositions comprising said plasticiser. The invention further relates to methods for replacing all or part of the exogenous plasticiser and/or solvent in a polyurethane resin by adding said polymerisable plasticiser.

    Abstract translation: 本发明涉及由烃链形成的可聚合增塑剂，所述烃链的一端具有多于一个异氰酸酯官能团，所述烃链包含和/或被芳环和/或脂肪族环和/或所述烃链取代 被至少两个可包含不饱和度的烃链取代，并且异氰酸酯官能团的数量严格大于1，优选大于1.2，并且更优选大于1.5但小于或等于2.2。 本发明还涉及液体聚氨酯树脂组合物，并且特别涉及包含所述增塑剂的稳定的即用型液体聚氨酯树脂组合物。 本发明还涉及通过添加所述可聚合增塑剂来置换聚氨酯树脂中的全部或部分外源增塑剂和/或溶剂的方法。

    NEUROPROTECTIVE MULTIFUNCTIONAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM
    8.
    发明申请
    NEUROPROTECTIVE MULTIFUNCTIONAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM 审中-公开
    神经保护性多功能化合物和包含它们的药物组合物

    公开(公告)号：WO2010086860A2

    公开(公告)日：2010-08-05

    申请号：PCT/IL2010/000080

    申请日：2010-01-31

    Applicant: Yeda Research and Development Co. Ltd. ,  Technion Research and Development Foundation Ltd. ,  YOUDIM, Moussa B.H. ,  FRIDKIN, Mati ,  ZHENG, Hailin

    Inventor： YOUDIM, Moussa B.H. ,  FRIDKIN, Mati ,  ZHENG, Hailin

    IPC: C07C211/38

    CPC classification number: C07C259/10 ,  C07C211/38 ,  C07C271/40 ,  C07C2602/08 ,  C07C2603/74 ,  C07D215/34 ,  C07D401/06 ,  C07D401/12

    Abstract: Multifunctional compounds are provided, comprising two or more functional moieties selected from: (i) a moiety that imparts an iron chelator function; (ii) a moiety that imparts a neuroprotective function; (iii) a moiety that imparts combined antiapoptotic, neuroprotective and/or neurorestorative functions; (iv) a moiety that imparts brain MAO inhibition, preferably with little or no MAO inhibition in liver and small intestine; (v) a moiety that imparts cholinesterase inhibitory function; and (vi) a moiety that imparts an N-methyl-D-aspartic acid receptor (NMDAR) inhibition, and pharmaceutically acceptable salts and optical isomers thereof. The multifunctional compounds are useful in the treatment or prevention of diseases, disorders or conditions that can be prevented and/or treated by iron chelation therapy, and/or neuroprotection and/or neurorestoration, and/or apoptosis inhibition and/or MAO inhibition and/or cholinesterase inhibition and/or NMADR inhibition.

    Abstract translation: 提供多官能化合物，其包含两个或多个选自以下的官能部分：（i）赋予铁螯合剂功能的部分; （ii）赋予神经保护功能的部分; （iii）赋予组合的抗细胞凋亡，神经保护和/或神经恢复功能的部分; （iv）赋予脑MAO抑制的部分，优选在肝脏和小肠中几乎没有MAO抑制作用; （v）赋予胆碱酯酶抑制功能的部分; 和（vi）赋予N-甲基-D-天冬氨酸受体（NMDAR）抑制的部分及其药学上可接受的盐和旋光异构体。 多官能化合物可用于治疗或预防可通过铁螯合治疗和/或神经保护和/或神经恢复，和/或凋亡抑制和/或MAO抑制和/或MAO抑制和/或治疗的/ 或胆碱酯酶抑制和/或NMADR抑制。

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