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公开(公告)号：EP3898247B1
公开(公告)日：2022-11-02
申请号：EP19831695.2
申请日：2019-12-19
发明人： HORN, Michael , STALLING, Timo
IPC分类号： B41M5/333 , C07C311/15 , C07C311/21 , C07C317/14 , C07C317/26 , B41M5/327 , B41M5/337 , C07C317/42
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公开(公告)号：EP3993793A1
公开(公告)日：2022-05-11
申请号：EP20835213.8
申请日：2020-06-29
申请人： Qian, Ligang , Zhang, Chunbo
发明人： Qian, Ligang , Zhang, Chunbo
IPC分类号： A61K31/445 , C07C311/15 , C07D401/12
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公开(公告)号：EP2921476B1
公开(公告)日：2018-05-16
申请号：EP15157382.1
申请日：2015-03-03
申请人： Lanxess Ltd.
发明人： Stevens, Russel
IPC分类号： C07C303/36 , C07C311/15 , C08J9/00 , C08J9/10 , C08K3/26 , C08K5/25
CPC分类号： C08J9/105 , C08J9/0023 , C08J9/0033 , C08J9/08 , C08J2203/02 , C08J2203/04 , C08J2203/18 , C08J2300/22 , C08J2300/26 , C08J2327/06
摘要： The present invention relates to a new composition comprising 4,4'-oxybis(benzenesulfonylhydrazide) (OBSH) and sodium hydrogen carbonate (SBC), process for the manufacturing thereof and its use as blowing agent for the manufacturing of expanded thermoplastic materials and rubber compounds.
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公开(公告)号：EP3212196A1
公开(公告)日：2017-09-06
申请号：EP15854524.4
申请日：2015-10-29
发明人： RAINES, Ronald T. , WINDSOR, Ian , PALTE, Michael , LUKESH, John
IPC分类号： A61K31/69 , A61P31/18 , C07C311/15
CPC分类号： C07F5/025 , A61K31/00 , A61K31/34 , A61K31/341 , A61K31/366 , A61K31/427 , A61K31/44 , A61K31/4433 , A61K31/69 , A61K33/22 , A61K2300/00
摘要： Protease inhibitors, particularly aspartyl protease inhibitors, and more particularly HIV protease inhibitors which are boronated to enhance activity or to enhance entry into cells. Compounds, prodrugs and salts thereof of this invention contain phenylboronate groups, in particular p -B(OH)2-phenyl groups, benzoxaborole groups or borono-pyridyl groups or analogous groups in which the boronate group is protected. Methods for treating AIDS and ARC as well as providing a method for treating or preventing HIV infection.
摘要翻译： 蛋白酶抑制剂，特别是天冬氨酰蛋白酶抑制剂，更特别是硼化以增强活性或增强进入细胞的HIV蛋白酶抑制剂。 本发明的化合物，前药和盐包含苯基硼酸酯基团，特别是p-B（OH）2 - 苯基基团，苯并氧杂硼杂环戊二烯基团或硼代吡啶基团或其中硼酸酯基团被保护的类似基团。 治疗艾滋病和ARC的方法以及提供治疗或预防HIV感染的方法。
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公开(公告)号：EP1507756B1
公开(公告)日：2015-07-22
申请号：EP03755422.7
申请日：2003-05-21
IPC分类号： C07C311/14 , C07C311/15 , C07D213/02 , C07D237/06 , C07D239/69 , A61K31/18 , A61K31/44 , A61K31/4965 , A61K31/505 , A61P29/00
CPC分类号： C07C311/29 , C07C311/21 , C07C311/44 , C07C311/46 , C07C317/34 , C07C323/49 , C07D213/46 , C07D213/50 , C07D213/65 , C07D213/70 , C07D213/71 , C07D213/75 , C07D213/76 , C07D213/80 , C07D213/89 , C07D237/08 , C07D239/26 , C07D239/42 , C07D333/34 , C07D333/62 , C07D401/06 , C07D405/06 , C07D409/04 , C07D409/06 , C07D413/04 , C07D413/14 , C07D513/04
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6.发明公开
公开(公告)号：EP2155711A1
公开(公告)日：2010-02-24
申请号：EP08770082.9
申请日：2008-06-04
申请人： Sanofi-Aventis
发明人： CAULFIELD, Thomas, J. , CLEMENS, Jennifer , FRANCIS, Robert S. , FREED, Brian S. , JOHN, Stanly , LE, Tieu-Binh , PEDGRIFT, Brian , RAMOS, Antonio D. , ROSSE, Gerard , SMRCINA, Martin , THORPE, David S. , WIRE, William , ZHAO, Jianhong
IPC分类号： C07D333/68 , C07D333/78 , C07C233/63 , C07C235/54 , C07C235/84 , C07C311/15 , C07C317/14 , C07C323/62 , A61K31/33 , A61K31/16 , A61P11/06 , A61P19/02 , A61P29/00
CPC分类号： C07D333/78 , C07C233/52 , C07C233/63 , C07C233/81 , C07C235/42 , C07C235/54 , C07C235/62 , C07C235/84 , C07C237/42 , C07C255/13 , C07C255/57 , C07C311/09 , C07C311/29 , C07C317/44 , C07C323/62 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07C2603/26 , C07C2603/28 , C07C2603/74 , C07D213/81 , C07D307/79 , C07D333/68 , C07D401/04
摘要： The present invention relates to novel compounds of the formula Ia: in any of its stereoisomeric forms or a mixture of stereoisomeric forms in any ratio, or a physiologically acceptable salt thereof, wherein the substituents are as described herein. The inventive compounds have CXCR5 inhibitory activity, and are particularly useful in treating or preventing various inflammatory diseases, such as rheumatoid arthritis, multiple sclerosis, lupus, Crohn's Disease, associated with the modulation of the human CXCR5 receptor.
摘要翻译： 本发明涉及式Ia的新型化合物：其任何立体异构形式或任何比例的立体异构形式的混合物或其生理学上可接受的盐，其中取代基如本文所述。 本发明化合物具有CXCR5抑制活性，并且特别可用于治疗或预防与人CXCR5受体的调节相关的各种炎性疾病，例如类风湿性关节炎，多发性硬化，狼疮，克罗恩病。
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公开(公告)号：EP1476423A4
公开(公告)日：2005-12-14
申请号：EP03735124
申请日：2003-01-29
申请人： TULARIK INC
发明人： JIAO XIAN YUN , KAYSER FRANK , KOPECKY DAVID J , MCKENDRY SHARON , PIPER DEREK E , SHIAU ANDREW K
IPC分类号： C07D233/64 , A61K31/18 , A61K31/196 , A61K31/216 , A61K31/277 , A61K31/381 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/4174 , A61K31/4184 , A61K31/426 , A61K31/4402 , A61K31/4406 , A61K31/50 , A61K31/505 , A61K31/695 , A61K45/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/10 , A61P35/04 , A61P43/00 , C07C311/21 , C07C317/32 , C07D207/32 , C07D207/33 , C07D207/333 , C07D207/335 , C07D213/30 , C07D231/12 , C07D233/54 , C07D235/12 , C07D237/02 , C07D239/26 , C07D257/04 , C07D263/02 , C07D277/22 , C07D277/24 , C07D333/34 , C07F7/08 , C07F7/10 , C07C311/08 , A61K31/625 , A61K31/63 , C07C311/13 , C07C311/15 , C07C311/16 , C07C311/20
CPC分类号： C07D207/33 , C07C311/21 , C07C317/32 , C07C2601/08 , C07C2601/16 , C07D207/333 , C07D207/335 , C07D213/30 , C07D213/42 , C07D231/12 , C07D233/61 , C07D233/64 , C07D235/12 , C07D235/14 , C07D239/26 , C07D257/04 , C07D277/24 , C07D277/28 , C07D333/34 , C07F7/0818
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公开(公告)号：EP1476423A2
公开(公告)日：2004-11-17
申请号：EP03735124.4
申请日：2003-01-29
申请人： Tularik Inc.
发明人： JIAO, Xian, Yun , KAYSER, Frank , KOPECKY, David, J. , MCKENDRY, Sharon , PIPER, Derek, E. , SHIAU, Andrew, K.
IPC分类号： C07C311/08 , C07C311/13 , C07C311/15 , C07C311/16 , C07C311/20 , C07C311/21 , A61K31/18 , A61K31/625 , A61K31/63 , A61P3/04 , A61P3/06
CPC分类号： C07D207/33 , C07C311/21 , C07C317/32 , C07C2601/08 , C07C2601/16 , C07D207/333 , C07D207/335 , C07D213/30 , C07D213/42 , C07D231/12 , C07D233/61 , C07D233/64 , C07D235/12 , C07D235/14 , C07D239/26 , C07D257/04 , C07D277/24 , C07D277/28 , C07D333/34 , C07F7/0818
摘要： Arylsulfonamidobenzyl alcohols, amines and sulfonamides are provided which are useful in treating lipid disorders, metabolic diseases and cell-proliferative diseases.
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9.发明授权N-SUBSTITUTED AMINOTETRALINS AS LIGANDS FOR THE NEUROPEPTIDE Y Y5 RECEPTOR USEFUL IN THE TREATMENT OF OBESITY AND OTHER DISORDERS 有权N-取代AS氨基萘满神经肽Y Y5受体配体和它们用于肥胖等疾病的治疗
公开(公告)号：EP1076644B1
公开(公告)日：2004-06-23
申请号：EP99918500.2
申请日：1999-04-12
发明人： DAX, Scott, L. , LOVENBERG, Timothy, Walter , MCNALLY, James, J. , REITZ, Allen, B. , YOUNGMAN, Mark, Andrew
IPC分类号： C07C311/15 , C07C311/20 , C07C311/21 , C07C311/37 , C07C311/25 , C07D333/34 , C07D213/38 , C07D233/54 , C07D307/52 , C07D333/20 , A61K31/18 , A61K31/44 , A61K31/34 , A61K31/38 , A61K31/415
CPC分类号： C07D233/64 , C07C311/18 , C07C311/29 , C07C311/37 , C07C317/14 , C07D213/38 , C07D307/52 , C07D333/20 , C07D333/34
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公开(公告)号：EP0896531A4
公开(公告)日：2002-10-30
申请号：EP96929723
申请日：1996-08-21
发明人： WIDDOWSON KATHERINE LOUISA , VEBER DANIEL FRANK , JUREWICZ ANTHONY JOSEPH , RUTLEDGE MELVIN CLARENCE JR , HERTZBERG ROBERT PHILIP
IPC分类号： A61K31/17 , A61K31/18 , A61K31/223 , A61K31/275 , A61K31/277 , A61K31/36 , A61K31/381 , A61K31/426 , A61K31/47 , A61P29/00 , A61P37/00 , C07C253/14 , C07C255/53 , C07C275/34 , C07C275/36 , C07C275/38 , C07C275/40 , C07C275/42 , C07C307/04 , C07C307/10 , C07C309/15 , C07C311/10 , C07C311/13 , C07C311/15 , C07C311/21 , C07C311/29 , C07C311/46 , C07C317/42 , C07C323/44 , C07C335/16 , C07C335/18 , C07D213/30 , C07D213/71 , C07D215/36 , C07D217/02 , C07D277/36 , C07D277/46 , C07D317/66 , C07D333/28 , C07D333/34 , C07D333/36 , C07D409/04
CPC分类号： C07D213/30 , A61K31/17 , A61K31/18 , A61K31/223 , A61K31/275 , A61K31/277 , A61K31/36 , A61K31/381 , A61K31/426 , A61K31/47 , C07C275/34 , C07C275/38 , C07C275/40 , C07C275/42 , C07C307/10 , C07C309/15 , C07C311/10 , C07C311/13 , C07C311/21 , C07C311/29 , C07C311/46 , C07C317/42 , C07C323/44 , C07C335/18 , C07C2602/08 , C07C2603/18 , C07D213/71 , C07D215/36 , C07D217/02 , C07D277/36 , C07D277/46 , C07D317/66 , C07D333/28 , C07D333/34 , C07D333/36 , C07D409/04
摘要： This invention relates to the novel use of phenyl ureas in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
摘要翻译： 本发明涉及苯脲类治疗由趋化因子介导的疾病状态白细胞介素-8（IL-8）的新用途。
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