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    USE OF MULLERIAN INHIBITING SUBSTANCE (MIS) PROTEINS FOR CONTRACEPTION AND OVARIAN RESERVE PRESERVATION
    2.
    发明申请
    USE OF MULLERIAN INHIBITING SUBSTANCE (MIS) PROTEINS FOR CONTRACEPTION AND OVARIAN RESERVE PRESERVATION 审中-公开
    使用MULLERIAN抑制物质（MIS）蛋白质进行收缩和OVARIAN RESERVE保存

    公开(公告)号：WO2015089321A2

    公开(公告)日：2015-06-18

    申请号：PCT/US2014/069829

    申请日：2014-12-11

    申请人： THE GENERAL HOSPITAL CORPORATION

    发明人： DONAHOE, Patricia, K. ,  PEPIN, David

    IPC分类号： A61K38/17

    CPC分类号： A61K38/22 ,  A61K9/0019 ,  A61K38/17 ,  C12N7/00 ,  C12N2750/14142 ,  C12N2750/14171

    摘要： One aspect of the invention provides a method of contraception by administering to a female subject a composition comprising Mullerian inhibiting substance (MIS). The MIS can be produced endogenously in the subject by a vector, where the vector comprises a polynucletide encoding a recombinant MIS protein. In some embodiments, the contraception is permanent and only requires administration of the composition once. Another aspect of the invention relates to a method of preserving an ovarian reserve, the method comprising administering to a female subject a composition comprising MIS or an inducible vector that comprises a polynucleotide encoding a recombinant MIS protein.

    摘要翻译： 本发明的一个方面提供了一种通过向女性受试者施用包含穆勒抑制物质（MIS）的组合物来避孕的方法。 可以通过载体在受试者内部产生MIS，其中载体包含编码重组MIS蛋白的多核苷酸。 在一些实施方案中，避孕是永久性的，并且仅需要施用组合物一次。 本发明的另一方面涉及一种保存卵巢储备的方法，所述方法包括向雌性受试者施用包含MIS或包含编码重组MIS蛋白的多核苷酸的可诱导载体的组合物。

    MYOSTATIN INHIBITION FOR ENHANCING MUSCLE AND/OR IMPROVING MUSCLE FUNCTION
    10.
    发明申请
    MYOSTATIN INHIBITION FOR ENHANCING MUSCLE AND/OR IMPROVING MUSCLE FUNCTION 审中-公开
    肌醇激素增强肌肉和/或改善肌肉功能的抑制作用

    公开(公告)号：WO2008067480A3

    公开(公告)日：2008-10-30

    申请号：PCT/US2007085960

    申请日：2007-11-29

    申请人： NATIONWIDE CHILDRENS HOSPITAL ,  KASPAR BRIAN K ,  MENDELL JERRY R

    发明人： KASPAR BRIAN K ,  MENDELL JERRY R

    IPC分类号： A61K38/17 ,  A61K38/18 ,  A61K48/00 ,  A61P21/00 ,  C12N15/861

    CPC分类号： A61K48/00 ,  A61K9/0019 ,  A61K35/761 ,  A61K38/00 ,  A61K38/18 ,  C07K14/4703 ,  C12N7/00 ,  C12N15/86 ,  C12N2750/14142 ,  C12N2750/14143 ,  C12N2799/025

    摘要： The present invention relates to methods for inhibiting myostatin, a regulator of muscle mass, for muscle enhancement (including inducing hypertrophy and/or hyperplasia) as well as improving muscle function (including decreasing atrophy and/or increasing endurance, force and/or strength). The methods involve delivering genes to cells using gene delivery in order to inhibit myostatin. Examples of genes to be delivered are genes encoding' proteins such as Follistatin, Follistatin- related gene-1 (FLRG-I), growth differentiation factor associated protein- 1 (GASP-I) and myostatin precursor propeptide. The genes are delivered using a recombinant Adeno-associated virus (rAAV) lacking rep and cap DNA capable of infecting the cells. Following introduction, the genes are expressed in the cell body of the infected cell and the encoded proteins are secreted systemically. In other methods-of the invention expression of proteins such as activin lib and myostatin is inhibited by oligonucleotide techniques to effect muscle enhancement. All the methods have applications in the treatment of musculoskeletal and neurodegenerative disorders among others, as well as enhancing muscle in livestock.

    摘要翻译： 本发明涉及抑制肌肉生长调节剂肌肉增强（包括诱导肥大和/或增生）以及改善肌肉功能（包括减少萎缩和/或增加耐力，力和/或强度）的肌生成抑制素的方法， 。 该方法涉及使用基因递送将基因递送至细胞以抑制肌生成抑制素。 要传递的基因的实例是编码诸如Follistatin，Follistatin相关基因-1（FLRG-1），生长分化因子相关蛋白-1（GASP-1）和肌生成抑制素前体前肽的蛋白质的基因。 使用缺乏能够感染细胞的rep和cap DNA的重组腺相关病毒（rAAV）递送基因。 引入后，基因在感染细胞的细胞体中表达，编码的蛋白质系统地分泌。 在其它方法中，本发明的蛋白质例如激活素III和肌生成抑制素的表达被寡核苷酸技术抑制以实现肌肉增强。 所有方法都可用于治疗肌肉骨骼和神经退行性疾病，以及增强家畜的肌肉。