公开(公告)号：EP3153497A3

公开(公告)日：2017-07-05

申请号：EP16196800.3

申请日：2010-08-03

申请人： Bayer CropScience AG

发明人： Mihara, Jun ,  Araki, Koichi ,  Mori, Takuma ,  Murata, Tetsuya ,  Yoneta, Yasushi ,  Watanabe, Yukiyoshi ,  Shimojo, Eiichi ,  Ichihara, Teruyuki ,  Ataka, Masashi ,  Shibuya, Katsuhiko ,  Görgens, Ulrich

IPC分类号： C07C251/44 ,  C07C251/48 ,  C07C255/19 ,  C07C255/57 ,  C07C271/22 ,  C07C275/24 ,  C07D209/48 ,  C07D213/61 ,  C07D213/81 ,  C07D213/82 ,  C07D213/84 ,  C07D213/85

CPC分类号： C07C233/66 ,  A01N37/42 ,  A01N37/44 ,  A01N37/48 ,  A01N37/50 ,  A01N43/40 ,  A01N43/56 ,  C07C235/84 ,  C07C237/40 ,  C07C237/42 ,  C07C237/48 ,  C07C251/44 ,  C07C251/48 ,  C07C255/19 ,  C07C255/57 ,  C07C271/22 ,  C07C275/24 ,  C07C309/66 ,  C07C311/06 ,  C07C323/60 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/10 ,  C07C2601/14 ,  C07C2602/08 ,  C07C2602/10 ,  C07D209/48 ,  C07D213/61 ,  C07D213/81 ,  C07D213/82 ,  C07D213/84 ,  C07D213/85 ,  C07D231/12 ,  C07D231/16 ,  C07D249/08 ,  C07D249/18 ,  C07D249/20 ,  C07D257/04 ,  C07D295/155 ,  C07D401/12

摘要： The object of the present invention is to provide novel carboxamidcs which exhibit an excellent pesticidal activity as pesticides. Disclose are the carboxamides represented by the following Formula (I):

wherein each substituent is as defined in the specification, and use thereof as pesticides and animal parasite controlling agents.

公开(公告)号：EP1714958B1

公开(公告)日：2016-12-21

申请号：EP04808120.2

申请日：2004-12-24

申请人： Mitsui Chemicals Agro, Inc.

发明人： YOSHIDA, Kei ,  WAKITA, Takeo ,  KATSUTA, Hiroyuki ,  KAI, Akiyoshi ,  CHIBA, Yutaka ,  TAKAHASHI, Kiyoshi ,  KATO, Hiroko ,  KAWAHARA, Nobuyuki ,  NOMURA, Michikazu ,  DAIDO, Hidenori ,  MAKI, Junji ,  BANBA, Shinichi

IPC分类号： C07C237/42 ,  C07C317/40 ,  C07C323/42 ,  C07C327/48 ,  C07D207/16 ,  C07D213/81 ,  C07D213/82 ,  C07D231/12 ,  C07D241/24 ,  C07D261/18 ,  C07D307/68 ,  A01N37/22 ,  A01N43/08 ,  A01N43/10 ,  A01N43/36

CPC分类号： C07D333/38 ,  A01N37/22 ,  A01N37/44 ,  A01N43/08 ,  A01N43/10 ,  A01N43/12 ,  A01N43/16 ,  A01N43/30 ,  A01N43/40 ,  A01N43/42 ,  A01N43/54 ,  A01N43/56 ,  A01N43/58 ,  A01N43/60 ,  A01N43/78 ,  A01N43/80 ,  C07C237/42 ,  C07C237/48 ,  C07C317/40 ,  C07C323/42 ,  C07C327/48 ,  C07D207/34 ,  C07D207/416 ,  C07D213/64 ,  C07D213/73 ,  C07D213/81 ,  C07D213/82 ,  C07D213/89 ,  C07D215/52 ,  C07D231/14 ,  C07D231/16 ,  C07D239/28 ,  C07D239/30 ,  C07D241/24 ,  C07D261/18 ,  C07D263/34 ,  C07D275/03 ,  C07D277/56 ,  C07D307/24 ,  C07D307/68 ,  C07D307/84 ,  C07D307/85 ,  C07D309/08 ,  C07D309/28 ,  C07D317/46 ,  C07D317/62 ,  C07D333/68

摘要： An object of the present invention is to provide a compound represented by Formula (1): wherein A 1 , A 2 , A 3 and A 4 each represent a carbon atom, a nitrogen atom or an oxidized nitrogen atom; R 1 and R 2 each represent a hydrogen atom, an optionally substituted alkyl group or an optionally substituted C1-C4 alkylcarbonyl group; G 1 and G 2 each represent an oxygen atom or a sulfur atom; X, which may be identical or different each other, represents a hydrogen atom, a halogen atom, a C1-C3 alkyl group or a trifluoromethyl group; n is an integer of 0 to 4; and Q 1 represents an optionally substituted phenyl group, an optionally substituted naphthyl group or an optionally substituted heterocyclic group; Q 2 represents a phenyl group or heterocyclic group having one or more substituents, at least one of the substituent being any of a C1-C4 haloalkoxy group, a C2-C6 perfluoroalkyl group, a C1-C6 perfluoroalkylthio group, a C1-C6 perfluoroalkylsulfinyl group and a C1-C6 perfluoroalkylsulfonyl group, an insecticide comprising the compound as the active ingredient, and a process for preparation thereof.

公开(公告)号：EP2981522A4

公开(公告)日：2016-08-31

申请号：EP14778531

申请日：2014-04-04

申请人： SALK INST FOR BIOLOGICAL STUDI ,  MITOBRIDGE INC

发明人： EVANS RONALD ,  BAIGA THOMAS J ,  BOCK MARK G ,  DOWNES MICHAEL ,  EMBLER EMI KANAKUBO ,  FAN WEIWEI ,  KEANA JOHN F W ,  KLUGE ARTHUR F ,  NOEL JOSEPH P ,  PATANE MIKE A

IPC分类号： C07D213/56 ,  A61K31/166 ,  A61K31/19 ,  A61K31/215 ,  A61K31/341 ,  A61K31/381 ,  A61K31/415 ,  A61K31/4155 ,  C07C233/24 ,  C07C233/87 ,  C07C235/34 ,  C07C237/06 ,  C07C259/06 ,  C07D231/12 ,  C07D295/15 ,  C07D307/54 ,  C07D333/24 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

CPC分类号： C07C233/87 ,  A61K31/164 ,  A61K31/341 ,  A61K31/381 ,  A61K31/4025 ,  A61K31/4178 ,  A61K31/422 ,  A61K31/427 ,  A61K31/44 ,  A61K31/5377 ,  C07C233/73 ,  C07C235/42 ,  C07C235/48 ,  C07C235/84 ,  C07C237/22 ,  C07C237/32 ,  C07C237/48 ,  C07C255/57 ,  C07C259/06 ,  C07C317/44 ,  C07C2101/02 ,  C07C2601/02 ,  C07D207/04 ,  C07D209/34 ,  C07D213/56 ,  C07D231/12 ,  C07D271/12 ,  C07D295/13 ,  C07D305/06 ,  C07D307/54 ,  C07D307/83 ,  C07D309/06 ,  C07D333/24 ,  C07D405/04 ,  C07D405/10 ,  C07D405/12 ,  C07D407/12 ,  C07D413/04 ,  C07D413/10 ,  C07D413/12 ,  C07D417/04 ,  C07D417/10 ,  C07D417/12

摘要： Provided herein are compounds and compositions useful in increasing PPARδ activity. The compounds and compositions provided herein are useful for the treatment of PPARδ related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).

摘要翻译： 本文提供了可用于增加PPARδ活性的化合物和组合物。 本文提供的化合物和组合物可用于治疗PPARδ相关疾病（例如肌肉疾病，血管疾病，脱髓鞘疾病和代谢疾病）。

公开(公告)号：EP2725013A4

公开(公告)日：2014-12-03

申请号：EP12804621

申请日：2012-06-26

申请人： SINOPHARM A THINK PHARMACEUTICAL CO LTD ,  SHANGHAI INST PHARM INDUSTRY

发明人： LI JIANQI ,  ZHANG QINGWEI ,  JIA ZHIDAN ,  WANG JIAJING

IPC分类号： C07D209/04 ,  A61K31/166 ,  A61K31/44 ,  A61K31/444 ,  A61P5/00 ,  A61P25/00 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00 ,  C07C233/88 ,  C07D213/02 ,  C07D235/02 ,  C07D271/12 ,  C07D283/00 ,  C07D307/77 ,  C07D327/02 ,  C07D333/52

CPC分类号： C07C237/48 ,  C07C237/42 ,  C07D209/42 ,  C07D213/75 ,  C07D235/24 ,  C07D307/85 ,  C07D307/87 ,  C07D307/88 ,  C07D333/70 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

摘要： Disclosed in the present invention is a novel histone deacetylase inhibitor of benzamides and use thereof. The inhibitor has good efficacy in treating diseases caused by abnormal gene expression, such as tumours, endocrine disorders, immune system diseases, genetic diseases and nerve system diseases. The histone deacetylase inhibitor of benzamides is a compound of the following general chemical structural formula (I) or a salt thereof.

公开(公告)号：EP1648859B1

公开(公告)日：2013-02-27

申请号：EP04756012.3

申请日：2004-06-25

申请人： Paratek Pharmaceuticals, Inc.

发明人： NELSON, Mark, L. ,  OHEMENG, Kwasi ,  AMOO, Victor ,  KIM, Oak ,  ABATO, Paul ,  ASSEFA, Haregewein ,  BERNIAC, Joel ,  BHATIA, Beena ,  BOWSER, Todd ,  CHEN, Jackson ,  GRIER, Mark ,  HONEYMAN, Laura ,  ISMAIL, Mohamed, Y. ,  MECHICHE, Rachid ,  MATHEWS, Jude

IPC分类号： C07C237/26 ,  C07C271/22 ,  C07C271/54 ,  C07C275/28 ,  C07C275/30

CPC分类号： C07C237/48 ,  A61K31/65 ,  C07C237/26 ,  C07C271/22 ,  C07C271/54 ,  C07C275/28 ,  C07C275/30 ,  C07C2601/02 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2603/46

摘要： A compound of Formula I: wherein: X is CHC(R 13 Y'Y), CR 6' R 6 , S, NR 6 , or O; R 2 , R 2' , R 4' , and R 4" are each independently hydrogen, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, arylalkyl, aryl, heterocyclic, heteroaromatic or a prodrug moiety; R 4 is NR 4' R 4" , alkyl, alkenyl, alkynyl, hydroxyl, halogen, or hydrogen; R 2' , R 3 , R 10 , R 11 and R 12 are each hydrogen or a pro-drug moiety; R 5 is hydroxyl, hydrogen, thiol, alkanoyl, aroyl, alkaroyl, aryl, heteroaromatic, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, arylalkyl, alkyl carbonyloxy, or aryl carbonyloxy; R 6 and R 6' are each independently hydrogen, methylene, absent, hydroxyl, halogen, thiol, alkyl, alkenyl, alkynyl, aryl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, or an arylalkyl; R 7 is ethyl, perhalogenated alkenyl, substituted pyridinyl, pyrazinyl, furanyl, or pyrazolyl; R 8 is hydrogen, hydroxyl, halogen, thiol, alkyl, alkenyl, alkynyl, aryl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, or an arylalkyl; R 9 -CH 2 NR 9a R 9b ; R 9a and R 9b are each independently hydrogen, alkyl, alkenyl or linked to form a heterocycle; R 13 is hydrogen, hydroxy, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, or an arylalkyl; and Y' and Y are each independently hydrogen, halogen, hydroxyl, cyano, sulfhydryl, amino, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, or an arylalkyl, or a pharmaceutically acceptable salt thereof.

公开(公告)号：EP2231585B1

公开(公告)日：2013-02-13

申请号：EP08859864.4

申请日：2008-12-10

申请人： Theravance, Inc.

发明人： TRAPP, Sean, G. ,  LEADBETTER, Michael, R. ,  LONG, Daniel, D. ,  JACOBSEN, John, R. ,  VAN DYKE, Priscilla ,  COLSON, Pierre-Jean ,  RAPTA, Miroslav ,  YU, Ying

IPC分类号： C07C215/64 ,  C07C229/28 ,  C07C237/48 ,  A61K31/216 ,  A61K31/197 ,  A61P1/00

CPC分类号： C07C237/48 ,  A61K9/0075 ,  A61K9/2054 ,  A61K9/4858 ,  A61K31/197 ,  A61K31/485 ,  A61K45/06 ,  A61K47/02 ,  A61K47/12 ,  C07B2200/07 ,  C07C215/64 ,  C07C229/28 ,  C07C229/34 ,  C07C2601/14 ,  C07C2602/10 ,  Y10T436/173845

公开(公告)号：EP2509596A2

公开(公告)日：2012-10-17

申请号：EP10836598.2

申请日：2010-12-08

申请人： Case Western Reserve University

发明人： PALCZEWSKI, Krzysztof ,  MAEDA, Akiko ,  GOLCZAK, Marcin

IPC分类号： A61K31/428 ,  A61K31/4162 ,  A61K31/4184 ,  A61K31/56 ,  A61K9/22 ,  A61K9/20 ,  A61P27/02

CPC分类号： C07D487/04 ,  A61K9/0048 ,  A61K31/197 ,  A61K31/4162 ,  A61K31/4184 ,  A61K31/428 ,  A61K31/56 ,  C07C211/01 ,  C07C229/12 ,  C07C229/60 ,  C07C229/64 ,  C07C237/48 ,  C07C251/58 ,  C07C317/36 ,  C07D261/04

摘要： A method of treating an ocular disorder in a subject associated with aberrant all-trans-retinal clearance in the retina, the method comprising administering to the subject a therapeutically effective amount of a primary amine compound of formula: wherein R1 is an aliphatic and/or aromatic compound.

公开(公告)号：EP2332904A3

公开(公告)日：2012-04-11

申请号：EP11159024.6

申请日：2005-01-18

申请人： Paratek Pharmaceuticals, Inc.

发明人： Nelson, Mark

IPC分类号： C07C237/48 ,  A61K31/65 ,  A61P31/04

CPC分类号： C07C237/48 ,  C07C237/26 ,  C07C2603/46

摘要： Derivatives of tetracycline compounds of the formula (II), (III), (IV) or (I) are described.
The compounds are useful as antibiotics.



or

公开(公告)号：EP2319828A3

公开(公告)日：2011-07-06

申请号：EP10184700.2

申请日：2004-06-25

申请人： Paratek Pharmaceuticals, Inc.

发明人： Nelson, Mark, L. ,  Amoo, Victor ,  Kim, Oak, K. ,  Abato, Paul ,  Ohemeng, Kwasi ,  Assefa, Haregwein ,  Berniac, Joel ,  Bhatia, Beena ,  Bowser, Todd ,  Chen, Jackson ,  Grier, Mark ,  Honeyman, Laura ,  Ismail, Mohamed, Y. ,  Mechiche, Rachid ,  Mathews, Jude

IPC分类号： C07C237/26 ,  A61K31/65

CPC分类号： C07C237/48 ,  A61K31/65 ,  C07C237/26 ,  C07C271/22 ,  C07C271/54 ,  C07C275/28 ,  C07C275/30 ,  C07C2601/02 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2603/46

摘要： A compound selected from the group consisting of:

































and pharmaceutically acceptable salts, esters and prodrugs thereof.

公开(公告)号：EP2319828A2

公开(公告)日：2011-05-11

申请号：EP10184700.2

申请日：2004-06-25

申请人： Paratek Pharmaceuticals, Inc.

发明人： Nelson, Mark, L. ,  Amoo, Victor ,  Kim, Oak, K. ,  Abato, Paul ,  Ohemeng, Kwasi ,  Assefa, Haregwein ,  Berniac, Joel ,  Bhatia, Beena ,  Bowser, Todd ,  Chen, Jackson ,  Grier, Mark ,  Honeyman, Laura ,  Ismail, Mohamed, Y. ,  Mechiche, Rachid ,  Mathews, Jude

IPC分类号： C07C237/26 ,  A61K31/65

CPC分类号： C07C237/48 ,  A61K31/65 ,  C07C237/26 ,  C07C271/22 ,  C07C271/54 ,  C07C275/28 ,  C07C275/30 ,  C07C2601/02 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2603/46

摘要： A compound selected from the group consisting of:




























and pharmaceutically acceptable salts, esters and prodrugs thereof.

摘要翻译： 选自以下的化合物及其药学上可接受的盐，酯和前药：